| Budget Amount *help |
¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
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| Outline of Final Research Achievements |
Diabetic nephropathy is a leading cause of end-stage kidney disease requiring renal replacement therapy in the world. Therefore, it is of importance to examine the pathogenesis of progressive organ involvement in diabetic condition. Thus far, the presence of anemia is an independent risk factor for the progression of diabetic nephropathy. In this study, we focused on the role of erythropoietin (EPO) and its receptor (EPOR), which are closely related to anemia in kidney diseases, especially in the inflammatory processes during the progression of diabetic nephropathy. Endothelial cells express inflammatory and fibrotic mediators through the activation of inflammasome in response to high glucose conditions, which could be modulated by the presence of EPO. These results suggest that EPO-EPOR axis may play a role in the pathogenesis of diabetic nephropathy.
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