Immune regulation on autoimmune and allergic diseases by the TIM family molecules

• Project/Area Number: 26293087
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Juntendo University
• Principal Investigator: Okumura Ko 順天堂大学, 医学部, 教授 (50009700)
• Co-Investigator(Kenkyū-buntansha): 秋葉 久弥 順天堂大学, 医学(系)研究科(研究院), 准教授 (60338316)
• Co-Investigator(Renkei-kenkyūsha): KOJIMA Yuko 順天堂大学, 医学研究科, 助教 (60231312)
• Research Collaborator: KAMACHI Fumitaka ; HARADA Norihiro ; ABE Yoshiyuki ; ISSHIKI Takuma
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000); Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
• Keywords: 免疫学 / 自己免疫疾患 / アレルギー疾患 / 炎症 / アレルギー・ぜんそく

Outline of Final Research Achievements

In this study, we investigated the effects of anti-TIM-4 mAb in a murine model of mast cell-dependent anaphylaxis and lung inflammation. Accumulation of eosinophils and production of Th2 cytokines in the lung were significantly reduced in the anti-TIM-4-treated mice. We confirmed that TIM-4 through proteolytic cleavage of cell surface TIM-4. Moreover, TIM-4 regulated the cytokine production, but not degranulation, by mast cells through the interaction with leukocyte mono-Ig-like receptor 5 (LMIR5) and TIM-3. Taken together, it is possible that TIM-4 can be an appropriate target for the therapeutic treatment and/or the diagnostic marker of allergic diseases.

Academic Significance and Societal Importance of the Research Achievements

現在、TNF-αなど個々の炎症性サイトカインを標的にした抗体医薬品は実用されているが、多種の炎症性サイトカイン産生を総合的に根本から抑制することが可能になれば、個々の抗サイトカイン抗体療法に抵抗性を持つ患者さんの治療に繋がる。また抗TIM-4抗体による抗炎症作用は、関節炎に留まらず、他の難治性慢性炎症疾患の新たな治療ターゲット分子になる可能性があり、またsTIM-4は補助診断あるいは治療効果や予後予測に際して有用なバイオマーカーになる可能性がある。

Research Products

• [Journal Article] Critical Role of Transcription Factor PU.1 in the Function of the OX40L/TNFSF4 Promoter in Dendritic Cells. (2016)
  • Author(s): Yashiro T, Hara M, Ogawa H, Okumura K, Nishiyama C.
  • Journal Title: Sci Rep Volume: 6 Issue: 1 Pages: 34825-34825
  • DOI: 10.1038/srep34825
  • Peer Reviewed / Open Access
• [Journal Article] Angiogenic peptide (AG)-30/5C activates human keratinocytes to produce cytokines/chemokines and to migrate and proliferate via MrgX receptors. (2016)
  • Author(s): Kiatsurayanon C, Niyonsaba F, Chieosilapatham P, Okumura K, Ikeda S, Ogawa H.
  • Journal Title: J Dermatol Sci Volume: 83 Issue: 3 Pages: 190-9
  • DOI: 10.1016/j.jdermsci.2016.05.006
  • Peer Reviewed
• [Journal Article] Role of PU.1 in MHC class II Expression via CIITA Transcription in Plasmacytoid Dendritic Cells (2016)
  • Author(s): Miura R, Kasakura K, Nakano N, Hara M, Maeda K, Okumura K, Ogawa H, Yashiro T, Nishiyama C
  • Journal Title: PLOS ONE Volume: 11 Issue: 4 Pages: e0154094-e0154094
  • DOI: 10.1371/journal.pone.0154094
  • Peer Reviewed / Open Access
• [Journal Article] Subcutaneous Allergic Sensitization to Protease Allergen Is Dependent on Mast Cells but Not IL-33: Distinct Mechanisms between Subcutaneous and Intranasal Routes (2016)
  • Author(s): Kamijo S, Suzuki M, Hara M, Shimura S, Ochi H, Maruyama N, Matsuda A, Saito H, Nakae S, Suto H, Ichikawa S, Ikeda S, Ogawa H, Okumura K, Takai T.
