Clinical and Pathophysiological Analysis of Atypical Multiple Sclerosis

• Project/Area Number: 26293205
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Tohoku University
• Principal Investigator: FUJIHARA KAZUO 東北大学, 医学(系)研究科(研究院), 非常勤講師 (70280873)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000); Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
• Keywords: 多発性硬化症 / 非典型例 / 抗MOG抗体 / 視神経脊髄炎 / 脱髄疾患 / アストロサイトパチー / 脳神経疾患 / 神経免疫学

Outline of Final Research Achievements

Some cases with multiple sclerosis (MS) are atypical, and they may include unique clinical entities which can be distinguishable from typical MS in terms of the clinical and pathophysiological findings. In the present study, we applied a highly-specific cell-based assay to detect myelin oligodendrocyte glycoprotein (MOG) antibodies and clarified the unique clinical, MRI and pathological features and the therapeutic responses of the myelin antibody-positive cases which can be diagnosed with atypical MS. We also reported “MOG-antibody-positive, unilateral cerebral cortical encephalitis with epilepsy”, a new type of autoimmune encephalitis. Moreover, we found that the interplay between the tissue preconditioning to hypoxic stimuli and glial cell-derived cytokines associated with demyelination appears to contribute to the unique pathology of Balo’s concentric sclerosis.

Research Products

• [Int'l Joint Research] ウイーン医科大学(オーストリア)
• [Int'l Joint Research] ニッテ大学(インド)
• [Int'l Joint Research] リオグランデドスールカトリック教会大学(ブラジル)
• [Int'l Joint Research] ソウル大学(韓国)
• [Int'l Joint Research] Mayo Clinic/University of Calfornia, San Francisco/University of Colorado(米国)
• [Int'l Joint Research] Oxford University/Walton Center, Liverpool(United Kingdom)
• [Int'l Joint Research] University of Sao Paulo/Pontifical Catholic University of RGdS(Brazil)
• [Int'l Joint Research] Meidcal University Vienna(Austria)
• [Int'l Joint Research] National Cancer Center(韓国)
• [Int'l Joint Research]
• [Journal Article] Impact of the Great East Japan Earthquake in 2011 on MS and NMOSD: a study in Sendai, Japan (2017)
  • Author(s): Kanamori Y, Nakashima I, Takai Y, Misu T, Kuroda H, Nishiyama S, Takahashi T, Sato S, Fujimori J, Higuchi J, Itoyama Y, Aoki M, Fujihara K
  • Journal Title: J Neurol Neurosurg Psychiatry Volume: 88 Issue: 4 Pages: 362-364
  • DOI: 10.1136/jnnp-2016-313890
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Relapsing optic neuritis and isolated transverse myelitis are the predominant clinical phenotypes for patients with antibodies to myelin oligodendrocyte glycoprotein in India (2017)
  • Author(s): Pandit L, Sato DK, Mustafa S, Takahashi T, D’Cunha A, Malli C, Sudhir A, Fujihara K
  • Journal Title: Multiple Sclerosis Journal: Experimental, Translational and Clinical Volume: 印刷中
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] MOG-antibody-positive, benign, unilateral, cerebral cortical encephalitis with epilepsy (2017)
  • Author(s): Ogawa R, Nakashima I, Takahashi T, Kaneko K, Akaishi T, Takai Y, Sato DK, Nishiyama S, Misu T, Kuroda H, Aoki M, Fujihara K
  • Journal Title: Neurol Neuroimmunol Neuroinflamm Volume: 16 Issue: 2
  • DOI: 10.1212/nxi.0000000000000322
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Bilateral frontal cortex encephalitis and paraparesis in a patient with anti-MOG antibodies (2017)
  • Author(s): Fujimori J, Takai Y, Nakashima I, Sato DK, Takahashi T, Kaneko K, Nishiyama S, Watanabe M, Tanji H, Kobayashi M, Misu T, Aoki M, Fujihara K
