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Basic research to develop next generation cell therapy for improvement of liver fibrosis.

Research Project

Project/Area Number 26293175
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionNiigata University

Principal Investigator

TERAI Shuji  新潟大学, 医歯学系, 教授 (00332809)

Co-Investigator(Kenkyū-buntansha) 山際 訓  新潟大学, 医歯学系, 准教授 (10419327)
上村 顕也  新潟大学, 医歯学系, 助教 (00579146)
佐藤 祐一  新潟大学, 医歯学総合病院, 准教授 (00401761)
川合 弘一  新潟大学, 医歯学総合病院, 講師 (80419291)
土屋 淳紀  新潟大学, 医歯学総合病院, 助教 (70464005)
藤澤 浩一  山口大学, 医学(系)研究科(研究院), 助教 (00448284)
石川 剛  山口大学, 医学(系)研究科(研究院), 助教 (20569305)
高見 太郎  山口大学, 医学(系)研究科(研究院), 講師 (60511251)
坂井田 功  山口大学, 医学(系)研究科(研究院), 教授 (80263763)
岩本 拓也  山口大学, 医学部附属病院, 助教 (80634716)
山本 直樹  山口大学, 大学教育機構, 講師 (90448283)
Research Collaborator NISHINA Hiroshi  
TABATA Yasuhiko  
TOGUCHIDA Junya  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Keywords肝硬変 / 細胞療法 / 間葉系幹細胞 / マクロファージ / ライブイメージング / 再生医療 / 間葉系細胞 / 肝再生 / 線維化改善 / 移植・再生医療 / 再生医学 / 老化 / トランスレーショナルリサーチ / 細胞・組織
Outline of Final Research Achievements

Decompensated liver cirrhosis often progresses even after treatment. Autologous bone marrow cells infusion (ABMi) therapy was developed for liver cirrhosis, however the most effective cells in the heterogeneous bone marrow cells, detail behavior of administrated cells, and detailed mechanism of improvement of liver fibrosis and promotion of liver regeneration have not been elucidated. In this study we elucidated that mesenchymal stem cells (MSCs) and induced bone marrow derived macrophages (id-BMMs) combination therapy effectively regressed liver fibrosis and promoted liver regeneration. Combination therapy using both id-BMMs and MSCs had synergistic effects, affecting the host cells in a liver cirrhosis mouse model. We also elucidated that a large number of id-BMMs, which had M2 phenotype and phagocytized hepatocyte debris, and few MSCs migrated to the fibrotic area in the liver. We believe that this fact is important for future cell therapy for decompensated liver cirrhosis.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report

Research Products

(54 results)

All 2017 2016 2015 2014

All Journal Article Presentation Book

  • [Journal Article] Status of and candidates for cell therapy in liver cirrhosis: overcoming the "point of no return" in advanced liver cirrhosis.2017

    • Author(s)
      Terai S, Tsuchiya A.
    • Journal Title

      J Gastroenterol.

      Volume: Feb;52(2) Pages: 129-140

    • DOI

      10.1007/s00535-016-1258-1

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Phase 1 Clinical Study of siRNA Targeting Carbohydrate Sulphotransferase 15 in Crohn's Disease Patients with Active Mucosal Lesions.2017

    • Author(s)
      Suzuki K, Yokoyama J, Kawauchi Y, Honda Y, Sato H, Aoyagi Y, Terai S, Okazaki K, Suzuki Y, Sameshima Y, Fukushima T, Sugahara K, Atreya R, Neurath MF, Watanabe K, Yoneyama H, Asakura H:
    • Journal Title

      Journal of Crohn's & colitis

      Volume: Feb;11(2) Pages: 221-228

    • DOI

      10.1093/ecco-jcc/jjw143

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term outcomes of colorectal endoscopic submucosal dissection in elderly patients. International journal of colorectal disease2017

    • Author(s)
      Takahashi Y, Mizuno KI, Takahashi K, Sato H, Hashimoto S, Takeuchi M, Kobayashi M, Yokoyama J, Sato Y, Terai S
    • Journal Title

      International journal of colorectal disease

      Volume: Apr;32(4): Pages: 567-573

    • DOI

      10.1007/s00384-016-2719-y

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Muscle layer histopathology and manometry pattern of primary esophageal motility disorders including achalasia2017

    • Author(s)
      Nakajima N, Sato H, Takahashi K, Hasegawa G, Mizuno K, Hashimoto S, Sato Y, Terai S.
    • Journal Title

      Neurogastroenterol Motil.

