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Central neuronal mechanisms for descending antinociception and arousal states in the brain

Research Project

Project/Area Number 26293132
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Pain science
Research InstitutionNational Institute for Physiological Sciences

Principal Investigator

FURUE Hidemasa  生理学研究所, 基盤神経科学研究領域, 准教授(兼任) (20304884)

Co-Investigator(Kenkyū-buntansha) 神野 尚三  九州大学, 医学(系)研究科(研究院), 教授 (10325524)
深澤 有吾  福井大学, 医学部, 教授 (60343745)
Co-Investigator(Renkei-kenkyūsha) IMOTO Keiji  生理学研究所, 所長 (00176512)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Keywords覚醒 / 鎮静 / 鎮痛 / 青斑核 / チャネルロドプシン / 生理学 / 大脳皮質の活動 / 痛覚回路 / GABA / 光遺伝学
Outline of Final Research Achievements

We have studied how noradrenergic neurons in the locus coeruleus in the brain stem act on descending antnociception and arousal levels in the brain. We used virus vectors to control noradrenergic neuronal activity by using optogenetic tools. Locus coeruleus neurons were successfully activated by optic stimulation and how the locus coeruleus activation changes nociceptive behaviors and arousal levels was examined. In vivo electrophysiological analysis was also studied, and the descending and ascending neuronal circuits were identified with Immunohistochemical methods.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report

Research Products

(42 results)

All 2017 2016 2015 2014 Other

All Int'l Joint Research (2 results) Journal Article (11 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 9 results,  Open Access: 7 results,  Acknowledgement Compliant: 6 results) Presentation (28 results) (of which Int'l Joint Research: 6 results,  Invited: 6 results) Remarks (1 results)

  • [Int'l Joint Research] ブリストル大学(英国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] キョンヒ大学(韓国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Noradrenergic inhibition of spinal hyperexcitation elicited by cutaneous cold stimuli in rats with oxaliplatin-induced allodynia: electrophysiological and behavioral assessments.2017

    • Author(s)
      Choi S, Yamada A, Kim W, Kim SK, Furue H
    • Journal Title

      JPhysiol Sci.

      Volume: 67(3) Pages: 431-438

    • DOI

      10.1007/s12576-016-0505-9

    • NAID

      40021176454

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 4-isopropylcyclohexanol has potential analgesic effects through the inhibition of anoctamin 1, TRPV1 and TRPA1 channel activities.2017

    • Author(s)
      Takayama Y, Furue H, Tominaga M.
    • Journal Title

      Sci Rep.

      Volume: 7 Pages: 43132-43132

    • DOI

      10.1038/srep43132

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 脳幹における痛みの抑制と慢性疼痛発現の機構2017

    • Author(s)
      御領憲治、古江秀昌
    • Journal Title

      医学のあゆみ

      Volume: 260(2) Pages: 144-148

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Errata to “Structure-function correlations of rat trigeminal primary neurons: Emphasis on club-like endings, a vibrissal mechanoreceptor”2016

    • Author(s)
      Tonomura S, Ebara S, Bagdasarian K, Uta D, Ahissar E, Meir I, Lampl I, Kuroda D, Furuta T, Furue H, Kumamoto K.
    • Journal Title

      Proc. Jpn. Acad., Ser. B

      Volume: 91(10) Issue: 2 Pages: 560-576

    • DOI

      10.2183/pjab.92.76

    • NAID

      130005125605

    • ISSN
      0386-2208, 1349-2896
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Stimulation of dopamine D2-like receptors in the lumbosacral defecation centre causes propulsive co lorectal contractions in rats.2016

    • Author(s)
      Kiyotada Naitou, Hiroyuki Nakamori, Takahiko Shiina, Azusa Ikeda, Yuuta Nozue, Yuuki Sano, Takuya Yokoyama, Yoshio Yamamoto, Akihiro Yamada, Nozomi Akimoto, Hidemasa Furue, and Yasutake Shimizu
    • Journal Title

