| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2017: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Outline of Final Research Achievements |
We developed assay of Big angiotensin-25 (Bang-25) and measured urinary Bang-25. Human urinary Bang-25 had negative correlation with estimated glomerulus filtration rate, but did not correlate with the urine protein. Furthermore, when compared with diabetes mellitus patients, the urinary Bang-25 was higher than healthy volunteer. These results show that urinary Bang-25 is associated with kidney injury and diabetes mellitus.
Next, we analyzed the 14th glycosyl chain of Angiotensinogen (Aogen). One of the glycosyl chains of Aogen is same as Bang-25. The possibility that produce of angiotensin-related peptide including Bang-25 or Ang I was changed by the difference of the glycosyl chain of Aogen.
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