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The role of CL-K1 in DIC patients

Research Project

Project/Area Number 26293124
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Laboratory medicine
Research InstitutionAsahikawa Medical College

Principal Investigator

WAKAMIYA NOBUTAKA  旭川医科大学, 医学部, 教授 (20210867)

Co-Investigator(Kenkyū-buntansha) 松田 泰幸  旭川医科大学, 医学部, 助教 (10532252)
森 健一郎  旭川医科大学, 医学部, 助教 (70610236)
鈴木 定彦  北海道大学, 人獣共通感染症リサーチセンター, 教授 (90206540)
大谷 克城  旭川医科大学, 医学部, 准教授 (90396367)
松下 操  東海大学, 工学部, 教授 (00165812)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
KeywordsDIC / コレクチン / 感染症 / collectin / 補体 / 微生物 / 内科
Outline of Final Research Achievements

In collectin CL-K1 which Wakamiya discovered, it is supposed as well as conventional collectin that I have a natural immunity function. I performed DIC patient registration and performed sample collection of blood. I measured the inspection item of the DIC mainly on solidification fibrinolysis system. On the other hand, about collectin, I narrowed it down to two of CL-K1 and MBL. In the previous study, CL-K1 took the value that related to in progress of the DIC. However, in the measurement of this Japanese, the meaningful difference was not seen in presence of the DIC.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (30 results)

All 2017 2016 2015 2014 Other

All Journal Article (11 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 10 results,  Open Access: 6 results,  Acknowledgement Compliant: 5 results) Presentation (13 results) (of which Int'l Joint Research: 7 results,  Invited: 1 results) Book (2 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] Three pentraxins C-reactive protein, serum amyloid p component and pentraxin 3 mediate complement activation using Collectin CL-P12017

    • Author(s)
      2.Roy, N., Ohtani, K., Hidaka, Y., Amano, Y., Matsuda, Y., Mori, K., Hwang, I., Inoue, N., Wakamiya, N.
    • Journal Title

      Biochim Biophys Acta

      Volume: 861 Issue: 2 Pages: 1-14

    • DOI

      10.1016/j.bbagen.2016.11.023

    • NAID

      120006715888

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Collectin kidney 1 plays an important role in innate immunity against Streptococcus pneumoniae infection.2017

    • Author(s)
      Hwang I, Mori K, Ohtani K, Matsuda Y, Roy N, Kim Y, Suzuki Y, Wakamiya N
    • Journal Title

      J Innate Immun

      Volume: 9 Issue: 2 Pages: 217-228

    • DOI

      10.1159/000453316

    • NAID

      120006711670

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Collectin CL-P1 utilizes C-reactive protein for complement activation.2016

    • Author(s)
      5.Roy, N., Ohtani, K., Matsuda, Y., Mori, K., Hwang, I., Suzuki, Y., Inoue, N., Wakamiya, N.
    • Journal Title

      Biochim Biophys Acta

      Volume: 1860 Issue: 6 Pages: 1118-1128

    • DOI

      10.1016/j.bbagen.2016.02.012

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The collectins CL-L1, CL-K1 and CL-P1, and their roles in complement and innate immunity.2016

    • Author(s)
      Hansen SW, Ohtani K, Roy N, Wakamiya N
    • Journal Title

      Immunobiology

      Volume: 221 Issue: 10 Pages: 1058-1067

    • DOI

      10.1016/j.imbio.2016.05.012

    • NAID

      120006325059

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Molecular basis of sugar recognition by collectin-K1 and the effects of mutations associated with 3MC syndrome2015

    • Author(s)
      Venkatraman Girija U, Furze CM, Gingras AR, Yoshizaki T, Ohtani K, Marshall JE, Wallis AK, Schwaeble WJ, El-Mezgueldi M, Mitchell DA, Moody PC, Wakamiya N, Wallis R
    • Journal Title

      BMC Biol

      Volume: 13 Issue: 1 Pages: 27-27

    • DOI

      10.1186/s12915-015-0136-2

    • NAID

      120005828840

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Collectin CL-LK Is a Novel Soluble Pattern Recognition Receptor for Mycobacterium tuberculosis2015

    • Author(s)
      Troegeler A, Lugo-Villarino G, Hansen S, Rasolofo V, Henriksen ML, Mori K, Ohtani K, Duval C, Mercier I, Bénard A, Nigou J, Hudrisier D, Wakamiya N, Neyrolles O
    • Journal Title

      PLoS One

      Volume: 10 Issue: 7 Pages: e0132692-e0132692

    • DOI

      10.1371/journal.pone.0132692

    • NAID

      120005828841

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Molecular basis of sugar recognition by collectin-K1 and the defects caused by mutations associated with 3MC syndrome.2015

