Post-GWAS study for identification of druggable target of AF

• Project/Area Number: 26293052
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: General pharmacology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: FURUKAWA Tetsushi 東京医科歯科大学, 難治疾患研究所, 教授 (80251552)
• Co-Investigator(Renkei-kenkyūsha): 笹野 哲郎 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (00466898) ; 井原 健介 東京医科歯科大学, 難治疾患研究所, 教授 (50770210)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000); Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
• Keywords: 心房細動 / ゲノムワイド関連解析 / 1塩基多型 / GWAS / 酸化ストレス / 交感神経 / 不整脈 / 遺伝子多型 / 薬理学 / 循環器・高血圧 / マイクロRNA

Outline of Final Research Achievements

Genome-wide association study (GWAS) has been introduced as a tool to examine genetic risk of common diseases and to deploy personalized medicine. As a by-product of GWAS, it is also expected to identify novel pathogenic pathways and thus novel druggable targets. Atrial fibrillation (AF) is the most frequent arrhythmia and associated cerebral infarction (cardiogenic embolism) is the main cause of disability. We performed 3 GWASs for AF, and found 14 AF-sensitive single nucleotide polymorphisms (SNPs) in Japanese population. Against these 14 SNPs, we performed functional assay to identify novel druggable targets. There are SNPs associated with oxidative stress, myolysis, or differentiation of sympathetic nerve. These findings provide novel pathogenic pathways of AF, and are suggested to a potential targets of AF drugs.

Research Products

• [Int'l Joint Research] バンダービルド大学/ハーバード大学(米国)
• [Journal Article] Association of the Clinical and Genetic Factors With Superior Vena Cava Arrhythmogenicity in Atrial Fibrillation (2018)
  • Author(s): Ebana Y, Nitta J, Takahashi Y, Miyazaki S, Suzuki M, Liu L, Hirao K, Kanda E, Isobe M, Furukawa T
  • Journal Title: Circulation Journal Volume: 82 Issue: 1 Pages: 71-77
  • DOI: 10.1253/circj.CJ-17-0350
  • NAID: 130006281956
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Combined Analysis of Human and Experimental Murine Samples Identified Novel Circulating MicroRNAs as Biomarkers for Atrial Fibrillation (2018)
  • Author(s): Natsume Y, Oaku K, Takahashi K, Nakamura W, Oono A, Hamada S, Yamazoe M, Ihara K, Sasaki T, Goya M, Hirao K, Furukawa T, Sasano T.
  • Journal Title: Circulation Journal Volume: 82 Issue: 4 Pages: 965-973
  • DOI: 10.1253/circj.CJ-17-1194
  • NAID: 130006528576
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Combined analysis of human and experimental murine samples identified novel circulating microRNAs as biomarker for atrial fibrillation (2018)
  • Author(s): Natusme Y, Oaku K, Takahashi K, Nakamura W, Oono A, Hamada S, Yamazoe M, Ihara K, Sasaki T, Goya M, Hirao K, Furukawa T, Sasano T
  • Journal Title: Circ. J. Volume: 82 Issue: 6 Pages: 965-973
  • DOI: 10.1177/1358863x17724263
  • NAID: 130006528576
  • Peer Reviewed
• [Journal Article] Flecainide ameliorates arrhythmogenicity through NCX flux in Andersen-Tawil syndrome-iPS cell-derived cardiomyocytes. (2017)
  • Author(s): Kuroda Y, Yuasa S, Watanabe Y, Ito S, Egashira T, ・・・Horie M, Kamiya K, Fukuda K.
  • Journal Title: Biochemistry and Biophysics Reports Volume: 9 Pages: 245-256
  • DOI: 10.1016/j.bbrep.2017.01.002
  • Peer Reviewed / Open Access
• [Journal Article] Genetic variants associated with susceptibility to atrial fibrillation in Japanese population (2017)
  • Author(s): Liu L, Ebana Y, Nitta J, Takahashi Y, Miyazaki S, Tanaka T, Komura M, Isobe M, Furukawa T
  • Journal Title: Can. J. Cardiol. Volume: 33 Pages: 443-449
  • DOI: 10.1016/j.ijcard.2017.06.046
  • Peer Reviewed
• [Journal Article] Identification of six novel genetic loci associated with atrial fibrillation in Japanese population. (2017)
  • Author(s): Low SK, Takahashi A, Ebana Y, Ozaki K, Christophersen IE, Ellinor PT, AFGen Consortium, Ogishima S, Yamamoto M, Satoh M, Sasaki M, Yamaji T, Iwasaki M, Tsugane S, Tanaka K, Naito M, Wakai K, Tanaka H, Furukawa T, Kubo M, Ito K, Kamatani Y, Tanaka T.
