| Project/Area Number |
26293130
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
丸山 征郎 鹿児島大学, 医歯学総合研究科, 特任教授 (20082282)
大山 陽子 鹿児島大学, 医学部・歯学部附属病院, 特任助教 (20583470)
竹之内 和則 鹿児島大学, 医学部・歯学部附属病院, 医員 (30646758)
清水 利昭 鹿児島大学, 医歯学域医学系, 助教 (50468055)
橋口 照人 鹿児島大学, 医歯学域医学系, 教授 (70250917)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2016: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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| Keywords | microRNA / 血管内皮細胞 / 糖尿病 / miRNA / 一酸化窒素 / エクソゾーム / 単球 / マイクロRNA / TP53 |
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| Outline of Final Research Achievements |
Vascular dysfunction is the cause of various diseases, such as diabetes, atherosclerosis, and malignancy. Endothelial cells play a central role in controlling vascular function and maintaining vascular integrity. We identified a set of microRNAs (miRNAs) expressed in vascular endothelial cells, which regulate vascular malfunction. miRNAs are short-chain single-stranded RNA that suppress protein synthesis post-transcriptionally. We focused on several miRNAs expressed in endothelial cells. Among them, miR-424/503 are unique miRNAs, which are upregulated under hypoxic condition. We have shown three major things below. (1) miR-424/503 suppresses the production of vasorelaxant gas, nitric oxide. (2) miR-424/503 changes the phenotype of endothelial cells. (3) Secreted miRNAs alter the function of mononuclear cells.
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