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Effectiveness of clinical decision support system to prevent adverse drug events

Research Project

Project/Area Number 26293159
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Medical and hospital managemen
Research InstitutionHyogo Medical University

Principal Investigator

Morimoto Takeshi  兵庫医科大学, 医学部, 教授 (30378640)

Co-Investigator(Kenkyū-buntansha) 作間 未織  兵庫医科大学, 医学部, 講師 (60349587)
太田 好紀  兵庫医科大学, 医学部, 講師 (10516404)
岡本 里香  兵庫医科大学, 医学部, 講師 (50775814)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2016: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Keywords臨床決断支援システム / 薬剤性有害事象 / 医療安全 / 医療の質 / 社会医学 / 内科 / 医療・福祉
Outline of Final Research Achievements

We developed the clinical decision support system which predict the situation of high risk of adverse drug events and medication errors. We installed such system into the electronic health records and computerized physician ordering system which automatically alerted the healthcare professionals. We attested the effectiveness the system in terms of reduction of adverse drug events and medication errors.
We first developed the guidance system to adjust the doses of drugs according to renal function and alert the occurrence of antibiotics-associated diarrhea. As a result, the proportion of appropriate doses of medication was increased and the deterioration of renal function among admitted patients were decreased. On the other hand, the frequency of antibiotics-associated diarrhea did not change.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (31 results)

All 2018 2017 2016 2015 2014 2013

All Journal Article (17 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 17 results,  Open Access: 11 results,  Acknowledgement Compliant: 4 results) Presentation (14 results) (of which Int'l Joint Research: 9 results)

  • [Journal Article] Asian patients versus non-Asian patients in the efficacy and safety of direct oral anticoagulants relative to vitamin K antagonist for venous thromboembolism: A systemic review and meta-analysis.2018

    • Author(s)
      Yamashita Yugo, Morimoto Takeshi, Toyota Toshiaki, Shiomi Hiroki, Makiyama Takeru, Ono Koh, Kimura Takeshi.
    • Journal Title

      Thrombosis Research

      Volume: 166 Pages: 37-42

    • DOI

      10.1016/j.thromres.2018.04.008

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Improving the assessment of adverse drug reactions using the Naranjo Algorithm in daily practice: The Japan Adverse Drug Events Study.2018

    • Author(s)
      Murayama Hiroki, Sakuma Mio, Takahashi Yuri, Morimoto Takeshi.
    • Journal Title

      Pharmacology Research & Perspectives

      Volume: 6 Issue: 1

    • DOI

      10.1002/prp2.373

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differences in adverse drug events among pediatric patients with and without cancer: Sub-analysis of a retrospective cohort study.2017

    • Author(s)
      Koizumi Akira, Ohta Yoshinori, Sakuma Mio, Okamoto Rika, Matsumoto Chisa, Bates David W, Morimoto Takeshi.
    • Journal Title

      Drugs - Real World Outcomes

      Volume: 4 Issue: 3 Pages: 167-173

    • DOI

      10.1007/s40801-017-0115-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prevention of medication errors in hospitalized patients: The Japan Adverse Drug Events study.2016

    • Author(s)
      Noguchi C, Sakuma M, Ohta Y, Bates DW, Morimoto T.
    • Journal Title

      Drug Saf

      Volume: 39 Issue: 11 Pages: 1129-1137

    • DOI

      10.1007/s40264-016-0458-1

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Frequency and Severity of Adverse Drug Events by Medication Classes: The JADE Study.2016

    • Author(s)
      Sakuma M, Kanemoto Y, Furuse A, Bates DW, Morimoto T.
    • Journal Title

      Journal of Patient Safety

      Volume: 印刷中 Issue: 1 Pages: 30-35

    • DOI

      10.1097/pts.0000000000000235

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The epidemiology of adverse drug events and medication errors among psychiatric inpatients in Japan: The JADE study.2016

    • Author(s)
      Ayani N, Sakuma M, Morimoto T, Kikuchi T, Watanabe K, Narumoto J, Fukui K.
    • Journal Title

      BMC Psychiatry

      Volume: 16 Issue: 1 Pages: 303-303

    • DOI

      10.1186/s12888-016-1009-0

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epidemiology of adverse events and medical errors in the care of cardiology patients.2016

    • Author(s)
      Ohta Y, Miki I, Kimura T, Abe M, Sakuma M, Koike K, Morimoto T.
    • Journal Title

      J Patient Saf

      Volume: 印刷中 Issue: 3 Pages: 251-256

    • DOI

      10.1097/pts.0000000000000291

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] An Individual Patient Data Meta-Analysis on Factors Associated with Adverse Drug Events in Surgical and Nonsurgical Inpatients.2016

