A nested case-control study in the JACC Study to investigate biomarkers of premature death
| Project/Area Number |
26293138
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | Hokkaido University |
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Principal Investigator |
Tamakoshi Akiko 北海道大学, 医学(系)研究科(研究院), 教授 (90236737)
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| Co-Investigator(Kenkyū-buntansha) |
渡辺 能行 京都府立医科大学, 医学(系)研究科(研究院), 教授 (00191809)
磯 博康 大阪大学, 医学(系)研究科(研究院), 教授 (50223053)
鈴木 康司 藤田保健衛生大学, 保健学研究科, 准教授 (60288470)
藤野 善久 産業医科大学, 医学部, 准教授 (80352326)
山田 宏哉 藤田保健衛生大学, 医学部, 助教 (80610352)
若井 建志 名古屋大学, 医学(系)研究科(研究院), 教授 (50270989)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2014: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
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| Keywords | miRNA / ケースコホート研究 / 早世マーカー |
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| Outline of Final Research Achievements |
Using serum stored from the JACC Study, we measured levels of miRNA (miR-21, miR-29a and miR-216), Vitamin E, retinol and high-sensitivity C-reactive protein (hs-CRP) and compared 336 cases of death before 65 years old with 926 sub-cohort members randomly selected from those aged 40-64 years at baseline. Compared with those in the highest quartile, those whose miR-29a and hsCRP levels were in the lowest quartile had a significantly lower risk of premature death. A similar tendency was also found for miR-126 levels. However, it was not statistically significant. Other biomarkers shoed no meaningful associations. We will interpret the results carefully to ascertain the significance of these biomarkers.
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Report
(4 results)
Research Products
(13 results)
