Molecular mechanism of relapse and transformation of follicular lymphoma

• Project/Area Number: 26293078
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Okayama University
• Principal Investigator: Yoshino Tadashi 岡山大学, 医歯薬学総合研究科, 教授 (70183704)
• Co-Investigator(Kenkyū-buntansha): 竹内 真衣 岡山大学, 医歯薬学総合研究科, 助教 (10759666) ; 高田 尚良 岡山大学, 医歯(薬)学総合研究科, 講師 (90580259)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000); Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2014: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
• Keywords: リンパ腫 / 濾胞性リンパ腫 / がん幹細胞 / 形質転換 / 難治性 / リンパ増殖性疾患 / 分子基盤 / 遺伝子異常 / 病理学 / 高悪性度化 / 悪性リンパ腫

Outline of Final Research Achievements

Follicular lymphoma is one of the most frequent lymmphoma, and it has increased in number of patients: approximately 6000 new patients a year and it is almost 20% of all lymphoma. Although this lymphoma is quite indolent clinical course, it recurres so freqently, and high-grade transformation is the serious problem to control. We revealed that cancer initiating cells are present in this lymphoma which is closely associated with high frequent recurrence, and examined the role of c-MYC and BCL2 translocation at the course of high-grade transformation.

Research Products

• [Journal Article] Clinicopathological and genomic analysis of double-hit follicular lymphoma: comparison with high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements. (2018)
  • Author(s): Miyaoka M, Kikuti YY, Carreras J, Ikoma H, Hiraiwa S, Ichiki A, Kojima M, Ando K, Yokose T, Sakai R, Hoshikawa M, Tomita N, Miura I, Takata K, Yoshino T, Takizawa J, Bea S, Campo E, Nakamura N.
  • Journal Title: Mod Pathol. Volume: 31 Issue: 2 Pages: 313-316
  • DOI: 10.1038/modpathol.2017.134
  • Peer Reviewed
• [Journal Article] Gastrointestinal follicular lymphoma: Current knowledge and future challenges. (2018)
  • Author(s): Takata K, Miyata-Takata T, Sato Y, Iwamuro M, Okada H, Tari A, Yoshino T.
  • Journal Title: Pathol Int. Volume: 68 Issue: 1 Pages: 1-6
  • DOI: 10.1111/pin.12621
  • Peer Reviewed
• [Journal Article] A watch-and-wait policy versus rituximab-combined chemotherapy in Japanese patients with intestinal follicular lymphoma (2018)
  • Author(s): Tari A, Kitadai Y, Mouri R, Takigawa H, Asaoku H, Mihara K, Takata K, Fujihara M, Yoshino T, Koga T, Fujimori S, Tanaka S, Chayama K.
  • Journal Title: J Gastroenterol Hepatol Volume: Jan 29 Issue: 8 Pages: 1461-1468
  • DOI: 10.1111/jgh.14100
  • Peer Reviewed
• [Journal Article] The Usefulness of Colonoscopy for the Detection of Ileal Involvement in Intestinal Follicular Lymphoma Patients (2017)
  • Author(s): Iwamuro M, Takata K, Hayashi E, Kawano S, Hiraoka S, Kawahara Y, Yoshino T, Okada H
  • Journal Title: Acta Medica Okayama Volume: 71 Issue: 5 Pages: 391-398
  • DOI: 10.18926/AMO/55436
  • NAID: 120006352358
  • URL: https://ousar.lib.okayama-u.ac.jp/55436
  • Peer Reviewed
• [Journal Article] Colorectal Manifestation of Follicular Lymphoma (2016)
  • Author(s): Iwamuro M, Okada H, Takata K, Takenaka R, Inaba T, Mizuno M, Kobashi H, Tanaka S, Yoshioka M, Kondo E, Yoshino T, Yamamoto K.