      J Physiol

      Volume: 594 Pages: 4339-4350

    • DOI

      10.1113/jp272073

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Intravenous administration of lidocaine directly acts on spinal dorsal horn and produces analgesic effect: An in vivo patch-clamp analysis.2016

    • Author(s)
      Kurabe M, Furue H, Kohno T
    • Journal Title

      Scientific Reports

      Volume: 6 Pages: 0-0

    • DOI

      10.1038/srep26253

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Changes in synaptic transmission of substantia gelatinosa neurons after spinal cord hemisection revealed by analysis using in vivo patch-clamp recording.2016

    • Author(s)
      Kozuka Y, Kawamata M, Furue H, Ishida T, Tanaka S, Namiki A, Yamakage M
    • Journal Title

      Mol Pain.

      Volume: 12 Pages: 1-14

    • DOI

      10.1177/1744806916665827

    • NAID

      120007100116

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Involvement of Brain-Enriched Guanylate Kinase-Associated Protein (BEGAIN) in Chronic Pain after Peripheral Nerve Injury.2016

    • Author(s)
      Katano T, Fukuda M, Furue H, Yamazaki M, Abe M, Watanabe M, Nishida K, Yao I, Yamada A, Hata Y, Okumura N, Nakazawa T, Yamamoto T, Sakimura K, Takao T, Ito S.
    • Journal Title

      eNeuro

      Volume: 3(5) Pages: 110-16

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pain-enhancing mechanism through interaction between TRPV1 and anoctamin 1 in sensory neurons2015

    • Author(s)
      Takayama Y, Uta D, Furue H, Tominaga M
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 112(16) Pages: 5213-8

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 神経障害性疼痛で生じるCl-イオン濃度勾配はGABAで痛みが生じるほど大きな変化でしょうか?2015

    • Author(s)
      山田彬博, 古江秀昌
    • Journal Title

      LiSA

      Volume: 22 Pages: 130-132

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Three-dimensional distribution of sensory stimulation-evoked neuronal activity of spinal dorsal horn neurons analyzed by in vivo calcium imaging2014

    • Author(s)
      Nishida K, Matsumura S, Taniguchi W, Uta D, Furue H, Ito S.
    • Journal Title

      PLoS ONE

      Volume: 9(8)

    • DOI

      10.1371/journal.pone.0103321

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 覚醒下前帯状回皮質感覚応答のIn vivo解析2017

    • Author(s)
      山田彬博, 大澤匡弘, 粂和彦, 井本敬二, 古江秀昌
    • Organizer
      94回日本生理学会大会
    • Place of Presentation
      アクトシティ浜松(静岡県浜松市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] ノルアドレナリン神経による上行性および下行性の痛覚調節機構2017

    • Author(s)
      古江秀昌
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長﨑ブリックホール(長崎県長崎市)
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Spinal Nociceptive Transmission from the Lower Urinary Tract2016

    • Author(s)
      N.Akimoto, A.Hakozaki, M.Kawatani, K.Imoto, M.Kawatani, H.Furue
    • Organizer
      International Association for the Study of Pain (IASP)
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-09-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of ethanol on GABAergic synaptic transmission in the rat spinal dorsal horn.2016

    • Author(s)
      A.Yamada, M.Ohsawa, K.Kume, K.Imoto, H.Furue
    • Organizer
      International Association for the Study of Pain (IASP)
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-09-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Noradrenergic inhibition of spinal hyperexcitation elicited by cutaneous cold stimuli in rats with oxaliplatin-induced allodynia: Electrophysiological and behavioral assessments2016

    • Author(s)
      S. Choi, S. Kim, S. Oh, H. Furue
    • Organizer
      International Association for the Study of Pain (IASP)
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-09-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Electrophysiological analysis of local anesthetic actions on nociceptive synaptic transmission in the adult rat spinal cord.2016