      Volume: Mar;29(3).

    • DOI

      10.1111/nmo.12968

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Natural regression of fibrosis in chronic hepatitis B.2016

    • Author(s)
      Ohkoshi S, Hirono H, Watanabe K, Hasegawa K, Kamimura K, Yano M.
    • Journal Title

      World J Gastroenterol

      Volume: 22 Pages: 5459-5466

    • DOI

      10.3748/wjg.v22.i24.5459

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of BCL11B as a regulator of adipogenesis.2016

    • Author(s)
      Inoue J, Ihara Y, Tsukamoto D, Yasumoto K, Hashidume T, Kamimura K, Nakai Y, Hirano S, Shimizu M, Kominami R, Sato R.
    • Journal Title

      Sci Rep

      Volume: 6: 32750. Pages: 1-13

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of Fibrotic Tissue on Liver-targeted Hydrodynamic Gene Delivery2016

    • Author(s)
      Kobayashi Y, Kamimura K, Abe H, Yokoo T, Ogawa K, Shinagawa Y, Goto R, Inoue R, Ohtsuka M, Miura H, Kanefuji T, Suda T, Tsuchida M, Aoyagi Y, Zhang G, Liu D, Terai S.
    • Journal Title

      Molecular Therapy - Nucleic Acids

      Volume: . 5: e359. Pages: 1-8

    • DOI

      10.1038/mtna.2016.63

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Liver-targeted hydrodynamic gene therapy: Recent advances in the technique.2016

    • Author(s)
      Yokoo T, Kamimura K, Abe H, Kobayashi Y, Kanefuji T, Ogawa K, Goto R, Suda T, Oda M, and Terai S.
    • Journal Title

      World Journal of Gastroenterology

      Volume: 22: Pages: 8862-8868

    • DOI

      10.3748/wjg.v22.i40.8862

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Case of severe alcoholic hepatitis treated with granulocytapheresis.2016

    • Author(s)
      Watanabe Y, Kamimura K, Iwasaki T, Abe H, Takahashi S, Mizuno KI, Takeuchi M, Eino A, Narita I, Terai S.
    • Journal Title

      World J Clin Cases

      Volume: 4: Pages: 369-374

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The combination therapy of dissolution using carbonated liquid and endoscopic procedure for bezoars: pragmatical and clinical review2016

    • Author(s)
      Ogawa K, Kamimura K, Mizuno KI, Shinagawa Y, Kobayashi Y, Abe H, Watanabe Y, Takahashi S, Hayashi K, Yokoyama J, Takeuchi M, Kobayashi M, Yamagiwa S, Sato Y, Terai S.
    • Journal Title

      Gastroenterol Res Pract

      Volume: 7456242 Pages: 1-11

    • DOI

      10.1155/2016/7456242

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diagnosis and management of gastrointestinal foreign bodies.2016

    • Author(s)
      Kamimura K, Evans DC, Mizuno KI, Sola JE.
    • Journal Title

      Gastroenterol Res Pract

      Volume: 5692650 Pages: 1-2

    • DOI

      10.1155/2016/5692650

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Endoscopic Removal of Ingested Dentures and Dental Instruments: A Retrospective Analysis.2016

    • Author(s)
      Mizuno KI, Takahashi K, Tominaga K, Nishigaki Y, Sato H, Ikarashi S, Hayashi K, Yamamoto T, Honda Y, Hashimoto S, Kamimura K, Takeuchi M, Yokoyama J, Sato Y, Kobayashi M, Terai S:
    • Journal Title

      Gastroenterology research and practice.

