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Developments of new therapies following investigations of the effects of sleep disturbance on secular changes in airway and systemic diseases

Research Project

Project/Area Number 26293198
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionKyoto University

Principal Investigator

Chin Kazuo  京都大学, 医学(系)研究科(研究院), 教授 (90197640)

Co-Investigator(Kenkyū-buntansha) 松田 文彦  京都大学, 医学(系)研究科(研究院), 教授 (50212220)
田原 康玄  京都大学, 医学(系)研究科(研究院), 准教授 (00268749)
若村 智子  京都大学, 医学(系)研究科(研究院), 教授 (40240452)
室 繁郎  京都大学, 医学(系)研究科(研究院), 講師 (60344454)
谷澤 公伸  京都大学, 医学(系)研究科(研究院), 助教 (20639140)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2014: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Keywords睡眠呼吸障害 / 気道疾患 / 睡眠時無呼吸 / 睡眠時間 / 客観的睡眠時間 / 生活習慣病 / 経年変化 / 慢性閉塞性肺疾患 / 気管支喘息 / 呼吸器病学 / 内科学 / 肺機能測定 / 大規模コホート / アクチグラフ / 睡眠障害
Outline of Final Research Achievements

Of 8,294 individuals, we could get data for analysis on several factors simultaneously on almost 5,750 persons. Included were data on pulmonary function, objective sleep duration, and sleep apnea. Now, we have sufficient data to investigate if there is an association between the severity of sleep disordered breathing and objective sleep duration. In addition, we can also investigate associations between sleep disordered breathing or objective sleep duration and lifestyle-related factors. From previous data, we reported the associations between sleep duration and esophagitis or knee or back pain. We also reported the components of non-restorative sleep (NRS) in clinical and lifestyle factors. Factors independently associated with subjective NRS were younger age, use of a hypnotic drug, irregular sleep schedule, short sleep duration, frequent sleepiness, routine stress, no habitual exercise, nocturia symptoms, symptoms of gastroesophageal reflux disease, and depression (all P <0.001).

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (34 results)

All 2017 2016 2015 2014

All Journal Article (15 results) (of which Peer Reviewed: 15 results,  Open Access: 13 results,  Acknowledgement Compliant: 9 results) Presentation (19 results) (of which Int'l Joint Research: 5 results,  Invited: 19 results)

  • [Journal Article] Combined association of clinical and lifestyle factors with non-restorative sleep: The Nagahama Study.2017

    • Author(s)
      Matsumoto T, Tabara Y, Murase K, Takahashi Y, Setoh K, Kawaguchi T, Muro S, Kadotani H, Kosugi S, Sekine A, Yamada R, Nakayama T, Mishima M, Matsuda F, Chin K.
    • Journal Title

      PLoS One.

      Volume: 12 Issue: 3 Pages: e0171849-e0171849

    • DOI

      10.1371/journal.pone.0171849

    • NAID

      120006539727

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Relationship between obstructive sleep apnea and endogenous carbon monoxide.2017

    • Author(s)
      Azuma M, Murase K, Tachikawa R, Hamada S, Matsumoto T, Minami T, Inouchi M, Tanizawa K, Handa T, Oga T, Mishima M, Chin K.
    • Journal Title

      J Appl Physiol (1985)

      Volume: 122 Pages: 104-111

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Microalbuminuria in patients with obstructive sleep apnea-chronic obstructive pulmonary disease overlap syndrome.2016

    • Author(s)
      Matsumoto T, Murase K, Tachikawa R, Minami T, Hamada S, Tanizawa K, Inouchi M, Handa T, Oga T, Yanagita M, Mishima M, Chin K.
    • Journal Title

      Ann Am Thorac Soc

      Volume: 13 Issue: 6 Pages: 917-25

    • DOI

      10.1513/annalsats.201510-655oc

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Plasma incretin levels and dipeptidyl peptidase-4 activity in patients with obstructive sleep apnea.2016

    • Author(s)
      Matsumoto T, Harada N, Azuma M, Chihara Y, Murase K, Tachikawa R, Minami T, Hamada S, Tanizawa K, Inouchi M, Oga T, Mishima M, Chin K.
    • Journal Title

      Ann Am Thorac Soc

      Volume: 13 Issue: 8 Pages: 1378-87

    • DOI

      10.1513/annalsats.201510-697oc

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Changes in Energy Metabolism After Continuous Positive Airway Pressure for Obstructive Sleep Apnea.2016

    • Author(s)
      Tachikawa R, Ikeda K, Minami T, Matsumoto T, Hamada S, Murase K, Tanizawa K, Inouchi M, Oga T, Akamizu T, Mishima M, Chin K.
    • Journal Title

