Regulation of immune responses via C-type lectin receptor family that recognize mycobacteria

• Project/Area Number: 26293099
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Bacteriology (including mycology)
• Research Institution: Kyushu University
• Principal Investigator: Yamasaki Sho 九州大学, 生体防御医学研究所, 教授 (40312946)
• Co-Investigator(Kenkyū-buntansha): 大村谷 昌樹 熊本大学, 学内共同利用施設等, 准教授 (60398229)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000); Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
• Keywords: C型レクチン / 自然免疫 / 細菌感染 / 糖脂質

Outline of Final Research Achievements

Phosphatidyl-inositol mannosides (PIM) are unique mycobacterial glycolipids that stimulate host immune responses. Mycobacteria activated reporter cells expressing DCAR and delipidation of mycobacteria abolished this activity. Further, tri- and tetra-acylated PIMs (AcPIM2 and Ac2PIM2) purified from mycobacteria lipids were ligands for DCAR. DCAR was predominantly expressed in small peritoneal macrophages (SPMs) and monocyte-derived inflammatory cells in lungs and spleen. PIM treatment induced these cells to produce MCP-1, and production of MCP-1 was abrogated in the absence of DCAR or FcRγ. Upon mycobacterial infection, DCAR-deficient mice showed reduced numbers of monocyte-derived inflammatory cells at the infection site, impaired IFNγ production by CD4+ T cells, and an increased bacterial load. These results demonstrate that DCAR is a critical receptor for mycobacterial PIM and functions to promote Th1 responses against mycobacteria.

Research Products

• [Int'l Joint Research] Victoria University of Wellington(ニュージーランド)
• [Int'l Joint Research] Melbourne University(オーストラリア)
• [Int'l Joint Research] Institut Curie/INSERM(フランス)
• [Int'l Joint Research] Aberdeen University(英国)
• [Int'l Joint Research] Victoria University(ニュージーランド)
• [Int'l Joint Research] Melbourne University(オーストラリア)
• [Int'l Joint Research] Institut Curie/INSERM(フランス)
• [Int'l Joint Research] Aberdeen University(英国)
• [Journal Article] Intracellular metabolite β-glucosylceramide is an endogenous Mincle ligand possessing immunostimulatory activity (2017)
  • Author(s): Masahiro Nagata, Yoshihiro Izumi, Eri Ishikawa, Ryoko Kiyotake, Rieko Doi, Satoru Iwai, Zakaria Omahdi, Toshiyuki Yamaji, Tomofumi Miyamoto, Takeshi Bamba, Sho Yamasaki
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 114 Issue: 16
  • DOI: 10.1073/pnas.1618133114
  • Peer Reviewed / Open Access
• [Journal Article] C-Type Lectin Receptor Dectin-2 Binds to an Endogenous Protein β-Glucuronidase on Dendritic Cells (2017)
  • Author(s): Mori D, Shibata K, Yamasaki S
  • Journal Title: PLoS One Volume: 12 Issue: 1 Pages: e0169562-e0169562
  • DOI: 10.1371/journal.pone.0169562
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] C-Type Lectin Receptor DCAR Recognizes Mycobacterial Phosphatidyl-Inositol Mannosides to Promote a Th1 Response during Infection (2016)
  • Author(s): Toyonaga K, Torigoe S, Motomura Y, Kamichi T, Hayashi JM, Morita YS, Noguchi N, Chuma Y, Kiyohara H, Matsuo K, Tanaka H, Nakagawa Y, Sakuma T, Ohmuraya M, Yamamoto T, Umemura M, Matsuzaki G, Yoshikai Y, Yano I, Miyamoto T, Yamasaki S.
