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Prevention of diabetic vascular injury and atherosclerosis

Research Project

Project/Area Number 26293152
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Hygiene and public health
Research InstitutionOkayama University

Principal Investigator

Ogino Keiki  岡山大学, 医歯(薬)学総合研究科, 教授 (70204104)

Co-Investigator(Kenkyū-buntansha) 長岡 憲次郎  岡山大学, 医歯(薬)学総合研究科, 助教 (40752374)
杉山 斉  岡山大学, 医歯(薬)学総合研究科, 教授 (60325090)
久保 正幸  岡山大学, 医歯(薬)学総合研究科, 助教 (60420519)
江口 依里  岡山大学, 医歯(薬)学総合研究科, 助教 (60635118)
竹本 圭  岡山大学, 医歯(薬)学総合研究科, 助教 (60723252)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Keywordsアルギナーゼ / NO / アルギニン / 喘息 / 酸化ストレスマーカー / アルギナーゼI / NO2- / NO3- / 仕事ストレス / 糖負荷 / P38MAPK / 一酸化窒素 / 肥満 / 予防 / L-アルギニン / ケルセチン / 糖尿病 / 一酸化窒素(NO) / 一酸化窒素合成酵素(NOS)
Outline of Final Research Achievements

In asthma, serum arginase I was augmented in human study and experimental mice model. Elevated serum arginase I derived from inflammatory lung reduced L-arginine levels and reduced NO generation in bronchial smooth muscle. Moreover, serum arginase I was positively associated with 8-OHdG, a biomarker of oxidative stress and negatively associated with L-arginine. Therefore, serum arginase I may assocated with atherosclerosis by regulating serum L-aginine levels and NO in vascular endothelial cells.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (24 results)

All 2017 2016 2015 2014 2013

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Acknowledgement Compliant: 3 results,  Open Access: 5 results) Presentation (12 results) Book (6 results)

  • [Journal Article] Relationship between serum arginase I and L-arginine or exhaled nitric oxide in asthma.2016

    • Author(s)
      Ogino K, Obase Y, Ito T, Fujimura M, Eguchi E, Kubo M, Kenjiro N, Nakamura H
    • Journal Title

      Free Radic Res.

      Volume: 50 Issue: 11 Pages: 1156-1172

    • DOI

      10.1080/10715762.2016.1202407

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Involvement of Xanthine Oxidoreductase-related Oxidative Stress in a Dermatophagoides farinae-induced Asthma Model of NC/Nga Mice.2016

    • Author(s)
      Setiawan H, Nagaoka K, Kubo M, Fujikura Y, Ogino K.
    • Journal Title

      Acta Med Okayama

      Volume: 70 Pages: 175-182

    • NAID

      120005770685

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rebamipide suppresses mite-induced asthmatic responses in NC/Nga mice2015

    • Author(s)
      Murakami I, Zhang R, Kubo K, Nagaoka K, Eguchi E, Ogino K
    • Journal Title

      Am J Physiol Lung Cell Mol Physiol

      Volume: 309 Pages: 872-878

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] L-Arginine administration attenuates airway inflammation by altering L-arginine metabolism in an NC/Nga mouse model of asthma.2015

    • Author(s)
      Zhang R, Kubo M, Murakami I, Setiawan H, Takemoto K, Inoue K, Fujikura Y, Ogino K
    • Journal Title

      J. Clin. Biochem. Nutr.

      Volume: 56 Pages: 201-207

    • NAID

      130005068179

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] L-Arginine administration attenuates airway inflammation by altering L-arginine metabolism in an NC/Nga mouse model of asthma2015

    • Author(s)
      Zhang R, Kubo M, Murakami I, Setiawan H, Takemoto K, Inoue K, Fujikura Y, Ogino K
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 56 Issue: 3 Pages: 201-207

    • DOI

      10.3164/jcbn.14-140

    • NAID

      130005068179

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] omparison of serum ferritin and oxidative stress biomarkers between Japanese workers with and without metabolic syndrome2013

    • Author(s)
      Iwanaga S, Sakano N, Taketa K, Takahashi N, Wang DH, Takahashi H, Kubo M, Miyatake N, Ogino K
    • Journal Title

      Obesity Research & Clinical Practice

      Volume: (in press) Issue: 3 Pages: 271-282

    • DOI

      10.1016/j.orcp.2013.01.003

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 生活習慣病前におけるアルギナーゼⅠとL-アルギニン代謝物のバイオマーカーとしての可能性:初期肥満マウスでの検討.2016

    • Author(s)
      久保正幸, 長岡憲次郎, 舟久保徳美, Heri Setiawan, 岡瑛良, 江口依里, 伊藤達男, 藤倉義久, 荻野景規
    • Organizer
      第14回日本予防医学会学術総会
    • Place of Presentation
      日本科学未来館(東京)
    • Year and Date
      2016-06-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] ヒトラクトフェリンはNC/Ngaマウスにおける喘息様症状を誘導する.2016

    • Author(s)
      長岡憲次郎, 久保正幸, 江口依里, 藤倉義久, 荻野景規
    • Organizer
      第14回日本予防医学会学術総会
    • Place of Presentation
      日本科学未来館(東京)
    • Year and Date
      2016-06-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] 初期化肥満マウスでは肝臓アルギナーゼⅠの発現が増加し、血中アルギニン代謝が変化する.2016

