Elucidation of molecular mechanisms of the selection and maturation of thymocytes
| Project/Area Number |
26293108
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
小迫 英尊 徳島大学, 藤井節朗記念医科学センター, 教授 (10291171)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2016: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Keywords | T細胞分化 / シグナル情報伝達 / カルシウム / ヘルパーT細胞 / IL-4 / ヒストン脱メチル化 / 免疫シグナル伝達 / T細胞 |
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| Outline of Final Research Achievements |
To elucidate the molecular mechanisms of the selection and maturation of thymocytes, we have analyzed the role of calcium signaling in T lymphocytes using cell-type specific Stim1 and Stim2 doubly or calcineurin b1 knockout mice. Using Foxp3-IRES-YFP/Cre Tg mice, we found that the store-operated calcium entry－calcium signaling axis is not essential for maintenance of Foxp3 expression in regulatory T cells after maturation, but is necessary for their inhibitory function. Cell maintenance of iNKT cells after maturation was normal in the absence of store-operated calcium entry. These results indicate that calcium signaling positively regulates differentiation of agonist selected thymocytes, while it positively regulates cell functions rather than cell maintenance after maturation.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Dectin-2 is a direct receptor for mannose-capped lipoarabinomannan of mycobacteria.2014
Author(s)
Yonekawa A, Saijo S, Hoshino Y, Miyake Y, Ishikawa E, Suzukawa M, Inoue H, Tanaka M, Yoneyama M, Oh-Hora M, Akashi K, Yamasaki S.
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Journal Title
Immunity
Volume: 41
Issue: 3
Pages: 402-13
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Endoplasmic reticulum calcium sensors, Stim1 and Stim2, control dendritic cell functions.2015
Author(s)
Soichiro Yoshikawa, Masatsugu Oh-hora, Kensuke Miyake, Lihua Li, Takuya Ohta, Kayo Horiguchi, Yoshinori Yamanishi, Hajime Karasuyama
Organizer
NIPS International Workshop, TRPs and SOCs
Place of Presentation
岡崎
Year and Date
2015-06-04
Related Report
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