Regulation of axon regeneration in C. elegans
| Project/Area Number |
26293063
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
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| Keywords | C. elegans / 細胞内シグナル伝達 / 軸索再生 / 神経軸索再生 / 神経科学 / C.エレガンス |
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| Outline of Final Research Achievements |
In a nematode Caenorhabditis elegans, initiation of axon regeneration in injured neuron is positively regulated by SVH-1, which activates a JNK MAP kinase cascade via a c-Met-like receptor tyrosine kinase SVH-2. In this study, we demonstrated that SVH-4, a receptor tyrosine kinase that is activated by collagen, acts upstream of the SVH-2-JNK pathway. We also found that SVH-1 controls larval growth via an extracellular matrix component FBL-1. Furthermore, we showed that HIF-1-mediated activation of 5-HT signaling promotes axon regeneration by activating both the RhoA and cAMP pathways.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Chaperone complex BAG2-HSC70 regulates localization of Caenorhabditis elegans leucine-rich repeat kinase LRK-1 to the Golgi2016
Author(s)
Fukuzono T, Pastuhov SI, Fukushima O1, Li C, Hattori A, Iemura SI, Natsume T, Shibuya H, Hanafusa H, Matsumoto K, Hisamoto N.
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Journal Title
Genes Cells．
Volume: 21(4)
Issue: 4
Pages: 311-24
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Axotomy-induced HIF-serotonin signallyng axis promotes axon regeneration in C. elegans.2016
Author(s)
Alam T, Maruyama H, Li C, Pastuhov SI, Nix P, Bastiani M, Hisamoto N, Matsumoto K.
Organizer
Neuronal development, synaptic function & behavior C. elegans topic meeting 2016. Nagoya, Japan, Jul. 27-30, 2016.
Related Report
Int'l Joint Research
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[Presentation] Axotomy-induced HIF-serotonin signallyng axis promotes axon regeneration in C. elegans.2016
Author(s)
Alam T, Maruyama H, Li C, Pastuhov SI, Nix P, Bastiani M, Hisamoto N, Matsumoto K.
Organizer
7th Asia-pacific C. elegans meeting, Beijing, China, Jun. 25-29, 2016.
Related Report
Int'l Joint Research
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[Presentation] UNC-16 regulates early steps of synaptic vesicle protein trafficking via LRK-1 and UNC-101.2015
Author(s)
Choudhary B, Kamak M, Kumar M, Awasthi A, Fukuzono T, Li C, Nguyen K, Matsumoto K, Hisamoto N, Koushika S.
Organizer
20th International C. elegans Meeting
Place of Presentation
Los Angeles, USA
Year and Date
2015-06-25
Related Report
Int'l Joint Research
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[Presentation] The Chaperone Complex BAG2-HSC70/HSP70 determines localization of C. elegans leucine-repeat kinase LRK-1 in the regulation of Axonal-Dendritic Polarity.2014
Author(s)
Alam T, Fukuzono T, Pastuhov, SI, Fukushima O, Li C, Hattori A, Hanafusa H, Matsumoto K, Hisamoto N.
Organizer
Society for Neuroscience 2014
Place of Presentation
Wasington, USA
Year and Date
2014-11-15 – 2014-11-19
Related Report
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