  • Journal Title: Internal Medicine Volume: 55 Issue: 1 Pages: 1-8
  • DOI: 10.2169/internalmedicine.55.5393
  • NAID: 130005116794
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Frequent MYD88 L265P and CD79B Mutations in Primary Breast Diffuse Large B-Cell Lymphoma. (2016)
  • Author(s): Taniguchi K, Takata K, Chuang SS, Miyata-Takata T, Sato Y, Satou A, Hashimoto Y, Tamura M, Nagakita K, Ohnishi N, Noujima-Harada M, Tabata T, Kikuti YY, Maeda Y, Nakamura N, Tanimoto M, Yoshino T.
  • Journal Title: Am J Surg Pathol. Volume: 40 Issue: 3 Pages: 324-34
  • DOI: 10.1097/pas.0000000000000592
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Diagnosis of follicular lymphoma of the gastrointestinal tract: A better initial diagnostic workup. (2016)
  • Author(s): Iwamuro M, Kondo E, Takata K, Yoshino T, Okada H.
  • Journal Title: World J Gastroenterology Volume: 22 Issue: 4 Pages: 1674-83
  • DOI: 10.3748/wjg.v22.i4.1674
  • Peer Reviewed / Open Access
• [Journal Article] Endoscopic detection of the gastric lesions of peripheral T-cell lymphoma. (2016)
  • Author(s): Iwamuro M, Kimura K, Kondo E, Nada T, Nakamura E, Takata K, Tanaka T, Otsuka F, Yoshino T, Okada H
  • Journal Title: Ecancermedicalscience Volume: vol.10 Pages: 625-625
  • DOI: 10.3332/ecancer.2016.625
  • Peer Reviewed / Open Access
• [Journal Article] Detection of Minute Duodenal Follicular Lymphoma Lesions Using Magnifying Endoscopy. (2016)
  • Author(s): Iwamuro M, Kondo E, Otsuka F, Takata K, Yoshino T, Kawahara Y, Okada H
  • Journal Title: Acta Med Okayama. Volume: vol.70 Pages: 139-144
  • NAID: 120005749832
  • Peer Reviewed / Open Access
• [Journal Article] Aberrant differential expression of EZH1 and EZH2 in Polycomb repressive complex 2 among B- and T/NK-cell neoplasms. (2016)
  • Author(s): Abdalkader L, Oka T, Takata K, Sato H, Murakami I, Otte AP, Yoshino T
  • Journal Title: Pathology Volume: vol.40 Issue: 5 Pages: 467-482
  • DOI: 10.1016/j.pathol.2016.05.002
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Characteristic Distribution Pattern of CD30-positive Cytotoxic T Cells Aids Diagnosis of Kikuchi-Fujimoto Disease. (2016)
  • Author(s): Tabata T, Takata K, Miyata-Takata T, Sato Y, Ishizawa S, Kunitomo T, Nagakita K, Ohnishi N, Taniguchi K, Noujima-Harada M, Maeda Y, Tanimoto M, Yoshino T
  • Journal Title: Appl Immunohistochem Mol Morphol. Volume: - Issue: 4 Pages: 274-282
  • DOI: 10.1097/pai.0000000000000411
  • Peer Reviewed
• [Journal Article] Clinicopathological features of 49 primary gastrointestinal diffuse large B-cell lymphoma cases; comparison with location, cell-of-origin, and frequency of MYD88 L265P. (2016)
  • Author(s): Nagakita K, Takata K, Taniguchi K, Miyata-Takata T, Sato Y, Tari A, Ohnishi N, Noujima-Harada M, Omote S, Nakamura N, Iwamuro M, Maeda Y, Okada H, Tanimoto M, Yoshino T
  • Journal Title: Pathol Int. Volume: vol.66 Issue: 8 Pages: 444-452
  • DOI: 10.1111/pin.12439
  • Peer Reviewed / Open Access
• [Journal Article] CD10 down expression in follicular lymphoma correlates with the gastrointestinal lesion involving the stomach and large intestine. (2016)