      Volume: 3537147 Pages: 1-5

    • DOI

      10.1155/2016/3537147

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pivotal role of carbohydrate sulfotransferase 15 in fibrosis and mucosal healing in mouse colitis2016

    • Author(s)
      Suzuki K, Arumugam S, Yokoyama J, Kawauchi Y, Honda Y, Sato H, Aoyagi Y, Terai S, Okazaki K, Suzuki Y, Mizumoto S, Sugahara K, Atreya R, Neurath MF, Watanabe K, Hashiguchi T, Yoneyama H, Asakura H: .
    • Journal Title

      PLoS ONE

      Volume: 11 Pages: 1-17

    • DOI

      10.1371/journal.pone.0158967

    • NAID

      120005906913

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A novel training model composed of nonbiological materials for endoscopic submucosal dissection.2016

    • Author(s)
      Mizuno K, Sato H, Hashimoto S, Sato Y, Terai S
    • Journal Title

      Gastrointestinal endoscopy

      Volume: 84 Pages: 373-374

    • DOI

      10.1016/j.gie.2016.03.786

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An Unusual Case of an Extremely Large α-Fetoprotein-Producing Tumor.2016

    • Author(s)
      Takahashi K, Tsuchiya A, Terai S.
    • Journal Title

      Gastroenterology.

      Volume: Dec;151(6): Pages: 1077-1080

    • DOI

      10.1053/j.gastro.2016.08.018

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stomach Dysfunction Is a Potential Risk Factor for Wernicke's Encephalopathy2016

    • Author(s)
      Nakano O, Tsuchiya A, Yamagiwa S, Terai S.
    • Journal Title

      Intern. Med.

      Volume: 55(24) Issue: 24 Pages: 3679-3680

    • DOI

      10.2169/internalmedicine.55.7483

    • NAID

      130005250350

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effectiveness and safety of tolvaptan in liver cirrhosis patients with edema: Interim results of post-marketing surveillance of tolvaptan in liver cirrhosis (START study).2016

    • Author(s)
      Sakaida I, Terai S, Kurosaki M, Yasuda M, Okada M, Bando K, Fukuta Y.
    • Journal Title

      Hepatol Res.

      Volume: Dec 13.

    • DOI

      10.1111/hepr.12852

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vonoprazan 20 mg vs lansoprazole 30 mg for endoscopic submucosal dissection-induced gastric ulcers.2016

    • Author(s)
      Takahashi K, Sato Y, Kohisa J, Watanabe J, Sato H, Mizuno K, Hashimoto S, Terai S.
    • Journal Title

      World J Gastrointest Endosc.

      Volume: Nov 16;8(19): Pages: 716-722

    • DOI

      10.4253/wjge.v8.i19.716

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Myofibroblast distribution is associated with invasive growth types of colorectal cancer2016

    • Author(s)
      Takatsuna M, Morohashi S, Yoshizawa T, Hirai H, Haga T, Ota R, Saito K, Wu Y, Seino H, Aoyagi Y, Terai S, Kijima H.
    • Journal Title

      Oncol Rep,

      Volume: 36 Pages: 3154-3160

    • DOI

      10.3892/or.2016.5202

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Risk of metastasis in adenocarcinoma of the esophagus: a multicenter retrospective study in a Japanese population2016

    • Author(s)
      Ishihara R, Oyama T, Terai S, Ozawa S, Kawano T, Seto Y et al.
    • Journal Title

      J Gastroenterol.

      Volume: Oct 18. Pages: 800-808

    • DOI

      10.1007/s00535-016-1275-0

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Management of gastric and duodenal neuroendocrine tumors.2016

    • Author(s)
      Sato Y, Hashimoto S, Mizuno K, Takeuchi M, Terai S.
    • Journal Title

      World J Gastroenterol.

      Volume: Aug 14;22(30): Pages: 6817-28

    • DOI

      10.3748/wjg.v22.i30.6817

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic or spontaneous Helicobacter pylori eradication can obscure magnifying narrow-band imaging of gastric tumors.2016

    • Author(s)
      Kobayashi M, Hashimoto S, Mizuno K, Takeuchi M, Sato Y, Watanabe G, Ajioka Y, Azumi M, Akazawa K, Terai S.
    • Journal Title

      Endosc Int Open.