  • Journal Title: Nature Genetics Volume: - Issue: 6 Pages: 953-958
  • DOI: 10.1038/ng.3842
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical utility and functional analysis of variants in atrial fibrillation-associated locus 4q25. (2017)
  • Author(s): Ebana Y, Ozaki K, Liu L, Hachiya H, Hirao K, Isobe M, Kubo M, Tanaka T, Furukawa T.
  • Journal Title: Journal of Cardiology Volume: - Issue: 4 Pages: 366-373
  • DOI: 10.1016/j.jjcc.2016.11.016
  • Peer Reviewed
• [Journal Article] Overexpression of KCNJ2 in induced pluripotent stem cell-derived cardiomyocytes for the assessment of QT-prolonging drugs. (2017)
  • Author(s): Li, M., Kanda, Y., Ashihara, T., Sasano, T., Nakai, Y., Kodama, M., Hayashi, E., Sekino, Y., Furukawa, T., and Kurokawa, J.
  • Journal Title: J. Pharm. Sci. Volume: 134 Issue: 2 Pages: 75-85
  • DOI: 10.1016/j.jphs.2017.05.004
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association of ZFHX3 gene variation with atrial fibrillation, cerebral infarction, and lung thromboembolism: An autopsy study. (2016)
  • Author(s): Zaw KT, Sato N, Ikeda S, Thu KS, Mieno MN, Arai T, Mori S, Furukawa T, Sasano T, Sawabe M, Tanaka M, Muramatsu M.
  • Journal Title: J Cardiol Volume: S0914-5087 Issue: 2 Pages: 30290-30298
  • DOI: 10.1016/j.jjcc.2016.11.005
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Autosomal gsdf acts as a male sex initiator in the fish medaka (2016)
  • Author(s): Zhang Xi、Guan Guijun、Li Mingyou、Zhu Feng、Liu Qizhi、Naruse Kiyoshi、Herpin Amaury、Nagahama Yoshitaka、Li Jiale、Hong Yunhan
  • Journal Title: Sci Rep Volume: 6 Issue: 1 Pages: 19738-19738
  • DOI: 10.1038/srep19738
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] High-fat diet increases vulnerability to atrial arrhythmia by conduction disturbance via miR-27b (2016)
  • Author(s): Takahashi K, Sasano T, Sugiyama K, Kurokawa J, Tamura N, Soejima Y, Sawabe M, Isobe M, Furukawa T.
  • Journal Title: J Mol Cell Cardiol. Volume: 90 Pages: 38-46
  • DOI: 10.1016/j.yjmcc.2015.11.034
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Oxidative Stress Induced Ventricular Arrhythmia and Impairment of Cardiac Function in <i>Nos1ap</i> Deleted Mice (2016)
  • Author(s): Sugiyama K, Sasano T, Kurokawa J, Takahashi K, Okamura T, Kato N, Isobe M and Furukawa T
  • Journal Title: International Heart Journal Volume: 57 Issue: 3 Pages: 341-349
  • DOI: 10.1536/ihj.15-471
  • NAID: 130005153706
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Genetic defects in a His-Purkinje system transcription factor, IRX3, cause lethal cardiac arrhythmias. (2016)
  • Author(s): Koizumi A, Sasano T, Kimura W, Miyamoto Y, Aiba T, Ishikawa T, Nogami A, Fukamizu S, Sakurada H, Takahashi Y, Nakamura H, Ishikura T, Koseki H, Arimura T, Kimura A, Hirao K, Isobe M, Shimizu W, Miura N, Furukawa T.
