Role of the novel adipocytokine in regulation of cardiovascular disease

• Project/Area Number: 26293185
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Nagoya University
• Principal Investigator: Ouchi Noriyuki 名古屋大学, 医学(系)研究科(研究院), 寄附講座教授 (00595514)
• Co-Investigator(Kenkyū-buntansha): 大橋 浩二 名古屋大学, 医学(系)研究科(研究院), 寄附講座助教 (10595515) ; 柴田 玲 名古屋大学, 医学(系)研究科(研究院), 寄附講座准教授 (70343689) ; 室原 豊明 名古屋大学, 医学(系)研究科(研究院), 教授 (90299503)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000); Fiscal Year 2016: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
• Keywords: 分子心臓病態学 / 虚血性心疾患 / 循環器・高血圧

Outline of Final Research Achievements

Here we investigated the role of the novel adipokine adipolin in regulation of cardiovascular disease. We found that adipolin knockout mice had increased myocardial infarct size and reduced cardiac function following ischemia-reperfusion compared with control mice, which were accompanied by enhanced inflammatory response in ischemic heart. Furthermore, adipolin reduced inflammatory responses in cultured cardiac myocytes and macrophages, and attenuated endothelial cell apoptosis. Thus, adipolin can serve as a cardiovascular protective adipocytokine.