  • Journal Title: J Immunol Volume: 196 Issue: 9 Pages: 3559-3569
  • DOI: 10.4049/jimmunol.1500717
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Epicutaneous allergic sensitization by cooperation between allergn protease activity and mechanical skin barrier damage in mice (2016)
  • Author(s): Shimura S, Takai T, Iida H, Maruyama N, Ochi H, Kamijo S, Nishioka I, Hara M, Matsuda A, Saito H, Nakae S, Ogawa H, Okumura K, Ikeda S.
  • Journal Title: J Invest Dermatol Volume: 136 Issue: 7 Pages: 1408-1417
  • DOI: 10.1016/j.jid.2016.02.810
  • Peer Reviewed
• [Journal Article] A pilot study of operational tolerance with a regulatory T cell-based cell therapy in living donor liver transplantation. (2016)
  • Author(s): ①Todo S, Yamashita K, Goto R, Zaitsu M, Nagatsu A, Oura T, Watanabe M, Aoyagi T, Suzuki T, Shimamura T, Kamiyama T, Sato N, Sugita J, Hatanaka K, Bashuda H, Habu S, Demetris AJ, Okumura K
  • Journal Title: Hepatology Volume: 00 Issue: 2 Pages: 00-00
  • DOI: 10.1002/hep.28459
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Release from Th1-type immune tolerance in spleen and enhanced production of IL-5 in Peyer's patch by cholera toxin B induce the glomerular deposition of IgA. (2016)
  • Author(s): Yamanaka T, Tamauchi H, Suzuki Y, Suzuki H, Horikoshi S, Terashima M, Iwabuchi K, Habu S, Okumura K, Tomino Y.
  • Journal Title: Immunobiol Volume: 221 Issue: 4 Pages: 577-585
  • DOI: 10.1016/j.imbio.2015.12.001
  • Peer Reviewed / Open Access
• [Journal Article] Innate basophil IL-4 responses against allergens, endotoxin, and cytokines require the Fc receptor γ-chain. (2016)
  • Author(s): Kamijo S, Nunomura S, Ra C, Kanaguchi Y, Suzuki Y, Ogawa H, Okumura K, Takai T.
  • Journal Title: J Allergy Clin Immunol Volume: 137 Issue: 5 Pages: 1613-1615
  • DOI: 10.1016/j.jaci.2015.10.037
  • Peer Reviewed
• [Journal Article] Presensitization to Ascaris antigens promotes induction of mite-specific IgE upon mite antigen inhalation in mice (2016)
  • Author(s): Suzuki M, Hara M, Ichikawa S, Kamijo S, Nakazawa T, Hatanaka H, Akiyama K, Ogawa H, Okumura K, Takai T
  • Journal Title: Allergology International Volume: 65 Issue: 1 Pages: 44-51
  • DOI: 10.1016/j.alit.2015.07.003
  • NAID: 130005290333
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] An antimicrobial peptide with angiogenic properties, AG-30/5C, activates human mast cells through the MAPK and NF-κB pathways. (2016)
  • Author(s): Kanazawa K, Okumura K, Ogawa H, Niyonsaba F.
  • Journal Title: Immunol Res Volume: 64 Issue: 2 Pages: 594-603
  • DOI: 10.1007/s12026-015-8759-5
  • NAID: 130007632014
  • Peer Reviewed
• [Journal Article] PU.1 Suppresses Th2 Cytokine Expression via Silencing of GATA3 Transcription in Dendritic Cells (2015)
  • Author(s): Yashiro T, Kubo M, Ogawa H, Okumura K, Nishiyama C
  • Journal Title: PLoS One Volume: 10(9) Issue: 9 Pages: e0137699-e0137699
  • DOI: 10.1371/journal.pone.0137699
  • Peer Reviewed / Open Access
• [Journal Article] Secreted tyrosine sulfated-eIF5A mediates oxidative stress-induced apoptosis. (2015)
  • Author(s): Seko Y, Fujimura T, Yao T, Taka H, Mineki R, Okumura K, Murayama K.