    • Author(s)
      D.Uta, M.Yoshimura, R.Kawatsu, K.Imoto, H.Furue
    • Organizer
      International Association for the Study of Pain (IASP)
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-09-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Spinal GABAergic Synaptic Responses Elicited by Optogenetic Activation of Descending Noradrenergic System2016

    • Author(s)
      H.Furue, L.Hickey, Y.Li, A.Pickering, K.Imoto
    • Organizer
      International Association for the Study of Pain (IASP)
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-09-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 顔面領域刺激による青斑核ノルアドレナリンニューロンの賦活化と痛み伝達の調節2016

    • Author(s)
      古江秀昌
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター,北海道札幌市
    • Year and Date
      2016-03-24
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ANO1阻害剤の検討とそのTRPV1関連疼痛に対する効果2016

    • Author(s)
      高山靖規,秋元望,古江秀昌,富永真琴
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター,北海道札幌市
    • Year and Date
      2016-03-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] In vivo細胞外記録およびパッチクランプ法を用いた前帯状回皮質感覚応答の解析2016

    • Author(s)
      山田彬博, 大澤匡弘, 粂和彦, 井本敬二, 古江秀昌
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター,北海道札幌市
    • Year and Date
      2016-03-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 脳/脊髄ノルアドレナリンネットワーク人為的操作と鎮痛機構の解析2016

    • Author(s)
      古江秀昌
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜,神奈川県横浜市
    • Year and Date
      2016-03-10
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Descending pain modulatory system and its activation by systemic alpha 2 agonist2015

    • Author(s)
      Hidemasa Furue
    • Organizer
      12th World congress of Veterinary Anaesthesiology
    • Place of Presentation
      国立京都国際会館,京都府京都市
    • Year and Date
      2015-09-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 下部尿路から脊髄に入力する痛覚伝達機構の in vivo 解析2015

    • Author(s)
      秋元望, 箱崎敦志, 河谷正仁, 井本敬二, 古江秀昌
    • Organizer
      第37回日本疼痛学会
    • Place of Presentation
      市民会館崇城大学ホール,熊本県熊本市
    • Year and Date
      2015-07-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] 髄後角シナプス伝達に対するエタノールの作用2015

    • Author(s)
      山田彬博, 大澤匡弘, 粂和彦, 井本敬二, 古江秀昌
    • Organizer
      第37回日本疼痛学会
    • Place of Presentation
      市民会館崇城大学ホール,熊本県熊本市
    • Year and Date
      2015-07-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] ラット脊髄におけるTRPA1発現線維からの入力を受ける膠様質細胞の発火パターンについて-in vitro及びin vivoパッチクランプ解析を用いて-2015

    • Author(s)
      歌大介, 井本敬二, 古江秀昌
    • Organizer
      第37回日本疼痛学会
    • Place of Presentation
      市民会館崇城大学ホール,熊本県熊本市
    • Year and Date
      2015-07-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] カプサイシン感受性(TRPV1発現)求心性線維によるin vivo感覚シナプス伝達の調節機構2015

    • Author(s)
      古江秀昌
    • Organizer
      第92回日本生理学会大会
    • Place of Presentation
      神戸交際会議場・展示場(兵庫県神戸市)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Selective excitatory effect of TRPA1 agonists on synaptic transmission in superficial spinal dorsal horn neurons of the adult rat.2015

    • Author(s)
      Uta D, Imoto K and Furue H
    • Organizer
      The 88th Annual Meeting of the Japan Pharmacological Society
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-03-18 – 2015-03-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] 成熟ラット脊髄後角膠様質ニューロンへの後根刺激誘起のシナプス伝達に対するTRPA1作動薬の応答2015

    • Author(s)
      歌 大介, 吉村 恵, 井本敬二, 古江秀昌
    • Organizer
      第36回脊髄機能診断研究会
    • Place of Presentation
      JPタワーホール&カンファレンス(東京都千代田区)
    • Year and Date
      2015-02-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] Electrophysiological analysis of spinal dorsal horn neurons receiving pruriceptive afferents in the adult rat spinal cord.2014