  • Journal Title: European Heart Journal. Volume: 37 (18) Issue: 18 Pages: 1469-1475
  • DOI: 10.1093/eurheartj/ehv449
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A distribution analysis of action potential parameters obtained from patch-clamped human stem cell-derived cardiomyocytes. (2016)
  • Author(s): Lopez-Redondo F, Kurokawa J, Nomura F, Kaneko T, Hamada T, Furukawa T, Yasuda K
  • Journal Title: J Pharmacol Sci Volume: 131 Issue: 2 Pages: 141-145
  • DOI: 10.1016/j.jphs.2016.04.015
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Novel dielectric coagulation identifies hypercoagulability in patients with a high CHADS2 score without atrial fibrillation (2016)
  • Author(s): 99. Hasegawa Y, Hamada S, Nishimura T, Sasaki T, Ebana Y, Kawabata M, Goya M, Isobe M, Koyama T, Furukawa T, Hirao K, Sasano T
  • Journal Title: PLoS ONE Volume: 11 Issue: 6 Pages: e0156557-e0156557
  • DOI: 10.1371/journal.pone.0156557
  • Peer Reviewed / Open Access
• [Journal Article] Partial IK1 blockade destabilizes spiral wave rotation center without inducing wave breakup and facilitates termination of reentrant arrhythmias in ventricles (2016)
  • Author(s): Kushiyama Y, Honjo H, Niwa R, Takanari H, Yamazaki M, Takemoto Y, Sakuma I, Kodama I, Kamiya K
  • Journal Title: American Journal of Physiology Heart and Circulatory Physiology Volume: 311 Issue: 1 Pages: 750-758
  • DOI: 10.1038/srep34198
  • NAID: 120005946586
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genetic variants associated with susceptibility to atrial fibrillation in Japanese population (2016)
  • Author(s): Liu L, Ebana Y, Nitta JI, Takahashi Y, Miyazaki S, Tanaka T, Komura M, Isobe M, Furukawa T
  • Journal Title: Canadean Journal of Cardiology Volume: 33 Issue: 4 Pages: 443-449
  • DOI: 10.1016/j.cjca.2016.10.029
  • Peer Reviewed / Open Access
• [Journal Article] Intravital imaging of Ca(2+) signals in lymphocytes of Ca(2+) biosensor transgenic mice: indication of autoimmune diseases before the pathological onset. (2016)
  • Author(s): Yoshikawa S, Usami T, Kikuta J, Ishii M, Sasano T, Sugiyama K, Furukawa T, Nakasho E, Takayanagi H, Tedder TF, Karasuyama H, Miyawaki A, Adachi T.
  • Journal Title: Sci Rep. 2016 Jan 6;6:18738. Volume: 6 Issue: 1 Pages: 18738-18738
  • DOI: 10.1038/srep18738
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Screening system for drug-induced arrhythmogenic risk combining patch clamp and a heart simulator. (2015)
  • Author(s): Okada J, Yoshinaga T, Kurokawa J, Washio T, Furukawa T, Sawada K, Sugiura S, Hisada T.
  • Journal Title: Sience Advances Volume: 1 Issue: 4
  • DOI: 10.1126/sciadv.1400142
  • Peer Reviewed / Open Access
• [Journal Article] Aromatase knockout mice reveal an impact of estrogen on drug-induced alternation of murine electrocardiography parameters (2015)
  • Author(s): Kurokawa, J., Sasano, T., Kodama, M., Li, M., Ebana, Y., Harada, N., Honda, S.-I., Nakaya, H., & Furukawa, T.
  • Journal Title: J. Toxicol. Sci. Volume: 40 Issue: 3 Pages: 339-348
  • DOI: 10.2131/jts.40.339
  • NAID: 130005068413
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Strategies for heart regeneration: approaches ranging from induced pluripotent stem cells to direct cardiac reprogramming. (2015)
  • Author(s): Yamakawa H, Ieda M.
  • Journal Title: Int Heart J Volume: 56 Issue: 6 Pages: 1-5
  • DOI: 10.1016/j.stemcr.2015.10.019
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Enhancement of Spontaneous Activity by HCN4 overexpression in Mouse Embryonic Stem Cell-derived Cardiomyocytes - a Possible Biological Pacemaker. (2015)
  • Author(s): SaitoY, Nakamura K, Yoshida M, Sugiyama H, Ohe T, Kurokawa J, Furukawa T, Takano M, Nagase S, Morita H, Kusano KF, Ito H.