Research Products

• [Journal Article] C1q/TNF-related protein 1 prevents neointimal formation after arterial injury. (2017)
  • Author(s): Kanemura N, Shibata R, Ohashi K, Ogawa H, Hiramatsu-Ito M, Enomoto T, Yuasa D, Ito M, Hayakawa S, Otaka N, Murohara T, Ouchi N.
  • Journal Title: Atherosclerosis. Volume: 257 Pages: 138-145
  • DOI: 10.1016/j.atherosclerosis.2017.01.014
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Association of circulating follistatin-like 1 levels with inflammatory and oxidative stress markers in healthy men. (2016)
  • Author(s): Hayakawa S, Ohashi K, Shibata R, Takahashi R, Otaka N, Ogawa H, Ito M, Kanemura N, Hiramatsu-Ito M, Ikeda N, Murohara T, Ouchi N.
  • Journal Title: PLoS One Volume: 11
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Increased expression of the adipocytokine omentin in the epicardial adipose tissue of coronary artery disease patients. (2016)
  • Author(s): Harada K, Shibata R, Ouchi N, Tokuda Y, Funakubo H, Suzuki M, Kataoka T, Nagao T, Okumura S, Shinoda N, Kato B, Sakai S, Kato M, Marui N, Ishii H, Amano T, Matsubara T, Murohara T.
  • Journal Title: Atherosclerosis. Volume: 251 Pages: 299-304
  • DOI: 10.1016/j.atherosclerosis.2016.07.003
  • Peer Reviewed / Open Access
• [Journal Article] C1q/TNF-related protein-1 functions to protect against acute ischemic injury in the heart (2016)
  • Author(s): Yuasa D.,Ohashi K.,Shibata R.,Mizutani N.,Kataoka Y.,Kambara T.,Uemura Y.,Matsuo K.,Kanemura N.,Hayakawa S.,Hiramatsu-Ito M.,Ito M.,Ogawa H.,Murate T.,Murohara T. and Ouchi N.
  • Journal Title: FASEB J Volume: 30 Issue: 3 Pages: 1065-1075
  • DOI: 10.1096/fj.15-279885
  • Peer Reviewed
• [Journal Article] Omentin attenuates atherosclerotic lesion formation in apolipoprotein E-deficient mice. (2016)
  • Author(s): Hiramatsu-Ito M, Shibata R, Ohashi K, Uemura Y, Kanemura N, Kambara T, Enomoto T, Yuasa D, Matsuo K, Ito M, Hayakawa S, Ogawa H, Otaka N, Kihara S, Murohara T and Ouchi N.
  • Journal Title: Cardiovasc Res. Volume: 110 Issue: 1 Pages: 107-117
  • DOI: 10.1093/cvr/cvv282
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] FGF21 attenuates pathological myocardial remodeling following myocardial infarction through the adiponectin-dependent mechanism. (2015)
  • Author(s): Joki Y, Ohashi K, Yuasa D, Shibata R, Ito M, Matsuo K, Kambara T, Uemura Y, Hayakawa S, Hiramatsu-Ito M, Kanemura N, Ogawa H, Daida H, Murohara T, Ouchi N.
  • Journal Title: Biochem Biophys Res Commun. Volume: 459 Issue: 1 Pages: 124-30
  • DOI: 10.1016/j.bbrc.2015.02.081
  • Peer Reviewed
• [Journal Article] C1q/TNF-related protein 9 protects against acute myocardial injury through an AdipoR1-AMPK dependent mechanism. (2015)
  • Author(s): Kambara T, Shibata R, Ohashi K, Matsuo K, Hiramatsu-Ito M, Enomoto T, Yuasa D, Ito M, Hayakawa S, Ogawa H, Aprahamian T, Walsh K, Murohara T, Ouchi N.
  • Journal Title: Mol Cell Biol. Volume: 35 Issue: 12 Pages: 2173-85
  • DOI: 10.1128/mcb.01518-14
  • Peer Reviewed
• [Journal Article] Cardiac myocyte-derived follistatin-like 1 prevents renal injury in a subtotal nephrectomy model (2015)
  • Author(s): Satoko Hayakawa, Koji Ohashi, Rei Shibata, Yoshiyuki Kataoka, Megumi Miyabe, Takashi Enomoto, Yusuke Joki, Yuuki Shimizu, Takahiro Kambara, Yusuke Uemura, Daisuke Yuasa, Hayato Ogawa, Kazuhiro Matsuo, Mizuho Hiramatsu-Ito, Maurice J.B. van den Hoff, Kenneth Walsh, Toyoaki Murohara and Noriyuki Ouchi
  • Journal Title: Journal of American Society of Nephrology Volume: 26 Issue: 3 Pages: 636-646
  • DOI: 10.1681/asn.2014020210
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Adipose-derived protein omentin prevents neointimal formation after arterial injury. (2015)
  • Author(s): Uemura Y, Shibata R, Kanemura N, Ohashi K, Kambara T, Hiramatsu-Ito M, Enomoto T, Yuasa D, Joki Y, Matsuo K, Ito M, Hayakawa S, Ogawa H, Murohara T, Ouchi N.
  • Journal Title: FASEB J. Volume: 29 Issue: 1 Pages: 141-51
  • DOI: 10.1096/fj.14-258129
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Omentin functions to attenuate cardiac hypertrophic response. (2015)
  • Author(s): Matsuo K, Shibata R, Ohashi K, Kambara T, Uemura Y, Hiramatsu-Ito M, Enomoto T, Yuasa D, Joki Y, Ito M, Hayakawa S, Ogawa H, Kihara S, Murohara T, Ouchi N.
  • Journal Title: J Mol Cell Cardiol. Volume: 79 Pages: 195-202
  • DOI: 10.1016/j.yjmcc.2014.11.019
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Neuron-derived neurotrophic factor ameliorates adverse cardiac remodeling after experimental myocardial infarction. (2015)
  • Author(s): Joki Y, Ohashi K, Yuasa D, Shibata R, Kataoka Y, Kambara T, Uemura Y, Matsuo K, Hayakawa S, Hiramatsu-Ito M, Kanemura N, Ito M, Ogawa H, Daida H, Murohara T, Ouchi N.
  • Journal Title: Circ Heart Fail. Volume: 8 Issue: 2 Pages: 342-51
  • DOI: 10.1161/circheartfailure.114.001647
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Omentin prevents myocardial ischemic injury through AMP-activated protein kinase- and Akt-dependent mechanisms. (2014)
  • Author(s): Kataoka Y, Shibata R, Ohashi K, Kambara T, Enomoto T, Uemura Y, Ogura Y, Yuasa D, Matsuo K, Nagata T, Oba T, Yasukawa H, Numaguchi Y, Sone T, Murohara T, Ouchi N.
  • Journal Title: J Am Coll Cardiol Volume: 63 Issue: 24 Pages: 2722-2733
  • DOI: 10.1016/j.jacc.2014.03.032
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Association of circulating C1q/TNF-related protein 1 levels with coronary artery disease in men. (2014)
  • Author(s): Yuasa D, Ohashi K, Shibata R, Takeshita K, Kikuchi R, Takahashi R, Kataoka Y, Miyabe M, Joki Y, Kambara T, Uemura Y, Matsuo K, Hayakawa S, Hiramatsu-Ito M, Ito M, Ikeda N, Murohara T, Ouchi N.
  • Journal Title: PLoS One Volume: 8 Issue: 6 Pages: e99846-e99846
  • DOI: 10.1371/journal.pone.0099846
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The potential of adipokines as therapeutic agents for cardiovascular disease. (2014)
  • Author(s): Shibata R, Ohashi K, Murohara T, Ouchi N.
  • Journal Title: Cytokine Growth Factor Rev. Volume: 25 Issue: 4 Pages: 483-7
  • DOI: 10.1016/j.cytogfr.2014.07.005
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] アディポサイトカイン「オメンチン」の心血管病における役割 (2016)
  • Author(s): 大内乗有、大橋浩二、室原豊明
  • Organizer: 第37回日本肥満学会
  • Place of Presentation: 東京ファッションタウン（東京都江東区）
  • Year and Date: 2016-10-07
  • Invited
• [Presentation] Molecular link between obesity and cardiovascular disease. (2016)
  • Author(s): 大内乗有
  • Organizer: The 10th Congress of the Asian-Pacific Society of Atherosclerosis and Vascular Diseases
  • Place of Presentation: 京王プラザホテル （東京都新宿区）
  • Year and Date: 2016-07-12
  • Int'l Joint Research / Invited
• [Presentation] Role of follistatin-like 1 as a myokine in cardiovascular disease. (2015)
  • Author(s): 大内乗有
  • Organizer: The 4th International Congress on Lipid Metabolism & Atherosclerosis
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2015-09-11
  • Int'l Joint Research / Invited
• [Presentation] A novel adipocytokine omentin and cardiovascular disease. (2015)
  • Author(s): 大内乗有
  • Organizer: 第47回日本動脈硬化学会総会学術集会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2015-07-09
  • Invited
• [Presentation] アディポサイトカインと血管疾患 (2014)
  • Author(s): 大内乗有, 大橋浩二, 柴田玲, 室原豊明
  • Organizer: 脳心血管抗加齢研究会2014
  • Place of Presentation: 梅田スカイビル（大阪市北区）
  • Year and Date: 2014-12-06 – 2014-12-07
  • Invited
• [Presentation] Role of adipocytokines in cardiovascular complication. (2014)
  • Author(s): 大内乗有
  • Organizer: 2014 International Conference on Diabetes and Metabolism
  • Place of Presentation: Gyeonggido (Korea)
  • Year and Date: 2014-10-16 – 2014-10-18
  • Invited