  • Journal Title: Immunity Volume: 45 Issue: 6 Pages: 1245-1257
  • DOI: 10.1016/j.immuni.2016.10.012
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1 (2016)
  • Author(s): Ishikawa E, Kosako H, Yasuda T, Ohmuraya M, Araki K, Kurosaki T, Saito T, Yamasaki S
  • Journal Title: Nat Commun Volume: 7 Issue: 1 Pages: 12756
  • DOI: 10.1038/ncomms12756
  • NAID: 120006535062
  • URL: https://tokushima-u.repo.nii.ac.jp/records/2005595
  • Peer Reviewed / Open Access
• [Journal Article] Signalling through MyD88 drives surface expression of the mycobacterial receptors MCL (Clecsf8, Clec4d) and Mincle (Clec4e) following microbial stimulation. (2016)
  • Author(s): Kerscher B, Dambuza IM, Christofi M, Reid DM, Yamasaki S, Willment JA, Brown GD.
  • Journal Title: Microbes Infect. Volume: 印刷中 Issue: 7-8 Pages: 505-509
  • DOI: 10.1016/j.micinf.2016.03.007
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Mycobacterial receptor, Clec4d (CLECSF8, MCL), is coregulated with Mincle and upregulated on mouse myeloid cells following microbial challenge. (2016)
  • Author(s): Kerscher B, Wilson GJ, Reid DM, Mori D, Taylor JA, Besra GS, Yamasaki S, Willment JA, Brown GD.
  • Journal Title: Eur J Immunol. Volume: 46 Issue: 2 Pages: 381-9
  • DOI: 10.1002/eji.201545858
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Mycobacterium tuberculosis β-gentiobiosyl diacylglycerides signal through the pattern recognition receptor Mincle: total synthesis and structure activity relationships. (2015)
  • Author(s): Richardson MB, Torigoe S, Yamasaki S, Williams SJ.
  • Journal Title: Chemical Communications Volume: 51 Issue: 81 Pages: 15027-15030
  • DOI: 10.1039/c5cc04773k
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Human Mincle Binds to Cholesterol Crystals and Triggers Innate Immune Responses. (2015)
  • Author(s): Kiyotake R, Oh-Hora M, Ishikawa E, Miyamoto T, Ishibashi T, Yamasaki S.
  • Journal Title: J Biol Chem. Volume: 290 Issue: 42 Pages: 25322-32
  • DOI: 10.1074/jbc.m115.645234
  • Peer Reviewed
• [Journal Article] C-Type Lectin Receptor MCL Facilitates Mincle Expression and Signaling through Complex Formation. (2015)
  • Author(s): Miyake Y, Masatsugu OH, Yamasaki S.
  • Journal Title: J Immunol. Volume: 194 Issue: 11 Pages: 5366-74
  • DOI: 10.4049/jimmunol.1402429
  • Peer Reviewed
• [Journal Article] Identification of Pathogenic Cardiac CD11c+ Macrophages in Nod1-Mediated Acute Coronary Arteritis. (2015)
  • Author(s): Motomura Y, et al.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 35 Issue: 6 Pages: 1423-33
  • DOI: 10.1161/atvbaha.114.304846
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Corynomycolic acid-containing glycolipids signal through the pattern recognition receptor Mincle. (2015)
  • Author(s): van der Peet PL, Gunawan C, Torigoe S, Yamasaki S, Williams SJ.
  • Journal Title: Chem Commun (Camb) Volume: 51 Issue: 24 Pages: 5100-5103
  • DOI: 10.1039/c5cc00085h
  • Peer Reviewed
• [Journal Article] C-Type lectin receptor MCL facilitates Mincle expression and signaling through complex formation. (2015)
  • Author(s): Miyake Y, Oh-Hora M, Yamasaki S.
  • Journal Title: J Immunol. Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Identification of pathogenic cardiac CD11c+ macrophages in Nod1-mediated acute coronary arteritis. (2015)
  • Author(s): Motomura Y, Kanno S, Asano K, Tanaka M, Hasegawa Y, Katagiri H, Saito T, Hara H, Nishio H, Hara T, Yamasaki S.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 印刷中
  • Peer Reviewed
• [Journal Article] The C-type lectin receptor CLECSF8/CLEC4D is a key component of anti-mycobacterial immunity. (2015)
  • Author(s): Wilson GJ, Marakalala MJ, Hoving JC, van Laarhoven A, Drummond RA, Kerscher B, Keeton R, van de Vosse E, Ottenhoff TH, Plantinga TS, Alisjahbana B, Govender D, Besra GS, Netea MG, Reid DM, Willment JA, Jacobs M, Yamasaki S, van Crevel R, Brown GD.