  • Journal Title: PLoS ONE Volume: 10 Issue: 9 Pages: e0138193-e0138193
  • DOI: 10.1371/journal.pone.0138193
  • Peer Reviewed / Open Access
• [Journal Article] Integrating genetic, transcriptional, and functional analyses to identify five novel genes for atrial fibrillation (2014)
  • Author(s): Sinner MF, Tucker N, Lunetta K, Ozaki K, Smith G, Trompet S, Bis J, Lin H, Chung M, Nielsen JB, Lubitz S, Krijthe B, Magnani J, Ye J, Gollob M, Tsunoda T, Müller-Nurasyid M, Lichtner P, Peters A, Dolmatova E, Kubo M, Smith J, Psaty B, Smith N, Jukema JW, Chasman D, Ebana Y, Furukawa T, et al. (他27名)
  • Journal Title: Circulation Volume: 130 Issue: 15 Pages: 1225-1235
  • DOI: 10.1161/circulationaha.114.009892
  • Peer Reviewed / Open Access
• [Presentation] コモン不整脈の遺伝的リスク&nbsp; (2017)
  • Author(s): 古川哲史
  • Organizer: 第243回日本循環器学会関東甲信越地方会
  • Place of Presentation: ステーションカンファレンス東京、千代田区、東京
  • Year and Date: 2017-02-04
  • Invited
• [Presentation] コモン不整脈の遺伝的リスク (2017)
  • Author(s): 古川哲史
  • Organizer: 第２４３回日本循環器学会関東甲信越地方会
  • Invited
• [Presentation] Common genetic variants indicate the risk of atrial fibrillation in Japanese population (2017)
  • Author(s): Liu L, Ebana Y, Nitta J, Takahashi Y, Miyazaki S, Tanaka T, Mokura M, Isobe M, Furukawa T
  • Organizer: 第６３回日本不整脈心電学会学術集会
  • Invited
• [Presentation] Effect of SNP 9q22 (rs6479562) on the progression from patoxysmal atrial fibrillation to persistent atrial fibrillation (2017)
  • Author(s): Sekigawa M, Satoh A, Nitta J, Sato Y, Honda Y, Kuroda S, Kanoh M, Suzuki M, Inaba O, Muramatsu K, Yamato T, Matsumura Y, Asakawa K, Ebana Y, Furukawa T, Hirao K, Isobe M
  • Organizer: The 78th Annual Scientific Meeting of the Japanese Circulation Society
• [Presentation] Impact of SNP on IL6R (rs7514452) for age at onset of atrial fibrillation (2017)
  • Author(s): Sato Y, Satoh A, Nitta J, Honda Y, Kuroda S, Skigawa M, Kanoh M, Suzuki M, Inaba O, Muramatsu K, Yamato T, Matsumura Y, Asakawa K, Eban Y, Furukawa T, Hirao K, Isobe M
  • Organizer: The 78th Annual Scientific Meeting of the Japanese Circulation Society
• [Presentation] Disease modeling using iPS cells (2017)
  • Author(s): Furukawa T, Okata S, Yuasa S, Suzuki T, Makita N, Kurokawa J, Egashira T, Yamakawa H, Seki T, Aizawa T, Hashimoto H, Kuroda Y, Tanaka A, Yae K, Kurata M, Aiba T, Shimizu W, Horie M, Kodama I, Ogawa S, Fukuda K
  • Organizer: The 78th Annual Scientific Meeting of the Japanese Circulation Society
  • Invited
• [Presentation] Effects of hydrogel culture substrate on contractile properties and gene expression profiles of human iPS cell-derived cardiomyocytes (2017)
  • Author(s): Kurokawa J, Fujizuka M, Hayashi E, Ashihara T, Kanda Y, Sekino Y, Furukawa T
  • Organizer: 日本薬学会
• [Presentation] 女性ホルモンが心電図QT間隔に与える影響 (2016)
  • Author(s): 田村文弥、家田真樹、鈴木岳之、福田恵一、中谷晴昭、原田信広、古川哲史、 黒川洵子
  • Organizer: 日本適応医 学会学術集会
  • Place of Presentation: 東京コンファレンスセンター、港区、東京
  • Year and Date: 2016-12-16
• [Presentation] ヒト iPS由来心筋細胞の動きベクトル解析による抗がん剤心毒性の評価法 (2016)
