Possibility as diagnostic agent and the role in vivo of Big angiotensin-25
| Project/Area Number |
26293191
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
鶴田 敏博 宮崎大学, 医学部, 准教授 (10389570)
加藤 丈司 宮崎大学, フロンティア科学実験総合センター, 教授 (20274780)
桑迫 健二 宮崎大学, フロンティア科学実験総合センター, 准教授 (20381098)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2017: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Keywords | Bang-25 / アンジオテンシン / バイオマーカー / 糖鎖ペプチド / 生合成酵素 / 抗Bang-25抗体 / Big angiotensin-25 / 抗Big angiotensin-25抗体 |
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| Outline of Final Research Achievements |
We developed assay of Big angiotensin-25 (Bang-25) and measured urinary Bang-25. Human urinary Bang-25 had negative correlation with estimated glomerulus filtration rate, but did not correlate with the urine protein. Furthermore, when compared with diabetes mellitus patients, the urinary Bang-25 was higher than healthy volunteer. These results show that urinary Bang-25 is associated with kidney injury and diabetes mellitus.
Next, we analyzed the 14th glycosyl chain of Angiotensinogen (Aogen). One of the glycosyl chains of Aogen is same as Bang-25. The possibility that produce of angiotensin-related peptide including Bang-25 or Ang I was changed by the difference of the glycosyl chain of Aogen.
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Report
(5 results)
Research Products
(36 results)
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[Journal Article] Inhibitory effects of two G protein-coupled receptor kinases on the cell surface expression and signaling of the human adrenomedullin receptor.2016
Author(s)
Kuwasako, K., Sekiguchi, T., Nagata, S., Jiang, D., Hayashi, H., Murakami, M., Hattori, Y., Kitamura, K. and Kato, J.
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Journal Title
Biochem. Biophys. Res. Commun.
Volume: 470
Issue: 4
Pages: 894-899
DOI
Related Report
Peer Reviewed
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[Journal Article] Differential expression of the angiotensin-(1-12)/chymase axis in human atrial tissue.2015
Author(s)
Nagata S, Varagic J, Kon ND, Wang H, Groban L, Simington SW, Ahmad S, Dell'Italia LJ, VonCannon JL, Deal D, Ferrario CM
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Journal Title
Ther Adv Cardiovasc Dis.
Volume: 9(4)
Issue: 4
Pages: 168-180
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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