| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Outline of Final Research Achievements |
We demonstrated that proximal tubule injury induces the transdifferentiation of fibroblasts to myofibroblasts, and that the transdifferentiation is reversible when the proximal tubule injury is mild.
We also demonstrated that fibroblasts in aged kidney acquire the ability to produce homeostatic chemokines after injury, attract lymphocytes and trigger the formation of tertiary lymphoid tissues (TLTs). TLT formation in aged kidneys causes prolonged inflammation and delayed regeneration, and is frequently observed in aged human kidneys.
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