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Creation of New Diagnostic Information based on multi-scale inference of bio-structures by using diffusion MRI

Research Project

Project/Area Number 26293134
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Medical Physics and Radiological Technology
Research InstitutionHiroshima City University

Principal Investigator

Masutani Yoshitaka  広島市立大学, 情報科学研究科, 教授 (20345193)

Co-Investigator(Renkei-kenkyūsha) AOKI Shigeki  順天堂大学, 医学部, 教授 (80222470)
HORI Masaaki  順天堂大学, 医学部, 准教授 (40334867)
Suzuki Yuichi  東京大学, 医学部附属病院, 技師 (70420221)
INO Kenji  東京大学, 医学部附属病院, 技師 (10420217)
Research Collaborator NOMURA Yukihiro  東京大学, 医学部附属病院, 特任研究員
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2016: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywords拡散MRI / 信号値モデル / 放射基底関数 / 拡散尖度 / Q空間 / 脳白質線維 / マルチスケール解析 / マルチスケール / 微細構造 / 脳白質線維束 / モデリング
Outline of Final Research Achievements

In this project, several topics regarding diffusion MRI have been studied including inference of axon diameter or diffusional kurtosis along the radial orientation of fibers as local information of brain white matter fiber tracts, that is global information. Based on a novel approach of Q-space interpolation and reconstruction by using radial basis functions, methodology for extraction of multi-scale information (from global tract structure to local information such as axon diameter) was achieved. It did not reach to creation of completely new diagnostic information, but several successful results in this project implied that extension of this study would develop to such contribution to clinical information processing.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (17 results)

All 2017 2016 2015 2014

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (12 results) (of which Int'l Joint Research: 1 results,  Invited: 4 results)

  • [Journal Article] Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer’s disease cases.2017

    • Author(s)
      Taoka T, Masutani Y, Kawai H, Nakane T, Matsuoka K, Yasuno F, Kishimoto T, Naganawa S.
    • Journal Title

      Jpn J Radiol

      Volume: 35 Issue: 4 Pages: 172-178

    • DOI

      10.1007/s11604-017-0617-z

    • NAID

      120006323685

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Time Course of Diffusion Kurtosis in Cerebral Infarctions of Transient Middle Cerebral Artery Occlusion Rat Model.2016

    • Author(s)
      Taoka T, Fujioka M, Kashiwagi Y, Obata A, Rokugawa T, Hori M, Masutani Y, Aoki S, Naganawa S, Abe K.
    • Journal Title

      J Stroke Cerebrovasc Dis.

      Volume: 25 Issue: 3 Pages: 610-617

    • DOI

      10.1016/j.jstrokecerebrovasdis.2015.11.028

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fast and Robust Estimation of Diffusional Kurtosis Imaging (DKI) Parameters by General Closed-form Expressions and their Extensions2014

    • Author(s)
      Y. Masutani, S. Aoki
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 13 Issue: 2 Pages: 97-115

    • DOI

      10.2463/mrms.2013-0084

    • NAID

      130003393002

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cervical spondylosis: Evaluation of microstructural changes in spinal cord white matter and gray matter by diffusional kurtosis imaging2014

    • Author(s)
      Hori M., Tsutsumi S., Yasumoto Y., et al.
    • Journal Title

      Magnetic Resonance Imaging

      Volume: 32 Issue: 5 Pages: 428-432

    • DOI

      10.1016/j.mri.2014.01.018

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Multiple sclerosis: Benefits of q-space imaging in evaluation of normal-appearing and periplaque white matter2014

    • Author(s)
      Masaaki Hori, Mariko Yoshida, Kazumasa Yokoyama, Koji Kamagata, Fumitaka Kumagai, Issei Fukunaga , Kouhei Kamiya, Michimasa Suzuki, Yoshitaka Masutani, Nozomi Hamasaki ,Yuriko Suzuki, Shinsuke Kyogoku, Nobutaka Hattori, Shigeki Aoki
    • Journal Title

      Magn Reson Imaging.

      Volume: Mar 18. Issue: 6 Pages: 1-5

    • DOI

      10.1016/j.mri.2014.02.024

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Toward Analytic Computation of Fiber-Radial Diffusional Kurtosis by Q-space Data Representation with Radial Basis Functions2017

    • Author(s)
      Yoshitaka Masutani
    • Organizer
      25th Annual International Society for Magnetic Resonance in Medicine
    • Place of Presentation
      ハワイコンベンションセンター
    • Year and Date
      2017-04-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 拡散MRIの信号値モデルについて2016

    • Author(s)
      増谷佳孝
    • Organizer
      医用画像と数理に関する4プロジェクト合同セミナー
    • Place of Presentation
      北海道大学
    • Year and Date
      2016-09-21
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 拡散MR画像による脳白質軸索半径の推定と可視化2016

    • Author(s)
      増谷佳孝
    • Organizer
      日本医用画像工学会JAMIT2016
    • Place of Presentation
      千葉大学
    • Year and Date
      2016-07-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] 拡散MRI解析の基礎2016

    • Author(s)
      増谷佳孝
    • Organizer
      第111回日本医学物理学会学術大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-04-14
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 拡散MRIのQ空間データにおける補間および線積分に基づく線維方向およびその垂直方向の拡散尖度の計算方法2016

    • Author(s)
      増谷佳孝
    • Organizer
      電子情報通信学会医用画像研究会
    • Place of Presentation
      鳥取大学
    • Related Report
      2016 Annual Research Report
  • [Presentation] MRIを用いた生体内水分子の拡散現象の計測と解剖構造推定への応用2016

    • Author(s)
      増谷佳孝
    • Organizer
      電子情報通信学会スマートインフォメディア研究会, 広島, 2016年12月
    • Place of Presentation
      広島市立大学
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 拡散 MRI の基礎から最近の新展開まで2016

    • Author(s)
      増谷佳孝
    • Organizer
      電子情報通信学会スマートインフォメディア研究会
    • Place of Presentation
      徳島大学
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] An Algorithm Dedicated to Corticospinal Tract Tracking by Tensor Field Replacement for Crossing Fiber Cancelling2015

    • Author(s)
      Masutani Y
    • Organizer
      MICCAI DTI Challenge on Tractography for Brain Tumor Surgery
    • Place of Presentation
      Munich, Germany
    • Year and Date
      2015-10-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] Unstructured sampling and RBF-based ODF reconstruction in Q-space for diffusion MR tractography2015

    • Author(s)
      Y. Masutani, M. Hori, and S. Aoki
    • Organizer
      Computer Assisted Radiology and Surgery
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2015-06-24 – 2015-06-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Unstructured sampling and RBF-based ODF reconstruction in Q-space for diffusion MR tractography Computer-Assisted Radiology and Surgery2015

    • Author(s)
      Masutani Y, Hori M, and Aoki S
    • Organizer
      Computer-Assisted Radiology and Surgery 2015
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 拡散MRIにおけるMPG方向およびb値の自由配置サンプルデータからのq空間およびPDF再構成2014

    • Author(s)
      増谷佳孝,堀正明,青木茂樹
    • Organizer
      第42回日本磁気共鳴医学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-09-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] On the Effect of Diffusion Tensor Estimation Accuracy for Pyramidal Tract Tracking with Crossing Fiber Cancelling2014

    • Author(s)
      Masutani Y
    • Organizer
      MICCAI 2014 DTI Challenge
    • Place of Presentation
      Boston, USA
    • Year and Date
      2014-09-14
    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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