  • Journal Title: Cell Host Microbe. Volume: 17 Issue: 2 Pages: 252-259
  • DOI: 10.1016/j.chom.2015.01.004
  • Peer Reviewed
• [Journal Article] Activation of an innate immune receptor, Nod1, accelerates atherogenesis in Apoe-/- mice. (2015)
  • Author(s): Kanno S, Nishio H, Tanaka T, Motomura Y, Murata K, Ihara K, Onimaru M, Yamasaki S, Kono H, Sueishi K, Hara T.
  • Journal Title: J Immunol. Volume: 194 Issue: 2 Pages: 773-780
  • DOI: 10.4049/jimmunol.1302841
  • Peer Reviewed / Open Access
• [Journal Article] Dectin-2 deficiency promotes Th2 response and mucin production in the lungs after pulmonary infection with Cryptococcus neoformans. (2015)
  • Author(s): Nakamura Y, Sato K, Yamamoto H, Matsumura K, Matsumoto I, Nomura T, Miyasaka T, Ishii K, Kanno E, Tachi M, Yamasaki S, Saijo S, Iwakura Y, Kawakami K.
  • Journal Title: Infect Immun. Volume: 83 Issue: 2 Pages: 671-681
  • DOI: 10.1128/iai.02835-14
  • Peer Reviewed
• [Journal Article] Macrophage-Inducible C-Type Lectin Mincle-Expressing Dendritic Cells Contribute to Control of Splenic Mycobacterium bovis BCG Infection in Mice (2015)
  • Author(s): Friederike Behler, Regina Maus, Jennifer Bohling, Sarah Knippenberg, Gabriele Kirchhof, Masahiro Nagata, Danny Jonigk, Nicole Izykowski, Lavinia Mägel, Tobias Welte, Sho Yamasaki, Ulrich A. Maus
  • Journal Title: Infection and Immunity Volume: 83 Issue: 1 Pages: 184-196
  • DOI: 10.1128/iai.02500-14
  • Peer Reviewed
• [Journal Article] 3-O-sulfo-β-d-galactose moiety of endogenous sulfoglycolipids is a potential ligand for immunoglobulin-like receptor LMIR5 (2015)
  • Author(s): Phongsisay V, Iizasa E, Hara H, Yamasaki S
  • Journal Title: Molecular Immunology Volume: 63 Issue: 2 Pages: 595-595
  • DOI: 10.1016/j.molimm.2014.07.023
  • Peer Reviewed
• [Journal Article] Macrophage-inducible C-type lectin underlies obesity-induced adipose tissue fibrosis. (2014)
  • Author(s): Tanaka M, Ikeda K, Suganami T, et al.
  • Journal Title: Nat Commun Volume: 5 Issue: 1 Pages: 4982-4982
  • DOI: 10.1038/ncomms5982
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Dectin-2 is a direct receptor for mannose-capped lipoarabinomannan of mycobacteria. (2014)
  • Author(s): Yonekawa A, Saijo S, Hoshino Y, Miyake Y, Ishikawa E, Suzukawa M, Inoue H, Tanaka M, Yoneyama M, Oh-Hora M, Akashi K, Yamasaki S.
  • Journal Title: Immunity Volume: 41 Issue: 3 Pages: 402-13
  • DOI: 10.1016/j.immuni.2014.08.005
  • Peer Reviewed / Open Access
• [Journal Article] Application of oocyte cryopreservation technology in TALEN-mediated mouse genome editing. (2014)
  • Author(s): Nakagawa Y, Sakuma T, Nakagata N, Yamasaki S, Takeda N, Ohmuraya M, Yamamoto T.
  • Journal Title: Exp Anim. Volume: 63 Pages: 349-355
  • NAID: 130004677827
  • Peer Reviewed
• [Journal Article] The tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) imposes a brake on antitumor activity of CD8 T cells. (2014)
  • Author(s): Giordano M, Roncagalli R, Bourdely P, Chasson L, Buferne M, Yamasaki S, Beyaert R, van Loo G, Auphan-Anezin N, Schmitt-Verhulst AM, Verdeil G.
