The molecular basis for persistent inflammation in Helicobacter pylori-infected gastric mucosa and their application to a novel vaccine
| Project/Area Number |
26293095
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Mimuro Hitomi 東京大学, 医科学研究所, 准教授 (80396887)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Keywords | 持続感染 / 病原体 / 細菌 / ヘリコバクターピロリ / 感染症 |
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| Outline of Final Research Achievements |
In this study we performed the following studies, to develop a more comprehends understanding of mechanisms underlying persistent inflammation in Helicobacter pylori-infected gastric mucosa, and to try to apply the outcome to vaccine development. (1) Control mechanisms of gastric responses: we have discovered a novel mechanism to regulate adherence function of bacterial adhesin BabA during persistent infection. (2) Control mechanisms of intestinal Peyer’s patches: we comprehensively analyzed outer membrane protein profiles of H. pylori under anaerobic conditions, and identified candidate factors for the interaction of bacteria with antigen presenting cells. (3) Vaccine: we analyzed prophylactic vaccine effect of anaerobic cultured bacteria for H. pylori infection using a Mongolian gerbil animal model of H. pylori infection.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Epidemiological study on feline gastric <i>Helicobacter</i> spp. in Japan2017
Author(s)
〇Sanae Kubota-Aizawa, Koichi Ohno, Hideyuki Kanemoto, Ko Nakashima, Kenjiro Fukushima, Kazuyuki Uchida, James K. Chambers, Yuko Goto-Koshino, Hitomi Mimuro, Takayasu Watanabe, Tsutomu Sekizaki, Hajime Tsujimoto
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Journal Title
Journal of Veterinary Medical Science
Volume: 79
Issue: 5
Pages: 876-880
DOI
NAID
ISSN
0916-7250, 1347-7439
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] The Immune Receptor NOD1 and Kinase RIP2 Interact with Bacterial Peptidoglycan on Early Endosomes to Promote Autophagy and Inflammatory Signaling2014
Author(s)
Irving AT, Mimuro H, Kufer TA, Lo C, Wheeler R, Turner LJ, Thomas BJ, Malosse C, Gantier MP, Casillas LN, Votta BJ, Bertin J, Boneca IG, Sasakawa C, Philpott DJ, Ferrero RL, Kaparakis-Liaskos M
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Journal Title
Cell Host Microbe
Volume: 15
Issue: 5
Pages: 623-635
DOI
Related Report
Peer Reviewed
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[Journal Article] Disease severity is associated with differential gene expression at the early and late phases of infection in nonhuman primates infected with different H5N1 highly pathogenic avian influenza viruses.2014
Author(s)
Muramoto Y, Shoemaker JE, Le MQ, Itoh Y, Tamura D, Sakai-Tagawa Y, Imai H, Uraki R, Takano R, Kawakami E, Ito M, Okamoto K, Ishigaki H, Mimuro H, Sasakawa C, Matsuoka Y, Noda T, Fukuyama S, Ogasawara K, Kitano H, Kawaoka Y.
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Journal Title
Journal of Virlogy
Volume: 88(16)
Issue: 16
Pages: 8981-8997
DOI
Related Report
Peer Reviewed / Open Access
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