| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Outline of Final Research Achievements |
The 5-year survival rate of pancreatic cancer is approximately 10% and has not improved for 30 years. Especially in advanced pancreatic cancer, the prognosis is still less than 6 months. The fact suggests that the efficacy of the administered anti-tumor agents are not enough.
In this study, we investigated the role of drug delivery pathway: via 1) tumor blood vessel and 2) tumor fibrous tissue.
For the purpose we constructed a novel three dimensional culture system in this study using cells derived from human pancreatic cancer, especially pancreatic stellate cells (PSC) derived from human patients. We investigated the developed model from the viewpoint of molecular biology and behavior of nanomedicine. As a result, we were able to construct a method of three-dimensional culture / co-culture with reproducibility using PSC, and succeeded in using the model for the analysis of drug delivery.
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