  • Journal Title: Sci Rep. Volume: 8;5 Issue: 1 Pages: 13737-13751
  • DOI: 10.1038/srep13737
  • Peer Reviewed / Open Access
• [Journal Article] The Transcription Factor Ehf Is Involved in TGF-β-Induced Suppression of FcεRI and c-Kit Expression and FcεRI-Mediated Activation in Mast Cells. (2015)
  • Author(s): Yamazaki S, Nakano N, Honjo A, Hara M, Maeda K, Nishiyama C, Kitaura J, Ohtsuka Y, Okumura K, Ogawa H, Shimizu T
  • Journal Title: Journal of immunology Volume: 195(7) Issue: 7 Pages: 3427-3435
  • DOI: 10.4049/jimmunol.1402856
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Circadian Gene Clock Regulates Psoriasis-Like Skin Inflammation in Mice. (2015)
  • Author(s): Ando N, Nakamura Y, Aoki R, Ishimaru K, Ogawa H, Okumura K, Shibata S, Shimada S, Nakao A
  • Journal Title: J Invest Dermatol Volume: 135 Issue: 12 Pages: 3001-3008
  • DOI: 10.1038/jid.2015.316
  • Peer Reviewed / Open Access
• [Journal Article] IL-25 and IL-33 Contribute to Development of Eosinophilic Airway Inflammation in Epicutaneously Antigen-Sensitized Mice. (2015)
  • Author(s): Morita H, Arae K, Unno H, Toyama S, Motomura K, Matsuda A, Suto H, Okumura K, Sudo K, Takahashi T, Saito H, Matsumoto K, Nakae S.
  • Journal Title: PLoS One. Volume: 10 Issue: 7 Pages: e0134226-e0134226
  • DOI: 10.1371/journal.pone.0134226
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] An Interleukin-33-Mast Cell-Interleukin-2 Axis Suppresses Papain-Induced Allergic Inflammation by Promoting Regulatory T Cell Numbers. (2015)
  • Author(s): Morita H, Arae K, Unno H, Miyauchi K, Toyama S, Nambu A, Oboki K, Ohno T, Motomura K, Matsuda A, Yamaguchi S, Narushima S, Kajiwara N, Iikura M, Suto H, McKenzie AN, Takahashi T, Karasuyama H, Okumura K, Azuma M, Moro K, Akdis CA, Galli SJ, Koyasu S, Kubo M, Sudo K, Saito H, Matsumoto K, Nakae S.
  • Journal Title: Immunity Volume: 43 Issue: 1 Pages: 175-86
  • DOI: 10.1016/j.immuni.2015.06.021
  • NAID: 40020962854
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Characteristics of alveolar macrophages from murine models of OVA-induced allergic airway inflammation and LPS-induced acute airway inflammation (2015)
  • Author(s): 1)Katsura Y, Harada N, Harada S, Ishimori A, Makino F, Ito J, Kamachi F, Okumura K, Akiba H, Atsuta R, Takahashi K
  • Journal Title: Experimental Lung Research Volume: 41 Issue: 7 Pages: 370-382
  • DOI: 10.3109/01902148.2015.1044137
  • Peer Reviewed
• [Journal Article] Involvement of PU.1 in NFATc1 promoter function in osteoclast development (2015)
  • Author(s): Ishiyama K, Yashiro T, Nakano N, Kasakura K, Miura R, Hara M, Kawai F, Maeda K, Tamura N, Okumura K, Ogawa H, Takasaki Y, Nishiyama C
  • Journal Title: Allergology International Volume: 64 Issue: 3 Pages: 241-247
  • DOI: 10.1016/j.alit.2015.01.006
  • NAID: 130005290298
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] Notch signaling enhances FceRI-mediated cytokine production by mast cells through direct and indirect mechanisms (2015)
  • Author(s): Nakano, N., Nishiyama, C., Yagita, H., Hara, M., Motomura, Y., Kubo, M., Okumura, K., and Ogawa, H
  • Journal Title: J. Immunol Volume: 194(9) Issue: 9 Pages: 4535-44
  • DOI: 10.4049/jimmunol.1301850
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Cysteine protease antigens cleave CD123, the α subunit of murine IL-3 receptor, on basophils and suppress IL-3-mediated basophil expansion (2015)
  • Author(s): Nishikado H, Fujimura T, Taka H, Mineki R, Ogawa H, Okumura K, Takai T
  • Journal Title: Biochem Biophys Res Commun Volume: 印刷中 Issue: 2 Pages: 261-266
  • DOI: 10.1016/j.bbrc.2015.03.022
  • Peer Reviewed / Open Access
• [Journal Article] Roles of retinoic acid-inducible gene-I-like receptors (RLRs), Toll-like receptor (TLR) 3 and 2'-5' oligoadenylate synthetase as viral recognition receptors on human mast cells in response to viral infection. (2015)
  • Author(s): Tsutsui-Takeuchi M, Ushio H, Fukuda M, Yamada T, Niyonsaba F, Okumura K, Ogawa H, Ikeda S.
