Creation of New Diagnostic Information based on multi-scale inference of bio-structures by using diffusion MRI
| Project/Area Number |
26293134
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical Physics and Radiological Technology
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| Research Institution | Hiroshima City University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
AOKI Shigeki 順天堂大学, 医学部, 教授 (80222470)
HORI Masaaki 順天堂大学, 医学部, 准教授 (40334867)
Suzuki Yuichi 東京大学, 医学部附属病院, 技師 (70420221)
INO Kenji 東京大学, 医学部附属病院, 技師 (10420217)
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| Research Collaborator |
NOMURA Yukihiro 東京大学, 医学部附属病院, 特任研究員
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2016: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 拡散MRI / 信号値モデル / 放射基底関数 / 拡散尖度 / Q空間 / 脳白質線維 / マルチスケール解析 / マルチスケール / 微細構造 / 脳白質線維束 / モデリング |
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| Outline of Final Research Achievements |
In this project, several topics regarding diffusion MRI have been studied including inference of axon diameter or diffusional kurtosis along the radial orientation of fibers as local information of brain white matter fiber tracts, that is global information. Based on a novel approach of Q-space interpolation and reconstruction by using radial basis functions, methodology for extraction of multi-scale information (from global tract structure to local information such as axon diameter) was achieved. It did not reach to creation of completely new diagnostic information, but several successful results in this project implied that extension of this study would develop to such contribution to clinical information processing.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Multiple sclerosis: Benefits of q-space imaging in evaluation of normal-appearing and periplaque white matter2014
Author(s)
Masaaki Hori, Mariko Yoshida, Kazumasa Yokoyama, Koji Kamagata, Fumitaka Kumagai, Issei Fukunaga , Kouhei Kamiya, Michimasa Suzuki, Yoshitaka Masutani, Nozomi Hamasaki ,Yuriko Suzuki, Shinsuke Kyogoku, Nobutaka Hattori, Shigeki Aoki
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Journal Title
Magn Reson Imaging.
Volume: Mar 18.
Issue: 6
Pages: 1-5
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 拡散MRI解析の基礎2016
Author(s)
増谷佳孝
Organizer
第111回日本医学物理学会学術大会
Place of Presentation
パシフィコ横浜
Year and Date
2016-04-14
Related Report
Invited
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