| Project/Area Number |
26293141
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | Saga University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
原 めぐみ 佐賀大学, 医学部, 准教授 (90336115)
西田 裕一郎 佐賀大学, 医学部, 講師 (50530185)
島ノ江 千里 佐賀大学, 医学部, 助教 (10734064)
大桃 秀樹 岩手医科大学, その他, 助教 (90453406)
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| Co-Investigator(Renkei-kenkyūsha) |
HIGAKI Yasuki 福岡大学, スポーツ科学部, 教授 (10228702)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2016: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | 身体活動 / 末梢血DNAメチル化 / 炎症マーカー / 生活習慣病 / 脳梗塞 / ASC遺伝子 / コホート研究 / 分子遺伝疫学 / DNAメチル化解析 / 全身性炎症 |
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| Outline of Final Research Achievements |
We examined the association of accelerometer-determined physical activity (PA) with ASC gene methylation in white blood cells, based on a cohort study of about 12 thousand residents in Saga city. We also evaluated the association between PA and ischemic stroke and if it is mediated by ASC methylation. In cross-sectional and longitudinal studies, PA (particularly with low intensity) was positively associated with ASC methylation while ASC methylation was inversely associated with blood inflammatory markers. In a case-cohort study, neither an association between PA and ischemic stroke nor a mediating role of ASC methylation was evident. PA may cause higher ASC methylation, thereby leading to lower systemic inflammation.
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