Spatial and genetic epidemiological study on the pathogenesis of obesity and diabetes

• Project/Area Number: 26293153
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: Fujita Health University
• Principal Investigator: Yatsuya Hiroshi 藤田保健衛生大学, 医学部, 教授 (30324437)
• Co-Investigator(Kenkyū-buntansha): 青山 温子 名古屋大学, 医学系研究科, 教授 (40184056) ; 玉腰 浩司 名古屋大学, 医学系研究科(保健), 教授 (30262900) ; 平川 仁尚 名古屋大学, 医学系研究科, 准教授 (00378168) ; 上村 真由 名古屋大学, 医学系研究科, 助教 (60754786) ; 太田 充彦 藤田保健衛生大学, 医学部, 准教授 (80346709) ; 内藤 久雄 藤田保健衛生大学, 医学部, 講師 (90547556) ; 山田 宏哉 藤田保健衛生大学, 医学部, 講師 (80610352) ; 李 媛英 藤田保健衛生大学, 医学部, 助教 (20701288) ; 大塚 礼 国立研究開発法人国立長寿医療研究センター, その他部局等, その他 (00532243) ; 村田 千代栄 国立研究開発法人国立長寿医療研究センター, その他部局等, その他 (40402250) ; 埴淵 知哉 中京大学, 公私立大学の部局等, 准教授 (40460589) ; Esayas Hilawe 名古屋大学, 医学(系)研究科(研究院), 助教 (60752615) ; 柿崎 真沙子 藤田保健衛生大学, 医学部, 講師 (20580872)
• Co-Investigator(Renkei-kenkyūsha): HANIBUCHI Tomoya 中京大学, 国際教養学部, 教授 (40460589)
• Research Collaborator: TOYOSHIMA Hideaki 名古屋大学 ; KOH Keihatsu (CHIANG Chifa) 名古屋大学 ; YAMASHITA Kentaro 名古屋大学 ; WANG Chaochen 名古屋大学 ; ZHANG Yan 名古屋大学 ; KANEKO Kayo 名古屋大学 ; AL-SHOAIBI Abubakr Ahmed Abdullah 名古屋大学 ; GEBREMARIAM Lemlem Weldegerima 名古屋大学 ; HE Yupeng 名古屋大学 ; SUZUKI Koji 藤田保健衛生大学 ; SAYEED Shurovi 藤田保健衛生大学 ; KATOH Yoshiji 藤田保健衛生大学 ; FUJISAWA Akiko 藤田保健衛生大学 ; MATSUNAGA Masaaki 藤田保健衛生大学 ; KHINE May Thet 藤田保健衛生大学
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000); Fiscal Year 2017: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2016: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2015: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
• Keywords: 地理情報システム / 職域コホート / ウォーカビリティ / 肥満 / 糖尿病 / メチル化 / 地理的情報 / コホート研究 / 生活習慣病 / 職域 / エピジェネティクス / 循環器疾患

Outline of Final Research Achievements

The associations of a neighborhood’s built environment on health via its effects on physical activity, diet, or other unknown mediators have been suggested, but little studied in Japan. A composite measure of geographic characteristics, walkability index, was obtained in the present study using geographic information system (GIS), which consists of population density, road density, access to parks, and access to retail areas (Hanibuchi, et al., 2015). As the results, the degree of residence neighborhood walkability was associated with self-reported leisure-time physical activities among workers living in an urban-suburban area. Also, distance between one's home and the workplace was positively associated with self-reported duration of walking.

Research Products

• [Journal Article] A Point System for Predicting 10-Year Risk of Developing Type 2 Diabetes Mellitus in Japanese Men: Aichi Workers’ Cohort Study (2018)
  • Author(s): Yatsuya Hiroshi、Li Yuanying、Hirakawa Yoshihisa、Ota Atsuhiko、Matsunaga Masaaki、Haregot Hilawe Esayas、Chiang Chifa、Zhang Yan、Tamakoshi Koji、Toyoshima Hideaki、Aoyama Atsuko
  • Journal Title: Journal of Epidemiology Volume: 28 Issue: 8 Pages: 347-352
  • DOI: 10.2188/jea.JE20170048
  • NAID: 130007431029
  • ISSN: 0917-5040, 1349-9092
  • Year and Date: 2018-08-05
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 肥満と動脈硬化 (2018)
  • Author(s): 八谷寛、李媛英、金子佳世、太田充彦
  • Journal Title: 食と医療 Volume: 4 Pages: 72-79
• [Journal Article] Long-term weight-change slope, weight fluctuation and risk of type 2 diabetes mellitus in middle-aged Japanese men and women: findings of Aichi Workers' Cohort Study. (2017)
  • Author(s): Zhang Y, Yatsuya H, Li Y, Chiang C, Hirakawa Y, Kawazoe N, Tamakoshi K, Toyoshima H, Aoyama A.
