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Roles of the PrRP-oxytocin system in the control of stress and social behavior

Research Project

Project/Area Number 26293049
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Environmental physiology(including physical medicine and nutritional physiology)
Research InstitutionJichi Medical University

Principal Investigator

Onaka Tatsushi  自治医科大学, 医学部, 教授 (90177254)

Research Collaborator TAKAYAHAGI Yuki  
YOSHID Masahide  
INUTSUKA Ayumu  
OKABE Shota  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
KeywordsPrRP / オキシトシン / ストレス / オキシトシン受容体 / 社会的敗北
Outline of Final Research Achievements

I have previously shown that the medullary prolactin releasing peptide (PrRP)-producing neuron-hypothalamic oxytocin-producing neuron system is activated by food intake and that activation of the PrRP-oxytocin system terminates food intake. In the preset study, I investigated physiological roles of the PrRP-oxytocin system in the control of conditioned fear or social stress-related responses. The PrRP-oxytocin system was activated following conditioned fear and social defeat stimuli. PrRP deficiency facilitated freezing behavior during conditioned fear stimuli, suggesting inhibitory roles of PrRP in conditioned fear-induced freezing behavior. On the other hand, oxytocin receptor deficiency attenuated defeat posture during social defeat stress, suggesting facilitative roles of oxytocin in the social defeat posture. All these data are consistent with a view that the PrRP-oxytocin system plays different roles in the control of stress responses dependent upon stressful stimuli used.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (18 results)

All 2017 2016 2015 2014

All Journal Article (8 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results,  Acknowledgement Compliant: 4 results) Presentation (10 results) (of which Int'l Joint Research: 1 results,  Invited: 7 results)

  • [Journal Article] Activation of supraoptic oxytocin neurons by secretin facilitates social recognition.2015

    • Author(s)
      Takayanagi Y, Yoshida M, Takashima A, Takanami K, Yoshida S, Nishimori K, Nishijima I, Sakamoto H, Yamagata T, Onaka T
    • Journal Title

      Biological Psychiatry

      Volume: in press Issue: 3 Pages: 243-251

    • DOI

      10.1016/j.biopsych.2015.11.021

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Activation of hypothalamic oxytocin neurons following tactile stimuli in rats.2015

    • Author(s)
      Okabe S, Yoshida M, Takayanagi Y, Onaka T
    • Journal Title

      Neuroscience Letters

      Volume: 600 Pages: 22-27

    • DOI

      10.1016/j.neulet.2015.05.055

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Noxious or Non-Noxious Inputs to Oxytocin Neurons: Possible Roles in the Control of Behaviors.2015

    • Author(s)
      Onaka T, Okabe S, Takayanagi Y, Yoshida M
    • Journal Title

      Interdisciplinary Information Sciences

      Volume: 21 Issue: 3 Pages: 189-195

    • DOI

      10.4036/iis.2015.b.03

    • NAID

      110009966527

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] オキシトシンと社会的行動2015

    • Author(s)
      尾仲達史
    • Journal Title

      Clinical Neuroscience

      Volume: 33 Pages: 177-181

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 不安・恐怖とオキシトシン2015

    • Author(s)
      尾仲達史、吉田匡秀、高柳友紀
    • Journal Title

      アンチエイジング医学

      Volume: 11 Pages: 24-33

    • Related Report
      2014 Annual Research Report
  • [Journal Article] The medial amygdala - medullary PrRP-synthesizing neuron pathway mediates neuroendocrine responses to contextual conditioned fear in male rodents.2014

    • Author(s)
      Yoshida M, Takayanagi Y, Onaka T
    • Journal Title

      Endocrinology

      Volume: 155 Issue: 8 Pages: 2996-3004

    • DOI

      10.1210/en.2013-1411

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] ストレス・摂食・社会行動の相互作用:オキシトシンの働き2014

    • Author(s)
      尾仲達史
    • Journal Title

      心身医学

      Volume: 54 Pages: 643-656

    • Related Report
      2014 Annual Research Report
  • [Journal Article] オキシトシンの働きと老化2014

    • Author(s)
      尾仲達史
    • Journal Title

      最新医学

      Volume: 69 Pages: 1021-1031

    • Related Report
      2014 Annual Research Report
  • [Presentation] オキシトシンとストレス、エネルギー代謝、社会行動2017

    • Author(s)
      尾仲達史
    • Organizer
      第90回日本内分泌学会学術総会
    • Place of Presentation
      ロームシアター京都・京都勧業館みやこめっせ(京都府京都市)
    • Year and Date
      2017-04-20
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] オキシトシンをめぐる最近の話題2016

    • Author(s)
      尾仲達史
    • Organizer
      第43回日本神経内分泌学会学術集会
    • Place of Presentation
      アクトシティ浜松 コングレスセンター(静岡県浜松市)
    • Year and Date
      2016-10-14
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] オキシトシンとストレス感受性2016

    • Author(s)
      尾仲達史
    • Organizer
      第9回脳・神経・内分泌系から運動の意義を考える会
    • Place of Presentation
      岩手県民情報交流センター(アイーナ)(岩手県盛岡市)
    • Year and Date
      2016-09-22
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 幸せホルモンとエイジング2016

    • Author(s)
      尾仲達史
    • Organizer
      第10回見た目のアンチエイジング研究会
    • Place of Presentation
      東京大学伊藤国際学術研究センター(東京都文京区)
    • Year and Date
      2016-07-17
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Neuroendocrine and behavioral responses to fear-related or affiliative stimuli: roles of oxytocin.2016

    • Author(s)
      Onaka T, Takayanagi Y, Yoshida M, Okabe S
    • Organizer
      The 93rd Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      札幌
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 接触刺激に対するラット視床下部オキシトシン産生細胞の活性化と超音波発声2015

    • Author(s)
      岡部祥太、吉田匡秀、高柳友紀、尾仲達史
    • Organizer
      第42回日本神経内分泌学会 第23回日本神経行動内分泌研究会 合同学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2015-09-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Noxious or Non-Noxious Inputs to Oxytocin Neurons: Possible Roles in the Control of Behaviors.2015

    • Author(s)
      Onaka T, Takayanagi Y, Yoshida M, Okabe S
    • Organizer
      Parvo- and Magnocellular Symposium in Senda
    • Place of Presentation
      Sendai
    • Year and Date
      2015-09-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] オキシトシンによる情動・社会行動の制御.2015

    • Author(s)
      高柳友紀、吉田匡秀、尾仲達史
    • Organizer
      第92回日本生理学会大会
    • Place of Presentation
      神戸国際会議場・展示場
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 条件恐怖ストレスの神経内分泌反応における内側扁桃体の働き2015

    • Author(s)
      尾仲達史、吉田匡秀、高柳友紀
    • Organizer
      第92回日本生理学会大会
    • Place of Presentation
      神戸国際会議場・展示場
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Lesions of vasopressin neurons by use of vasopressin-DTR transgenic rats.2014

    • Author(s)
      Onaka T, Yoshida M, Takayanagi Y
    • Organizer
      Satellite meeting of ICN 2014 in Sydney“Recent and Future Trends in Neuroendocrinology-from Asia and Oceania to Global-”
    • Place of Presentation
      Sydney
    • Year and Date
      2014-08-16
    • Related Report
      2014 Annual Research Report
    • Invited

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Published: 2014-04-04   Modified: 2018-03-22  

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