  • Journal Title: Proc Natl Acad Sci USA Volume: 111 Issue: 30 Pages: 11115-11120
  • DOI: 10.1073/pnas.1406259111
  • Peer Reviewed
• [Journal Article] LMIR5 extracellular domain activates myeloid cells through Toll-like receptor 4. (2014)
  • Author(s): Phongsisay V, Iizasa E, Hara H, Yamasaki S
  • Journal Title: Molecular Immunology Volume: 62 Issue: 1 Pages: 169-169
  • DOI: 10.1016/j.molimm.2014.06.012
  • Peer Reviewed
• [Journal Article] Glycerol monomycolate is a novel ligand for the human, but not mouse macrophage inducible C-type lectin, Mincle. (2014)
  • Author(s): Hattori Y, Morita, D, Fujiwara N, Mori D, Nakamura T, Harashima H, Yamasaki S, Sugita M.
  • Journal Title: The Journal of Biological Chemistry Volume: 289(22) Issue: 22 Pages: 15405-12
  • DOI: 10.1074/jbc.m114.566489
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] LAPTM5 promotes lysosomal degradation of intracellular but not the cell surface CD3ζimmunol.. (2014)
  • Author(s): Kawai, Y., Ouchida, R., Yamasaki, S., Dragone, L., Tsubata, T. and Wang, J.-Y.
  • Journal Title: Cell Biol. Volume: 92 Issue: 6 Pages: 527-534
  • DOI: 10.1038/icb.2014.18
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Quantitative proteomic analysis of signalsome dynamics in primary T cells identifies the CD6 surface receptor as a LAT-independent TCR signaling hub (2014)
  • Author(s): Roncagalli R., Hauri S., Fiore F., Liang Y., Chen Z., Sansoni A., Kanduri K., Joly R., Malzac A., Lahdesmaki H., Lahesmaa R., Yamasaki S., Saito T., Malissen M., Aebersold R., Gstaiger M., and Malissen B.
  • Journal Title: Nat. Immunol. Volume: 15 Issue: 4 Pages: 384-392
  • DOI: 10.1038/ni.2843
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Characterization of the receptors for mycobacterial cord factor in Guinea pig. (2014)
  • Author(s): Toyonaga K, Miyake Y, Yamasaki S.
  • Journal Title: PLoS One Volume: 9 Issue: 2 Pages: e88747-e88747
  • DOI: 10.1371/journal.pone.0088747
  • Peer Reviewed
• [Presentation] Immune Responses against Mycobacteria through C-type Lectin Receptors (2017)
  • Author(s): Sho Yamasaki
  • Organizer: US-Japan Cooperative Medical Science Program Mycobacterial Panel Meeting
  • Place of Presentation: Korea
  • Year and Date: 2017-02-07
  • Int'l Joint Research / Invited
• [Presentation] 結核菌アジュバント認識機構と免疫応答 (2017)
  • Author(s): 山崎晶
  • Organizer: 第10回次世代アジュバント研究会
  • Place of Presentation: 大阪
  • Year and Date: 2017-01-23
  • Invited
• [Presentation] レクチン受容体を介する脂質認識と免疫応答 (2017)
  • Author(s): 山崎晶
  • Organizer: アレルギークリニカルカンファレンス
  • Place of Presentation: 千葉
  • Invited
• [Presentation] Recognition of mycobacterial glycolipids through lectin receptors (2016)
  • Author(s): Sho Yamasaki
  • Organizer: IUBMB Meeting
  • Place of Presentation: 台湾
  • Year and Date: 2016-12-14
  • Int'l Joint Research / Invited
• [Presentation] Regulation of Immune Responses through C-type lectin receptors (2016)
  • Author(s): Sho Yamasaki
  • Organizer: The International Symposium on Molecular Cell Biology of Macrophages
  • Place of Presentation: 横浜
  • Year and Date: 2016-06-04
  • Invited
