Roles of the PrRP-oxytocin system in the control of stress and social behavior

• Project/Area Number: 26293049
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: Jichi Medical University
• Principal Investigator: Onaka Tatsushi 自治医科大学, 医学部, 教授 (90177254)
• Research Collaborator: TAKAYAHAGI Yuki ; YOSHID Masahide ; INUTSUKA Ayumu ; OKABE Shota
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000); Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2014: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
• Keywords: PrRP / オキシトシン / ストレス / オキシトシン受容体 / 社会的敗北

Outline of Final Research Achievements

I have previously shown that the medullary prolactin releasing peptide (PrRP)-producing neuron-hypothalamic oxytocin-producing neuron system is activated by food intake and that activation of the PrRP-oxytocin system terminates food intake. In the preset study, I investigated physiological roles of the PrRP-oxytocin system in the control of conditioned fear or social stress-related responses. The PrRP-oxytocin system was activated following conditioned fear and social defeat stimuli. PrRP deficiency facilitated freezing behavior during conditioned fear stimuli, suggesting inhibitory roles of PrRP in conditioned fear-induced freezing behavior. On the other hand, oxytocin receptor deficiency attenuated defeat posture during social defeat stress, suggesting facilitative roles of oxytocin in the social defeat posture. All these data are consistent with a view that the PrRP-oxytocin system plays different roles in the control of stress responses dependent upon stressful stimuli used.

Research Products

• [Journal Article] Activation of supraoptic oxytocin neurons by secretin facilitates social recognition. (2015)
  • Author(s): Takayanagi Y, Yoshida M, Takashima A, Takanami K, Yoshida S, Nishimori K, Nishijima I, Sakamoto H, Yamagata T, Onaka T
  • Journal Title: Biological Psychiatry Volume: in press Issue: 3 Pages: 243-251
  • DOI: 10.1016/j.biopsych.2015.11.021
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Activation of hypothalamic oxytocin neurons following tactile stimuli in rats. (2015)
  • Author(s): Okabe S, Yoshida M, Takayanagi Y, Onaka T
  • Journal Title: Neuroscience Letters Volume: 600 Pages: 22-27
  • DOI: 10.1016/j.neulet.2015.05.055
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Noxious or Non-Noxious Inputs to Oxytocin Neurons: Possible Roles in the Control of Behaviors. (2015)
  • Author(s): Onaka T, Okabe S, Takayanagi Y, Yoshida M
  • Journal Title: Interdisciplinary Information Sciences Volume: 21 Issue: 3 Pages: 189-195
  • DOI: 10.4036/iis.2015.b.03
  • NAID: 110009966527
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] オキシトシンと社会的行動 (2015)
  • Author(s): 尾仲達史
  • Journal Title: Clinical Neuroscience Volume: 33 Pages: 177-181
• [Journal Article] 不安・恐怖とオキシトシン (2015)
  • Author(s): 尾仲達史、吉田匡秀、高柳友紀
  • Journal Title: アンチエイジング医学 Volume: 11 Pages: 24-33
• [Journal Article] The medial amygdala - medullary PrRP-synthesizing neuron pathway mediates neuroendocrine responses to contextual conditioned fear in male rodents. (2014)
  • Author(s): Yoshida M, Takayanagi Y, Onaka T
  • Journal Title: Endocrinology Volume: 155 Issue: 8 Pages: 2996-3004
  • DOI: 10.1210/en.2013-1411
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] ストレス・摂食・社会行動の相互作用：オキシトシンの働き (2014)
  • Author(s): 尾仲達史
  • Journal Title: 心身医学 Volume: 54 Pages: 643-656
• [Journal Article] オキシトシンの働きと老化 (2014)
  • Author(s): 尾仲達史
  • Journal Title: 最新医学 Volume: 69 Pages: 1021-1031
• [Presentation] オキシトシンとストレス、エネルギー代謝、社会行動 (2017)
  • Author(s): 尾仲達史
  • Organizer: 第90回日本内分泌学会学術総会
  • Place of Presentation: ロームシアター京都・京都勧業館みやこめっせ（京都府京都市）
  • Year and Date: 2017-04-20
  • Invited
• [Presentation] オキシトシンをめぐる最近の話題 (2016)
  • Author(s): 尾仲達史
  • Organizer: 第43回日本神経内分泌学会学術集会
  • Place of Presentation: アクトシティ浜松 コングレスセンター（静岡県浜松市）
  • Year and Date: 2016-10-14
  • Invited
• [Presentation] オキシトシンとストレス感受性 (2016)
  • Author(s): 尾仲達史
  • Organizer: 第9回脳・神経・内分泌系から運動の意義を考える会
  • Place of Presentation: 岩手県民情報交流センター（アイーナ）（岩手県盛岡市）
  • Year and Date: 2016-09-22
  • Invited
• [Presentation] 幸せホルモンとエイジング (2016)
  • Author(s): 尾仲達史
  • Organizer: 第10回見た目のアンチエイジング研究会
  • Place of Presentation: 東京大学伊藤国際学術研究センター（東京都文京区）
  • Year and Date: 2016-07-17
  • Invited
• [Presentation] Neuroendocrine and behavioral responses to fear-related or affiliative stimuli: roles of oxytocin. (2016)
  • Author(s): Onaka T, Takayanagi Y, Yoshida M, Okabe S
  • Organizer: The 93rd Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: 札幌
  • Year and Date: 2016-03-22
• [Presentation] 接触刺激に対するラット視床下部オキシトシン産生細胞の活性化と超音波発声 (2015)
  • Author(s): 岡部祥太、吉田匡秀、高柳友紀、尾仲達史
  • Organizer: 第42回日本神経内分泌学会 第23回日本神経行動内分泌研究会 合同学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2015-09-18
• [Presentation] Noxious or Non-Noxious Inputs to Oxytocin Neurons: Possible Roles in the Control of Behaviors. (2015)
  • Author(s): Onaka T, Takayanagi Y, Yoshida M, Okabe S
  • Organizer: Parvo- and Magnocellular Symposium in Senda
  • Place of Presentation: Sendai
  • Year and Date: 2015-09-17
  • Int'l Joint Research / Invited
• [Presentation] オキシトシンによる情動・社会行動の制御. (2015)
  • Author(s): 高柳友紀、吉田匡秀、尾仲達史
  • Organizer: 第92回日本生理学会大会
  • Place of Presentation: 神戸国際会議場・展示場
  • Year and Date: 2015-03-21 – 2015-03-23
• [Presentation] 条件恐怖ストレスの神経内分泌反応における内側扁桃体の働き (2015)
  • Author(s): 尾仲達史、吉田匡秀、高柳友紀
  • Organizer: 第92回日本生理学会大会
  • Place of Presentation: 神戸国際会議場・展示場
  • Year and Date: 2015-03-21 – 2015-03-23
  • Invited
• [Presentation] Lesions of vasopressin neurons by use of vasopressin-DTR transgenic rats. (2014)
  • Author(s): Onaka T, Yoshida M, Takayanagi Y
  • Organizer: Satellite meeting of ICN 2014 in Sydney“Recent and Future Trends in Neuroendocrinology-from Asia and Oceania to Global-”
  • Place of Presentation: Sydney
  • Year and Date: 2014-08-16
  • Invited