    • Author(s)
      Uta D, Andoh T, Kuraishi Y, Imoto K and Furue H.
    • Organizer
      The 37th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Action of Chemokine (C-C motif) ligand 1 on synaptic transmission in the spinal superficial dorsal horn.2014

    • Author(s)
      Akimoto N, Uta D, Honda K, Takano Y, Imoto K, Noda M, Furue H
    • Organizer
      2014NIPS-KU/YU Symposium.
    • Place of Presentation
      岡崎カンファレンスセンター(愛知県岡崎市)
    • Year and Date
      2014-07-01 – 2014-07-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] 下行性疼痛制御機構解明のためのマイルストーン研究2014

    • Author(s)
      古江秀昌
    • Organizer
      第36回日本疼痛学会
    • Place of Presentation
      KKRホテル大阪(大阪府大阪市)
    • Year and Date
      2014-06-20 – 2014-06-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Effects of TRPA1 and TRPV1 agonists on synaptic transmission evoked in morphologically distinct cell types in the substantia gelatinosa of the adult rat spinal cord.2014

    • Author(s)
      Uta D, Imoto K, Furue H
    • Organizer
      第36回日本疼痛学会
    • Place of Presentation
      KKRホテル大阪(大阪府大阪市)
    • Year and Date
      2014-06-20 – 2014-06-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] ラット脊髄後角表層GABAニューロンへの興奮性シナプス入力に対するP2X3受容体の役割2014

    • Author(s)
      古賀啓祐, 津田 誠, 井上和秀, 井本敬二, 古江秀昌
    • Organizer
      第36回日本疼痛学会
    • Place of Presentation
      KKRホテル大阪(大阪府大阪市)
    • Year and Date
      2014-06-20 – 2014-06-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脊髄後角シナプス伝達に対するCCL-1の作用と疼痛発現機構2014

    • Author(s)
      秋元 望, 歌 大介, 本多健治, 高野行夫, 井本敬二, 野田百美, 古江秀昌
    • Organizer
      第36回日本疼痛学会
    • Place of Presentation
      KKRホテル大阪(大阪府大阪市)
    • Year and Date
      2014-06-20 – 2014-06-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 低用量デクスメデトミジンは逆説的にノルアドレナリン下行性抑制系を賦活化する2014

    • Author(s)
      舟井優介, 井本敬二, 古江秀昌
    • Organizer
      第36回日本疼痛学会
    • Place of Presentation
      KKRホテル大阪(大阪府大阪市)
    • Year and Date
      2014-06-20 – 2014-06-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 末梢神経におけるTRV1とアノクタミン1の相互作用による疼痛とその抑制2014

    • Author(s)
      高山靖規, 歌 大介, 古江秀昌, 富永真琴
    • Organizer
      第36回日本疼痛学会
    • Place of Presentation
      KKRホテル大阪(大阪府大阪市)
    • Year and Date
      2014-06-20 – 2014-06-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 電気生理学的及び形態学的解析を用いたラット脊髄膠様質におけるTRPA1及びTRPV1作動薬の作用比較2014

    • Author(s)
      歌大介、井本敬二、古江秀昌
    • Organizer
      第36回日本疼痛学会
    • Place of Presentation
      KKRホテル大阪(大阪府大阪市)
    • Year and Date
      2014-06-20 – 2014-06-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 生理学からみた内因性の鎮痛メカニズム2014

    • Author(s)
      古江秀昌
    • Organizer
      第6回信州Opioid研究会
    • Place of Presentation
      信州大学医学部旭総合研究棟(長野県松本市)
    • Year and Date
      2014-06-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Remarks] 生理学研究所神経シグナルホームページ

    • URL

      http://www.nips.ac.jp/~furue/index.html

    • Related Report
      2016 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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