| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Outline of Final Research Achievements |
Cerebrospinal fluid (CSF) inorganic phosphate (Pi) may regulate a central NaPi transporter expression and transduce signals to initiate the appetitive behavior and saliva Pi adaptations. However, the regulation of salivary Pi concentration remains unknown. In the salivary gland duct cell, Npt2b is localized and regulates the concentration of salivary Pi concentrations. Salivary Pi levels are controlled by dietary phosphorus contents and Npt2b is undergoing rapid regulation. In addition, in the chronic kidney disease (CKD) model, salivary Pi concentrations were significantly increased in Npt2b (-/+) mice compared with those in Npt2b (+/+) mice. In conclusion, Npt2b in the salivary glands may be important molecule for Pi homeostasis as well as Npt2a in the kidney.
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