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Development of a novel oncolytic virus by regulating the processing of virus-derived non-coding RNA

Research Project

Project/Area Number 26293118
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Applied pharmacology
Research InstitutionOsaka University

Principal Investigator

SAKURAI FUMINORI  大阪大学, 大学院薬学研究科, 准教授 (70370939)

Co-Investigator(Renkei-kenkyūsha) MIZUGUCHI HIROYUKI  大阪大学, 大学院薬学研究科, 教授 (50311387)
TACHIBANA MASASHI  大阪大学, 大学院薬学研究科, 特任准教授 (80513449)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Keywordsアデノウイルス / 非コードRNA / 腫瘍溶解性ウイルス / Dicer / 腫瘍溶解性アデノウイルス / 癌 / microRNA / プロセシング
Outline of Final Research Achievements

An adenovirus (Ad) genome encodes two non-coding RNAs, VA-RNA I and VA-RNA II. Previous studies demonstrated that VA-RNAs enhance Ad infection and that Dicer processes VA-RNAs, producing miRNA-like small RNAs (mivaRNA); however, relationship between Dicer-mediated processing of VA-RNAs and VA-RNA-mediated enhancement of Ad infection remained to be elucidated. In this study, we examined the effects of Dicer-mediated processing of VA-RNAs on Ad infection. We demonstrated that Dicer-mediated proessing of VA-RNA I resulted in loss of promotion activity of VA-RNA I for Ad infection. Based on these findings, we developed a novel oncolytic Ad showing superior antitumor effects.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (52 results)

All 2018 2017 2016 2015 2014

All Journal Article (11 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 11 results,  Open Access: 8 results,  Acknowledgement Compliant: 9 results) Presentation (41 results) (of which Invited: 4 results)

  • [Journal Article] Type I interferons impede short-hairpin RNA-mediated RNA interference via inhibition of dicer-mediated processing to small interfering RNA.2017

    • Author(s)
      Machitani M., Sakurai F., Wakabayashi K., Takayama K., Tachibana M., Mizuguchi H.
    • Journal Title

      Mol. Ther. Nucleic Acids,

      Volume: 6 Pages: 173-182

    • DOI

      10.1016/j.omtn.2016.12.007

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Inhibition of CRISPR/Cas9-Mediated Genome Engineering by a Type I Interferon-Induced Reduction in Guide RNA Expression2017

    • Author(s)
      Machitani M., Sakurai F., Wakabayashi K., Nakatani K., Takayama K., Tachibana M., Mizuguchi H.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 40 Issue: 3 Pages: 272-277

    • DOI

      10.1248/bpb.b16-00700

    • NAID

      130005398474

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] MicroRNA miR-27 Inhibits Adenovirus Infection by Suppressing the Expression of SNAP25 and TXN2.2017

    • Author(s)
      Machitani M, Sakurai F, Wakabayashi K, Nakatani K, Tachibana M, Mizuguchi H
    • Journal Title

      Journalof Virology

      Volume: 印刷中 Issue: 12

    • DOI

      10.1128/jvi.00159-17

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Enhanced oncolytic activities of the telomerase-specific replication-competent adenovirus expressing short-hairpin RNA against Dicer2017

    • Author(s)
      Machitani M., Sakurai F., Wakabayashi K., Tachibana M., Fujiwara T., Mizuguchi H.
    • Journal Title

      Mol. Cancer Ther

      Volume: 16 Issue: 1 Pages: 251-259

    • DOI

      10.1158/1535-7163.mct-16-0383

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Dicer functions as an antiviral system against human adenoviruses via cleavage of adenovirus-encoded noncoding RNA.2016

    • Author(s)
      Machitani M, Sakurai F, Wakabayashi K, Tomita K, Tachibana M, Mizuguchi H
    • Journal Title

      Scientific Reports

      Volume: - Issue: 1 Pages: 27598-27598

    • DOI

      10.1038/srep27598

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] NF-κB promotes leaky expression of adenovirus genes in a replication-incompetent adenovirus vector.2016

    • Author(s)
      Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Kosuke Nakatani, Kahori Shimizu, Masashi Tachibana and Hiroyuki Mizuguchi
    • Journal Title

      Sci. Rep.

      Volume: 6 Issue: 1 Pages: 19922-19922

    • DOI

      10.1038/srep19922

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficient detection of human circulating tumor cells without significant production of false-positive cells by a novel conditionally replicating adenovirus.2016

    • Author(s)
      Sakurai F, Narii N, Tomita K, Togo S, Takahashi K, Machitani M, et al.
    • Journal Title

      Mol Ther Methods Clin Dev.