  • Journal Title: Nutr Diabetes Volume: 7(3) Issue: 3 Pages: e252-e252
  • DOI: 10.1038/nutd.2017.5
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Functional capacity, self-rated health status, and psychosocial characteristics of employed cancer survivors in Japan (2017)
  • Author(s): Katoh Y, Ota A, Yatsuya H, Li Y, Naito H, Fujisawa A, Matsunaga M, Hirakawa Y, Chiang C, Toyoshima H, Tamakoshi K, Aoyama A
  • Journal Title: Fujita Medical Journal Volume: 3 Issue: 3 Pages: 55-61
  • DOI: 10.20407/fmj.3.3_55
  • NAID: 130006068162
  • ISSN: 2189-7247, 2189-7255
  • Peer Reviewed / Open Access
• [Journal Article] わが国の循環器疾患の危険因子 (2017)
  • Author(s): 松永眞章、八谷寛
  • Journal Title: 日本循環器病予防学会誌 Volume: 52 Pages: 244-254
  • Peer Reviewed
• [Journal Article] Functional capacity, self-rated health status, and psychosocial characteristics of employed cancer survivors in Japan (2017)
  • Author(s): Katoh Y, Ota A, Yatsuya H, Li Y, Naito H, Fujisawa A, Matsunaga M, Hirakawa Y, Chiang C, Toyoshima H, Tamakoshi K, and Aoyama A
  • Journal Title: Fujita Medical Journal Volume: 印刷中
  • NAID: 130006068162
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Association between parental history of diabetes and the incidence of type 2 diabetes mellitus differs according to the sex of the parent and offspring's body weight: A finding from a Japanese worksite-based cohort study. (2015)
  • Author(s): Wang C, Yatsuya H, Tamakoshi K, Toyoshima H, Wada K, Li Y, Hilawe EH, Uemura M, Chiang C, Zhang Y, Otsuka R, Ota A, Hirakawa Y, Aoyama A.
  • Journal Title: Prev Med. Volume: 81 Pages: 49-53
  • DOI: 10.1016/j.ypmed.2015.07.021
  • Peer Reviewed
• [Journal Article] Breakfast Skipping is Positively Associated With Incidence of Type 2 Diabetes Mellitus: Evidence From the Aichi Workers’ Cohort Study (2015)
  • Author(s): Uemura M, Yatsuya H, Hilawe EH, Li Y, Wang C, Chiang C, Otsuka R, Toyoshima H, Tamakoshi K, Aoyama A.
  • Journal Title: Journal of Epidemiology Volume: 25 Issue: 5 Pages: 351-358
  • DOI: 10.2188/jea.JE20140109
  • NAID: 130005067871
  • ISSN: 0917-5040, 1349-9092
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Past Decline Versus Current eGFR and Subsequent Mortality Risk. (2015)
  • Author(s): Naimark DM, Grams ME, Matsushita K, Black C, Drion I, Fox CS, Inker LA, Ishani A, Jee SH, Kitamura A, Lea JP, Nally J, Peralta CA, Rothenbacher D, Ryu S, Tonelli M, Yatsuya H, Coresh J, Gansevoort RT, Warnock DG, Woodward M, de Jong PE; CKD Prognosis Consortium.
  • Journal Title: J Am Soc Nephrol. Volume: in press
  • Peer Reviewed
• [Journal Article] Smoking and Diabetes: Is the Association Mediated by Adiponectin, Leptin, or C-reactive Protein? (2015)
  • Author(s): Hilawe EH, Yatsuya H, Li Y, Uemura M, Wang C, Chiang C, Toyoshima H, Tamakoshi K, Zhang Y, Kawazoe N, Aoyama A.
