Double-face culture system for application of alveolar epithelial cells induced from human iPS cells
| Project/Area Number |
26293199
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
Isao Ito 京都大学, 医学(系)研究科(研究院), 助教 (40447975)
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| Co-Investigator(Kenkyū-buntansha) |
半田 知宏 京都大学, 医学(系)研究科(研究院), 助教 (10432395)
小寺 秀俊 京都大学, 工学(系)研究科(研究院), 教授 (20252471)
平井 豊博 京都大学, 医学(系)研究科(研究院), 准教授 (20359805)
劉 莉 京都大学, 学内共同利用施設等, 助教 (50380093)
三嶋 理晃 京都大学, 医学(系)研究科(研究院), 教授 (60190625)
室 繁郎 京都大学, 医学(系)研究科(研究院), 講師 (60344454)
新宅 博文 京都大学, 工学(系)研究科(研究院), 助教 (80448050)
長船 健二 京都大学, 学内共同利用施設等, 教授 (80502947)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | iPS細胞 / 肺胞上皮細胞 / 気道上皮細胞 / 肺前駆細胞 / ナノファイバー / 呼吸器疾患 / 肺気腫 / 再生医学 / 線毛上皮細胞 / 血管内皮細胞 / ES細胞 / nanofiber / microfluidics |
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| Outline of Final Research Achievements |
There are many kinds of difficult-to-treat respiratory diseases. In such cases, many patients die from respiratory failure. For most of the respiratory diseases, no curable treatment has been developed so far, and researches of the diseases have not reached the pathogenesis. If we could develop lung epithelial cells from human iPS cells and utilize the developed cells for researches and regenerative medicine, medicine in this field would largely progress. As such, we developed lung epithelial cells from human iPS cells and further tried to enhance the technique by merging with engineering technology such as nanofibers in this research program. It became possible to develop alveolar epithelial cells from iPS cells in three-dimension and to develop bronchial epithelial cells in two-dimension.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] CT-assessed large airway involvement and lung function decline in eosinophilic asthma: The association between induced sputum eosinophil differential counts and airway remodeling.2016
Author(s)
Inoue H, Ito I, Niimi A, Matsumoto H, Matsuoka H, Jinnai M, Takeda T, Oguma T, Otsuka K, Nakaji H, Tajiri T, Iwata T, Nagasaki T, Kanemitsu Y, Mishima M.
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Journal Title
J Asthma
Volume: 53
Issue: 9
Pages: 914-21
DOI
Related Report
Peer Reviewed
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[Journal Article] Directed induction of functional multi-ciliated cells in proximal airway epithelial spheroids from human pluripotent stem cells.2016
Author(s)
Konishi S, Gotoh S, Tateishi K, Yamamoto Y, Korogi Y, Matsumoto H, Muro S, Hirai T, Ito I, Tsukita S, Mishima M.
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Journal Title
Stem Cell Reports
Volume: 6
Issue: 1
Pages: 18-25
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Generation of alveolar epithelial spheroids via isolated progenitor cells from human pluripotent stem cells.2014
Author(s)
Gotoh S, Ito I, Nagasaki T, Yamamoto Y, Konishi S, Korogi Y, Matsumoto H, Muro S, Hirai T, Funato M, Mae S, Toyoda T, Sato-Otsubo A, Ogawa S, Osafune K, Mishima M
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Journal Title
Stem Cell Reports
Volume: 3
Issue: 3
Pages: 394-403
DOI
NAID
Related Report
Peer Reviewed / Open Access
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