  • Author(s): 黒川洵子、児玉昌美、高橋健太郎、諫田泰成、古川哲史
  • Organizer: 第26回日本循環薬理学会
  • Place of Presentation: 信州大学、松本市、長野県
  • Year and Date: 2016-12-02
• [Presentation] コモン不整脈の遺伝的リスク&nbsp; (2016)
  • Author(s): 古川哲史
  • Organizer: 第38回心筋生検研究会
  • Place of Presentation: 都立広尾病院、渋谷区、東京
  • Year and Date: 2016-11-26
  • Invited
• [Presentation] Effects of anticancer drugs on contractile behaviors of human- induced pluripotent stem cell-derived cardiomyocyte monolayers evaluated with an image-based analysis using motion field imaging technique (2016)
  • Author(s): Kurokawa J, Kanda Y, Kodama M, Sekino Y, Furukawa T
  • Organizer: 2016 SPS/JSPS/CSPT合同年会
  • Place of Presentation: バンクーバー、カナダ
  • Year and Date: 2016-09-19
  • Int'l Joint Research / Invited
• [Presentation] Individual evaluation of whole blood coagulability and factor Xa activity by novel dielectric blood coagulometry (2016)
  • Author(s): Sasano T, Hamada S, Hasegawa Y, Nishimura T, Yoshitake T, Shiohira S, Sasaki T, Kawabata M, Goya M, Isobe M, Furukawa T, Hirao K
  • Organizer: 第63回日本不整脈心電学会
  • Place of Presentation: 札幌コンベンションセンター、札幌市、北海道
  • Year and Date: 2016-07-17
• [Presentation] Mechanisms of arrhythmias in heart failure and new advances in its management&nbsp; (2016)
  • Author(s): Furukawa T
  • Organizer: 第63回日本不整脈心電学会
  • Place of Presentation: 札幌コンベンションセンター、札幌市、北海道
  • Year and Date: 2016-07-16
  • Invited
• [Presentation] Common genetic variants indicate the risk of atrial fibrillation in Japanese population (2016)
  • Author(s): Liu L, Ebana Y, Nitta J, Takahashi Y, Miyazaki S, Tanaka T, Komura M, Isobe M, Furukawa T&nbsp;
  • Organizer: 第63回日本不整脈心電学会
  • Place of Presentation: 札幌コンベンションセンター、札幌市、北海道
  • Year and Date: 2016-07-16
  • Invited
• [Presentation] Add-on type cardiac development and arrhythmias&nbsp; (2016)
  • Author(s): Furukawa T
  • Organizer: 第63回日本不整脈心電学会
  • Place of Presentation: 札幌コンベンションセンター、札幌市、北海道
  • Year and Date: 2016-07-15
  • Invited
• [Presentation] トランスジェニックマウスを利用した心筋遅延整流性カリ ウムチャネル分子複合体の探索と解析&nbsp; (2016)
  • Author(s): 福田俊、児玉昌美、永森收志，五十棲規嘉、藤塚美紀，金井好克，古川哲史， 黒川洵子
  • Organizer: 第134回日本薬理学会関東部会
  • Place of Presentation: 国際医療福祉大学、大田原市、栃木県
  • Year and Date: 2016-07-09
• [Presentation] Oxidative Stress Induced Ventricular Arrhythmia and Impairment of Cardiac Function in Nos1ap Deleted Mice&nbsp; (2016)
  • Author(s): Sasano T, Sugiyama K, Kurokawa J, Takahashi K, Okamura T, Kato N, Isobe M, Furukawa T&nbsp;
  • Organizer: 第９回国際NO学会&nbsp;
  • Place of Presentation: 仙台国際センター、仙台市、宮城県
  • Year and Date: 2016-05-22
  • Int'l Joint Research
• [Presentation] Regulation of cardiac L-type Ca2+ channel via a progesterone receptor&nbsp; (2016)
  • Author(s): Kurokawa J, Kodama M, Furukawa T
  • Organizer: 第９回国際NO学会&nbsp;
  • Place of Presentation: 仙台国際センター、仙台市、宮城県
  • Year and Date: 2016-05-22
  • Int'l Joint Research
• [Presentation] Gene-Guided Therapy in A (2016)
  • Author(s): Furukawa T, Liu L, Ebana Y, Nitta J, Takahashi Y, Miyazaki M, Isobe M, Tanaka T
