| Budget Amount *help |
¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
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| Outline of Final Research Achievements |
In this study, we explored the nature of cancer stem cells, and sought the possibility of anti-cancer stem cell-targeting therapies. For that purpose, we performed the experiments as follows. 1) In the intestine, transcriptome of cancer stem cells was analyzed based on the expression of various stem cell markers, especially Dclk1. 2) The roles of Dclk1 and novel cancer stem cell-specific markers were investigated in mouse gastric, pancreatic, and gall bladder cancer models. 3) Therapeutic potentials of kinases and cell surface proteins in cancer stem cells were examined in mouse cancer models and cancer spheroids. Based on these experiments, basis for the development of anti-cancer stem cell therapies was established.
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