• [Presentation] Recognition of mycobacterial glycolipids through C-type lectin receptors (2016)
  • Author(s): Sho Yamasaki
  • Organizer: Glycoscience Japan-The Netherlands Joint Seminar 2016
  • Place of Presentation: The Netherlands
  • Year and Date: 2016-04-19
  • Int'l Joint Research / Invited
• [Presentation] 結核菌認識受容体と免疫応答 (2016)
  • Author(s): 山崎晶
  • Organizer: 感染免疫ミニシンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2016-03-17
  • Invited
• [Presentation] Recognition of mycobacteria through C-type lectin receptors (2016)
  • Author(s): 山崎晶
  • Organizer: 第89回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-03-09
  • Invited
• [Presentation] C型レクチンを介するアジュバント認識と免疫応答 (2016)
  • Author(s): 山崎晶
  • Organizer: 岡山免疫懇話会
  • Place of Presentation: 岡山
  • Year and Date: 2016-03-03
  • Invited
• [Presentation] Recognition of damaged self through C-type lectin receptors (2016)
  • Author(s): 山崎晶
  • Organizer: Environment controlling normal and diseased hematopoietic and immune systems
  • Place of Presentation: 横浜
  • Year and Date: 2016-03-02
  • Invited
• [Presentation] 結核菌アジュバント認識機構と免疫応答 (2016)
  • Author(s): 山崎晶
  • Organizer: 第9回次世代アジュバント研究会
  • Place of Presentation: 大阪
  • Year and Date: 2016-01-19
  • Invited
• [Presentation] C型レクチン受容体を介する免疫応答 (2016)
  • Author(s): 山崎晶
  • Organizer: Advanced Seminar
  • Place of Presentation: 大阪
  • Year and Date: 2016-01-05
  • Invited
• [Presentation] Recognition of Mycobacteria through C-Type Lectin Receptors (2016)
  • Author(s): Sho Yamasaki
  • Organizer: The 13th Korea - Japan International Symposium on Microbiology,
  • Place of Presentation: Korea
  • Int'l Joint Research / Invited
• [Presentation] C型レクチン受容体による病原体認識と免疫応答 (2016)
  • Author(s): 山崎晶
  • Organizer: 第81回日本インターフェロン・サイトカイン学会学術集会
  • Place of Presentation: 長崎
  • Invited
• [Presentation] レクチン受容体を介した結核菌に対する生体防御機構 (2016)
  • Author(s): 山崎晶
  • Organizer: 第27回日本生体防御学会学術総会
  • Place of Presentation: 福岡
  • Invited
• [Presentation] 免疫系による死細胞認識機構とその応答 (2016)
  • Author(s): 山崎晶
  • Organizer: 第31回日本Shock学会総会 (日本Cell Death学会合同シンポジウム)
  • Place of Presentation: 東京
  • Invited
• [Presentation] レクチン受容体群による結核菌アジュバントの認識と免疫応答 (2016)
  • Author(s): 山崎晶
  • Organizer: 千里ライフサイエンスセミナー
  • Place of Presentation: 大阪
  • Invited
• [Presentation] 結核菌アジュバント認識機構と免疫応答 (2015)
  • Author(s): 山崎晶
  • Organizer: 基盤研セミナー
  • Place of Presentation: 大阪
  • Year and Date: 2015-12-18
  • Invited
• [Presentation] レクチン受容体による糖脂質認識と免疫応答 (2015)
  • Author(s): 山崎晶
  • Organizer: 第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01
  • Invited
• [Presentation] Immune responses to mycobacteria through C-type lectin receptors (2015)
  • Author(s): Sho Yamasaki
  • Organizer: Seminar at Chungnam National University
  • Place of Presentation: Daejeon, Korea
  • Year and Date: 2015-11-06
  • Int'l Joint Research / Invited
• [Presentation] Recognition of Mycobacterial Adjuvants through C-type Lectin Receptors (2015)
  • Author(s): Sho Yamasaki
  • Organizer: International Meeting of the Federation of Korean Microbiological Societies
  • Place of Presentation: Ilsan, Korea
  • Year and Date: 2015-11-05
  • Int'l Joint Research / Invited
