| Project/Area Number |
26293167
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | National Center for Geriatrics and Gerontology (2016)
Osaka University (2014-2015) |
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Principal Investigator |
SATO Naoyuki 国立研究開発法人国立長寿医療研究センター, 分子基盤研究部, 部長 (70372612)
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| Co-Investigator(Kenkyū-buntansha) |
田中 稔久 大阪大学, 医学(系)研究科(研究院), 准教授 (10294068)
村山 繁雄 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 神経内科, 部長 (50183653)
宮崎 早月 大阪大学, 医学(系)研究科(研究院), 助教 (60452439)
内尾 こずえ 国立研究開発法人医薬基盤・健康・栄養研究所, 疾患モデル小動物研究室, 主任研究員 (70373397)
上田 裕紀 大阪大学, 医学(系)研究科(研究院), 招へい研究員 (90543463)
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| Co-Investigator(Renkei-kenkyūsha) |
IKEUCHI Takeshi 新潟大学, 脳研究所, 教授 (20372469)
TAKEYA Yasushi 大阪大学, 大学院医学系研究科, 助教 (70590339)
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| Research Collaborator |
TAKEYA Miyuki
MUKOUZONO Masahiro
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Keywords | 糖尿病 / 認知症 / 遺伝子 / 痴呆 / アルツハイマー病 / βアミロイド / タウ / 神経変性 |
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| Outline of Final Research Achievements |
Diabetes is known to be one of the risk factors for Alzheimer's disease (AD). β-amyloid is considered to be causative for AD. This study revealed the biological response to β-amyloid at the molecular level. The biological response to β-amyloid may contribute to homeostatic maintenance against AD. Furthermore, it was revealed that the biological response to β-amyloid failed due to diabetes. These results would lead to the development of therapeutic options for dementia.
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