| Project/Area Number |
26293152
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hygiene and public health
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| Research Institution | Okayama University |
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Principal Investigator |
Ogino Keiki 岡山大学, 医歯(薬)学総合研究科, 教授 (70204104)
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| Co-Investigator(Kenkyū-buntansha) |
長岡 憲次郎 岡山大学, 医歯(薬)学総合研究科, 助教 (40752374)
杉山 斉 岡山大学, 医歯(薬)学総合研究科, 教授 (60325090)
久保 正幸 岡山大学, 医歯(薬)学総合研究科, 助教 (60420519)
江口 依里 岡山大学, 医歯(薬)学総合研究科, 助教 (60635118)
竹本 圭 岡山大学, 医歯(薬)学総合研究科, 助教 (60723252)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
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| Keywords | アルギナーゼ / NO / アルギニン / 喘息 / 酸化ストレスマーカー / アルギナーゼI / NO2- / NO3- / 仕事ストレス / 糖負荷 / P38MAPK / 一酸化窒素 / 肥満 / 予防 / L-アルギニン / ケルセチン / 糖尿病 / 一酸化窒素(NO) / 一酸化窒素合成酵素(NOS) |
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| Outline of Final Research Achievements |
In asthma, serum arginase I was augmented in human study and experimental mice model. Elevated serum arginase I derived from inflammatory lung reduced L-arginine levels and reduced NO generation in bronchial smooth muscle. Moreover, serum arginase I was positively associated with 8-OHdG, a biomarker of oxidative stress and negatively associated with L-arginine. Therefore, serum arginase I may assocated with atherosclerosis by regulating serum L-aginine levels and NO in vascular endothelial cells.
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