| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
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| Outline of Final Research Achievements |
I have previously shown that the medullary prolactin releasing peptide (PrRP)-producing neuron-hypothalamic oxytocin-producing neuron system is activated by food intake and that activation of the PrRP-oxytocin system terminates food intake. In the preset study, I investigated physiological roles of the PrRP-oxytocin system in the control of conditioned fear or social stress-related responses. The PrRP-oxytocin system was activated following conditioned fear and social defeat stimuli. PrRP deficiency facilitated freezing behavior during conditioned fear stimuli, suggesting inhibitory roles of PrRP in conditioned fear-induced freezing behavior. On the other hand, oxytocin receptor deficiency attenuated defeat posture during social defeat stress, suggesting facilitative roles of oxytocin in the social defeat posture. All these data are consistent with a view that the PrRP-oxytocin system plays different roles in the control of stress responses dependent upon stressful stimuli used.
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