  • Author(s): Ohnishi N, Takata K, Miyata-Takata T, Sato Y, Tari A, Gion Y, Noujima-Harada M, Taniguchi K, Tabata T, Nagakita K, Omote S, Takahata H, Iwamuro M, Okada H, Maeda Y, Yanai H, Yoshino T
  • Journal Title: Cancer Sci. Volume: vol.107 Issue: 11 Pages: 1687-1695
  • DOI: 10.1111/cas.13031
  • Peer Reviewed / Open Access
• [Journal Article] Ocular adnexal marginal zone lymphoma arising in a patient with IgG4-related ophthalmic disease. (2016)
  • Author(s): Nishida K, Sogabe Y, Makihara A, Senoo A, Morimoto H, Takeuchi M, Gion Y, Yoshino T, Sato Y
  • Journal Title: Mod Rheumatol. Volume: vol.11 Pages: 1-5
  • Peer Reviewed
• [Journal Article] Okada H.Magnifying Endoscopic Features of Follicular Lymphoma Involving the Stomach: A Report of Two Cases. (2016)
  • Author(s): Iwamuro M, Takata K, Kawano S, Fujii N, Kawahara Y, Yoshino T
  • Journal Title: Case Rep Gastrointest Med. Volume: - Pages: 1-6
  • DOI: 10.1155/2016/2082698
  • Peer Reviewed / Open Access
• [Journal Article] Protocadherin γ A3 is expressed in follicular lymphoma irrespective of BCL2 status and is associated with tumor cell growth. (2016)
  • Author(s): Zhang X, Takata K, Cui W, Miyata-Takata T, Sato Y, Noujima-Harada M, Yoshino T
  • Journal Title: Mol Med Rep. Volume: vol.14 Issue: 5 Pages: 4622-4628
  • DOI: 10.3892/mmr.2016.5808
  • Peer Reviewed / Open Access
• [Journal Article] Genomic and immunohistochemical profiles of enteropathy-associated T-cell lymphoma in Japan. (2016)
  • Author(s): Tomita S, Kikuti YY, Esteban JC, Takata K, Yoshino T, Beà S, Campo E, Nakamura N.
  • Journal Title: Pathology Volume: - Pages: 1-6
  • Peer Reviewed / Open Access
• [Journal Article] Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma: Current Understanding and Differential Diagnosis. (2016)
  • Author(s): Nakamine H, Yamakawa M, Yoshino T, Fukumoto T, Enomoto Y, Matsumura I.
  • Journal Title: J Clin Exp Hematop. Volume: vol.56 Pages: 109-118
  • NAID: 130005433864
  • Peer Reviewed / Open Access
• [Journal Article] Two Relapsed Stage III Childhood Anaplastic Large Cell Lymphoma Patients with NPM-ALK Fusion in Bone Marrow from Initial Diagnosis. (2016)
  • Author(s): Kanazawa Y, Yamashita Y, Fujiwara M, Muraoka M, Washio K, Kanamitsu K, Ishida H, Nakano T, Yamada M, Horibe K, Tanaka T, Yoshino T, Shimada A.
  • Journal Title: Acta Med Okayama. Volume: vol.70 Issue: 2 Pages: 503-506
  • DOI: 10.3960/jslrt.56.109
  • NAID: 130005433864
  • Peer Reviewed / Open Access
• [Journal Article] The role of "watch and wait" in intestinal follicular lymphoma in rituximab era. (2016)
  • Author(s): Tari A, Asaoku H, Takata K, Fujimori S, Tanaka S, Fujihara M, Koga T, Yoshino T.
  • Journal Title: Scand J Gastroenterol Volume: 51 Issue: 3 Pages: 321-8
  • DOI: 10.3109/00365521.2015.1087589
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Elevation of serum interleukins 8, 4, and 1β levels in patients with gastrointestinal low-grade B-cell lymphoma. (2015)
  • Author(s): Miyata-Takata T, Takata K, Toji T, Goto N, Kasahara S, Takahashi T, Tari A, Noujima-Harada M, Miyata T, Sato Y, Yoshino T.