  • Organizer: Heart Rhythm Society's 37th Annual Scientific Sessions
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2016-05-06
  • Int'l Joint Research / Invited
• [Presentation] Contribution of pannexin-1 to cardioprotection and arrhythmogenicity induced by ischemia/reperfusion injury (2016)
  • Author(s): Takahashi K, Sasano T, Sugiyama K, Isobe M, Furukawa T
  • Organizer: The 80th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 仙台国際センター（宮城県/仙台市）
  • Year and Date: 2016-03-18
• [Presentation] The occurrence of ectopy from pulmonary veins in atrial fibrillation in middle-aged women (2016)
  • Author(s): Hayashi Y, Nitta J, Iwasaki T, Lee K, Watanabe K, Hirao T, Kato N, Inamura Y, Suzuki M, Negi K, Satoh A, Yamato T, Matsumurea Y, Asakawa K, Ebana Y, Furukawa T, Gohya M, Hirao K, Isobe M
  • Organizer: The 80th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 仙台国際センター（宮城県/仙台市）
  • Year and Date: 2016-03-18
• [Presentation] Neurl, ubiquitin E3 ligase, contributes to the maintenance of sarcomere structure and the regulation of autophagy (2016)
  • Author(s): Ito S, Ebana Y, Furukawa T
  • Organizer: The 80th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 仙台国際センター（宮城県/仙台市）
  • Year and Date: 2016-03-18
• [Presentation] The genotype of SNPs related whether ectopy is from pulmonary vein or others in atrial fibrillation (2016)
  • Author(s): Hayashi Y, Nitta J, Iwasaki T, Lee K, Watanabe K, Hirao T, Kato N, Inamura Y, Suzuki M, Negi K, Satoh A, Yamato T, Matsumurea Y, Asakawa K, Ebana Y, Furukawa T, Gohya M, Hirao K, Isobe M
  • Organizer: The 80th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 仙台国際センター（宮城県/仙台市）
  • Year and Date: 2016-03-18
• [Presentation] Novel dielectric blood coagulometry can evaluate factor Xa and thrombin activity individually (2016)
  • Author(s): 12.Hamada S, Hasegawa Y, Nishimura T, Furukawa T, Isobe M, Hirao K, Sasano T
  • Organizer: The occurrence of ectopy from pulmonary veins in atrial fibrillation in middle-aged women
  • Place of Presentation: 仙台国際センター（宮城県/仙台市）
  • Year and Date: 2016-03-18
• [Presentation] トランスジェニックマウスを利用した心筋IKsチャネル分子複合体の網羅的解析 (2016)
  • Author(s): 福田俊、児玉昌美、永森収志、五十嵐規嘉、藤森美紀、金井好克、古川哲史、黒川洵子
  • Organizer: 第89回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2016-03-09
• [Presentation] 内向き整流カリウムチャネルを過剰発現させたヒトiPS由来心筋細胞を用いた薬理作用解析 (2016)
  • Author(s): 林英里奈、木村麗子、李敏、安東朋子、芦原貴司、関野祐子、古川哲史、諫田泰成、黒川洵子
  • Organizer: 第89回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2016-03-09
• [Presentation] 胎生マウスの関血管形状に見られる性差 (2016)
  • Author(s): 児玉昌美、古川哲史、黒川洵子
  • Organizer: 第89回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2016-03-09
• [Presentation] ヒトiPS細胞由来心筋の活動電位形成に関連する遺伝子の定量的発現解析におけるリファレンス遺伝子の選定 (2016)
  • Author(s): 木村麗子、児玉昌美、古谷和春、諫田泰成、倉智嘉久、関野祐子、古川哲史、黒川洵子
  • Organizer: 第89回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2016-03-09
• [Presentation] Functional evaluation of murine cardiomyocytes using motion imaging technique (2016)
