| Project/Area Number |
26293126
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
和田 隆志 金沢大学, 医学系, 教授 (40334784)
岩田 恭宜 金沢大学, 大学病院, 助教 (90432137)
長船 健二 京都大学, 学内共同利用施設等, 教授 (80502947)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
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| Keywords | 腎コロボーマ症候群 / 急性腎障害 / PAX2 / KIF26B / 稀少遺伝性疾患 / 線維化 / 炎症 / 腎虚血再還流障害 / 造影剤腎症 |
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| Outline of Final Research Achievements |
In this study, gene analysis of renal coloboma syndrome, which is a rare genetic disease, and biomarker development of acute kidney injury, were evaluated from the viewpoint of PAX2 gene. In this study, four genes other than PAX2 were identified from cases of renal coloboma syndrome. Among them, we reported a case of human KIF 26 B gene mutation, which is the world's first report. In addition, in the study of acute kidney injury by animal models and cultured cell experiments, the roles of the Pax2 gene in pathogenesis of kidney disease and molecular mechanisms were revealed. Moreover, candidates of new biomarkers were discovered. In addition, the possibility of a new biomarker molecule was also evaluated in the study of human acute kidney injury.
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