  • Journal Title: Immunol Res Volume: 61 Issue: 3 Pages: 240-9
  • DOI: 10.1007/s12026-014-8617-x
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] CD26-mediated induction of EGR2 and IL-10 as potential regulatory mechanism for CD26 costimulatory pathway. (2015)
  • Author(s): Hatano R, Ohnuma K, Otsuka H, Komiya E, Taki I, Iwata S, Dang NH, Okumura K, Morimoto C.
  • Journal Title: J Immunol. Volume: Vol 194 Issue: 3 Pages: 960-72
  • DOI: 10.4049/jimmunol.1402143
  • Peer Reviewed / Open Access
• [Journal Article] Human β-defensin-3 increases the expression of interleukin-37 through CCR6 in human keratinocytes (2015)
  • Author(s): Smithrithee R, Niyonsaba F, Kiatsurayanon C, Ushio H, Ikeda S, Okumura K, Ogawa H
  • Journal Title: Journal of Dermatological Science Volume: 77(1) Issue: 1 Pages: 46-53
  • DOI: 10.1016/j.jdermsci.2014.12.001
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Potential role of myeloid cell/eosinophil-derived IL-17 in LPS-induced endotoxin shock. (2014)
  • Author(s): Shimura E, Shibui A, Narushima S, Nambu A, Yamaguchi S, Akitsu A, Leonard WJ, Iwakura Y, Matsumoto K, Suto H, Okumura K, Sudo K, Nakae S
  • Journal Title: Biochem Biophys Res Commun Volume: 453 Issue: 1 Pages: 1-6
  • DOI: 10.1016/j.bbrc.2014.09.004
  • Peer Reviewed / Open Access
• [Journal Article] Commensal Bacteria Regulate Thymic Aire Expression (2014)
  • Author(s): Nakajima A, Negishi N, Tsurui H, Kadowaki-Ohtsuji N, Maeda K, Nanno M, Yamaguchi Y, Shimizu N, Yagita H, Okumura K, Habu S.
  • Journal Title: PloS One Volume: 9 Issue: 8 Pages: e105904-e105904
  • DOI: 10.1371/journal.pone.0105904
  • Peer Reviewed / Open Access
• [Journal Article] The human cathelicidin LL-37 host defense peptide upregulates tight junction-related proteins and increases human epidermal keratinocyte barrier function. (2014)
  • Author(s): Akiyama T, Niyonsaba F, Kiatsurayanon C, Nguyen TT, Ushio H, Fujimura T, Ueno T, Okumura K, Ogawa H, Ikeda S
  • Journal Title: J Innate Immun Volume: 6 Issue: 6 Pages: 739-53
  • DOI: 10.1159/000362789
  • Peer Reviewed / Open Access
• [Journal Article] Expressions of tight junction proteins Occludin and Claudin-1 are under the circadian control in the mouse large intestine: implications in intestinal permeability and susceptibility to colitis (2014)
  • Author(s): Kyoko OO, Kono H, Ishimaru K, Miyake K, Kubota T, Ogawa H, Okumura K, Shibata S, Nakao A
  • Journal Title: PLoS One Volume: 9(5) Issue: 5 Pages: e98016-e98016
  • DOI: 10.1371/journal.pone.0098016
  • Peer Reviewed / Open Access
• [Journal Article] Epicutaneous Administration of Papain Induces IgE and IgG Responses in a Cysteine Protease Activity-Dependent Manner (2014)
  • Author(s): Iida H, Takai T, Hirasawa Y, Kamijo S, Shimura S, Ochi H, Nishioka I, Maruyama N, Ogawa H, Okumura K, Ikeda S
  • Journal Title: Allergology International Volume: 63 Issue: 2 Pages: 219-226
  • DOI: 10.2332/allergolint.13-OA-0621
  • NAID: 130004477213
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Critical Roles for PU.1, GATA1, and GATA2 in the Expression of Human FcεRI on Mast Cells: PU.1 and GATA1 Transactivate FCER1A, and GATA2 Transactivates FCER1A and MS4A2 (2014)
  • Author(s): Inage E, Kasakura K, Yashiro T, Suzuki R, Baba Y, Nakano N, Hara M, Tanabe A, Oboki K, Matsumoto K, Saito H, Niyonsaba F, Ohtsuka Y, Ogawa H, Okumura K, Shimizu T, and Nishiyama C
  • Journal Title: Journal of Immunology Volume: 192 Issue: 8 Pages: 3936-46
  • DOI: 10.4049/jimmunol.1302366
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Host Defense (Antimicrobial) Peptide, Human β-Defensin-3, Improves the Function of the Epithelial Tight-Junction Barrier in Human Keratinocytes. (2014)
  • Author(s): Kiatsurayanon C, Niyonsaba F, Smithrithee R, Akiyama T, Ushio H, Hara M, Okumura K, Ikeda S, Ogawa H.