  • Author(s): Kurokawa J, Takahashi K, Furukawa T
  • Organizer: 日本安全性薬理研究会
  • Place of Presentation: 東京大学（東京都/文京区）
  • Year and Date: 2016-02-19
• [Presentation] マウス冠血管形成における性差の起源の探索 (2015)
  • Author(s): 児玉昌美、古川哲史、黒川洵子
  • Organizer: 第38回日本分子生物学会・第88回日本生化学会合同大会
  • Place of Presentation: 神戸ポートアイランド(兵庫県/神戸市）
  • Year and Date: 2015-12-02
• [Presentation] iPS cells and Arrhythmia Mechanism (2015)
  • Author(s): Tetsushi Furukawa
  • Organizer: 2015 8th APHRS
  • Place of Presentation: メルボルン国際会議場メルボルン市（オーストラリア）
  • Year and Date: 2015-11-18
  • Invited
• [Presentation] OXIDATIVE STRESS INDUCED VENTRICULAR ARRHYTHMIA AND IMPAIRMENT CARDIAC FUNCTION IN NOS1AP DELETED MICE (2015)
  • Author(s): Koji Sugiyama, Tetsuo Sasano and Tetsushi Furukawa
  • Organizer: 2015 8th APHRS
  • Place of Presentation: メルボルン国際会議場メルボルン市（オーストラリア）
  • Year and Date: 2015-11-18
• [Presentation] Study of long QT syndrome type 3 using human iPS cell-derived cardiomyocytes (2015)
  • Author(s): Tetsushi Furukawa, Shinichi Okata, Shinsuke Yuasa, 他17名
  • Organizer: 第30回不整脈学会学術集会・第32回日本心電学会学術集会
  • Place of Presentation: 国立京都国際会議場（京都府/京都市）
  • Year and Date: 2015-07-28
  • Invited
• [Presentation] 心房細動はなぜ慢性化するのか：そのメカニズムと対策 (2015)
  • Author(s): 古川哲史
  • Organizer: 第30回不整脈学会学術集会・第32回日本心電学会学術集会
  • Place of Presentation: 国立京都国際会議場（京都府/京都市）
  • Year and Date: 2015-07-28
  • Invited
• [Presentation] 不整脈医が知っておくべき (2015)
  • Author(s): 古川哲史
  • Organizer: 第30回不整脈学会学術集会・第32回日本心電学会学術集会
  • Place of Presentation: 国立京都国際会議場（京都府/京都市）
  • Year and Date: 2015-07-28
  • Invited
• [Presentation] 心房細動とアンチエイジング (2015)
  • Author(s): 古川哲史
  • Organizer: 第15回日本抗加齢医学会総会
  • Place of Presentation: 福岡国際会議場（福岡県/福岡市）
  • Year and Date: 2015-05-30
  • Invited
• [Presentation] 網羅的全ゲノム相関解析と心房細動 (2014)
  • Author(s): 古川哲史
  • Organizer: 日本循環器学会第144回東海・第129回北陸合同学会
  • Place of Presentation: ウィンクあいち（名古屋）
  • Year and Date: 2014-10-25
  • Invited
• [Presentation] High-fat diet increases vulnerability of atrial arrhythmia by conduction disturbance by microRNA (2014)
  • Author(s): Takahashi K, Sasano T, Sugiyama K, Furukawa T
  • Organizer: The 29th Annual Meeting of The Japanese Heart Rhythm Society
  • Place of Presentation: 品川プリンスホテル（東京）
  • Year and Date: 2014-07-22
• [Presentation] Cardiac arrhythmias in the context of cardiac development (2014)
  • Author(s): Furukawa T
  • Organizer: The 29th Annual Meeting of The Japanese Heart Rhythm Society
  • Place of Presentation: 品川プリンスホテル（東京）
  • Year and Date: 2014-07-22
  • Invited
• [Book] 循環器薬の選び方と使い分け (2017)
  • Author(s): 古川哲史
  • Total Pages: 147
  • Publisher: 総合医学社
• [Book] 循環器治療薬パーフェクトガイド (2016)
  • Author(s): 古川哲史
  • Total Pages: 132
  • Publisher: 総合医学社
• [Book] 心臓イオンチャネルA to Z (2015)
  • Author(s): 古川哲史
  • Total Pages: 168
  • Publisher: ライフメディコム
• [Book] 目からウロコの心電図[改訂版] (2015)
  • Author(s): 古川哲史
  • Total Pages: 145
  • Publisher: ライフメディコム
• [Book] そうだったのか！臨床に役立つ心臓の発生・再生 (2015)
  • Author(s): 古川哲史
  • Total Pages: 178
  • Publisher: メディカル・サイエンス・インターナショナル