      Volume: Jun;4(6):

    • DOI

      10.1055/s-0042-105869

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Myofibroblasts of the muscle layer stimulate the malignant potential of colorectal cancer.2016

    • Author(s)
      Takatsuna M, Morohashi S, Yoshizawa T, Hirai H, Haga T, Ota R, Wu Y, Morohashi H, Hakamada K, Terai S, Kijima H.
    • Journal Title

      Oncol Rep.

      Volume: 36 Pages: 1251-1257

    • DOI

      10.3892/or.2016.4932

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Formulation for Effective Screening and Management of Nonalcoholic Steatohepatitis: Noninvasive NAFLD Management Strategy.2016

    • Author(s)
      Hirose K, Kanefuji T, Suda T, Sugitani S, Nagasaki K, Kubota T, Igarashi M, Terai S.
    • Journal Title

      Gastroenterol Res Pract.

      Volume: 6343656 Pages: 1-9

    • DOI

      10.1155/2016/6343656

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Deferasirox, an oral iron chelator, prevents hepatocarcinogenesis and adverse effects of sorafenib.2016

    • Author(s)
      Yamamoto N, Yamasaki T, Takami T, Uchida K, Fujisawa K, Matsumoto T, Saeki I, Terai S, Sakaida I.
    • Journal Title

      J Clin Biochem Nutr.

      Volume: May;58(3): Pages: 202-9

    • NAID

      130005149374

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel ex-vivo training model for peroral endoscopic myotomy using hydrogel.2016

    • Author(s)
      Sato H, Mizuno K, Terai S.
    • Journal Title

      Dig Endosc.

      Volume: Jul;28(5): Pages: 620-620

    • DOI

      10.1111/den.12670

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gastrointestinal: Salvage peroral endoscopic myotomy for outflow obstruction with growing esophageal diverticulum.2016

    • Author(s)
      Sato H, Sato Y, Hashimoto S, Mizuno K, Nakajima N, Terai S.
    • Journal Title

      J Gastroenterol Hepatol.

      Volume: Jul;31(7): Pages: 1237-1237

    • DOI

      10.1111/jgh.13397

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Three Times Repeated Portal Venous Gas after Meals2016

    • Author(s)
      Kobayashi T, Tsuchiya A, Suda T, Terai S.
    • Journal Title

      Intern. Med.

      Volume: 55(7): Issue: 7 Pages: 843-5

    • DOI

      10.2169/internalmedicine.55.6036

    • NAID

      130005141968

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Assessments of histologic changes after peroral endoscopic myotomy.2016

    • Author(s)
      Sato H, Sagara S, Suzuki K, Terai S, Yahagi N.
    • Journal Title

      Gastrointest Endosc.

      Volume: Aug;84(2): Pages: 377-8

    • DOI

      10.1016/j.gie.2016.01.011

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of Pancreatic Tumor-induced NAFLD with Pancrelipase2016

    • Author(s)
      Kuraoka N, Tsuchiya A, Suda T, Terai S
    • Journal Title

      Intern. Med.

      Volume: 55(1): Issue: 1 Pages: 89-90

    • DOI

      10.2169/internalmedicine.55.5729

    • NAID

      130005116798

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Rare Pancreatic Tumor That Underwent a Change in Morphology and Histopathologic Features During Chemotherapy.2016

    • Author(s)
      Seino S, Tsuchiya A, Natsui M
    • Journal Title

      Gastroenterology

      Volume: 150(2)

    • DOI

      10.1053/j.gastro.2015.06.049

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Circadian variations in the liver metabolites of medaka (Oryzias latipes).2016

    • Author(s)
      Fujisawa K, Takami T, Kimoto Y, Matsumoto T, Yamamoto N, Terai S, Sakaida I.
    • Journal Title

      Sci Rep

      Volume: - Pages: 20916-20916

    • DOI

      10.1038/srep20916

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Evidence for a Role of the Transcriptional Regulator Maid in Tumorigenesis and Aging.2015

    • Author(s)
      Fujisawa K, Terai S, Matsumoto T, Takami T, Yamamoto N, Nishina H, Furutani-Seiki M, Sakaida I.
    • Journal Title

      PLoS One.

