Clarification and application of a novel in vivo system which regulates interacting and homeostasis of organs
Project/Area Number |
26293183
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Cardiovascular medicine
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Research Institution | Shinshu University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
神吉 昭子 信州大学, 学術研究院医学系, 助教 (10397309)
村田 敏規 信州大学, 学術研究院医学系, 教授 (50253406)
谷口 俊一郎 信州大学, 学術研究院医学系, 教授 (60117166)
桜井 敬之 信州大学, 学術研究院医学系, 准教授 (80317825)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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Keywords | 分子血管病 / 分子血管学 |
Outline of Final Research Achievements |
Bioactive humoral molecules play central roles in the regulation of homeostasis as the method for communication by cells and organs. Adrenomedullin (AM), originally identified as a vasodilating peptide, is now recognized to be a pleiotropic molecule involved in both circulatory homeostasis and the pathogenesis of cardiovascular diseases. We reported that knockout mice deficient in AM or receptor activity-modifying protein 2 (RAMP2), an AM-receptor accessory protein, show vascular endothelial cell deformities that are embryonically lethal. To clarify the pathophysiological functions of the vascular AM-RAMP2 system directly, we generated vascular endothelial cell-specific RAMP2 knockout mice. Using these mice, we found that the AM-RAMP2 system is a key determinant of vascular integrity and organ homeostasis from prenatal stages through adulthood.
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Report
(4 results)
Research Products
(106 results)
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[Journal Article] Importance of endogenous atrial and brain natriuretic peptides in murine embryonic vascular and organ development.2016
Author(s)
Tokudome T, Kishimoto I, Shindo T, Kawakami H, Koyama T, Otani K, Nishimura H, Miyazato M, Kohno M, Nakao K, Kangawa K.
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Journal Title
Endocrinology
Volume: 157
Issue: 1
Pages: 358-367
DOI
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Peer Reviewed / Int'l Joint Research
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[Journal Article] Pathophysiological roles of adrenomedullin-RAMP2 system in acute and chronic cerebral ischemia2014
Author(s)
Igarashi K, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yamauchi A, Toriyama Y, Tanaka M, Liu T, Xian X, Imai A, Zhai L, Owa S, Arai T, Shindo T
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Journal Title
Peptides.
Volume: 62
Pages: 21-31
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Endogenous calcitonin gene-related peptide (CGRP) suppresses nerve injuries and progression of vascular dementia2017
Author(s)
Zhai L, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Liu T, Xian X, Imai A, Hirabayashi K, Dai K, Cui N, Tanimura K, Liu T, Wei Y, Shindo T.
Organizer
第81回日本循環器学会
Place of Presentation
金沢 金沢県立音楽堂他
Year and Date
2017-03-19
Related Report
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[Presentation] Adrenomedullin suppresses VEGF-induced vascular endothelial hyperpermeability, inflammation and progression of diabetic macular edema.2017
Author(s)
Imai A, Toriyama Y, Iesato Y, Hirabayashi K, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate K, Tanaka M, Liu T, Xian X, Zhai L, Dai K, Tanimura K, Liu T, Cui N, Wei Y, Yamauchi A, Murata T, Shindo T.
Organizer
第81回日本循環器学会
Place of Presentation
金沢 金沢県立音楽堂他
Year and Date
2017-03-19
Related Report
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[Presentation] Endogenous calcitonin gene-related peptide regulates lipid metabolism and energy homeostasis in vivo.2017
Author(s)
Liu T, Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Kawate H, Tanaka M, Xian X, Imai A, Zhai L, Hirabayashi K, Dai K, Tanimura K, Liu T, Cui N, Wei Y, Igarashi K, Yamauchi A, Shindo T.
Organizer
第81回日本循環器学会
Place of Presentation
金沢 金沢県立音楽堂他
Year and Date
2017-03-19
Related Report
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[Presentation] Vasoprotective activities of the adrenomedullin-RAMP2 system in endothelial cells.2017
Author(s)
Xian X, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Tanaka M, Koyama T, Kawate H, Liu T, Imai A, Zhai L, Hirabayashi K, Dai K, Tanimura K, Liu T, Cui N, Wei Y, Igarashi K, Yamauchi A, Shindo T.
Organizer
第81回日本循環器学会
Place of Presentation
金沢 金沢県立音楽堂他
Year and Date
2017-03-19
Related Report
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[Presentation] The endothelial adrenomedullin-RAMP2 system regulates vascular entegrity and suppresses tumor metastasis2016
Author(s)
Tanaka M, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Liu T, Xian X, Imai A, Zhai L, Hirabayashi K, Owa S, Dai K, Cui N, Liu T, Yamauchi A, Igarashi K, Shindo T.