    • Author(s)
      久保正幸, 長岡憲次郎, 舟久保徳美, へリセティアワン, 岡瑛良, 江口依里, 伊藤達男, 藤倉義久, 荻野景規
    • Organizer
      第86回日本衛生学会学術総会
    • Place of Presentation
      旭川市民文化会館(北海道 旭川市)
    • Year and Date
      2016-05-12
    • Related Report
      2016 Annual Research Report
  • [Presentation] 健診受診者の企業別のアレルギー性疾患とアルギナーゼ1との関連.2015

    • Author(s)
      石井香代子, 坂野紀子, 張燃, ヘリセティアワン, 久保正幸, 江口依里, 長岡憲次郎, 井上清美, 荻野景規
    • Organizer
      第88回日本産業衛生学会学術総会
    • Place of Presentation
      グランフロント大阪
    • Year and Date
      2015-05-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] アルギニンによるNC/Ngaマウス喘息の軽減作用2015

    • Author(s)
      張燃,久保正幸,村上育夫,へリセティアワン,竹本圭,江口依里,長岡憲次郎,井上清美,藤倉義久,荻野景規
    • Organizer
      第85回日本衛生学会学術総会
    • Place of Presentation
      和歌山市
    • Year and Date
      2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 肥満におけるアルギナーゼ動態とスタチンの作用について2015

    • Author(s)
      舟久保徳美,へリセティアワン,久保正幸,竹本圭,張燃,長岡憲次郎,吉田純子,築山依果,江口依里,荻野景規
    • Organizer
      第85回日本衛生学会学術総会
    • Place of Presentation
      和歌山市
    • Year and Date
      2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] ダニ誘発マウス喘息モデルに対するrebamipideの効果2015

    • Author(s)
      村上育夫,張燃,久保正幸,荻野景規
    • Organizer
      第85回日本衛生学会学術総会
    • Place of Presentation
      和歌山市
    • Year and Date
      2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] マウスの呼気NO(一酸化窒素)に関する研究2014

    • Author(s)
      波多野詠巳, 張燃, 村上育郎, ヘリセティアワン, 久保正幸, 竹本圭, 荻野景規
    • Organizer
      第84回日本衛生学会学術総会
    • Place of Presentation
      岡山市
    • Year and Date
      2014-05-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 日本人健常人集団における酸化ストレスバイオマーカーとしての血清arginase-1の評価2014

    • Author(s)
      村上育郎, 大本安一, 坂東政彦, へリセティアワン, 築山依果, 坂野紀子, 髙橋秀和, 久保正幸, 汪達紘, 荻野景規
    • Organizer
      第84回日本衛生学会学術総会
    • Place of Presentation
      岡山市
    • Year and Date
      2014-05-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 健常労働者における血清アルギナーゼとL-アルギニン、ニトロチロシン、呼気NOの関連性2014

    • Author(s)
      Heri Setiawan, 汪達紘, 久保正幸, 閻付林, 髙橋秀和, 張燃, 築山依果, 吉田純子, 鄒宇, 荻野景規
    • Organizer
      第84回日本衛生学会学術総会
    • Place of Presentation
      岡山市
    • Year and Date
      2014-05-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] ダニ蛋白誘発喘息モデルマウスにおけるアルギナーゼ阻害剤及びステロイド剤の抗炎症効果2014

    • Author(s)
      張燃, 竹本圭, 久保正幸, 吉田純子, 村上育郎, 鄒宇, ヘリセティアワン, 汪達紘, 荻野景規
    • Organizer
      第87回日本産業衛生学会
    • Place of Presentation
      岡山市
    • Year and Date
      2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] 血中のアルギニン、アルギナーゼとの関連性2014

    • Author(s)
      舟久保徳美, 張燃, ヘリセティアワン, 汪達紘, 久保正幸, 竹本圭, 三宅優紀, 築山依果, 吉田純子, 井上清美, 坂野紀子, 正富千絵, 荻野景規
    • Organizer
      第87回日本産業衛生学会
    • Place of Presentation
      岡山市
    • Year and Date
      2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Book] Serum arginase in healthy subject and nitric oxide in L-Arginine in Clinical Nutrition2017

    • Author(s)
      Keiki Ogino, Kei Takemoto
    • Total Pages
      645
    • Publisher
      Humana Press
    • Related Report
      2016 Annual Research Report
  • [Book] PHP Business THE212015

    • Author(s)
      荻野景規
    • Total Pages
      112
    • Publisher
      PHP研究所
    • Related Report
      2015 Annual Research Report
  • [Book] General Methods in Biomarker Research and their Applications2015

    • Author(s)
      Wang DH, Ogino K, Sato Y, Sakano N, Kubo M, Takemoto K, Masatomi C
    • Total Pages
      1324
    • Publisher
      Springer
    • Related Report
      2015 Annual Research Report
  • [Book] 予防医学テキスト改訂第二版2015

    • Author(s)
      荻野景規
    • Total Pages
      294
    • Publisher
      大樹舎
    • Related Report
      2015 Annual Research Report
  • [Book] General Methods in Biomarker Research and their Applications2015

    • Author(s)
      Wang DH, Ogino K, Sato Y, Sakano N, Kubo M, Takemoto K, Masatomi C
    • Total Pages
      494
    • Publisher
      Springer, New York
    • Related Report
      2014 Annual Research Report
  • [Book] Oxidative Stress in Applied Basic Research and Clinical Practice - Pediatric Disorders2014

    • Author(s)
      Kubo M, Ogino K
    • Total Pages
      494
    • Publisher
      Springer, New York
    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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