Construction of immunosurveillance system by symbiotic network in the Peyer's patches
Project/Area Number |
26293111
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Immunology
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Research Institution | National Institutes of Biomedical Innovation, Health and Nutrition |
Principal Investigator |
KUNISAWA Jun 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所 ワクチン・アジュバント研究センター, プロジェクトリーダー (80376615)
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
|
Keywords | 共生細菌 / 炎症 / IgA抗体 / LPS / 免疫学 / 細菌 / 粘膜免疫 / 腸内細菌 |
Outline of Final Research Achievements |
The intestinal immune system is involved in the maintenance of immunological homeostasis in the gut. It is known that Peyer’s patches play a central role in regulating intestinal immunity, which is at least partly regulated by intestinal bacteria. In this study, we aim to clarify the function of Alcaligenes, a symbiotic bacteria found in Peyer's patches, in the regulation of intestinal immunity and found that Alcaligenes itself and Alcaligenes LPS possess unique features to moderately regulate intestinal immunity without induction of excessive inflammation.
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Report
(5 results)
Research Products
(126 results)
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[Journal Article] Lymphoid tissue-resident Alcaligenes LPS induces IgA production without excessive inflammatory responses via weak TLR4 agonist activity2018
Author(s)
N. Shibata, J. Kunisawa, K. Hosomi, Y. Fujimoto, K. Mizote, N. Kitayama, A. Shimoyama, H. Mimuro, S. Sato, N. 5 Kishishita, K. J. Ishii, K. Fukase, and H. Kiyono
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Journal Title
Mucosal Immunology
Volume: -
Issue: 3
Pages: 693-702
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Impaired airway mucociliary function reduces antigen-specific IgA immune response to immunization with a claudin-4-targeting nasal vaccine in mice2018
Author(s)
Suzuki H, Nagatake T, Nasu A, Lan H, Ikegami K, Setou M, Hamazaki Y, Kiyono H, Yagi K, Kondoh M, Kunisawa J
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Journal Title
Scientific Reports
Volume: 8
Issue: 1
Pages: 2904-2904
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] 17,18-EpETE-GPR40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques2017
Author(s)
Nagatake T, Shiogama Y, Inoue A, Kikuta J, Honda T, Tiwari P, Kishi T, Yanagisawa A, Isobe Y, Matsumoto N, Shimojou M, Morimoto S, Suzuki H, Hirata S, Steneberg P, Edlund H, Aoki J, Arita M, Kiyono H, Yasutomi Y, Ishii M, Kabashima K, Kunisawa J
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Journal Title
Journal of Allergy and Clinical Immunology
Volume: S0091-6749
Issue: 2
Pages: 32949-32944
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] IL-22BP dictates characteristics of Peyer's patch follicle-associated epithelium for antigen uptake2017
Author(s)
Kanaya T, Hase K, Sakakibara S, Kato T, Tachibana N, Sasaki T, Hashimoto Y, Sato T, Watarai H, Kunisawa J, Shibata N, Williams I, Kiyono H and Ohno H
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Journal Title
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Lymphoid tissue-resident commensal bacteria promote members of the IL-10 cytokine family to establish mutualism2016
Author(s)
Fung C.F, Bessman N.J, Hepworth M.R, Kumar N, Shibata N, Kobuley D, Wang K, Ziegler C.G, Goc J, Shima T, Umesaki Y, Sartor R.B, Sullivan K.V, Lawley T.D, Kunisawa J, Kiyono H, Sonnenberg G.F
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Journal Title
Immunity
Volume: 15;44(3)
Issue: 3
Pages: 634-46
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Mode of bioenergetic metabolism during B cell differentiation in the intestine determines the distinct requirement for vitamin B12015
Author(s)
J. Kunisawa, Y. Sugiura, T. Wake, T. Nagatake, H. Suzuki, R. Nagasawa, S. Shikata, K. Honda, E. Hashimoto, Y. Suzuki, M. Setou, M. Suematsu, H. Kiyono
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Journal Title
Cell Rep
Volume: 13
Issue: 1
Pages: 122-131
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Innate lymphoid cells regulate intestinal epithelial cell glycosylation.2014
Author(s)
Goto Y, Obata T, Kunisawa J, Sato S, Ivanov II, Lamichhane A, Takeyama N, Kamioka M, Sakamoto M, Matsuki T, Uematsu S, Akira S, Domino SE, Kulig P, Becher B, Renauld JC, Sasakawa C, Umesaki Y, Benno Y, Kiyono H
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Journal Title
Science
Volume: 345
Issue: 6202
Pages: 1254009-1254009
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The enzyme cyp26b1 mediates inhibition of mast cell activation by fibroblasts to maintain skin-barrier homeostasis.2014
Author(s)
Kurashima Y, Amiya T, Fjisawa K, Shibata N, Suzuki Y, Kogure Y, Hashimoto E, Otsuka A, Kabashima K, Sato S, Sato T, Kubo M, Akira S, Miyake K, Kunisawa J, Kiyono H.
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Journal Title
Immunity
Volume: 40
Issue: 4
Pages: 530-541
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Optimization of DNA preparation method from feces in guanidine thiocyanate solution for 16S rRNA-based profiling of human microbiota diversity2017
Author(s)
Koji Hosomi, Haruka Murakami, Yayoi Natsume-Kitatani, Chen Yi-An, Harumi Ohno, Kumpei Tanisawa, Hitoshi Kawashima, Tomomi Nishino, Ayu Matsunaga, Soichiro Hirata, Hidehiko Suzuki, Takahiro Nagatake, Kenji Mizuguchi, Motohiko Miyachi, Jun Kunisawa
Organizer
Cold Spring Harbor Asia
Related Report
Int'l Joint Research
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