    • Author(s)
      Boeker EB, Ram K, Klopotowska JE, de Boer M, Creus MT, de Andres A, Sakuma M, Morimoto T, Boermeester MA, Dijkgraaf MG.
    • Journal Title

      Br J Clin Pharmacol

      Volume: 79 Issue: 4 Pages: 548-557

    • DOI

      10.1111/bcp.12504

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comparative efficacy and safety of novel oral anticoagulants in patients with atrial fibrillation: A network meta-analysis with the adjustment for the possible bias from open label studies.2015

    • Author(s)
      Morimoto T, Crawford B, Wada K, Ueda S.
    • Journal Title

      J Cardiol

      Volume: 66 Issue: 6 Pages: 466-474

    • DOI

      10.1016/j.jjcc.2015.05.018

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Investigating the Quality of Care in Cardiovascular Medicine2015

    • Author(s)
      Morimoto T.
    • Journal Title

      Circulation Journal

      Volume: 79 Issue: 5 Pages: 966-968

    • DOI

      10.1253/circj.CJ-15-0371

    • NAID

      130005066277

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Adverse drug events and medication errors in Japanese pediatric inpatients: A retrospective cohort study.2014

    • Author(s)
      Sakuma Mio,Ida H, Nakamura T, Ohta Y, Yamamoto K, Seki S, Hiroi K, Kikuchi K, Nakayama K, Bates DW, Morimoto T
    • Journal Title

      BMJ Qual Saf

      Volume: 印刷中 Issue: 10 Pages: 830-837

    • DOI

      10.1136/bmjqs-2013-002658

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of adverse drug events on morbidity and mortality in intensive care units: the JADE study.2014

    • Author(s)
      Ohta Y, Sakuma M, Koike K, Bates DW, Morimoto T.
    • Journal Title

      Int J Qual Health Care

      Volume: 26 Issue: 6 Pages: 573-578

    • DOI

      10.1093/intqhc/mzu081

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Public attitudes toward practice by medical students: A nationwide survey in Japan.2014

    • Author(s)
      Murata K, Sakuma M, Seki S, Morimoto T.
    • Journal Title

      Teach Learn Med

      Volume: 26 Issue: 4 Pages: 335-343

    • DOI

      10.1080/10401334.2014.945030

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A randomised controlled trial for the evaluation of risk for type 2 diabetes in hypertensive patients receiving thiazide diuretics: Diuretics In the Management of Essential hypertension (DIME) study2014

    • Author(s)
      Ueda S, Morimoto T, Ando S, Takishita S, Kawano Y, Shimamoto K, Ogihara T, Saruta T; DIME Investigators.
    • Journal Title

      BMJ Open

      Volume: 4 Issue: 7 Pages: e004576-e004576

    • DOI

      10.1136/bmjopen-2013-004576

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relation of Contrast-Induced Nephropathy to Long-Term Mortality after Percutaneous Coronary Intervention2014

    • Author(s)
      Abe M, Morimoto T, Akao M, Furukawa Y, Nakagawa Y, Shizuta S, Ehara N, Taniguchi R, Doi T, Nishiyama K, Ozasa N, Saito N, Hoshino K, Mitsuoka H, Toma M, Tamura T, Haruna Y, Kita T, Kimura T.
    • Journal Title

      Am J Cardiol.

      Volume: 114 Issue: 3 Pages: 362-368

    • DOI

      10.1016/j.amjcard.2014.05.009

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evolution in practice patterns and long-term outcomes of coronary revascularization from bare-metal stent era to drug-eluting stent era in Japan.2014

    • Author(s)
      Shiomi H, Morimoto T, Makiyama T, Ono K, Furukawa Y, Nakagawa Y, Kadota K, Onodera T, Takatsu Y, Mitsudo K, Kita T, Sakata R, Okabayashi H, Hanyu M, Komiya T, Yamazaki F, Nishiwaki N, Kimura T; CREDO-Kyoto Investigators.
    • Journal Title

      Am J Cardiol.

      Volume: 113 Issue: 10 Pages: 1652-9

    • DOI

      10.1016/j.amjcard.2014.02.037

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Two-year outcome of a randomized trial comparing second-generation drug-eluting stents using biodegradable or durable polymer2013

    • Author(s)
      Natsuaki M, Kozuma K, Morimoto T, Kadota K, Muramatsu T, Nakagawa Y, Akasaka T, Igarashi K, Tanabe K, Morino Y, Ishikawa T, Nishikawa H, Awata M, Abe M, Okada H, Takatsu Y, Ogata N, Kimura K, Urasawa K, Tarutani Y, Shiode N, Kimura T; NEXT Investigators.
    • Journal Title

      J Am Coll Cardiol.