  • Journal Title: Journal of Epidemiology Volume: 25 Issue: 2 Pages: 99-109
  • DOI: 10.2188/jea.JE20140055
  • NAID: 130004704584
  • ISSN: 0917-5040, 1349-9092
  • Peer Reviewed / Open Access
• [Journal Article] Body Mass Index-Modified Relationship of Chronic Mental Stress With Resting Blood Pressure During 5 Years in Japanese Middle-Aged Male Workers (2014)
  • Author(s): Toyoshima H, Otsuka R, Hashimoto S, Tamakoshi K, Yatsuya H
  • Journal Title: Circulation Journal Volume: 78 Issue: 6 Pages: 1379-1386
  • DOI: 10.1253/circj.CJ-13-1086
  • NAID: 130003391123
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Independent association of liver fat accumulation with insulin resistance (2013)
  • Author(s): Yatsuya H, Nihashi T, Li Y, Hotta Y, Matsushita K, Muramatsu T, Otsuka R, Matsunaga M, Yamashita K, Wang C, Uemura M, Harada A, Fukatsu H, Toyoshima H, Aoyama A, Tamakoshi K
  • Journal Title: Obes Res Clin Pract Volume: 未定 Issue: 4 Pages: e350-e355
  • DOI: 10.1016/j.orcp.2013.08.002
  • Peer Reviewed
• [Presentation] 自宅から鉄道駅、バス停、職場までの距離と歩行時間との関連―愛知職域コホート (2018)
  • Author(s): 八谷寛、李媛英、埴淵知哉、平川仁尚、太田充彦、加藤善士、藤澤明子、松永眞章、大塚礼、村田千代栄、江啓発、玉腰浩司、豊嶋英明、青山温子
  • Organizer: 第28回日本疫学会学術総会
• [Presentation] Social capital and health among civil servants in Japan (2017)
  • Author(s): Murata C, Yatsuya H, Li Y, Ota a, Otsuka R, Toyoshima H, Tamakoshi K, Aoyama A
  • Organizer: the 21st International Epidemiological Association (IEA), World Congress of Epidemiology (WCE2017)
  • Place of Presentation: Saitama, Japan
  • Year and Date: 2017-08-19
  • Int'l Joint Research
• [Presentation] A point-based prediction model for predicting 10-year risk of developing type 2 diabetes mellitus in Japanese men: Aichi Workers’ Cohort Study. (2017)
  • Author(s): Li Y, Yatsuya H, Hirakawa Y, Ota A, Matsunaga M, Haregot H, Chiang C, Zhang Y, Tamakoshi K, Toyoshimad H, Aoyama A
  • Organizer: 2017 Scientific Sessions, Epidemiology and Prevention | Lifestyle and Cardiometabolic Health, American Heart Association
  • Place of Presentation: Portland, USA
  • Year and Date: 2017-03-07
  • Int'l Joint Research
• [Presentation] GISにより評価した自宅近隣のwalkabilityと散歩・早歩き習慣との関連－愛知職域コホート (2017)
  • Author(s): 李媛英、八谷寛、埴淵知哉、平川仁尚、太田充彦、加藤善士、藤澤明子、松永眞章、大塚礼、村田千代栄、江啓発、玉腰浩司、豊嶋英明、青山温子
  • Organizer: 第27回日本疫学会学術総会
  • Place of Presentation: 甲府市、ベルクラシック甲府
  • Year and Date: 2017-01-27
• [Presentation] 地理的剥奪・ソーシャルキャピタルと主観的健康感の関連－愛知職域コホート (2017)
  • Author(s): 村田千代栄、八谷寛、埴淵知哉、李媛英、豊嶋英明、平川仁尚、太田充彦、加藤善士、藤澤明子、松永眞章、大塚礼、江啓発、玉腰浩司、中谷友樹、青山温子
  • Organizer: 第27回日本疫学会学術総会
  • Place of Presentation: 甲府市、ベルクラシック甲府
  • Year and Date: 2017-01-27
• [Presentation] Social capital and health among civil servants in Japan. (2017)
  • Author(s): Murata C, Yatsuya H, Li Y, Ota A, Otsuka R, Toyoshima H, Tamakoshi K, and Aoyama A.