      Volume: 10(6)

    • DOI

      10.1371/journal.pone.0129950

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Histological and Transcriptomic Analysis of Adult Japanese Medaka Sampled Onboard the International Space Station.2015

    • Author(s)
      Yasuhiko Murata, Takako Yasuda, Tomomi Watanabe-Asaka, Shoji Oda, Akiko, Mantoku, Kazuhiro Takeyama, Masahiro Chatani, Akira Kudo, Satoko Uchida, Hiromi Suzuki, Fumiaki Tanigaki, Masaki Shirakawa, Koichi Fujisawa, Yoshihiko, Hamamoto, *Shuji Terai, *Hiroshi Mitani
    • Journal Title

      PLoS One

      Volume: 10

    • DOI

      10.1371/journal.pone.0138799

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Fatty acid binding protein 7 regulates phagocytosis and cytokine production in Kupffer cells during liver2014

    • Author(s)
      Miyazaki, H., Sawada, T., Kiyohira, M., Yu, Z., Nakamura, K., Yasumoto, Y., Kagawa, Y., Ebrahimi, M., Islam, A., Sharifi, K., Kawamura, S., Kodama, T., Yamamoto, Y., Adachi, Y., Tokuda, N., Terai, S., Sakaida, I., Ishikawa, T. and Owada, Y.
    • Journal Title

      Am J Pathol.

      Volume: 184 Pages: 2505-2515

    • DOI

      10.1016/j.ajpath.2014.05.015

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Status and prospects of liver cirrhosis treatment by using bone marrow-derived cells and mesenchymal cells2014

    • Author(s)
      Terai S, Takami T, Yamamoto N, Fujisawa K, Ishikawa T, Urata Y, Tanimoto H, Iwamoto T, Mizunaga Y, Matsuda T, Oono T, Marumoto M, Burganova G, Fernando Quintanilha L, Hidaka I, Marumoto Y, Saeki I, Uchida K, Yamasaki T, Tani K, Taura Y, Fujii Y, Nishina H, Okita K, Sakaida I.
    • Journal Title

      Tissue Eng Part B Rev.

      Volume: 20(3) Pages: 206-210

    • DOI

      10.1089/ten.teb.2013.0527

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 肝硬変に対する自己由来細胞を用いた再生療法から他家細胞を用いた再生医療へ2017

    • Author(s)
      寺井崇二、土屋淳紀
    • Organizer
      日本再生医療学会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 骨髄由来間葉系幹細胞と培養マクロファージの混合投与療法による肝硬変治療2017

    • Author(s)
      渡邉雄介、土屋淳紀、寺井崇二
    • Organizer
      日本再生医療学会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 間葉系幹細胞、マクロファージの相互作用による新しい肝硬変治療を目指して2016

    • Author(s)
      土屋淳紀
    • Organizer
      日本肝臓学会東部会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2016-12-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] Frequency of CCR7-PD-1+ follicular helper T cell subset as a possible diagnostic marker of autoimmune hepatitis2016

    • Author(s)
      山際訓
    • Organizer
      AASLD 2016
    • Place of Presentation
      Boston (USA)
    • Year and Date
      2016-11-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Significance of hepatic progenitor cell marker-positive hepatocellular carcinoma and its possible prediction by AFP-L32016

    • Author(s)
      土屋淳紀
    • Organizer
      AASLD 2016
    • Place of Presentation
      Boston (USA)
    • Year and Date
      2016-11-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Combination therapy with mesenchymal stem cells and macrophages from bone marrow shows favorable outcome in mouse CCl4-induced liver cirrhosis model2016

    • Author(s)
      渡邉雄介、土屋淳紀、寺井崇二
    • Organizer
      AASLD 2016
    • Place of Presentation
      Boston (USA)
    • Year and Date
      2016-11-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Platinum-based transhepatic arterial chemotherapy using a combination miriplatin and CDDP powder in patients with hepatocellular carcinoma2016