      Volume: 3 Pages: 16001-16001

    • DOI

      10.1038/mtm.2016.1

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Proteolytic disassembly of viral outer capsid proteins is crucial for reovirus-mediated type-I interferon induction in both reovirus-susceptible and -refractory tumor cells2015

    • Author(s)
      Katayama et al.
    • Journal Title

      Biomed Research International

      Volume: 2015 Pages: 1-12

    • DOI

      10.1155/2015/468457

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Quantitative Analysis of Virus-associated RNAI Expression following Transduction with a Replication-incompetent Adenovirus Vector In Vitro and In Vivo.2015

    • Author(s)
      Wakabayashi K., Machitani M., Shimizu K., Tachibana M., Sakurai F., Mizuguchi H.
    • Journal Title

      J. Mol. Genet. Med.

      Volume: 9 Issue: 02 Pages: 169-169

    • DOI

      10.4172/1747-0862.1000169

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Activity levels of cathepsins B and L in tumor cells are a biomarker for efficacy of reovirus-mediated tumor cell killing2015

    • Author(s)
      Terasawa Y et l
    • Journal Title

      Cancer Gene Therapy

      Volume: 未定 Issue: 4 Pages: 188-197

    • DOI

      10.1038/cgt.2015.4

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Reovirus double-stranded RNA genomes and poly I:C induce down-regulation of hypoxia-inducible factor 12015

    • Author(s)
      Hotani et al
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 未定 Issue: 4 Pages: 1041-1046

    • DOI

      10.1016/j.bbrc.2015.03.147

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Post-transcriptional Gene Silencing機構を利用した高機能型遺伝子組換えアデノウイルスの開発2018

    • Author(s)
      櫻井文教
    • Organizer
      阪大薬ー医薬基盤健栄研ランチミーティング
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] アデノウイルスがコードするマイクロRNAのウイルス増殖促進機構の解明2017

    • Author(s)
      若林圭作、町谷充洋、櫻井文教、立花雅史、水口裕之
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] Adenovirus vector-induced hepatotoxicity during the early phase of adenoviral treatment is attributed to inflammatory cytokine-induced leaky expression of adenovirus genes2017

    • Author(s)
      Kahori Shimizu, Fuminori Sakurai, Shunsuke Iizuka, Masashi Tachibana, Toru Nishinaka, Tomoyuki Terada, Hiroyuki Mizuguchi
    • Organizer
      20th annual meeting of American society of Gene and Cell Therapy
    • Related Report
      2017 Annual Research Report
  • [Presentation] miR-27 inhibits adenovirus infection via the suppression of SNAP25 and TXN2 expressions2017

    • Author(s)
      Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Masashi Tachibana, Hiroyuki Mizuguchi
    • Organizer
      第23回日本遺伝子細胞治療学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Promotion of adenovirus infection by a microRNA derived from adenovirus Virus-Associated RNA II.2017

    • Author(s)
      Keisaku Wakabayashi, Mitsuhiro Machitani, Masashi Tachibana, Fuminori Sakurai, Hiroyuki Mizuguchi
    • Organizer
      第23回日本遺伝子細胞治療学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Adenovirus vector-induced hepatotoxicity during the early phase after systemic administration is attributed to inflammatory cytokine-induced leaky expression of adenovirus genes2017

    • Author(s)
      Kahori Shimizu, Fuminori Sakurai, Shunsuke Iizuka, Masashi Tachibana, Toru Nishinaka, Tomoyuki Terada, Hiroyuki Mizuguchi
    • Organizer
      第23回日本遺伝子細胞治療学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 宿主miR-27によるSNAP25及びTXN2の発現抑制はアデノウイルス感染を阻害する2017

    • Author(s)
      町谷充洋、櫻井文教、若林圭作、立花雅史、水口裕之
    • Organizer
      第65回日本ウイルス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 肝臓特異的なマイクロRNAを利用して肝障害性を低減させた新規アデノウイルスベクターによる血友病遺伝子治療に関する検討2017

    • Author(s)
      飯塚俊輔、櫻井文教、立花雅史、大橋一夫、水口裕之
    • Organizer
      第33回日本DDS学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] アデノウイルス由来マイクロRNAによるウイルス増殖の促進2017

    • Author(s)
      若林圭作、町谷充洋、立花雅史、櫻井文教、水口裕之
    • Organizer
      第65回日本ウイルス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] アデノウイルスが発現するマイクロRNAの機能解析2016

    • Author(s)
      若林圭作、町谷充洋、櫻井文教、立花雅史、水口裕之
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      東京
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] I型IFNによるCRISPR/Cas9システムを用いたゲノム編集効率の低下2016