      Am J Respir Crit Care Med

      Volume: 未定 Issue: 6 Pages: 729-38

    • DOI

      10.1164/rccm.201511-2314oc

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of Bone Mineral Density by Computed Tomography in Patients with Obstructive Sleep Apnea.2016

    • Author(s)
      Hamada S, Ikezoe K, Hirai T, Oguma T, Tanizawa K, Inouchi M, Handa T, Oga T, Mishima M, Chin K
    • Journal Title

      J Clin Sleep Med

      Volume: 12 Issue: 01 Pages: 25-34

    • DOI

      10.5664/jcsm.5386

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Obstructive sleep apnea and abdominal aortic calcification: Is there an association independent of comorbid risk factors?2015

    • Author(s)
      Tachikawa R, Koyasu S, Matsumoto T, (他9名)
    • Journal Title

      Atherosclerosis.

      Volume: 241 Issue: 1 Pages: 6-11

    • DOI

      10.1016/j.atherosclerosis.2015.04.801

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Knee Pain and Low Back Pain Additively Disturb Sleep in the General Population: A Cross-Sectional Analysis of the Nagahama Study.2015

    • Author(s)
      Murase K, Tabara Y, Ito H, Kobayashi M, Takahashi Y, Setoh K, Kawaguchi T, Muro S, Kadotani H, Kosugi S, Sekine A, Yamada R, Nakayama T, Mishima M, Matsuda S, Matsuda F, Chin K.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 10 Pages: e0140058-e0140058

    • DOI

      10.1371/journal.pone.0140058

    • NAID

      120005756275

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of Obstructive Sleep Apnea on Liver Fat Accumulation According to Sex and Visceral Obesity.2015

    • Author(s)
      Toyama Y, Tanizawa K, Kubo T, Chihara Y, Harada Y, Murase K, Azuma M, Hamada S, Hitomi T, Handa T, Oga T, Chiba T, Mishima M, Chin K.
    • Journal Title

      PLoS One.

      Volume: 10 Issue: 6 Pages: e0129513-e0129513

    • DOI

      10.1371/journal.pone.0129513

    • NAID

      120005753891

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gastroesophageal reflux disease symptoms and dietary behaviors are significant correlates of short sleep duration in the general population: The Nagahama Study.2014

    • Author(s)
      Murase, K., Tabara, Y., Takahashi, Y., Muro, S., Yamada, R., Setoh, K., Kawaguchi, T., Kadotani, H., Kosugi, S., Sekine, A., Nakayama, T., Mishima, M., Chiba, T., Chin, K., Matsuda, F
    • Journal Title

      Sleep

      Volume: 37 Issue: 11 Pages: 1809-15

    • DOI

      10.5665/sleep.4176

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Obesity hypoventilation syndrome in Japan and independent determinants of artgroup. erial carbon dioxide levels.2014

    • Author(s)
      Harada Y, Chihara Y, Azuma M, Murase K, Toyama Y, Yoshimura C, Oga T, Nakamura H, Mishima M, Chin K and Japan respiratory failure.
    • Journal Title

      Respirology

      Volume: 19 Issue: 8 Pages: 1233-1240

    • DOI

      10.1111/resp.12367

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Associations among chronic obstructive pulmonary disease and sleep disordered breathing in an urban male working population in Japan.2014

    • Author(s)
      Azuma M, Chin K, Yoshimura C, Takegami M, Takahashi K, Sumi K, Nakamura T, Nakayama-Ashida Y, Minami I, Horita S, Oka Y, Oga T,Wakamura T, Fukuhara S, Mishima M, Kadotani H.
    • Journal Title

      Respiration

      Volume: 88 Issue: 3 Pages: 234-243

    • DOI

      10.1159/000366064

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Impact of obstructive sleep apnea on abdominal aortic diameters.2014

    • Author(s)
      Tachikawa R, Hamada S, Azuma M, Toyama Y, Murase K, Tanizawa K, Inouchi M, Handa T, Oga T, Mishima M, Chin K.
    • Journal Title

      Am J Cardiol

      Volume: 114 Issue: 4 Pages: 618-623

    • DOI

      10.1016/j.amjcard.2014.05.044

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The additive impact of periodic limb movements during sleep on inflammation in obstructive sleep apnea patients.2014

    • Author(s)
      Murase K, Hitomi T, Hamada S, Azuma M, Toyama Y, Harada Y, Tanizawa K, Handa T, Yoshimura C, Oga T, Mishima M, Chin K.
    • Journal Title

      Ann Am Thorac Soc

      Volume: 11 Issue: 3 Pages: 375-382

    • DOI

      10.1513/annalsats.201306-144oc

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The Additive Impact of Periodic Limb Movements during Sleep on Inflammation in Obstructive Sleep Apnea Patients.2014

    • Author(s)
      Murase K, Hitomi T, Hamada S, Azuma M, Toyama Y, Harada Y, Tanizawa K, Handa T, Yoshimura C, Oga T, Mishima M, Chin K.
    • Journal Title

      Ann Am Thorac Soc.