      Volume: 311 Issue: 20 Pages: 2125

    • DOI

      10.1001/jama.2014.3584

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] The relationship between antipsychotic polypharmacy and adverse drug events: The JADE study.2017

    • Author(s)
      Ayani Nobutaka, Sakuma Mio, Narumoto Jin, Morimoto Takeshi.
    • Organizer
      34th International Conference of the International Society for Quality in Health Care
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Assessing adverse drug events using modified Naranjo algorithm: The JADE Study.2016

    • Author(s)
      Murayama H, Sakuma M, Morimoto T.
    • Organizer
      33rd International Conference of the International Society for Quality in Health Care
    • Place of Presentation
      東京国際フォーラム(東京都・千代田区)
    • Year and Date
      2016-10-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Impact of age and renal function on incidence of adverse drug event: The JADE Study.2016

    • Author(s)
      Takahashi Y, Sakuma M, Morimoto T.
    • Organizer
      33rd International Conference of the International Society for Quality in Health Care
    • Place of Presentation
      東京国際フォーラム(東京都・千代田区)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In-hospital adverse events among surgical patients in Japan: the JET study.2016

    • Author(s)
      Ohta Y, Sakuma M, Bates DW, Morimoto T.
    • Organizer
      European Society of Intensive Care Medicine 2016
    • Place of Presentation
      Milan, Italy
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Epidemiology of medical errors among inpatients in Japan: The JET Study.2015

    • Author(s)
      Morimoto T, Ohta Y, Sakuma M, Bates DW.
    • Organizer
      32nd International Conference of the International Society for Quality in Health Care
    • Place of Presentation
      Doha, Qatar
    • Year and Date
      2015-10-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The Implementation of the diarrhoea alert system for antibiotics-related diarrhoea: The JADE Study.2015

    • Author(s)
      Sakuma M, Nakamura T, Bates DW, Morimoto T.
    • Organizer
      32nd International Conference of the International Society for Quality in Health Care
    • Place of Presentation
      Doha, Qatar
    • Year and Date
      2015-10-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The Epidemiology of adverse events in ICU patients in Japan: The JET Study.2015

    • Author(s)
      Ohta Y, Sakuma M, Bates DW, Morimoto T.
    • Organizer
      32nd International Conference of the International Society for Quality in Health Care
    • Place of Presentation
      Doha, Qatar
    • Year and Date
      2015-10-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The Epidemiology of adverse drug events and medication errors in psychiatric inpatients in Japan: The JADE Study.2015

    • Author(s)
      Ayani N, Sakuma M, Narumoto J, Morimoto T.
    • Organizer
      32nd International Conference of the International Society for Quality in Health Care
    • Place of Presentation
      Doha, Qatar
    • Year and Date
      2015-10-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Physician's perspective on clinical decision support system for adverse drug events.2015

    • Author(s)
      Nakamura T, Sakuma M, Sonoyama T, Morimoto T.
    • Organizer
      32nd International Conference of the International Society for Quality in Health Care
    • Place of Presentation
      Doha, Qatar
    • Year and Date
      2015-10-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ICUにおける薬剤性有害事象の疫学研究2015

    • Author(s)
      太田好紀,作間未織,David W Bates,森本剛.
    • Organizer
      日本麻酔科学会第62回学術集会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県・神戸市)
    • Year and Date
      2015-05-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 小児入院患者における薬剤関連エラーの疫学 第2報:The JADE Study.2015

    • Author(s)
      作間未織,井田博幸,森本剛.
    • Organizer
      第118回日本小児科学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪府・大阪市)
    • Year and Date
      2015-04-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] Incidence and nature of injuries due to medical care in Japan: the JET Study.2014

    • Author(s)
      Morimoto T, Sakuma M, Ohta Y, Bates DW.
    • Organizer
      31th International Conference of the International Society for Quality in Health Care
    • Place of Presentation
      Rio de Janeiro, Brazil
    • Year and Date
      2014-10-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] The implementation of decision support system for reducing adverse drug events and medication errors in Japanese inpatients: the JADE Study.2014

    • Author(s)
      Sakuma M, Ohta Y, Bates DW, Morimoto T.
    • Organizer
      31th International Conference of the International Society for Quality in Health Care
    • Place of Presentation
      Rio de Janeiro, Brazil
    • Year and Date
      2014-10-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] The epidemiology of operation related adverse events in inpatients: the JET Study.2014

    • Author(s)
      Ohta Y, Sakuma M, Bates DW, Morimoto T.
    • Organizer
      31th International Conference of the International Society for Quality in Health Care
    • Place of Presentation
      Rio de Janeiro, Brazil
    • Year and Date
      2014-10-06
    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2019-03-29  

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