The role of CL-K1 in DIC patients
Project/Area Number |
26293124
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Laboratory medicine
|
Research Institution | Asahikawa Medical College |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
松田 泰幸 旭川医科大学, 医学部, 助教 (10532252)
森 健一郎 旭川医科大学, 医学部, 助教 (70610236)
鈴木 定彦 北海道大学, 人獣共通感染症リサーチセンター, 教授 (90206540)
大谷 克城 旭川医科大学, 医学部, 准教授 (90396367)
松下 操 東海大学, 工学部, 教授 (00165812)
|
Project Period (FY) |
2014-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
|
Keywords | DIC / コレクチン / 感染症 / collectin / 補体 / 微生物 / 内科 |
Outline of Final Research Achievements |
In collectin CL-K1 which Wakamiya discovered, it is supposed as well as conventional collectin that I have a natural immunity function. I performed DIC patient registration and performed sample collection of blood. I measured the inspection item of the DIC mainly on solidification fibrinolysis system. On the other hand, about collectin, I narrowed it down to two of CL-K1 and MBL. In the previous study, CL-K1 took the value that related to in progress of the DIC. However, in the measurement of this Japanese, the meaningful difference was not seen in presence of the DIC.
|
Report
(5 results)
Research Products
(30 results)
-
[Journal Article] Three pentraxins C-reactive protein, serum amyloid p component and pentraxin 3 mediate complement activation using Collectin CL-P12017
Author(s)
2.Roy, N., Ohtani, K., Hidaka, Y., Amano, Y., Matsuda, Y., Mori, K., Hwang, I., Inoue, N., Wakamiya, N.
-
Journal Title
Biochim Biophys Acta
Volume: 861
Issue: 2
Pages: 1-14
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
[Journal Article] Collectin CL-P1 utilizes C-reactive protein for complement activation.2016
Author(s)
5.Roy, N., Ohtani, K., Matsuda, Y., Mori, K., Hwang, I., Suzuki, Y., Inoue, N., Wakamiya, N.
-
Journal Title
Biochim Biophys Acta
Volume: 1860
Issue: 6
Pages: 1118-1128
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
[Journal Article] Molecular basis of sugar recognition by collectin-K1 and the effects of mutations associated with 3MC syndrome2015
Author(s)
Venkatraman Girija U, Furze CM, Gingras AR, Yoshizaki T, Ohtani K, Marshall JE, Wallis AK, Schwaeble WJ, El-Mezgueldi M, Mitchell DA, Moody PC, Wakamiya N, Wallis R
-
Journal Title
BMC Biol
Volume: 13
Issue: 1
Pages: 27-27
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
-
[Journal Article] Collectin CL-LK Is a Novel Soluble Pattern Recognition Receptor for Mycobacterium tuberculosis2015
Author(s)
Troegeler A, Lugo-Villarino G, Hansen S, Rasolofo V, Henriksen ML, Mori K, Ohtani K, Duval C, Mercier I, Bénard A, Nigou J, Hudrisier D, Wakamiya N, Neyrolles O
-
Journal Title
PLoS One
Volume: 10
Issue: 7
Pages: e0132692-e0132692
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
-
[Journal Article] Molecular basis of sugar recognition by collectin-K1 and the defects caused by mutations associated with 3MC syndrome.2015
Author(s)
Umakhanth Venkatraman Girija, Christopher Furze, Alexandre Gingras, Takayuki Yoshizaki, Katsuki Ohtani, Jamie Marshall, Wilhelm Schwaeble, Mohammed El-Mezgueldi, Daniel Mitchell, Peter Moody, Nobutaka Wakamiya, and Russell Wallis.:
-
Journal Title
BMC biology
Volume: 13
Pages: 27-27
Related Report
-
-
-
-
-
-
-
[Presentation] Establishment of a comprehensive complement examination system for complement-related diseases by the Japanese Association for Complement Research.2017
Author(s)
Yoshihiko Hidaka, Norimitsu Inoue, Yasufumi Ohtsuka, Toshihiro Sawai, Toshiyuki Miyata, Isao Osawa, Katsuki Ohtani, Hidechika Okada, Taroh Kinoshita, Hideharu Sekine, Hiroshi Tsukamoto, Miki Nakao, Masashi Mizuno, Yoshiko Murakami, Takahiko Horiuchi, Nobutaka Wakamiya
Organizer
6th International Conference HUS & related disorders.
Related Report
Int'l Joint Research
-
[Presentation] Establishment of a comprehensive complement examination system for complement-related diseases by the Japanese Association for Complement Research (JACR).2017
Author(s)
Yoshihiko Hidaka, Norimitsu Inoue, Yasufumi Ohtsuka, Toshihiro Sawai, Toshiyuki Miyata, Isao Osawa, Hidechika Okada, Taroh Kinoshita, Hideharu Sekine, Katsuki Ohtani, Hiroshi Tsukamoto, Miki Nakao, Yoshiko Murakami, Masashi Mizuno, Takahiko Horiuchi, Nobutaka Wakamiya.
Organizer
16th European Meeting on Complement in Human Disease.
Related Report
Int'l Joint Research
-
-
-
-
[Presentation] Establishment of the comprehensive complement examination system for complement-related diseases by the Japanese association for complement research.2016
Author(s)
Yoshihiko Hidaka, Norimitsu Inoue, Yasufumi Ohtsuka, Toshihiro Sawai, Toshiyuki Miyata, Isao Osawa, Hidechika Okada, Tarou Kinoshita, Hideharu Sekine, Minoru Takahashi, Hiroshi Tsukamoto, Miki Nakao, Masaru Nonaka, Misao Matsushita, Tetsurou Yamamoto, Takahiko Horiuchi, Nobutaka Wakamiya
Organizer
26th International Complement Workshop.
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-