Cooperative regulation of cardiac function by insulin and IGF

• Project/Area Number: 26293194
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Kansai Medical University
• Principal Investigator: Shiojima Ichiro 関西医科大学, 医学部, 教授 (90376377)
• Co-Investigator(Renkei-kenkyūsha): IWASAKI Masayoshi 関西医科大学, 医学部, 講師 (30548706)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000); Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
• Keywords: 心機能 / インスリン / IGF / 循環器・高血圧

Outline of Final Research Achievements

Insulin/Insulin-like growth factor (IGF) signaling regulates multiple cellular processes including glucose homeostasis and cell growth/proliferation. To investigate the role of insulin and IGF signaling in the regulation of contractile function, insulin receptor (IR) or IGF receptor (IGFR) was deleted in cardiac muscle cells either alone or in combination. Although contractile function was not affected by cardiac-specific IR deletion or IGFR deletion, simultaneous deletion of IR/IGFR in the heart resulted in a marked decline in contractility associated with left ventricular dilatation. Our results suggest the cooperative and redundant roles of cardiac insulin/IGF signaling in the regulation of contractile function.