Involvement of Cxcl12/Cxcr4 signaling deficits in schizophrenia
| Project/Area Number |
26293074
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Research Institute, Shiga Medical Center |
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Principal Investigator |
Tanigaki Kenji 滋賀県立成人病センター(研究所), 神経病態研究部門, 専門研究員 (70362473)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
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| Keywords | 統合失調症 / Cxcr4 / Cxcl12 / ケモカイン / SDF1 / 22q11 deletion syndrome / Dgcr8 / Schizophrenia / lymphoblastoid cell line / EBV / lymphoblastoid cell / schizophrenia / 脳神経疾患 / miRNA / 神経発生 / 22q11欠損症候群 / NMDAR / PPI |
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| Outline of Final Research Achievements |
22q11 deletion syndrome is a chromosome disorder. 20-30% of the patients with this deletion develop schizophrenia. We previously showed that the heterozygous deletion of Dgcr8 caused Cxcl12/Cxcr4 signaling deficits, leading to developmental abnormalities in the dentate gyrus of the hippocampus and interneruons. In this study, we examined whether Cxcl12/Cxcr4 signal deficits can cause schizophrenia-like behavioral abnormalities using Cxcr4-floxed mice, and whether Cxcl12/Cxcr4 signal deficits exist in sporadic schizophrenia patients using lymphodblastic cell lines.
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Report
(5 results)
Research Products
(14 results)
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[Journal Article] Copy number elevation of 22q11.2 genes arrests the developmental maturation of working memory capacity and adult hippocampal neurogenesis.2018
Author(s)
Boku S, Izumi T, Abe S, Takahashi T, Nishi A, Nomaru H, Naka Y, Kang G, Nagashima M, Hishimoto A, Enomoto S, Duran-Torres G, Tanigaki K, Zhang J, Ye K, Kato S, Männistö PT, Kobayashi K, Hiroi N.
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Journal Title
Mol Psychiatry.
Volume: 23
Issue: 4
Pages: 985-992
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Preparation of Robust Metal-Free Magnetic Nanoemulsions Encapsulating Low-Molecular-Weight Nitroxide Radicals and Hydrophobic Drugs Directed Toward MRI-Visible Targeted Delivery.2017
Author(s)
Nagura K, Takemoto Y, Moronaga S, Uchida Y, Shimono S, Shiino A, Tanigaki K, Amano T, Yoshino F, Noda Y, Koizumi S, Komatsu N, Kato T, Yamauchi J, Tamura R.
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Journal Title
Chemistry.
Volume: 23
Pages: 15713-15720
Related Report
Peer Reviewed
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[Journal Article] Polymorphism within a Neuronal Activity-Dependent Enhancer of NgR1 Is Associated with Corpus Callosum Morphology in Humans2015
Author(s)
Isobe M, Tanigaki K, Muraki K, Miyata J, Takemura A, Sugihara G, Takahashi H, Aso T, Fukuyama H, Hazama M, Murai T
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Journal Title
Mol Neuropsychiatry
Volume: 1
Issue: 2
Pages: 105-115
DOI
Related Report
Peer Reviewed
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[Journal Article] Arsenic trioxide sensitizes glioblastoma to a myc inhibitor.2015
Author(s)
Yoshimura Y, Shiino A, Muraki K, Fukami T, Yamada S, Satow T, Fukuda M, Saiki M, Hojo M, Miyamoto S, Onishi N, Saya H, Inubushi T, Nozaki K, Tanigaki.
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Journal Title
Plos One
Volume: 10
Issue: 6
Pages: e0128288-e0128288
DOI
NAID
Related Report
Peer Reviewed / Open Access
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