  • Journal Title: Scientific Reports Volume: 5 Issue: 1 Pages: 18434-18434
  • DOI: 10.1038/srep18434
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Clinicopathologic Analysis of 6 Lymphomatoid Gastropathy Cases: Expanding the Disease Spectrum to CD4-CD8+ Cases. (2015)
  • Author(s): Takata K, Noujima-Harada M, Miyata-Takata T, Ichimura K, Sato Y, Miyata T, Naruse K, Iwamoto T, Tari A, Masunari T, Sonobe H, Okada H, Iwamuro M, Mizobuchi K, Gion Y, Yoshino T.
  • Journal Title: Am J Surg Pathol. 2015 Apr 28. Volume: 39 Pages: 1259-66
  • Peer Reviewed / Open Access
• [Journal Article] Serum level of soluble interleukin-2 receptor correlates with CD25 expression in patients with T lymphoblastic lymphoma. (2015)
  • Author(s): Toji T, Takata K, Sato Y, Miyata-Takata T, Hayashi E, Habara T, Maeda Y, Tanimoto M, Yoshino T.
  • Journal Title: J Clin Pathol. Volume: 68 Issue: 8 Pages: 622-7
  • DOI: 10.1136/jclinpath-2015-202934
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Genomic and immunohistochemical profiles of enteropathy-associated T-cell lymphoma in Japan. (2015)
  • Author(s): Tomita S, Kikuti YY, Carreras J, Kojima M, Ando K, Takasaki H, Sakai R, Takata K, Yoshino T, Bea S, Campo E, Nakamura N.
  • Journal Title: Modern Pathology Volume: 28 Issue: 10 Pages: 1286-96
  • DOI: 10.1038/modpathol.2015.85
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Detection of T-cell receptor γ gene rearrangement in paraffin-embedded T or natural killer/T-cell lymphoma samples using the BIOMED-2 protocol. (2014)
  • Author(s): Miyata-Takata T, Takata K, Yamanouchi S, Sato Y, Harada M, Oka T, Tanaka T, Maeda Y, Tanimoto M, Yoshino T.
  • Journal Title: Leuk Lymphoma. Volume: 55 Issue: 9 Pages: 2161-2164
  • DOI: 10.3109/10428194.2013.871634
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Merkel cell polyomavirus DNA sequences in peripheral blood and tissues from patients with Langerhans cell histiocytosis. (2014)
  • Author(s): Murakami I, Matsushita M, Iwasaki T, Kuwamoto S, Kato M, Horie Y, Hayashi K, Imamura T, Morimoto A, Imashuku S, Gogusev J, Jaubert F, Takata K, Oka T, Yoshino T.
  • Journal Title: Hum Pathol. Volume: 45 Issue: 1 Pages: 119-126
  • DOI: 10.1016/j.humpath.2013.05.028
  • Peer Reviewed
• [Journal Article] Elevated soluble IL-2 receptor levels correlate with tumor bulk of follicular lymphomas with intestinal involvement. (2014)
  • Author(s): Iwamuro M, Shinagawa K, Okada H, Takata K, Yoshino T, Yamamoto K.
  • Journal Title: Clin Biochem Volume: 47 Issue: 3 Pages: 191-195
  • DOI: 10.1016/j.clinbiochem.2013.11.026
  • Peer Reviewed
• [Journal Article] T helper 2 and regulatory T cell cytokine production by mast cells: A key factor in the pathogenesis of IgG4-related disease. (2014)
  • Author(s): Takeuchi, M., Sato, Y., Ohno, K., Tanaka, S., Takata, K., Gion, Y., Orita,Y., Ito, T., Tachibana, T. and Yoshino, T.
