Central neuronal mechanisms for descending antinociception and arousal states in the brain
| Project/Area Number |
26293132
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | National Institute for Physiological Sciences |
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Principal Investigator |
FURUE Hidemasa 生理学研究所, 基盤神経科学研究領域, 准教授(兼任) (20304884)
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| Co-Investigator(Kenkyū-buntansha) |
神野 尚三 九州大学, 医学(系)研究科(研究院), 教授 (10325524)
深澤 有吾 福井大学, 医学部, 教授 (60343745)
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| Co-Investigator(Renkei-kenkyūsha) |
IMOTO Keiji 生理学研究所, 所長 (00176512)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Keywords | 覚醒 / 鎮静 / 鎮痛 / 青斑核 / チャネルロドプシン / 生理学 / 大脳皮質の活動 / 痛覚回路 / GABA / 光遺伝学 |
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| Outline of Final Research Achievements |
We have studied how noradrenergic neurons in the locus coeruleus in the brain stem act on descending antnociception and arousal levels in the brain. We used virus vectors to control noradrenergic neuronal activity by using optogenetic tools. Locus coeruleus neurons were successfully activated by optic stimulation and how the locus coeruleus activation changes nociceptive behaviors and arousal levels was examined. In vivo electrophysiological analysis was also studied, and the descending and ascending neuronal circuits were identified with Immunohistochemical methods.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Errata to “Structure-function correlations of rat trigeminal primary neurons: Emphasis on club-like endings, a vibrissal mechanoreceptor”2016
Author(s)
Tonomura S, Ebara S, Bagdasarian K, Uta D, Ahissar E, Meir I, Lampl I, Kuroda D, Furuta T, Furue H, Kumamoto K.
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Journal Title
Proc. Jpn. Acad., Ser. B
Volume: 91(10)
Issue: 2
Pages: 560-576
DOI
NAID
ISSN
0386-2208, 1349-2896
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Stimulation of dopamine D2-like receptors in the lumbosacral defecation centre causes propulsive co lorectal contractions in rats.2016
Author(s)
Kiyotada Naitou, Hiroyuki Nakamori, Takahiko Shiina, Azusa Ikeda, Yuuta Nozue, Yuuki Sano, Takuya Yokoyama, Yoshio Yamamoto, Akihiro Yamada, Nozomi Akimoto, Hidemasa Furue, and Yasutake Shimizu
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Journal Title
J Physiol
Volume: 594
Pages: 4339-4350
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Involvement of Brain-Enriched Guanylate Kinase-Associated Protein (BEGAIN) in Chronic Pain after Peripheral Nerve Injury.2016
Author(s)
Katano T, Fukuda M, Furue H, Yamazaki M, Abe M, Watanabe M, Nishida K, Yao I, Yamada A, Hata Y, Okumura N, Nakazawa T, Yamamoto T, Sakimura K, Takao T, Ito S.
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Journal Title
eNeuro
Volume: 3(5)
Pages: 110-16
Related Report
Peer Reviewed
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