Analysis on molecular mechanisms of antiviral innate immune regulation via RNA sensors
| Project/Area Number |
26293107
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
Kawai Taro 奈良先端科学技術大学院大学, バイオサイエンス研究科, 教授 (50456935)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Keywords | 自然免疫 / ウイルス感染 / シグナル伝達 / サイトカイン / 免疫学 |
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| Outline of Final Research Achievements |
Virus infection is usually sensed by innate immune receptors for foreign RNAs such as RIG-I-like receptors (RLRs). In this research, we have identified Arl5b as a negative regulator for RLRs signaling. Moreover, we have discovered a lipid kinase PIKfyve as a positive regulator for RLRs. Moreover, we have identified RNA-binding protein HuR as a positive regulator for RLR signaling. We found that HuR binds to mRNA encoding the kinase Plk2 and it plays a critical roles in induction of type I interferon during RLR signaling. These findings demonstrate that HuR-mediated stabilization of Plk2 mRNA regulates antiviral innate immunity.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response.2017
Author(s)
Kozaki T, Komano J, Kanbayashi D, Takahama M, Misawa T, Satoh T, Takeuchi O, Kawai T, Shimizu S, Matsuura Y, Akira S, Saitoh T
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Journal Title
Proc Natl Acad Sci U S A
Volume: 114
Issue: 10
Pages: 2681-2686
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] IPS-1 differentially induces TRAIL, BCL2, BIRC3 and PRKCE in type I interferons-dependent and -independent anticancer activity.2015
Author(s)
Kumar S, Ingle H, Mishra S, Mahla RS, Kumar A, Kawai T, Akira S, Takaoka A, Raut AA, Kumar H.
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Journal Title
Cell Death Dis.
Volume: 6
Issue: 5
Pages: e1758-e1758
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] RIG-I detects mRNA of intracellular Salmonella enterica serovar Typhimurium during bacterial infection.2014
Author(s)
Schmolke M, Patel JR, de Castro E, Sánchez-Aparicio MT, Uccellini MB, Miller JC, Manicassamy B, Satoh T, Kawai T, Akira S, Merad M, García-Sastre A.
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Journal Title
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Nucleic acid sensing by T cells initiates Th2 cell differentiation.2014
Author(s)
Imanishi T, Ishihara C, Badr Mel S, Hashimoto-Tane A, Kimura Y, Kawai T, Takeuchi O, Ishii KJ, Taniguchi S, Noda T, Hirano H, Brombacher F, Barber GN, Akira S, Saito T
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Journal Title
Nat Commun
Volume: 10
Issue: 1
Pages: 3566-3566
DOI
Related Report
Peer Reviewed / Open Access
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