| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2016: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Outline of Final Research Achievements |
Here we investigated the role of the novel adipokine adipolin in regulation of cardiovascular disease. We found that adipolin knockout mice had increased myocardial infarct size and reduced cardiac function following ischemia-reperfusion compared with control mice, which were accompanied by enhanced inflammatory response in ischemic heart. Furthermore, adipolin reduced inflammatory responses in cultured cardiac myocytes and macrophages, and attenuated endothelial cell apoptosis. Thus, adipolin can serve as a cardiovascular protective adipocytokine.
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