    • Author(s)
      町谷充洋、櫻井文教、若林圭作、中谷光佑、高山和雄、立花雅史、水口裕之
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      東京
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] Small RNA derived from Adenovirus Virus-Associated RNA II, mivaRNA II, promotes Ad replication via post-transcriptional gene silencing2016

    • Author(s)
      Keisaku Wakabayashi, Mitsuhiro Machitani, Masashi Tachibana、Fuminori Sakurai、Hiroyuki Mizuguchi
    • Organizer
      The 24th Annual Congress of European Society of Gene and Cell Therapy
    • Place of Presentation
      フィレンツェ、イタリア
    • Year and Date
      2016-10-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] Type I interferons impede short-hairpin RNA-mediated RNA interference via inhibition of dicer-mediated processing to small interfering RNA2016

    • Author(s)
      Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Masashi Tachibana, Hiroyuki Mizuguchi
    • Organizer
      The 22nd annual meeting of JSGCT
    • Place of Presentation
      東京
    • Year and Date
      2016-07-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] miR-27によるCyclin G1の発現抑制がアデノウイルス感染に与える影響2016

    • Author(s)
      町谷充洋、櫻井文教、若林圭作、立花雅史、水口裕之
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] アデノウイルス外殻蛋白質に対する抗体がアデノウイルスベクターによる遺伝子導入に与える影響の解析2016

    • Author(s)
      冨田恭子、櫻井文教、町谷充洋、立花雅史、水口裕之
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] アデノウイルス感染に対する防御機構としてのDicerの役割2015

    • Author(s)
      町谷充洋、櫻井文教、若林圭作、立花雅史、水口裕之
    • Organizer
      第38回 日本分子生物学会年会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Inhibition of in vivo transduction with adenovirus vectors via antibodies against adenovirus capsid proteins2015

    • Author(s)
      Tomita et al.
    • Organizer
      The 63rd Annual Meetingof the Japanese Society for Virology
    • Place of Presentation
      福岡県福岡市
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Expression profile of virus-associated RNAI following transduction with a replication-incompetent adenovirus vector in vitro and in vivo2015

    • Author(s)
      Wakabayashi et al.
    • Organizer
      The 63rd Annual Meetingof the Japanese Society for Virology
    • Place of Presentation
      福岡県福岡市
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Inhibition of NF-kB leads to suppression of Ad vector-mediated hepatotoxicities via reduction in the leaky expression of Ad genes2015

    • Author(s)
      Machitani et al.
    • Organizer
      The 63rd Annual Meetingof the Japanese Society for Virology
    • Place of Presentation
      福岡県福岡市
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] アデノウイルス由来小分子RNAの機能特性に立脚した新規腫瘍溶解性ウイルスの開発2015

    • Author(s)
      町谷充洋、櫻井文教、若林圭作、立花雅史、藤原俊義、水口裕之
    • Organizer
      第65回日本薬学会近畿支部総会・大会
    • Place of Presentation
      大阪府富田林市
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] Reduction in the leaky expression of Ad genes from a replication-incompetent adenovirus vector by inhibition of NF-kB2015

    • Author(s)
      Machitani et al.
    • Organizer
      The 74th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      愛知県名古屋市
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] Elucidation of mechanism of reovirus-mediated reduction in hypoxia inducible factor-1α following infection in tumor cells2015

    • Author(s)
      Hotani et al.
    • Organizer
      The 74th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      愛知県名古屋市
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] Quantitative analysis of virus-associated RNAI expression following transduction with a replication-incompetent adenovirus vector in vitro and in vivo2015

    • Author(s)
      Wakabayashi et al.
    • Organizer
      The 21th Annual Meeting of Japan Society of Gene Therapy
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2015-07-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] Suppression of adenovirus vector-induced hepatotoxicity at the early phase via suppression of leaky expression of adenovirus genes2015

    • Author(s)
      Shimizu et al.
    • Organizer
      The 21th Annual Meeting of Japan Society of Gene Therapy
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2015-07-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] Development of a potent oncolytic adenovirus via regulation of dicer-mediated processing of virus-associated RNAs2015

    • Author(s)
      Sakurai et al.
    • Organizer
      The 21th Annual Meeting of Japan Society of Gene Therapy
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2015-07-24
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] NF-kB mediates leaky expression of adenovirus genes in a replication-incompetent adenovirus vector2015

    • Author(s)
      Machitani et al.
    • Organizer
      The 21th Annual Meeting of Japan Society of Gene Therapy
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2015-07-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] Inhibitory effects of adenovirus neutralizing antibodies against different adenoviral capsid proteins on transduction with an adenovirus vector2015