    • Author(s)
      Umakhanth Venkatraman Girija, Christopher Furze, Alexandre Gingras, Takayuki Yoshizaki, Katsuki Ohtani, Jamie Marshall, Wilhelm Schwaeble, Mohammed El-Mezgueldi, Daniel Mitchell, Peter Moody, Nobutaka Wakamiya, and Russell Wallis.:
    • Journal Title

      BMC biology

      Volume: 13 Pages: 27-27

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Scavenger receptor CL-P1 mediates endocytosis by associating with AP-2μ2.2014

    • Author(s)
      Jang S, Ohtani K, Fukuoh A, Mori K, Yoshizaki T, Kitamoto N, Kim Y, Suzuki Y, Wakamiya N.
    • Journal Title

      Biochim Biophys Acta.

      Volume: 1840(11) Issue: 11 Pages: 734-734

    • DOI

      10.1016/j.bbagen.2014.07.019

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Scavenger receptor CL-P1 mainly utilizes a collagen-like domain to uptake microbe and modified LDL.2014

    • Author(s)
      Mori K, Ohtani K, Jang S-J, Kim Y-U, Hwang I-S., Roy N., Matsuda Y., Suzuki Y, Wakamiya N
    • Journal Title

      Biochimica et Biophysica Acta

      Volume: 1840 Issue: 12 Pages: 3345-56

    • DOI

      10.1016/j.bbagen.2014.08.015

    • NAID

      120005511014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Elevated plasma CL-K1 level is associated with a risk of developing disseminated intravascular coagulation (DIC)2014

    • Author(s)
      Takahashi K, Ohtani K, Larvie M, Moyo P, Chigweshe L, Van Cott EM, Wakamiya N
    • Journal Title

      J Thromb Thrombolysis

      Volume: 38 Issue: 3 Pages: 331-338

    • DOI

      10.1007/s11239-013-1042-5

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional analysis of the receptor binding domain of SARS coronavirus S1 region and its monoclonal antibody2014

    • Author(s)
      Hyun Kim, Yeongjin Hong, Keigo Shibayama, Yasuhiko Suzuki, Nobutaka Wakamiya, Youn Uck Kim
    • Journal Title

      Genes & Genomics

      Volume: 36;3 Issue: 3 Pages: 387-397

    • DOI

      10.1007/s13258-014-0186-9

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] コレクチンCL-P1はPentraxin を介して補体系を活性化する2017

    • Author(s)
      ロイ ニタイ、大谷克城、日高義彦、天野芳郎、松田泰幸、森健一郎、黄 仁秀、井上徳光、若宮伸隆
    • Organizer
      第36回日本糖質学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] スカベンジャー受容体CL-P1は、Pentraxinを介して補体系を活性化する2017

    • Author(s)
      ロイ ニタイ、大谷克城、日高義彦、天野芳郎、松田泰幸、森健一郎、黄 仁秀、井上徳光、若宮伸隆
    • Organizer
      第54回日本補体学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Establishment of a comprehensive complement examination system for complement-related diseases by the Japanese Association for Complement Research.2017

    • Author(s)
      Yoshihiko Hidaka, Norimitsu Inoue, Yasufumi Ohtsuka, Toshihiro Sawai, Toshiyuki Miyata, Isao Osawa, Katsuki Ohtani, Hidechika Okada, Taroh Kinoshita, Hideharu Sekine, Hiroshi Tsukamoto, Miki Nakao, Masashi Mizuno, Yoshiko Murakami, Takahiko Horiuchi, Nobutaka Wakamiya
    • Organizer
      6th International Conference HUS & related disorders.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Establishment of a comprehensive complement examination system for complement-related diseases by the Japanese Association for Complement Research (JACR).2017

    • Author(s)
      Yoshihiko Hidaka, Norimitsu Inoue, Yasufumi Ohtsuka, Toshihiro Sawai, Toshiyuki Miyata, Isao Osawa, Hidechika Okada, Taroh Kinoshita, Hideharu Sekine, Katsuki Ohtani, Hiroshi Tsukamoto, Miki Nakao, Yoshiko Murakami, Masashi Mizuno, Takahiko Horiuchi, Nobutaka Wakamiya.
    • Organizer
      16th European Meeting on Complement in Human Disease.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Structural characterization of novel collectins, CL-K1, CL-L1, and CL-LK in blood.2016

    • Author(s)
      Yasuyuki Matsuda, Katsuki Ohtani, Nitai Roy, Insu Hwang, Kenichiro Mori, Nobutaka Wakamiya
    • Organizer
      26th International Complement Workshop.
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In vitro and in vivo roles in Collectin Kidney 1 (CL-K1) with innate immunity against Streptococcus pneumoniae.2016