Organizer
第80回日本循環器学会
Place of Presentation
仙台 仙台国際センター
Year and Date
2016-03-18
Related Report
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[Presentation] Calcitonin gene-related peptide directly regulates lipid metabolism of white adipose tissue and energy balance2016
Author(s)
Liu T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Xian X, Imai A, Zhai L, Hirabayashi K, Owa S, Dai K, Cui N, Liu T, Yamauchi A, Igarashi K, Shindo T.
Organizer
第80回日本循環器学会
Place of Presentation
仙台 仙台国際センター
Year and Date
2016-03-18
Related Report
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[Presentation] Vasoprotective roles of adrenomedullin-RAMP2 system in vascular endothelial cells2016
Author(s)
Xian X, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Liu T, Imai A, Zhai L, Hirabayashi K, Owa S, Dai K, Cui N, Liu T, Yamauchi A, Igarashi K, Shindo T.
Organizer
第80回日本循環器学会
Place of Presentation
仙台 仙台国際センター
Year and Date
2016-03-18
Related Report
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[Presentation] Pathophysiological significance of adrenomedullin-RAMP2 system in the response to cardiovascular stresses2016
Author(s)
Owa S, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Liu T, Xian X, Imai A, Zhai L, Hirabayashi K, Dai K, Cui N, Liu T, Yamauchi A, Igarashi K, Shindo T.
Organizer
第80回日本循環器学会
Place of Presentation
仙台 仙台国際センター
Year and Date
2016-03-18
Related Report
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[Presentation] Adrenomedullin-RAMP2 system regulates differentiation and lipid metabolism of white and brown adipose tissues2016
Author(s)
Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Kawate H, Tanaka M, Liu T, Xian X, Imai A, Zhai L, Hirabayashi K, Owa S, Dai K, Cui N, Liu T, Yamauchi A, Igarashi K, Shindo T.
Organizer
第80回日本循環器学会
Place of Presentation
仙台 仙台国際センター
Year and Date
2016-03-18
Related Report
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[Presentation] Pathophysiological roles of adrenomedullin-RAMP2 system in acute and chronic cerebral ischemia2015
Author(s)
Kyoko Igarashi, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Ichikawa-Shindo, Hisaka Kawate, Akihiro Yamauchi, Yuichi Toriyama, Megumu Tanaka, Tian Liu, Xian Xian, Akira Imai, Liuyu Zhai, Shinji Owa, Teruhide Koyama, Takayuki Shindo
Organizer
第79回日本循環器学会
Place of Presentation
大阪 大阪国際会議場
Year and Date
2015-04-26
Related Report
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[Presentation] Pathophysiological function of endogenous calcitonin gene-related peptide in ocular vascular diseases2015
Author(s)
Yuichi Toriyama, Yasuhiro Iesato, Akira Imai, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Ichikawa-Shindo, Hisaka Kawate, Akihiro Yamauchi, Kyoko Igarashi, Megumu Tanaka, Tian Liu, Xian Xian, Liuyu Zhai, Shinji Owa, Toshinori Murata, Takayuki Shindo
Organizer
第79回日本循環器学会
Place of Presentation
大阪 大阪国際会議場
Year and Date
2015-04-25
Related Report
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[Presentation] Vascular endothelial adrenomedullin-RAMP2 system regulates vascular homeostasis and suppresses tumor metastasis2015
Author(s)
Megumu Tanaka, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Ichikawa-Shindo, Hisaka Kawate, Akihiro Yamauchi, Kyoko Igarashi, Yuichi Toriyama, Tian Liu, Xian Xian, Akira Imai, Liuyu Zhai, Shinji Owa, Teruhide Koyama, Takayuki Shindo
Organizer
第79回日本循環器学会
Place of Presentation
大阪 大阪国際会議場
Year and Date
2015-04-25
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[Presentation] Adrenomedullin-RAMP2 system as a novel therapeutic target of tumor angiogenesis and metastasis2014
Author(s)
Megumu Tanaka, Takayuki Sakurai, Akiko Kamiyoshi, Hisaka Kawate, Yuka Ichikawa-Shindo, Akihiro Yamauchi, Kyoko Igarashi, Yuichi Toriyama, Akira Imai, Tian Liu, Xian Xian, Liuyu Zhai, Shinji Owa, Takayuki Shindo
Organizer
The Conference on Bioactive Peptides for Cell-Cell Communication 2014
Place of Presentation
京都、ホテルグランヴィア
Year and Date
2014-09-11
Related Report
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[Presentation] アドレノメデュリン活性調節タンパクRAMPサブアイソフォームの、脈管系恒常性維持における機能分化2014
Author(s)