  • Journal Title: J Neurol Neurosurg Psychiatry Volume: 印刷中 Issue: 6 Pages: 534-536
  • DOI: 10.1136/jnnp-2016-315094
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Whole brain and grey matter volume of Japanese patients with multiple sclerosis (2017)
  • Author(s): Akaishi T, Nakashima I, Mugikura S, Aoki M, Fujihara K
  • Journal Title: J Neuroimmunol Volume: 15 Pages: 68-75
  • DOI: 10.1016/j.jneuroim.2017.03.009
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Neuromyelitis optica spectrum disorders (2017)
  • Author(s): Akaishi T, Nakashima I, Sato DK, Takahashi T, Fujihara K
  • Journal Title: Neuroimaging Clin N Am Volume: 27 Pages: 251-265
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Differential diagnosis of neuromyelitis optica spectrum disorders (2017)
  • Author(s): Kim SM, Kim SJ, Lee HJ, Kuroda H, Palace J, Fujihara K
  • Journal Title: Ther Adv Neurol Disord Volume: 印刷中
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Lack of KIR4.1 autoantibodies in Japanese patients with MS and NMO (2016)
  • Author(s): Higuchi O, Nakane S, Sakai W, Maeda Y, Niino M, Takahashi T, Fukazawa T, Kikuchi S, Fujihara K, Matsuo H
  • Journal Title: Neurol Neuroimmunol Neuroinflamm Volume: 3 Issue: 5
  • DOI: 10.1212/nxi.0000000000000263
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Hypoxia-like tissue injury and glial response contribute to Balo’s concentric lesion development (2016)
  • Author(s): Takai Y, Misu T, Nishiyama S, Ono H, Kuroda H, Nakashima I, Saito R, Kanamori M, Sonoda Y, Kumabe T, Mugikura S, Watanabe M, Aoki M, Fujihara K
  • Journal Title: Neurology Volume: 87 Pages: 2000-2005
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Aquaporin 4-specific T cells and NMO-IgG cause primary retinal damage in experimental NMO/SD (2016)
  • Author(s): Zeka B, Hastermann M, Kaufmann N, Schanda K, Pende M, Misu T, Rommer P, Fujihara K, Nakashima I, Dahle C, Leutmezer F, Reindl M, Lassmann H, Bradl M
  • Journal Title: Acta Neuropathol Commun Volume: 4 Issue: 1 Pages: 82-82
  • DOI: 10.1186/s40478-016-0355-y
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Different etiologies and prognoses of optic neuritis in demyelinating diseases (2016)
  • Author(s): Akaishi T, Nakashima I, Takeshita T, Kaneko K, Mugikura S, Sato DK, Takahashi T, Nakazawa T, Aoki M, Fujihara K
  • Journal Title: J Neuroimmunol Volume: 299 Pages: 152-157
  • DOI: 10.1016/j.jneuroim.2016.09.007
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Experimental neuromyelitis optica induces a type I interferon signature in the spinal cord (2016)
  • Author(s): Oji S, Nicolussi E, Kaufmann N, Schanda K, Fujihara K, Illes Z, Reindl M, Lassmann H, Bradl M
  • Journal Title: PLoS ONE Volume: 11 Issue: 3 Pages: e0151244-e0151244
  • DOI: 10.1371/journal.pone.0151244
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Serological markers associated with neuromyelitis optica spectrum disorders in South India (2016)
  • Author(s): Pandit L, Sato DK, Mustafa S, Takahashi T, D'Cunha A, Malli C, Sudhir A, Fujihara K
  • Journal Title: Ann Indian Acad Neurol Volume: 19 Pages: 505-509
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Placebo-controlled study in neuromyelitis optica-Ethical and design considerations. (2016)
  • Author(s): Cree BA, Bennett JL, Sheehan M, Cohen J, Hartung HP, Aktas O, Kim HJ, Paul F, Pittock S, Weinshenker B, Wingerchuk D, Fujihara K, Cutter G, Patra K, Flor A, Barron G, Madani S, Ratchford JN, Katz E.