      Volume: 11 Issue: 3 Pages: 375-82

    • DOI

      10.1513/annalsats.201306-182oc

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Airway disease and sleep-disorderd breathing.2017

    • Author(s)
      Chin K.
    • Organizer
      The 15th annual meeting of Tiwan society of sleep medicine.
    • Place of Presentation
      Kaohsiung, Taiwan.
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Systemic diseases with and without OSA including body weight changes following CPAP treatment.2016

    • Author(s)
      Chin K
    • Organizer
      21st Congress of the Asian Pacific Society of Respirology.
    • Place of Presentation
      Bangkok, Thailand.
    • Year and Date
      2016-12-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 肥満と呼吸器疾患―睡眠時無呼吸を中心として―2016

    • Author(s)
      陳和夫
    • Organizer
      第37回日本肥満学会
    • Place of Presentation
      東京
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] OSA,from endothelial dysfunction to airway obstruction.2016

    • Author(s)
      Chin K
    • Organizer
      21st Congress of the Asian Pacific Society of Respirology.
    • Place of Presentation
      Bangkok, Thailand
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] OSASと睡眠時間及び認知機能を含む生活習慣病2016

    • Author(s)
      陳和夫
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      東京
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 閉塞性睡眠時無呼吸と生活習慣病2016

    • Author(s)
      立川良、陳和夫
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      東京
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 指定難病肺胞低換気症候群の概要と治療2016

    • Author(s)
      陳和夫
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      東京
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] なぜCPAPをすると体重が増えるのか?2016

    • Author(s)
      立川良、陳和夫
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      東京
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 睡眠障害における睡眠時無呼吸と全身疾患2016

    • Author(s)
      陳和夫
    • Organizer
      第113回日本内科学会学術講演会
    • Place of Presentation
      東京
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Obesity hypoventilation syndromes in Asians and Western countries.2015

    • Author(s)
      Chin K
    • Organizer
      20th Congress of the Asian Pacific Society of Respirology.
    • Place of Presentation
      Kuala Lumpur
    • Year and Date
      2015-12-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Updates on sleep-related breathing disorders in international classification of sleep disorders 3rd edition.2015

    • Author(s)
      Chin K
    • Organizer
      20th Congress of the Asian Pacific Society of Respirology.
    • Place of Presentation
      Kuala Lumpur
    • Year and Date
      2015-12-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 慢性心不全患者の睡眠呼吸障害に対する陽圧療法2015

    • Author(s)
      陳和夫
    • Organizer
      第63回日本心臓病学会学術集会
    • Place of Presentation
      横浜市
    • Year and Date
      2015-09-19
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 睡眠呼吸障害の病態と呼吸管理 ミート・ザ・エキスパート22015

    • Author(s)
      陳和夫
    • Organizer
      第37回日本呼吸療法医学会学術集会
    • Place of Presentation
      京都市
    • Year and Date
      2015-07-18
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Recent advances in biology of sleep-related breathing disorders.2015

    • Author(s)
      Chin K
    • Organizer
      第55回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2015-04-17
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] A different pathophysiology of OSA between men and women. Asian sleep forum.2015

    • Author(s)
      Chin K.
    • Organizer
      6th World Congress on sleep medicine.
    • Place of Presentation
      Seoul, Korea.
    • Year and Date
      2015-03-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Overview: Sleep-related breathing disorders and their treatment.2014

    • Author(s)
      Chin K.
    • Organizer
      19th Congress of the Asian Pacific Society of Respirology.
    • Place of Presentation
      Bali, Indonesia.
    • Year and Date
      2014-11-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 睡眠呼吸障害の現状と対応2014

    • Author(s)
      陳和夫
    • Organizer
      第123回日本結核病学会東海地方学会・第105回日本呼吸器学会東海地方学会・第8回日本サルコイドーシス/肉芽腫性疾患学会中部支部会・特別講演
    • Place of Presentation
      名古屋市
    • Year and Date
      2014-06-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 睡眠医療の新たな展開2014

    • Author(s)
      陳和夫
    • Organizer
      第54回日本呼吸器学会学術講演会・教育講演
    • Place of Presentation
      大阪市
    • Year and Date
      2014-04-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 睡眠呼吸障害と血管病変の関連と治療2014

    • Author(s)
      陳和夫
    • Organizer
      第111回日本内科学会講演会・シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2014-04-12
    • Related Report
      2014 Annual Research Report
    • Invited

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Published: 2014-04-04   Modified: 2018-03-22  

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