  • Journal Title: Mod. Pathol. Volume: 27 Issue: 8 Pages: 1126-1136
  • DOI: 10.1038/modpathol.2013.236
  • Peer Reviewed
• [Journal Article] Epstein-Barr virus-associated T/natural killer-cell lymphomas in the elderly: The first consensus meeting in Kofu (2014)
  • Author(s): Hamada T, Nakamura S, Ko YH, Yoshino T, Ohshima K, Matsuzawa T, Miura K, Takahashi T, Nomura H, Hoshino T, Suzuki D, Shimada S, Iwatsuki K
  • Journal Title: J Dermatol Volume: 41 Issue: 1 Pages: 40-42
  • DOI: 10.1111/1346-8138.12373
  • Peer Reviewed
• [Journal Article] Duodenal follicular lymphoma: Comprehensive gene expression analysis with insights into pathogenesis. (2014)
  • Author(s): Takata K, Tanino M, Ennishi D, Tari A, Sato Y, Okada H, Maeda Y, Goto N, Araki H, Harada M, Ando M, Iwamuro M, Tanimoto M, Yamamoto K, Gascoyne RD, Yoshino T.
  • Journal Title: Cancer Sci Volume: 6 Issue: 5 Pages: 608-615
  • DOI: 10.1111/cas.12392
  • Peer Reviewed
• [Journal Article] Epstein-Barr Virus-infected Cells in IgG4-related Lymphadenopathy With Comparison With Extranodal IgG4-related Disease. (2014)
  • Author(s): Takeuchi M, Sato Y, Yasui H, Ozawa H, Ohno K, Takata K, Gion Y, Orita Y, Tachibana T, Itoh T, Asano N, Nakamura S, Swerdlow SH, Yoshino T.
  • Journal Title: Am J Surg Pathol. Volume: － Issue: 7 Pages: 946-955
  • DOI: 10.1097/pas.0000000000000206
  • Peer Reviewed
• [Journal Article] Low-grade B-cell lymphoma presenting primarily in the bone marrow. (2014)
  • Author(s): Iwatani K, Takata K, Sato Y, Miyata-Takata T, Iwaki N, Cui W, Sawada-Kitamura S, Sonobe H, Tamura M, Saito K, Miyatani K, Yamasaki R, Yamadori I, Fujii N, Terasaki Y, Maeda Y, Tanimoto M, Nakamura N, Yoshino T.
  • Journal Title: Hum Pathol Volume: 26 Issue: 7 Pages: 1379-1387
  • DOI: 10.1016/j.humpath.2014.02.010
  • NAID: 120005473076
  • Peer Reviewed
• [Journal Article] Clinicopathological analysis of 17 primary cutaneous T-cell lymphoma of theγδphenotype from Japan (2014)
  • Author(s): Takahashi Y, Takata K, Kato S, Sato Y, Asano N, Ogino T, Hashimoto K, Tashiro Y, Takeuchi S, Masunari T, Hiramatsu Y, Maeda Y, Tanimoto M, Yoshino T
  • Journal Title: Cancer Sci Volume: (Epub ahead of print) Issue: 7 Pages: 912-923
  • DOI: 10.1111/cas.12439
  • Peer Reviewed
• [Presentation] リンパ腫におけるJC-virus感染細胞についての検討 (2016)
  • Author(s): 竹内真衣、祇園由佳、佐藤康晴、吉野正
  • Organizer: 第105回日本病理学会総会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2016-05-12
• [Presentation] 胃MALTリンパ腫から発生した、形質細胞への分化を示すびまん性大細胞型B細胞性リンパ腫の一例 (2016)
  • Author(s): 大西信彦、高田尚良、高田友子、竹内真衣、祇園由佳、西田俊博、佐藤康晴、吉野正
  • Organizer: 第105回日本病理学会総会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2016-05-12
• [Presentation] 中枢神経原発extranodal NK/T-cell lymphoma, nasal typeの一例 (2016)
  • Author(s): 能島舞、高田尚良、浜家一雄、能勢聡一郎、佐藤康晴、吉野正