    • Author(s)
      小川光平、上村顕也、寺井崇二
    • Organizer
      AASLD 2016
    • Place of Presentation
      Boston (USA)
    • Year and Date
      2016-11-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Transhepatic arterial chemotherapy using a combination of miriplatin and CDDP powder in patients with hepatocellular carcinoma.2016

    • Author(s)
      上村顕也
    • Organizer
      APDW 2016
    • Place of Presentation
      Kobe Convention Center (兵庫県神戸市)
    • Year and Date
      2016-11-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comparative effectiveness of mesenchymal stem cell therapy and macrophage cell therapy in a liver cirrhosis disease model2016

    • Author(s)
      土屋淳紀
    • Organizer
      APDW 2016
    • Place of Presentation
      Kobe Convention Center (兵庫県神戸市)
    • Year and Date
      2016-11-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Histological and Transcriptomic Analysis of Japanese Medaka Fish Sampled Onboard the International Space Station2016

    • Author(s)
      寺井崇二
    • Organizer
      APDW 2016
    • Place of Presentation
      Kobe Convention Center (兵庫県神戸市)
    • Year and Date
      2016-11-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effective Prevention of Liver Fibrosis by Hydrodynamic Gene Delivery2016

    • Author(s)
      阿部寛幸
    • Organizer
      FASEB 2016
    • Place of Presentation
      Florida (USA)
    • Year and Date
      2016-06-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Histological and Transcriptomic Analysis of Japanese Medaka Fish Sampled Onboard the International Space Station2016

    • Author(s)
      寺井崇二
    • Organizer
      FASEB 2016
    • Place of Presentation
      Florida (USA)
    • Year and Date
      2016-06-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 難治性消化器疾患に対する修復再生療法の開発2016

    • Author(s)
      寺井崇二
    • Organizer
      日本炎症・再生医学会
    • Place of Presentation
      みやこめっせ(京都府京都市)
    • Year and Date
      2016-06-16
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 肝硬変の治療メカニズム解析のための骨髄由来のMSC,マクロファージ培養および解析2016

    • Author(s)
      土屋淳紀
    • Organizer
      日本炎症・再生医学会
    • Place of Presentation
      みやこめっせ(京都府京都市)
    • Year and Date
      2016-06-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] 肝硬変症に対する細胞を用いた内在再生能活性化療法の開発2016

    • Author(s)
      寺井崇二
    • Organizer
      第15回日本再生医療学会
    • Place of Presentation
      大阪国際会議場(大阪府、大阪市)
    • Year and Date
      2016-03-19
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 肝線維化改善、再生促進に向け、骨髄からの選択的な間葉系幹細胞とマクロファージ培養の開発2016

    • Author(s)
      渡邉雄介、土屋淳紀、清野智、川田雄三、川合弘一、山際訓、寺井崇二
    • Organizer
      第15回日本再生医療学会
    • Place of Presentation
      大阪国際会議場(大阪府、大阪市)
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 他家骨髄由来の間葉系細胞を用いた急性肝不全に対する肝臓再生療法の可能性2014

    • Author(s)
      寺井崇二 他。
    • Organizer
      JDDW2014
    • Place of Presentation
      神戸
    • Year and Date
      2014-10-24
    • Related Report
      2014 Annual Research Report
  • [Book] Springer2015

    • Author(s)
      Dexi Liu, Atsunori Tsuchiya, Stuart J. Forbes, Taro Takami, Masahiro Ohira, Noriho Iida, Hiroaki Mizukami, Narumi Uno, Kenya Kamimura, Takashi Aoi, Matthias Renner, Hanayuki Okura, Akifumi Matsuyama, Mamoru Kokubo, james E. Akers, Junichi Mineno, Takeshi Suda, Shuji Terai.
    • Total Pages
      185
    • Publisher
      Gene Therapy and Cell Therapy Through the Liver: Current Aspects and Future Prospects
    • Related Report
      2015 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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