| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Outline of Final Research Achievements |
lysosomal small G protein Arl8b is associated with Toll-like Receptor 7(TLR7), which is an RNA sensor recognizing viral or bacterial RNA in endosome or lysosome. We clarified that Arl8b is essential for the development of Systemic lupus erythematosus (SLE) in TLR7 and type 1 Interferon dependent SLE mouse models, BXSB.Yaa and TMPD-induced SLE. We reported that Arl8b plays an important role for TLR7 dependent type 1 Interferon expression in pDC. We also analyzed another type of SLE model, MRL/lpr. It is not TLR7 and type 1 dependent SLE model so much. We found that Arl8b is also essential for the development of SLE in TLR7 and type 1 Interferon independent mechanism in MRL/lpr. Arl8b controls regulatory T cells and the development of SLE in this model.
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