Defect of growth/differentiation regulation caused psoriasis-like skin inflammation.
| Project/Area Number |
26293071
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
FUKAMI KIYOKO 東京薬科大学, 生命科学部, 教授 (40181242)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Keywords | リン脂質代謝 / 炎症性皮膚疾患 / 皮膚バリア / リン脂質代謝酵素 / 表皮バリア機能 / 細胞増殖分化機構 / バリア機能 / ホスフォリパーゼC / リン脂質 / 増殖・分化 / がん / 表皮 |
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| Outline of Final Research Achievements |
We showed here that downregulation of phospholipase C (PLC) δ1 impairs the barrier functions of the stratum corneum. PLCδ1 downregulation also impairs localization of tight junction proteins. Loss of PLCδ1 leads to a decrease in intracellular Ca2+ concentrations and nuclear factor of activated T cells (NFAT) activity, along with hyperactivation of p38 mitogen-activated protein kinase (MAPK) and inactivation of RhoA. These findings demonstrate that PLCδ1 is essential for epidermal barrier integrity. This study also suggests a possible link between PLCδ1 downregulation, p38 MAPK hyperactivation, and barrier defects in psoriasis-like skin inflammation.
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Report
(4 results)
Research Products
(49 results)
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[Journal Article] Phospholipase Cδ1 regulates p38 MAPK activity and skin barrier integrity.2017
Author(s)
Kaori Kanemaru, Yoshikazu Nakamura, Kengo Totoki, Takatsugu Fukuyama, Madoka Shoji, Hisae Kaneko, Kanako Shiratori, Atsuko Yoneda, Takafumi Inoue, Yoichiro Iwakura, Kenji Kabashima, Kiyoko Fukami
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Journal Title
Cell Death & Differentiation
Volume: in press
Issue: 6
Pages: 1079-1090
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] PNPLA1 has a crucial role in skin barrier function by directing acylceramide biosynthesis.2017
Author(s)
Hirabayashi T, Anjo T, Kaneko A, Senoo Y, Shibata A, Takama H, Yokoyama K, Nishito Y, Ono T, Taya C, Muramatsu K, Fukami K, Muñoz-Garcia A, Brash A, Ikeda K, Arita M, Akiyama M, Murakami M.
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Journal Title
Nat Commun
Volume: 8
Issue: 1
Pages: 14609-14609
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Phospholipase C δ1 in macrophages negatively regulates TLR4-induced proinflammatory cytokine production and Fcγ receptor-mediated phagocytosis.2015
Author(s)
1.Kudo, K., Uchida, T., Sawada, M., Nakamura, Y., Yoneda, A., and Fukami K.
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Journal Title
Adv. Biol. Regul.
Volume: S2212-4926(15)30022-1
Pages: 68-79
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Phospholipase C δ1 in macrophages negatively regulates TLR4-induced proinflammatory cytokine production and Fcγ receptor-mediated phagocytosis.2015
Author(s)
Kudo, K., Uchida, T., Sawada, M., Nakamura, Y., Yoneda, A., and Fukami K.
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Journal Title
Adv Biol Regul.
Volume: 15
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipocyte Differentiation.2015
Author(s)
Matsumura, Y., Nakaki, R., Inagaki, T., Yoshida, A., Kano, Y., Kimura, H., Tanaka, T., Tsutsumi, S., Nakao, M., Doi, T., Fukami, K., Osborne, TF., Kodama, T., Aburatani, H., Sakai, J.
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Journal Title
Molecular Cell
Volume: 60
Issue: 4
Pages: 584-596
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] The FBXL10/KDM2B Scaffolding Protein Associates with Novel Polycomb Repressive Complex-1 to Regulate Adipogenesis.2015
Author(s)
Inagaki T, Iwasaki S, Matsumura Y, Kawamura T, Tanaka T, Abe Y, Yamasaki A, Tsurutani Y, Yoshida A, Chikaoka Y, Nakamura K, Magoori K, Nakaki R, Osborne TF, Fukami K, Aburatani H, Kodama T, Sakai J
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Journal Title
J Biol Chem
Volume: 290
Issue: 7
Pages: 4163-77
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis2015
Author(s)
Abe Y, Rozqie R, Matsumura Y, Kawamura T, Nakaki R, Tsurutani Y, Tanimura-Inagaki K, Shiono A, Magoori K, Nakamura K, Ogi S, Kajimura S, Kimura H, Tanaka T, Fukami K, Osborne TF, Kodama T, Aburatani H, Inagaki T, Sakai J.
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Journal Title
Nat Commun
Volume: 6
Issue: 1
Pages: 1-14
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Phospholipase C delta 1 induces E-cadherin expression and suppresses malignancy in colorectal cancer cells2015
Author(s)
Reiko, Satow., Tamaki, Hirano,, Ryosuke, Batori., Tomomi, Nakamura., Yumi, Murayama., Kiyoko, Fukami.
Organizer
6th International Conference on Phospholipase A2 and Lipid Mediators
Place of Presentation
Tokyo
Year and Date
2015-02-11
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