  • Organizer: 第105回日本病理学会総会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2016-05-12
• [Presentation] Follicular lymphoma in situ で経過観察中にHodgkin lymphoma とのcomposite lymphoma を発症した一例 (2016)
  • Author(s): 田端哲也、高田尚良、高田友子、佐藤康晴、吉野正
  • Organizer: 第105回日本病理学会総会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2016-05-12
• [Presentation] 消化管原発濾胞性リンパ腫におけるCD10 発現低下とその意義 (2015)
  • Author(s): 大西信彦、高田尚良、高田友子、田利晶、佐藤康晴、吉野正
  • Organizer: 第55回日本リンパ網内系学会総会
  • Place of Presentation: 岡山
  • Year and Date: 2015-07-09
• [Presentation] 悪性リンパ腫診断のポイント (2015)
  • Author(s): 吉野 正
  • Organizer: 第104回日本病理学会総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2015-04-30
  • Invited
• [Presentation] ６．消化管低悪性度B細胞性リンパ腫患者では血清IL-8,IL-4,IL-1βは高値を示す (2015)
  • Author(s): 高田友子、高田尚良、都地友紘、後藤尚絵、笠原千嗣、高橋 健、田利 晶、佐藤康晴、吉野 正
  • Organizer: 第104回日本病理学会総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2015-04-30
• [Presentation] 特殊なびまん性大細胞型B細胞リンパ腫と中間型リンパ腫 (2014)
  • Author(s): 吉野 正
  • Organizer: 日本リンパ網内系学会
  • Place of Presentation: 山形
  • Year and Date: 2014-06-19 – 2014-06-21
  • Invited
• [Presentation] Intestinal follicular lymphoma (2014)
  • Author(s): 高田尚良、吉野 正
  • Organizer: 日本リンパ網内系学会
  • Place of Presentation: 山形
  • Year and Date: 2014-06-19 – 2014-06-21
  • Invited
• [Presentation] IgG4関連疾患vsリンパ増殖性疾患 (2014)
  • Author(s): 佐藤康晴、吉野 正
  • Organizer: 日本病理学会
  • Place of Presentation: 広島
  • Year and Date: 2014-04-24 – 2014-04-26
• [Presentation] 胃底腺型胃癌の検討症例 (2014)
  • Author(s): 田中健大、市村浩一、柳井広之、吉野 正
  • Organizer: 日本病理学会
  • Place of Presentation: 広島
  • Year and Date: 2014-04-24 – 2014-04-26
• [Presentation] B細胞腫瘍及びT/NK細胞腫瘍におけるポリコーム抑制性複合体２（PRC2)のEZH1とEZH2の特異的発現 (2014)
  • Author(s): 岡剛史、ABD Alkader Lamia, 高田尚良、佐藤妃映、村上一郎、都地友紘、真鍋明広、吉野 正
  • Organizer: 日本病理学会
  • Place of Presentation: 広島
  • Year and Date: 2014-04-24 – 2014-04-26
• [Book] 血液細胞アトラス 第６版 (2018)
  • Author(s): 吉野 正、佐藤康晴
  • Total Pages: 418
  • Publisher: 文光堂
  • ISBN: 9784830614262
• [Book] WHO classification of Tumours (Reveised 4th Ed) (2017)
  • Author(s): T. Yoshino, NL. Harris, BN Nathwani, SH Swerdlow, D de Jong, ES Jaffe, G Ott,
  • Total Pages: 585
  • Publisher: IARC Press, Lyon
  • ISBN: 9789283244943
• [Book] インフォームドコンセントのための図説シリーズ (2017)
  • Author(s): 吉野 正
  • Total Pages: 71
  • Publisher: 医薬ジャーナル社
  • ISBN: 9784753228553
• [Book] カラールービン病理学 改訂版 (2017)
  • Author(s): 吉野 正
  • Total Pages: 1441
  • Publisher: 西村書店
  • ISBN: 9784890134786
• [Book] 白血病・リンパ腫薬物療法ハンドブック (2016)
  • Author(s): 谷口恒平、吉野 正
  • Total Pages: 382
  • Publisher: 南江堂
• [Book] Hematopathology Second Edition (2016)
  • Author(s): Tadashi Yoshino, Elaine Jaffe, Daniel A. Arber, Elias Campo, Nancy Lee Harris, Leticia Quintanilla-Fend
  • Total Pages: 1136
  • Publisher: Elsevier