| Budget Amount *help |
¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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| Outline of Final Research Achievements |
It is likely that cancer chemoresistance is attributed to a subset of chemoresistant cells in cancer tissues. Therefore, it will be important to understand cancer heterogeneity to overcome cancer chemorisitance and cure refractory cancer. We aimed to elucidate cancer heterogeneity by examining mouse xenograft tumors derived from in-vitro cultivated human colon cancer stem cells. By performing single-cell gene expression analyses of the tumors, we demonstrated that a subset of Lgr5-positive stem-like cells are associated with chemoresitance. We also performed single-cell analyses in a mouse model of colon carcinogenesis and identified a stem cell group that is responsible for tumorigenicity of colon tumors.
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