  • Journal Title: J invest Deramatol Volume: 143 Issue: 8 Pages: 2163-73
  • DOI: 10.1038/jid.2014.143
  • Peer Reviewed
• [Journal Article] OX40 ligand regulates splenic CD8- dendritic cell-induced Th2 responses in vivo. (2014)
  • Author(s): Kamachi F, Harada N, Usui Y, Sakanishi T, Ishii N, Okumura K, Miyake S, Akiba H
  • Journal Title: Biochem Biophys Res Commun Volume: 444 Issue: 2 Pages: 235-240
  • DOI: 10.1016/j.bbrc.2014.01.060
  • Peer Reviewed
• [Journal Article] TSLP expression induced via Toll-like receptor pathways in human keratinocytes (2014)
  • Author(s): Takai T, Chen X, Xie Y, Vu AT, Le TA, Kinoshita H, Kawasaki J, Kamijo S, Hara M, Ushio H, Baba T, Hiramatsu K, Ikeda S, Ogawa H, Okumura K
  • Journal Title: Methods Enzymol Volume: 535 Pages: 371-387
  • DOI: 10.1016/b978-0-12-397925-4.00021-3
  • Peer Reviewed
• [Journal Article] Circadian regulation of allergic reactions by the mast cell clock in mice. (2014)
  • Author(s): Nakamura Y, Nakano N, Ishimaru K, Hara M, Ikegami T, Tahara Y, Katoh R, Ogawa H, Okumura K, Shibata S, Nishiyama C, Nakao A
  • Journal Title: J Allergy Clin Immunol Volume: 133(2) Issue: 2 Pages: 568-575
  • DOI: 10.1016/j.jaci.2013.07.040
  • Peer Reviewed
• [Journal Article] Sphingomyelin and ceramide are physiological ligands for human LMIR3/CD300f, inhibiting FceRI-mediated mast cell activation. (2014)
  • Author(s): Izawa, K., Isobe, M., Matsukawa, T., Ito, S., Maehara, A., Takahashi, M., Yamanishi, Y., Kaitani, A., Oki, T., Okumura, K., *Kitamura, T., and *Kitaura, J.
  • Journal Title: J. Allergy. Clin. Immunol. Volume: 133 Issue: 1 Pages: 270-273
  • DOI: 10.1016/j.jaci.2013.08.008
  • Peer Reviewed
• [Presentation] TIM-3 regulates pulmonary fibrosis through apoptotic cell clearance (2016)
  • Author(s): ISSHIKI Takuma, AKIBA Hisaya, NAKAYAMA Masafumi, HARADA Norihiro, OKUMURA Ko, MIYAKE Sachiko
  • Organizer: 第45回日本免疫学会
  • Place of Presentation: 沖縄コンベンションセンター、ラグナガーデンホテル
  • Year and Date: 2016-12-05
• [Presentation] The role of leukocyte mono-immunoglobulin -like receptor 8 (LMIR8)/CLM-6 in plasmacytoid dendritic cell (pDC) (2016)
  • Author(s): KAITANI Ayako, IZAWA Kumi, MAEHARA Akie, ISOBE Masamichi, Takamori Ayako, Uchida Shino, NAKANO Nobuhiro, MAEDA Keiko, ANDO Tomoaki, OKUMURA Ko, KITAMURA Toshio, KITAURA Jiro
  • Organizer: 第45回日本免疫学会
  • Place of Presentation: 沖縄コンベンションセンター、ラグナガーデンホテル
  • Year and Date: 2016-12-05
• [Presentation] A critical role of ceramide-CD300f interaction in septic peritonitis (2016)
  • Author(s): IZAWA Kumi, MAEHARA Akie, ISOBE Masamichi, KAITANI Ayako, NAKANO Nobuhiro, MAEDA Keiko, Takamori Ayako, OKUMURA Ko, KITAMURA Toshio, KITAURA Jiro
  • Organizer: 第45回日本免疫学会
  • Place of Presentation: 沖縄コンベンションセンター、ラグナガーデンホテル
  • Year and Date: 2016-12-05
• [Presentation] Notch signaling induces expression of MHC class II and CX3CR1 on mast cells (2016)
  • Author(s): HOMMA Yuki, NAKANO Nobuhiro, OKUMURA Ko, OGAWA Hideoki
  • Organizer: 第45回日本免疫学会
  • Place of Presentation: 沖縄コンベンションセンター、ラグナガーデンホテル
