Dissecting tolerance and resistance mechanism regulating vectorial competency of pathogen-transmitting vectors
| Project/Area Number |
26293092
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Parasitology (including sanitary zoology)
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
熊谷 正広 東京慈恵会医科大学, 医学部, 講師 (00271304)
案浦 健 国立感染症研究所, その他部局等, 研究員 (90407239)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Keywords | トレランス / レジスタンス / 蚊 / 感染症 / 節足動物 / ウイルス / 免疫応答 / 病原体媒介節足動物 / 感染 / コンピテンシー / 病原体 / 中間宿主 / 寄生虫 / 細菌 / 衛生動物 / 免疫 |
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| Outline of Final Research Achievements |
Blood-sucking arthropods, including mosquitoes transmit numerous virus diseases during blood feeding. Using a virus infection model in Drosophila and Aedes mosquito, we uncovered genetically encoded resistance of vector mosquito to virus infection as measured by the extent to which survival rate decreased via increasing virus burden. These results suggest that anti-virus responses of vector mosquito are not restricted to its survival but rather can be applied to capacity to employ virus mutualism during the disease transmission.
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Report
(4 results)
Research Products
(22 results)