  • Journal Title: Mult Scler Volume: 印刷中
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Th17 Cells Pathways in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders: Pathophysiological and Therapeutic Implications (2016)
  • Author(s): Passos GR, Sato DK, Becker J, Fujihara K
  • Journal Title: Mediators Inflamm Volume: 1 Pages: 5314541-5314541
  • DOI: 10.1155/2016/5314541
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Demyelinating diseases in Asia. (2016)
  • Author(s): Ochi H, Fujihara K.
  • Journal Title: Curr Opin Neurol Volume: 印刷中
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Pregnancy-related relapse risk factors in women with anti-AQP4 antibody positivity and neuromyelitis optica spectrum disorder. (2016)
  • Author(s): Shimizu Y, Fujihara K, Ohashi T, Nakashima I, Yokoyama K, Ikeguch R, Takahashi T, Misu T, Shimizu S, Aoki M, Kitagawa K.
  • Journal Title: Mult Scler Volume: 印刷中
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The clinical spectrum associated with myelin oligodendrocyte glycoprotein antibodies (anti-MOG-Ab) in Thai patients. (2016)
  • Author(s): Siritho S, Sato DK, Kaneko K, Fujihara K, Prayoonwiwat N.
  • Journal Title: Mult Scler Volume: 印刷中
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Efficacy of intravenous methylprednisolone pulse therapy in patients with multiple sclerosis and neuromyelitis optica (2016)
  • Author(s): Yamasaki R, Matsushita T, Fukazawa T, Yokoyama K, Fujihara K, Ogino M, Yokota T, Miyamoto K, Niino M, Nomura K, Tomioka R, Tanaka M, Kawachi I, Ohashi T, Kaida KI, Matsui M, Nakatsuji Y, Ochi H, Fukaura H, Kanda T, Nagaishi A, Togo K, Mizusawa H, Murai H, Kira JI
  • Journal Title: Mult Scler Volume: 印刷中
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Pregnancy outcomes in aquaporin-4-positive neuromyelitis optica spectrum disorder. (2016)
  • Author(s): Nour MM, Nakashima I, Coutinho E, Woodhall M, Sousa F, Revis J, Takai Y, George J, Kitley J, Santos ME, Nour JM, Cheng F, Kuroda H, Misu T, Martins-da-Silva A, DeLuca GC, Vincent A, Palace J, Waters P, Fujihara K, Leite MI
  • Journal Title: Neurology Volume: 86 Issue: 1 Pages: 79-87
  • DOI: 10.1212/wnl.0000000000002208
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Myelin injury without astrocytopathy in neuroinflammatory disorders with MOG antibodies (2016)
  • Author(s): Kaneko K, Sato DK, Nakashima I, Nishiyama S, Tanaka S, Marignier R, Hyun JW, Oliveira LM, Reindl M, Seifert-Held T, Sepulveda M, Siritho S, Waters PJ, Kurosawa K, Akaishi T, Kuroda H, Misu T, Prayoonwiwat N, Berger T, Saiz A, Kim HJ, Nomura K, Callegaro D, Fujihara K, Aoki M.
  • Journal Title: J Neurol Neurosurg Psychiatry Volume: 1 Issue: 11 Pages: 1257-1259
  • DOI: 10.1136/jnnp-2015-312676
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Lesion length of optic neuritis impacts visual prognosi in neuromyelitis optica (2016)
  • Author(s): Akaishi T, Ichiro Nakashima, Takeshita T, Mugikura S, Sato DK, Takahashi T, Nishiyama S, Kurosawa K, Misu T, Nakazawa T, Aoki M, Fujihara K
  • Journal Title: J Neuroimmunol Volume: 293 Pages: 28-33
  • DOI: 10.1016/j.jneuroim.2016.02.004
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] MRI characteristics of neuromyelitis optica spectrum disorder: an international update. (2015)
  • Author(s): Kim, HJ, Paul F, Lana-Peixoto MA, Tenembaum S, Asgari N, Palace J, Klawiter EC, Sato DK, de Seze J, Jens Wuerfel J, Banwell BL, Villoslada P, Saiz A, Fujihara K, Kim SH.