  • Year and Date: 2016-12-05
• [Presentation] Inhibition of Notch signaling suppresses food antigen-induced mucosal mast cell hyperplasia (2016)
  • Author(s): NAKANO Nobuhiro, HONJO Asuka, YAMAZAKI Susumu, OHTSUKA Yoshikazu, YAGITA Hideo, SHIMIZU Toshiaki, OKUMURA Ko, OGAWA hideoki
  • Organizer: 第45回日本免疫学会
  • Place of Presentation: 沖縄コンベンションセンター、ラグナガーデンホテル
  • Year and Date: 2016-12-05
• [Presentation] CD300f suppresses LPS-induced skin inflammation (2016)
  • Author(s): Watanabe Daiki, IZAWA Kumi, KAITANI Ayako, MAEHARA Akie, ISOBE Masamichi, Takamori Ayako, Uchida Shino, NAKANO Nobuhiro, MAEDA Keiko, ANDO Tomoaki, OKUMURA Ko, KITAMURA Toshio, KITAURA Jiro
  • Organizer: 第45回日本免疫学会
  • Place of Presentation: 沖縄コンベンションセンター、ラグナガーデンホテル
  • Year and Date: 2016-12-05
• [Presentation] GATA2 is involved in the expression of the decoy receptor for IL-33 by binding to the proximal promoter with chromosomal loop formation (2016)
  • Author(s): KASAKURA Kazumi, YASHIRO Takuya, HARA Mutsuko, OKUMURA Ko, NISHIYAMA Chiharu
  • Organizer: 第45回日本免疫学会
  • Place of Presentation: 沖縄コンベンションセンター、ラグナガーデンホテル
  • Year and Date: 2016-12-05
• [Presentation] Leukocyte mono-immunoglobulin-like receptor 6 (LMIR6) is an activating receptor expressed in patrolling monocytes (2016)
  • Author(s): ISOBE Masamichi, Takamori Ayako, IZAWA Kumi, MAEHARA Akie, KAITANI Ayako, Uchida Shino, NAKANO Nobuhiro, MAEDA Keiko, ANDO Tomoaki, OKUMURA Ko, KITAMURA Toshio, KITAURA Jiro
  • Organizer: 第45回日本免疫学会
  • Place of Presentation: 沖縄コンベンションセンター、ラグナガーデンホテル
  • Year and Date: 2016-12-05
• [Presentation] Contribution of IL-17A to papain-induced allergic responses in the skin and production of IL-17A from dendritic epidermal T cells in the papain-exposed skin (2016)
  • Author(s): KAMIJO Seiji, NAKAE Susumu, OGAWA Hideoki, OKUMURA Ko, TAKAI Toshiro
  • Organizer: 第45回日本免疫学会
  • Place of Presentation: 沖縄コンベンションセンター、ラグナガーデンホテル
  • Year and Date: 2016-12-05
• [Presentation] アレルゲン，LPSおよびサイトカイン刺激による好塩基球のIL-4産生はFc受容体γ鎖に依存する (2016)
  • Author(s): 上條 清嗣、布村 聡、羅 智靖、金口 泰彦、鈴木 祐介、小川 秀興、奥村 康、高井 敏朗
  • Organizer: 第65回日本アレルギー学会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2016-06-17
• [Presentation] マスト細胞に発現する活性化型受容体LMIR7のアレルギー反応における役割 (2016)
  • Author(s): 伊沢 久未、奥村 康、北村 俊雄、北浦 次郎
  • Organizer: 第65回日本アレルギー学会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2016-06-17
• [Presentation] フィラグリン発現量の初代培養ヒト鼻粘膜上皮における変化 (2016)
  • Author(s): 三輪 正人、Sharif Hasan、廣瀬 壮、中島 規幸、三輪 真由美、大久保 公裕、奥村 康
  • Organizer: 第65回日本アレルギー学会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2016-06-17
• [Presentation] 食物アレルギーモデルマウスを用いたNotchシグナルによるマスト細胞の機能制御 (2016)
  • Author(s): 本庄 明日香、中野 信浩、山崎 晋、森 真理、原 むつ子、大塚 宜一、奥村 康、清水 俊明
  • Organizer: 第65回日本アレルギー学会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2016-06-17
• [Presentation] The novel role of LMIR7/CLM-3 in mast cell- and IgE-dependent anaphylaxis. (2015)
  • Author(s): Masamichi Isobe
  • Organizer: 第44回日本免疫学会
  • Place of Presentation: 札幌コンベンションセンター
  • Year and Date: 2015-11-18