• [Presentation] Recognition of damaged self through Mincle (2015)
  • Author(s): Sho Yamasaki
  • Organizer: Japan Australia Meeting on Cell Death
  • Place of Presentation: Melbourne, Australia
  • Year and Date: 2015-10-21
  • Int'l Joint Research / Invited
• [Presentation] Identification of Pathogenic Cardiac CD11c+ Macrophages in Coronary Arteritis Similar to Kawasaki Disease (2015)
  • Author(s): Sho Yamasaki, Yoshitomo Motomura
  • Organizer: The 4th CSI/JSI/KAI Joint Symposium on Immunology
  • Place of Presentation: Suzhou, China
  • Year and Date: 2015-09-19
  • Int'l Joint Research / Invited
• [Presentation] レクチン受容体による糖脂質認識と免疫応答 (2015)
  • Author(s): 山崎晶
  • Organizer: 糖鎖免疫研究会Glyco-immunology 2015
  • Place of Presentation: 東京
  • Year and Date: 2015-08-19
  • Invited
• [Presentation] レクチン受容体を介する結核菌認識と免疫応答 (2015)
  • Author(s): 山崎晶
  • Organizer: 沖縄感染免疫シンポジウム2015
  • Place of Presentation: 沖縄
  • Year and Date: 2015-07-31
  • Invited
• [Presentation] レクチン受容体を介する免疫応答 (2015)
  • Author(s): 山崎晶
  • Organizer: 第17回免疫サマースクール2015
  • Place of Presentation: 淡路
  • Year and Date: 2015-07-21
  • Invited
• [Presentation] 死細胞認識受容体Mincleが認識する内因性糖脂質の探索 (2015)
  • Author(s): 山崎晶
  • Organizer: 第24回日本Cell Death学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-07-11
  • Invited
• [Presentation] Immune Responses to Mycobacterial components through C-type Lectin Receptors (2015)
  • Author(s): Sho Yamasaki
  • Organizer: FASEB Science Research Conferences “Signal Transduction in the Immune System”
  • Place of Presentation: Big Sky, USA
  • Year and Date: 2015-06-07
  • Int'l Joint Research / Invited
• [Presentation] C型レクチン受容体による糖脂質認識と免疫応答 (2015)
  • Author(s): 山崎晶
  • Organizer: 第57回日本脂質生化学会
  • Place of Presentation: 東京
  • Year and Date: 2015-05-28
  • Invited
• [Presentation] レクチン受容体を介した病原体認識と免疫応答 (2015)
  • Author(s): 山崎晶
  • Organizer: 東大医科研学友会セミナー
  • Place of Presentation: 東京
  • Year and Date: 2015-05-27
  • Invited
• [Presentation] Recognition of glycolipids through C-type lectin receptors and immune responses (2015)
  • Author(s): Sho Yamasaki
  • Organizer: Victoria University of Wellington Seminar
  • Place of Presentation: Wellington, New Zealand
  • Year and Date: 2015-04-16
  • Int'l Joint Research / Invited
• [Presentation] Regulation of immune responses through C-type lectin receptors (2015)
  • Author(s): Sho Yamasaki
  • Organizer: The 6th International Symposium of IFReC
  • Place of Presentation: 大阪
  • Year and Date: 2015-02-23 – 2015-02-24
  • Invited
• [Presentation] Recognition of fungal pathogens by C-type lectin receptors (2015)
  • Author(s): Sho Yamasaki
  • Organizer: Gordon Research Conferences 2015 Immunology of Fungal Infections
  • Place of Presentation: Galveston, USA
  • Year and Date: 2015-01-18 – 2015-01-23
  • Invited
• [Presentation] 損傷自己組織の認識と慢性炎症 (2014)
  • Author(s): 山崎 晶
  • Organizer: 第43回日本免疫学会学術集会オーバービュートーク
  • Place of Presentation: 京都
  • Year and Date: 2014-12-10 – 2014-12-12
  • Invited
• [Presentation] アジュバントの認識と免疫応答 (2014)
  • Author(s): 山崎 晶
  • Organizer: 第43回日本免疫学会学術集会アフィメトリクスランチョンセミナー
  • Place of Presentation: 京都
  • Year and Date: 2014-12-10 – 2014-12-12