  • Journal Title: Neurology Volume: 84 Issue: 11 Pages: 1165-1173
  • DOI: 10.1212/wnl.0000000000001367
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Neuromyelitis optica and multiple sclerosis: Seeing differences through Optical Coherence Tomography. (2015)
  • Author(s): Bennett JL, de Seze J, Lana-Peixoto M, Palace J, Waldman A, Schippling S, Tenembaum S, Banwell B, Greenberg B, Levy M, Fujihara K, Chan KH, Kim HJ, Asgari N, Sato DK, Klawiter EC, Saiz A, Wuerfel J, Zimmermann H, Green A, Villoslada P, Paul1 F
  • Journal Title: Mult Scler Volume: 21 Issue: 6 Pages: 678-688
  • DOI: 10.1177/1352458514567216
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Challenges and opportunities in designing clinical trials for neuromyelitis optica. (2015)
  • Author(s): 3.Weinshenker BG, Barron G, Behne JM, Bennett JL, Chin PS, Cree B, de Seze J, Armando Flor, Fujihara K, Greenberg BM, Higashi S, Holt W, Khan OA, Knappertz V, Levy M, Melia AT, Palace J, Smith TJ, Sormani MP, Van Herle K, VanMeter SA, Villoslada P, Walton MK, Wasiewski W, Wingerchuk D, Yeaman M.
  • Journal Title: Neurology Volume: 84 Issue: 17 Pages: 1805-1815
  • DOI: 10.1212/wnl.0000000000001520
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Use of Advanced Magnetic Resonance Imaging Techniques in Neuromyelitis Optica Spectrum Disorder. (2015)
  • Author(s): Kremer S, Renard F, Achard S, Lana-Peixoto MA, Palace J, Asgari N, Klawiter EC, Tenembaum SN, Banwell B, Greenberg BM, Bennett JL, Levy M, Villoslada P, Saiz A, Fujihara K, Chan KH, Schippling S, Paul F, Kim HJ, de Seze J, Wuerfel JT
  • Journal Title: JAMA Neurol Volume: 72 Issue: 7 Pages: 815-822
  • DOI: 10.1001/jamaneurol.2015.0248
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] International consensus diagnostic criteria for neuromyelitis optica spectrum disorders. (2015)
  • Author(s): Wingerchuk DM, Banwell B, Bennett JL, Cabre P, Carroll W, Chitnis T, de Seze J, Fujihara K, Greenberg B, Jacob A, Jarius S, Lana-Peixoto M, Levy M, Simon JH, Tenembaum S, Traboulsee AL, Waters P, Wellik KE, Weinshenker BG.
  • Journal Title: Neurology Volume: 85 Issue: 2 Pages: 177-189
  • DOI: 10.1212/wnl.0000000000001729
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] MRI and retinal abnormalities in isolated optic neuritis with myelin-oligodendrocyte glycoprotein and aquaporin-4 antibodies: a comparative study (2015)
  • Author(s): Akaishi T, Sato DK, Nakashima I, Takeshita T, Takahashi T, Doi H, Kurosawa K, Kaneko K, Kuroda H, Nishiyama S, Misu T, Nakazawa T, Fujihara K, Aoki M
  • Journal Title: J Neurol Neurosurg Psychiatry Volume: 未定 Issue: 4 Pages: 446-448
  • DOI: 10.1136/jnnp-2014-310206
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Neuropsychological Battery with Wechsler Adult Intelligence Scale-III and Wechsler Memory Scale-Revised in Japanese patients with Multiple Sclerosis. (2015)
  • Author(s): Fujimori J, Baba T, Meguro Y, Nakashima I, Mori E, Fujihara K, Aoki M.
  • Journal Title: Clin Exp Neuroimmunol Volume: 6 Issue: 3 Pages: 306-308
  • DOI: 10.1111/cen3.12215
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Depressive state and chronic fatigue in multiple sclerosis. (2015)
  • Author(s): Akaishi T, Nakashima I, Misu T, Fujihara K, Aoki M.