    • Author(s)
      Tomita et al.
    • Organizer
      The 21th Annual Meeting of Japan Society of Gene Therapy
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2015-07-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] Post-transcriptional Gene Silencing機構を利用した高機能型遺伝子組換えアデノウイルスの開発2015

    • Author(s)
      櫻井文教、水口裕之
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸学院大学
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] RNA干渉に関わる因子であるDicerはアデノウイルスに対する防御機構として機能する2015

    • Author(s)
      町谷充洋、櫻井文教、若林圭作、立花雅史、水口裕之
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸学院大学
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Dicerノックダウン細胞を用いたアデノウイルスベクター作製効率の改善に関する検討2015

    • Author(s)
      若林圭作、町谷充洋、櫻井文教、立花雅史、水口裕之
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸学院大学
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] レオウイルスによる低酸素誘導因子HIF-1α発現量低下に関する分子機構の解明2015

    • Author(s)
      宝谷拓磨、立花雅史、水口裕之、櫻井文教
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸学院大学
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 非コードRNAによる遺伝子発現制御機構を利用した遺伝子組換えアデノウイルスの開発2014

    • Author(s)
      櫻井文教
    • Organizer
      関西実験動物研究会 第124回研究会
    • Place of Presentation
      京都大学
    • Year and Date
      2014-12-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Dicerはアデノウイルス由来小分子RNA(VA-RNA)の切断を介してアデノウイルスの感染を抑制する2014

    • Author(s)
      櫻井文教、町谷充洋、若林圭作、立花雅史、水口裕之
    • Organizer
      第62回ウイルス学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Dicerのノックダウンによるアデノウイルスベクター用新規パッケージング細胞の開発2014

    • Author(s)
      若林圭作、町谷充洋、櫻井文教、立花雅史、水口裕之
    • Organizer
      第64回日本薬学会近畿支部総会・大会
    • Place of Presentation
      京都薬科大学
    • Year and Date
      2014-10-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] レオウイルスによる低酸素誘導因子HIF-1α発現量低下における核酸認識受容体の2014

    • Author(s)
      宝谷拓磨、立花雅史、水口裕之、櫻井文教
    • Organizer
      第64回日本薬学会近畿支部総会・大会
    • Place of Presentation
      京都薬科大学
    • Year and Date
      2014-10-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Development of a novel oncolytic adenovirus expressing a short-hairpin RNA against a microRNA processing factor2014

    • Author(s)
      Mitsuhiro Machitani, Fuminori Sakurai, Masashi Tachibana, Toshiyoshi Fujiwara, Hiroyuki Mizuguchi
    • Organizer
      第73回日本癌学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Activity levels of cathepsin B and L are crucial factors determining reovirus-mediated tumor cell lysis2014

    • Author(s)
      Fuminori Sakurai, Yuki Katayama, Masashi Tachibana, Hiroyuki Mizuguchi
    • Organizer
      第73回日本癌学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] MICRORNA PROCESSING FACTORS REGULATE ADENOVIRUS REPLICATION2014

    • Author(s)
      Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Masashi Tachibana, Hiroyuki Mizuguchi
    • Organizer
      第20回日本遺伝子治療学会総会
    • Place of Presentation
      慈恵医科大学
    • Year and Date
      2014-08-06 – 2014-08-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] マイクロRNAプロセシング因子の制御による腫瘍溶解性アデノウイルスの機能向上2014

    • Author(s)
      町谷充洋、櫻井文教、若林圭作、立花雅史、藤原俊義、水口裕之
    • Organizer
      第30回日本DDS学会学術集会
    • Place of Presentation
      慶応大学薬学部
    • Year and Date
      2014-07-30 – 2014-07-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] Evaluation of involvement of microRNA processing factors in adenovirus replication2014

    • Author(s)
      Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Masashi Tachibana, Hiroyuki Mizuguchi
    • Organizer
      American Society of Gene & Cell Therapy, 17th Annual Meeting
    • Place of Presentation
      ワシントンDC
    • Year and Date
      2014-05-21 – 2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Cathepsin activity levels in tumor cells are a crucial determinant for reovirus oncolysis2014

    • Author(s)
      Fuminori Sakurai, Yuichi Terasawa, Masahi Tachibana, Hiroyuki Mizuguchi
    • Organizer
      American Society of Gene & Cell Therapy, 17th Annual Meeting
    • Place of Presentation
      ワシントンDC
    • Year and Date
      2014-05-21 – 2014-05-24
    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2019-03-29  

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