  • Invited
• [Presentation] レクチン受容体による糖脂質認識と免疫応答 (2014)
  • Author(s): 山崎 晶
  • Organizer: 第12回日本糖鎖科学コンソーシアム（JCGG)シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2014-12-04 – 2014-12-05
  • Invited
• [Presentation] 結核菌を認識する受容体と免疫応答 (2014)
  • Author(s): 山崎 晶
  • Organizer: 感染症研究グローバルネットワークフォーラム2014
  • Place of Presentation: 千葉
  • Year and Date: 2014-11-15
  • Invited
• [Presentation] 細胞死に伴って放出される内因性アジュバントの同定 (2014)
  • Author(s): 山崎 晶
  • Organizer: 新学術領域研究「細胞死を起点とする生体制御ネットワークの解明」キックオフシンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2014-11-13
• [Presentation] Recognition of mycobacterial adjuvants through C-type lectin receptors (2014)
  • Author(s): Sho Yamasaki
  • Organizer: 8th Vaccine and ISV Congress
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2014-10-26 – 2014-10-28
  • Invited
• [Presentation] Immune responses against glycolipids through C-type lectin receptors (2014)
  • Author(s): Sho Yamasaki
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2014-10-15 – 2014-10-18
  • Invited
• [Presentation] Immune regulation through C-type lectin receptors (2014)
  • Author(s): Sho Yamasaki
  • Organizer: Novo Nordisk Innovation Summit
  • Place of Presentation: 東京
  • Year and Date: 2014-10-01 – 2014-10-02
  • Invited
• [Presentation] Recognition of bacterial adjuvants through C-type lectin receptors (2014)
  • Author(s): Sho Yamasaki
  • Organizer: 第13回あわじしま感染症・免疫フォーラム
  • Place of Presentation: 奈良
  • Year and Date: 2014-09-23 – 2014-09-26
  • Invited
• [Presentation] Adjuvant recognition through C-type lectin Receptors (2014)
  • Author(s): Sho Yamasaki
  • Organizer: 2014 Cold Spring Harbor Asia Conference on Frontiers of Immunology in Health and Diseases
  • Place of Presentation: Suzhou, China
  • Year and Date: 2014-09-02 – 2014-09-06
  • Invited
• [Presentation] Immune responses to pathogens through C-type lectin receptors (2014)
  • Author(s): Sho Yamasaki
  • Organizer: International Symposium of the Institute Network
  • Place of Presentation: 大阪
  • Year and Date: 2014-06-19 – 2014-06-20
  • Invited
• [Presentation] Adjuvant recognition through C-type lectin receptors (2014)
  • Author(s): Sho Yamasaki
  • Organizer: The 22nd International Symposium on Molecular Cell Biology of Macrophages
  • Place of Presentation: 神戸
  • Year and Date: 2014-06-02 – 2014-06-03
  • Invited
• [Book] C-Type Lectin Receptors in Immunity (2016)
  • Author(s): Masahiro Nagata, Zakaria Omahdi, Sho Yamasaki.
  • Total Pages: 215
  • Publisher: Springer
• [Patent(Industrial Property Rights)] 炎症性疾患の治療剤及びその使用 (2016)
  • Inventor(s): 山崎 晶
  • Industrial Property Rights Holder: 国立大学法人九州大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-014828
  • Filing Date: 2016-01-28
• [Patent(Industrial Property Rights)] Adjuvant (2015)
  • Inventor(s): 山崎 晶
  • Industrial Property Rights Holder: 国立大学法人九州大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-08-27
  • Overseas
• [Patent(Industrial Property Rights)] Adjuvant (2014)
  • Inventor(s): 山崎 晶
  • Industrial Property Rights Holder: 山崎 晶
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2014-173066
  • Filing Date: 2014-08-27