• [Presentation] Notch signaling enhances mast cell cytokine production through direct and indirect mechanisms. (2015)
  • Author(s): Nobuhiro Nakano
  • Organizer: 第44回日本免疫学会学術集会
  • Place of Presentation: 札幌コンベンションセンター
  • Year and Date: 2015-11-18
• [Presentation] PU.1 regulates expression of the Syk gene in mast cells. (2015)
  • Author(s): Yoshihito Oda
  • Organizer: 第44回日本免疫学会学術集会
  • Place of Presentation: 札幌コンベンションセンター
  • Year and Date: 2015-11-18
• [Presentation] A novel host defense peptide, AG-30/5C, activates human mast cell functions. (2015)
  • Author(s): Kazo Kanazawa
  • Organizer: 第44回日本免疫学会学術集会
  • Place of Presentation: 札幌コンベンションセンター
  • Year and Date: 2015-11-18
• [Presentation] In vitro induction of serial transfer of allospecific suppression potential in human peripheral T cells. (2015)
  • Author(s): Koichiro Uchida
  • Organizer: 第44回日本免疫学会学術集会
  • Place of Presentation: 札幌コンベンションセンター
  • Year and Date: 2015-11-18
• [Presentation] Possible potential of TIGHT for serial transfer of anergy status into activated naive T cells. (2015)
  • Author(s): Naoko Negishi
  • Organizer: 第44回日本免疫学会学術集会
  • Place of Presentation: 札幌コンベンションセンター
  • Year and Date: 2015-11-18
• [Presentation] Immune activation by the exopolysaccharide in yogurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 in mice. (2014)
  • Author(s): MAKINO Seiya
  • Organizer: 日本免疫学会総会
  • Place of Presentation: 京都
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] Commensal bacteria regulate thymic Aire expression. (2014)
  • Author(s): NAKAJIMA Akihto
  • Organizer: 日本免疫学会総会
  • Place of Presentation: 京都
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] The suppression of naive T cells are required cell to cell contact by TSST-1 induced anergy T cells. (2014)
  • Author(s): NEGISHI Naoko
  • Organizer: 日本免疫学会総会
  • Place of Presentation: 京都
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] Distinct mechanisms for allergic sensitization to protease allergen between subcutaneous and intranasal routes. (2014)
  • Author(s): KAMIJO Seiji
  • Organizer: 日本免疫学会総会
  • Place of Presentation: 京都
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] Regulation of soluble ST2 expression in mast cells. (2014)
  • Author(s): KASAKURA Kazumi
  • Organizer: 日本免疫学会総会
  • Place of Presentation: 京都
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] LMIR3/CD300f deficiency aggravates DSS-induced colitis. (2014)
  • Author(s): MATSUKAWA Toshihiro
  • Organizer: 日本免疫学会総会
  • Place of Presentation: 京都
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] Disrupting ceramide-LMIR3 interaction prevents bacterial sepsis by stimulating neutrophil recruitment. (2014)
  • Author(s): IZAWA Kumi
  • Organizer: 日本免疫学会総会
  • Place of Presentation: 京都
  • Year and Date: 2014-12-10 – 2014-12-12
• [Remarks] 順天堂大学 アトピー疾患研究センター
  • URL: http://www.juntendo.ac.jp/graduate/laboratory/labo/atopy_center/
• [Remarks] 順天堂大学大学院医学研究科アトピー疾患研究センター
  • URL: http://www.juntendo.ac.jp/graduate/laboratory/labo/atopy_center/