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Comprehensive analysis of inflammatory bowel disease using by genome-wid genetic and epigenetic association studies

Research Project

Project/Area Number 26293180
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionNihon University (2016-2017)
Institute of Physical and Chemical Research (2014-2015)

Principal Investigator

YAMAZAKI Keiko  日本大学, 医学部, 助教 (50415329)

Co-Investigator(Kenkyū-buntansha) 鈴木 康夫  東邦大学, 医学部, 教授 (40261911)
江崎 幹宏  九州大学, 大学病院, 講師 (50335957)
梅野 淳嗣  九州大学, 大学病院, 助教 (70621704)
LOW SIEWKEE  国立研究開発法人理化学研究所, 統合生命医科学研究センター, 研究員 (40634720)
Research Collaborator MOTOYA Satoshi  
FUYUNO Yuta  
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2014: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Keywords炎症性腸疾患 / 全ゲノム関連解析 / 薬剤応答性 / エピゲノム解析 / 薬剤反応性
Outline of Final Research Achievements

The aim of this project is to clarify the pathogenesis of inflammatory bowel disease (IBD) using by analysis of genome-wide genetic and epigenetic association. Since it is difficult to design using whole-genome epigenetic analysis for multifactorial disease except cancer, we focus the response of anti TNF-α monoclonal antibody in IBD. We have rescrueted patients with IBD who were treated with anti TNF-α antibody for the first time and examined methylation assays including whole-genome bisulfite sequncing.
Furthermore, we collaborated with the International IBD Genetics Consortium and conducted transancestry association study of IBD. Out trans-ethinic genome-wide association study clarified that the direction and magnitude of effect are consistent in European and non-European cohorts in spite of the genetic heterogeneity between divergent populations at several established risk loci driven by differences in allele frequency or effect size.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (9 results)

All 2018 2016 2015 2014 Other

All Int'l Joint Research (2 results) Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Open Access: 1 results,  Acknowledgement Compliant: 2 results) Presentation (2 results) (of which Invited: 1 results)

  • [Int'l Joint Research] University of Delhi South Campus/Deyanand Medical College and Hospital(インド)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] University Medical Centre Groningen(オランダ)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Intestinal Epithelial Cell-specific Deletion of α-Mannosidase II Ameliorates Experimental Colitis2018

    • Author(s)
      Suzuki K., Yamada T, Yamazaki K, Hirota M, Ishihara N, Sakamoto M, Takahashi D, Iijima H, Hase K.
    • Journal Title

      Cell Structure and Function

      Volume: 43 Issue: 1 Pages: 25-39

    • DOI

      10.1247/csf.17022

    • NAID

      130006513071

    • ISSN
      0386-7196, 1347-3700
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A cross-ethnic survey of CFB and SLC44A4, Indian ulcerative colitis GWAS hits, underscores their potential role in disease susceptibility2016

    • Author(s)
      Gupta Aditi、Juyal Garima、Sood Ajit、Midha Vandana、Yamazaki Keiko、Vich Vila Arnau、Esaki Motohiro、Matsui Toshiyuki、Takahashi Atsushi、Kubo Michiaki、Weersma Rinse K、Thelma B K
    • Journal Title

      European Journal of Human Genetics

      Volume: 25 Issue: 1 Pages: 111-122

    • DOI

      10.1038/ejhg.2016.131

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Disease susceptibility genes shared by primary biliary cirrhosis and Crohn’s disease in the Japanese population2015

    • Author(s)
      Yoshihiro Aiba, Keiko Yamazaki, Nao Nishida, Minae Kawashima, Yuki Hitomi, Hitomi Nakamura, Atsumasa Komori, Yuta Fuyuno, Atsushi Takahashi, Takaaki Kawaguchi, Masakazu Takazoe, Yasuo Suzuki, Satoshi Motoya Toshiyuki Matsui Motohiro Esaki, Takayuki Matsumoto, Michiaki Kubo, Katsushi Tokunaga, Minoru Nakamura
    • Journal Title

      Journal of Human Genetics

      Volume: 印刷中 Issue: 9 Pages: 525-531

    • DOI

      10.1038/jhg.2015.59

    • NAID

      40020589506

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations2015

    • Author(s)
      Liu JZ, van Sommeren S, Huang H et.al
    • Journal Title

      Nat Genet

      Volume: 47 Issue: 9 Pages: 979-86

    • DOI

      10.1038/ng.3359

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Genetic characteristics of inflammatory bowel disease in a Japanese population.2015

    • Author(s)
      Fuyuno Y, Yamazaki K, Takahashi A, Esaki M, Kawaguchi T, Takazoe M, Matsumoto T, Matsui T, Tanaka H, Motoya S, Suzuki Y, Kiyohara Y, Kitazono T, Kubo M.
    • Journal Title

      J Gastroenterol.

      Volume: 不明

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 炎症性腸疾患関連遺伝子解明の現状と将来展望2014

    • Author(s)
      山崎 慶子
    • Organizer
      第6回 日本炎症性腸疾患研究会学術集会
    • Place of Presentation
      品川 (日本)
    • Year and Date
      2014-12-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] A genome-wide association study by using imputed genotypes identifies a susceptibility locus for Crohn's disease in a Japanese population2014

    • Author(s)
      Yamazaki K, Umeno J, Takahashi A, Hirano A, Johnson T, Morizono T, Kawaguchi T, Takazoe M, Yamada T, Suzuki Y, Tanaka H, Motoya S, Hosokawa M, Arimura Y, Shinomura Y, Matsui T, Matsumoto T, Iida M, Tsunoda T, Nakamura Y, Kamatani N, Kubo M
    • Organizer
      ASHG (The American Society of Human Genetics) 61th Annual Meeting
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2014-10-18 – 2014-10-22
    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2019-03-29  

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