| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2016: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
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| Outline of Final Research Achievements |
Patients with brain injury may die immediately after receiving the impact to the head. Forensic diagnosis of cause of death in such patients is difficult, because edema and herniation may not have developed in the brain due to short survival period of time. This study was performed to identify the mechanisms of immediate death after head trauma. Experimental studies using animal models and analyses of autopsy cases revealed that blunt force impact to the parietal region of the head relates to the cardio-pulmonary arrest and immediate death after the impact. In addition, experimental studies using animal models identified neuronal degeneration in the brain stem after receiving impact to the head and suggested that senescent cells relate to the mechanisms of progression of traumatic brain injury.
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