山内啓弘, 桜井敬之, 神吉昭子, 河手久香, 新藤優佳, 田中愛, 小山晃英, 植竹龍一, 五十嵐恭子, 鳥山佑一, 今井章, 劉甜, 羨鮮, 新藤隆行
Organizer
第46回日本動脈硬化学会
Place of Presentation
東京、京王プラザホテル
Year and Date
2014-07-11
Related Report
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[Presentation] Vascular Endothelial Adrenomedullin-RAMP2 System Is Essential for Vascular Integrity and Organ Homeostasis2014
Author(s)
Teruhide Koyama, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Ichikawa-Shindo, Nobuyoshi Iinuma, Takuma Arai, Takahiro Yoshizawa, Yasuhiro Iesato, Lei Yang, Ryuichi Uetake, Ayano Okimura, Akihiro Yamauchi, Megumu Tanaka, Kyoko Igarashi, Yuichi Toriyama, Hisaka Kawate, Takayuki Shindo
Organizer
第46回日本動脈硬化学会
Place of Presentation
東京、京王プラザホテル
Year and Date
2014-07-10
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[Presentation] アドレノメデュリン-RAMP2系は、血管恒常性を維持し、「癌転移前土壌」の形成を抑制する2014
Author(s)
田中愛, 小山晃英, 桜井敬之, 神吉昭子, 河手久香, 新藤優佳, 植竹龍一, 山内啓弘, 五十嵐恭子, 鳥山佑一, 劉甜, 羨鮮, 今井章, 谷口俊一郎, 新藤隆行
Organizer
第35回日本炎症・再生医学会
Place of Presentation
沖縄、万国津梁館
Year and Date
2014-07-01 – 2014-07-04
Related Report
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[Presentation] アドレノメデュリン受容体システムの機能分化と、血管、リンパ管の制御機構2014
Author(s)
山内啓弘, 桜井敬之, 神吉昭子, 河手久香, 新藤優佳, 小山晃英, 植竹龍一, 五十嵐恭子, 鳥山佑一, 田中愛, 劉甜, 羨鮮, 今井章, 新藤隆行
Organizer
第38回 日本リンパ学会
Place of Presentation
東京、北里大学
Year and Date
2014-06-12
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[Presentation] Pathophysiological roles of endogenous calcitonin gene-related peptide in mouse model of laser induced choroidal neovascularization.2014
Author(s)
Yuichi Toriyama, Yasuhiro Iesato, Akira Imai, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Ichikawa-Shindo, Ryuichi Uetake, Akihiro Yamauchi, Megumu Tanaka, Xian Xian, Liu Tian, Takayuki Shindo, Toshinori Murata
Organizer
Association for Research in Vision and Ophthalmology (ARVO) 2014
Place of Presentation
オーランド、アメリカ
Year and Date
2014-05-04 – 2014-05-08
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[Presentation] Pathophysiological roles of adrenomedullin-RAMP2 system in acute and chronic brain ischemia.2014
Author(s)
Kyoko Igarashi, Takayuki Sakurai, Akiko Kamiyoshi, Hisaka Kawate, Yuka Ichikawa-Shindo, Teruhide Koyama, Ryuichi Uetake, Akihiro Yamauchi, Yuichi Toriyama, Megumu Tanaka, Tian Liu, Xian Xian, Akira Imai, Takayuki Shindo
Organizer
The 18th International Vascular Biology Meeting 2014
Place of Presentation
京都、みやこメッセ
Year and Date
2014-04-14 – 2014-04-17
Related Report
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[Presentation] Functional differentiation between RAMP2 and RAMP3 in their regulation of vascular system.2014
Author(s)
Akihiro Yamauchi, Takayuki Sakurai, Akiko Kamiyoshi, Hisaka Kawate, Yuka Shindo-Ichikawa, Teruhide Koyama, Ryuichi Uetake, Kyoko Igarashi, Yuichi Toriyama, Megumu Tanaka, Tian Liu, Xian Xian, Akira Imai, Takayuki Shindo
Organizer
The 18th International Vascular Biology Meeting 2014
Place of Presentation
京都、みやこメッセ
Year and Date
2014-04-14 – 2014-04-17
Related Report
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[Presentation] Adrenomedullin-RAMP2 system regulates lipid and energy metabolism in white and brown adipocytes.2014
Author(s)
Akiko Kamiyoshi, Takayuki Sakurai, Yuka Ichikawa-Shindo, Hisaka Kawate, Ryuichi Uetake, Akihiro Yamauchi, Kyoko Igarashi, Yuichi Toriyama, Megumu Tanaka, Akira Imai, Tian Liu, Xian Xian, Takayuki Shindo
Organizer
The 18th International Vascular Biology Meeting 2014
Place of Presentation
京都、みやこメッセ
Year and Date
2014-04-14 – 2014-04-17
Related Report
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[Presentation] Adrenomedullin-RAMP2 system of vascular endothelial cells inhibits the formation of "Pre-metastatic niche"2014
Author(s)
Megumu Tanaka, Teruhide Koyama, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Ichikawa-Shindo, Hisaka Kawate, Ryuichi Uetake, Akihiro Yamauchi, Kyoko Igarashi, Yuichi Toriyama, Takayuki Shindo
Organizer
The 18th International Vascular Biology Meeting 2014
Place of Presentation
京都、みやこメッセ
Year and Date
2014-04-14 – 2014-04-17
Related Report
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