    • Author(s)
      Insu Hwang, Kenichiro Mori, Katsuki Ohtani, Yasuyuki Matsuda, Nitai Roy, YounUck Kim, Nobutaka Wakamiya
    • Organizer
      26th International Complement Workshop.
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Collectin CL-P1 utilizes C-reactive protein for complement activation.2016

    • Author(s)
      Nitai Roy, Katsuki Ohtani, Yasuyuki Matsuda, Kenichiro Mori, Insu Hwang, Norimitsu Inoue, Nobutaka Wakamiya
    • Organizer
      26th International Complement Workshop.
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Establishment of the comprehensive complement examination system for complement-related diseases by the Japanese association for complement research.2016

    • Author(s)
      Yoshihiko Hidaka, Norimitsu Inoue, Yasufumi Ohtsuka, Toshihiro Sawai, Toshiyuki Miyata, Isao Osawa, Hidechika Okada, Tarou Kinoshita, Hideharu Sekine, Minoru Takahashi, Hiroshi Tsukamoto, Miki Nakao, Masaru Nonaka, Misao Matsushita, Tetsurou Yamamoto, Takahiko Horiuchi, Nobutaka Wakamiya
    • Organizer
      26th International Complement Workshop.
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 「補体関連疾患研究のための新しい補体検査整備」2015

    • Author(s)
      若宮伸隆
    • Organizer
      Atypical Hemolytic Uremic Syndrome Forum 2015
    • Place of Presentation
      東京
    • Year and Date
      2015-09-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 基調講演「補体関連疾患研究のための補体検査システムの構築」2015

    • Author(s)
      若宮伸隆
    • Organizer
      第52回日本補体学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-08-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 急性期応答蛋白質であるCRPと補体活性化についての検討2015

    • Author(s)
      Nitai Roy, 大谷克城、松田泰幸、森健一郎、黄仁秀、若宮伸隆
    • Organizer
      Glyco-Immunology2015 糖鎖免疫、平成27年度難治疾患共同研究拠点研究集会
    • Place of Presentation
      東京医科歯科大学M&Dタワー
    • Year and Date
      2015-08-19
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 新規コレクチンCL-K1の糖鎖認識と生物学的活性についての解析2015

    • Author(s)
      大谷克城、Umakhanth Venkatraman Girija、森健一郎、吉崎隆之、松田泰幸、黄仁秀、ロイニタイ、Russell Wallis、若宮伸隆
    • Organizer
      第34回日本糖質学会
    • Place of Presentation
      東京
    • Year and Date
      2015-07-31
    • Related Report
      2015 Annual Research Report
  • [Presentation] コレクチンCL-K1の凝固系への関与について2014

    • Author(s)
      大谷克城、Kazue Takahashi、早川峰司、森健一郎、黄仁秀、吉崎隆之、松田泰幸、ロイ.ニタイ、丸藤哲、若宮伸隆
    • Organizer
      第87回日本生化学会(2014年10月16日、京都)
    • Place of Presentation
      京都
    • Year and Date
      2014-10-14 – 2014-10-16
    • Related Report
      2014 Annual Research Report
  • [Book] 抗酸化機能分析研究センター20142015

    • Author(s)
      若宮伸隆
    • Total Pages
      73
    • Publisher
      抗酸化機能分析研究センター
    • Related Report
      2015 Annual Research Report
  • [Book] Glycoscience: Biology and Medicine2014

    • Author(s)
      Ohtani K, Suzuki Y, Wakamiya N.
    • Total Pages
      1568
    • Publisher
      Springer
    • Related Report
      2014 Annual Research Report
  • [Remarks] 旭川医科大学医学部微生物学講座

    • URL

      http://www.asahikawa-med.ac.jp/dept/mc/microbio/microbiology.html

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report 2014 Annual Research Report
  • [Remarks] 旭川医科大学医学部微生物学講座

    • URL

      http://www.asahikawa-med.ac.jp/dept/mc/microbio/microbiology.htm

    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 補体系を検査する方法及びそのためのキット2016

    • Inventor(s)
      若宮伸隆、大谷克城
    • Industrial Property Rights Holder
      若宮伸隆、大谷克城
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-159453
    • Filing Date
      2016
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] Methods of diagnosis and predicting risk of developing disseminated intravascular coagulation2014

    • Inventor(s)
      若宮伸隆、大谷克城、Kazue Takahashi, 扶桑薬品
    • Industrial Property Rights Holder
      若宮伸隆、大谷克城、Kazue Takahashi, 扶桑薬品
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-06-06
    • Related Report
      2014 Annual Research Report
    • Overseas

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Published: 2014-04-04   Modified: 2019-03-29  

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