  • Organizer: The 21st International Epidemiological Association World Congress of Epidemiology
  • Int'l Joint Research
• [Presentation] Long-term weight change slope and risk of type 2 diabetes mellitus in middle-aged Japanese men and women: findings of Aichi Workers’ Cohort Study. (2016)
  • Author(s): Zhang Y, Yatsuya H, Hirakawa Y, Chiang C, Li Y Kawazoe N, Tamakoshi K, and Aoyama A.
  • Organizer: 第75回日本公衆衛生学会総会
  • Place of Presentation: 大阪市、グランフロント大阪
  • Year and Date: 2016-10-26
• [Presentation] 危険因子の変化を考慮した糖尿病発症リスク予測 (2016)
  • Author(s): 李媛英、八谷寛、平川仁尚、松永眞章、太田充彦、江啓発、張燕、Hilawe Esayas Haregot、玉腰浩司、豊嶋英明、青山温子
  • Organizer: 第52回日本循環器病予防学会学術集会
  • Place of Presentation: さいたま市、埼玉県県民健康センター
  • Year and Date: 2016-06-16
• [Presentation] がんの既往歴を有する就労者の主観的健康感などについて (2015)
  • Author(s): 加藤善士、八谷寛、太田充彦、李媛英、藤澤明子、松永眞章、内藤久雄、平川仁尚、江啓発、豊嶋英明、玉腰浩司、青山温子
  • Organizer: 平成27年度日本産業衛生学会東海地方会学会
  • Place of Presentation: 愛知県名古屋市
  • Year and Date: 2015-11-14
• [Presentation] 健診および生活習慣要因による糖尿病発症リスクスコア開発：愛知職域コホート研究 (2015)
  • Author(s): 李媛英、八谷寛、玉腰浩司、上村真由、王超辰、平川仁尚、Esayas Haregot、江啓発、加藤善士、太田充彦、張燕、豊嶋英明、青山温子
  • Organizer: 第51回日本循環器病予防学会学術集会
  • Place of Presentation: 大阪府大阪市
  • Year and Date: 2015-06-27
• [Presentation] The number of metabolic syndrome components is more strongly associated with coronary artery disease than stroke. (2015)
  • Author(s): Yatsuya H, Tamakoshi K, Li Y, Ota A, Uemura M, Wang C, Hilawe EH, Otsuka R, Murata C, Chiang C, Zhang Y, Toyoshima H, Aoyama A.
  • Organizer: 第25回日本疫学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-01-23
• [Presentation] Positive association between breakfast skipping and incidence of type 2 diabetes mellitus: evidence from a Japanese worksite-based cohort. (2014)
  • Author(s): Uemura M, Yatsuya H, Li Y, Wang C, Hilawe EH, Chiang C, Toyoshima H, Tamakoshi K, Zhang Y, Aoyama A.
  • Organizer: The 20th IEA World Congress of Epidemiology
  • Place of Presentation: Anchorage
  • Year and Date: 2014-08-19
• [Presentation] Adiponectin, but neither Leptin nor C-reactive protein, mediates the association between smoking and diabetes (2014)
  • Author(s): Hilawe EH, Yatsuya H, Li Y, Uemura M, Wang C, Chiang C, Toyoshima H, Tamakoshi K, Zhang Y, Aoyama A
  • Organizer: The 20th IEA World Congress of Epidemiology
  • Place of Presentation: Anchorage
  • Year and Date: 2014-08-18
• [Presentation] Associations of parental history of diabetes mellitus with the offspring’s incidence is modified by offspring’s body weight, findings from a Japanese worksite-based cohort. (2014)
  • Author(s): Wang C, Yatsuya H, Tamakoshi K, Toyoshima H, Wada K, Li Y, Hilawe EH, Uemura M, Chiang C, Zhang Y, Aoyama A
  • Organizer: The 20th IEA World Congress of Epidemiology
  • Place of Presentation: Anchorage
  • Year and Date: 2014-08-18
• [Remarks] 愛知職域コホート
  • URL: http://koei-nagoya.blogspot.jp/
• [Remarks] 愛知職域コホート
  • URL: http://koei-nagoya.blogspot.com/
• [Remarks] 朝食欠食は2型糖尿病発症リスクの上昇と関連する
  • URL: http://www.med.nagoya-u.ac.jp/intnl-h/index.php?Topics