| Co-Investigator(Kenkyū-buntansha) |
神吉 昭子 信州大学, 学術研究院医学系, 助教 (10397309)
村田 敏規 信州大学, 学術研究院医学系, 教授 (50253406)
谷口 俊一郎 信州大学, 学術研究院医学系, 教授 (60117166)
桜井 敬之 信州大学, 学術研究院医学系, 准教授 (80317825)
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| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Outline of Final Research Achievements |
Bioactive humoral molecules play central roles in the regulation of homeostasis as the method for communication by cells and organs. Adrenomedullin (AM), originally identified as a vasodilating peptide, is now recognized to be a pleiotropic molecule involved in both circulatory homeostasis and the pathogenesis of cardiovascular diseases. We reported that knockout mice deficient in AM or receptor activity-modifying protein 2 (RAMP2), an AM-receptor accessory protein, show vascular endothelial cell deformities that are embryonically lethal. To clarify the pathophysiological functions of the vascular AM-RAMP2 system directly, we generated vascular endothelial cell-specific RAMP2 knockout mice. Using these mice, we found that the AM-RAMP2 system is a key determinant of vascular integrity and organ homeostasis from prenatal stages through adulthood.
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