Association of anti-erythropoietin receptor antibodies with organ involvement of diabetic complications
| Project/Area Number |
26293127
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kanazawa University |
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Principal Investigator |
Wada Takashi 金沢大学, 医学系, 教授 (40334784)
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| Co-Investigator(Kenkyū-buntansha) |
古市 賢吾 金沢大学, 大学病院, 准教授 (50432125)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
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| Keywords | 糖尿病性腎症 / 炎症 / エリスロポエチン / エリスロポエチン受容体 / 自己抗体 / バイオマーカー / 心血管病変 / バイオインフォマティクス / 臨床検査医学 / 糖尿病 |
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| Outline of Final Research Achievements |
Diabetic nephropathy is a leading cause of end-stage kidney disease requiring renal replacement therapy in the world. Therefore, it is of importance to examine the pathogenesis of progressive organ involvement in diabetic condition. Thus far, the presence of anemia is an independent risk factor for the progression of diabetic nephropathy. In this study, we focused on the role of erythropoietin (EPO) and its receptor (EPOR), which are closely related to anemia in kidney diseases, especially in the inflammatory processes during the progression of diabetic nephropathy. Endothelial cells express inflammatory and fibrotic mediators through the activation of inflammasome in response to high glucose conditions, which could be modulated by the presence of EPO. These results suggest that EPO-EPOR axis may play a role in the pathogenesis of diabetic nephropathy.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] Association of apoptosis inhibitor of macrophage (AIM) expression with urinary protein and kidney dysfunction.2017
Author(s)
Oshima M, Iwata Y, Furuichi K, Sakai N, Shimizu M, Hara A, Kitajima S, Toyama T, Shinozaki Y, Sagara A, Umeda E, Kaneko S, Arai S, Miyazaki T, Wada T.
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Journal Title
Clin Exp Nephrol
Volume: 21
Issue: 1
Pages: 35-42
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Serum Autotaxin Levels Are Associated with Proteinuria and Kidney Lesions in Japanese Type 2 Diabetic Patients with Biopsy-proven Diabetic Nephropathy2016
Author(s)
Shimizu M, Furuichi K, Toyama T, Yamahana J, Ohkawa R, Igarashi K, Aoki J, Kaneko S, Yatomi Y, Wada T
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Journal Title
Internal Medicine
Volume: 55
Issue: 3
Pages: 215-221
DOI
NAID
ISSN
0918-2918, 1349-7235
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Messenger RNA expression profile of sleep-related genes in peripheral blood cells in patients with chronic kidney disease.2015
Author(s)
Kitajima S, Iwata Y, Furuichi K, Sagara A, Shinozaki Y, Toyama T, Sakai N, Shimizu M, Sakurai T, Kaneko S, Wada T.
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Journal Title
Clin Exp Nephrol
Volume: 20
Issue: 2
Pages: 218-25
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Impact of kidney function and urinary protein excretion on intima-media thickness in Japanese patients with type 2 diabetes2015
Author(s)
Nakade Y, Toyama T, Furuichi K, Kitajima S, Miyajima Y, Fukamachi M, Sagara A, Shinozaki Y, Hara A, Shimizu M, Iwata Y, Oe H, Nagahara M, Horita H, Sakai Y, Kaneko S, Wada T
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Journal Title
Clin Exp Nephrol
Volume: in press
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] A new classification of Diabetic Nephropathy 2014: a report from Joint Committee on Diabetic Nephropathy2015
Author(s)
Haneda M, Utsunomiya K, Koya D, Babazono T, Moriya T, Makino H, Kimura K, Suzuki Y, Wada T, Ogawa S, Inaba M, Kanno Y, Shigematsu T, Masakane I, Tsuchiya K, Honda K, Ichikawa K, Shide K
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Journal Title
Clin Exp Nephrol
Volume: 19
Issue: 1
Pages: 1-5
DOI
Related Report
Open Access
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[Journal Article] Pro-inflammatory/Th1 gene expression shift in high glucose stimulated mesangial cells and tubular epithelial cells.2014
Author(s)
Iwata Y, Furuichi K, Hashimoto S, Yokota K, Yasuda H, Sakai N, Kitajima S, Toyama T, Shinozaki Y, Sagara A, Matsushima K, Kaneko S, Wada T.
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Journal Title
Biochem Biophys Res Commun
Volume: 443
Issue: 3
Pages: 969-974
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 糖尿病性腎症の病態と診療2015
Author(s)
和田隆志
Organizer
第53回日本内科学会四国支部生涯教育講演会
Place of Presentation
かがわ国際会議場（香川）
Year and Date
2015-12-06
Related Report
Invited
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[Presentation] 糖尿病性腎症と臨床検査2015
Author(s)
和田隆志
Organizer
第62回日本臨床検査学会学術集会
Place of Presentation
長良川国際会議場（岐阜）
Year and Date
2015-11-22
Related Report
Invited
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[Presentation] 糖尿病性腎症の臨床2015
Author(s)
和田隆志
Organizer
日本内科学会生涯教育講演会Ｂセッション
Place of Presentation
本多の森ホール（金沢市）
Year and Date
2015-10-18
Related Report
Invited
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