| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Outline of Final Research Achievements |
In this study we performed the following studies, to develop a more comprehends understanding of mechanisms underlying persistent inflammation in Helicobacter pylori-infected gastric mucosa, and to try to apply the outcome to vaccine development. (1) Control mechanisms of gastric responses: we have discovered a novel mechanism to regulate adherence function of bacterial adhesin BabA during persistent infection. (2) Control mechanisms of intestinal Peyer’s patches: we comprehensively analyzed outer membrane protein profiles of H. pylori under anaerobic conditions, and identified candidate factors for the interaction of bacteria with antigen presenting cells. (3) Vaccine: we analyzed prophylactic vaccine effect of anaerobic cultured bacteria for H. pylori infection using a Mongolian gerbil animal model of H. pylori infection.
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