  • Journal Title: J Neuroimmunol Volume: 283 Pages: 70-73
  • DOI: 10.1016/j.jneuroim.2015.05.007
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] MOG cell-based assay detects non-MS patients with inflammatory neurologic disease. (2015)
  • Author(s): Waters P, Woodhall M, O'Connor KC, Reindl M, Lang B, Sato DK, Juryńczyk M, Tackley G, Rocha J, Takahashi T, Misu T, Nakashima I, Palace J, Fujihara K, Leite MI, Vincent A.
  • Journal Title: Neurol Neuroimmunol Neuroinflamm. Volume: 2 Issue: 3
  • DOI: 10.1212/nxi.0000000000000089
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Leukoencephalopathy resolution after atypical mycobacterial treatment: a case report. (2015)
  • Author(s): Oliveira MC, Sato DK, Soares-Neto HR, Lucato LT, Callegaro D, Nitrini R, Medeiros RS, Misu T, Fujihara K, Castro LH.
  • Journal Title: BMC Neurol. Volume: 15 Issue: 1 Pages: 159-159
  • DOI: 10.1186/s12883-015-0415-0
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] High avidity chimeric monoclonal antibodies against the extracellular domains of human aquaporin-4 competing with the neuromyelitis optica autoantibody, NMO-IgG. (2015)
  • Author(s): Miyazaki-Komine K, Takai Y, Huang P, Kusano-Arai O, Iwanari H, Misu T, Koda K, Mitomo K, Sakihama T, Toyama Y, Fujihara K, Hamakubo T, Yasui M, Abe Y.
  • Journal Title: Br J Pharmacol Volume: 173 Issue: 1 Pages: 103-103
  • DOI: 10.1111/bph.13340
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Highly encephalitogenic aquaporin 4-specific T cells and NMO-IgG jointly orchestrate lesion location and tissue damage in the CNS. (2015)
  • Author(s): Zeka B, Hastermann M, Hochmeister S, Kögl N, Kaufmann N, Schanda K, Mader S, Misu T, Rommer P, Fujihara K, Illes Z, Leutmezer F, Sato DK, Nakashima I, Reindl M, Lassmann H, Bradl M.
  • Journal Title: Acta Neuropathol Volume: 130 Issue: 6 Pages: 783-783
  • DOI: 10.1007/s00401-015-1501-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Fulminant demyelinating encephalomyelitis: Insights from antibody studies and neuropathology (2015)
  • Author(s): Di Pauli F, Höftberger R, Reindl M, Beer R, Rhomberg P, Schanda K, Sato D, Fujihara K, Lassmann H, Schmutzhard E, Berger T
  • Journal Title: Neurol Neuroimmunol Neuroinflamm. Volume: 2 Issue: 6
  • DOI: 10.1212/nxi.0000000000000175
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Severely exacerbated neuromyelitis optica rat model with extensive astrocytopathy by high affinity anti-aquaporin-4 monoclonal antibody. (2015)
  • Author(s): Kurosawa K, Misu T, Takai Y, Sato DK, Takahashi T, Abe Y, Iwanari H, Ogawa R, Nakashima I, Fujihara K, Hamakubo T, Yasui M, Aoki M.
  • Journal Title: Acta Neuropathol Commun Volume: 4 Issue: 1 Pages: 783-783
  • DOI: 10.1186/s40478-015-0259-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Severe demyelination but no astrocytopathy in clinically definite neuromyelitis optica with anti-myelin-oligodendrocyte glycoprotein antibody. (2015)
  • Author(s): Ikeda K, Kiyota N, Kuroda H, Sato DK, Nishiyama S, Takahashi T, Misu T, Nakashima I, Fujihara K, Aoki M.
  • Journal Title: Mult Scler Volume: 21 Issue: 5 Pages: 656-659
  • DOI: 10.1177/1352458514551455
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Acute callosal disconnection syndrome as an initial manifestation of neuromyelitis optica spectrum disorders (2015)
  • Author(s): Kobayashi J, Kuroda H, Ezura M, Sugeno N, Shibui A, Takahashi T, Misu T, Fujihara K, Mori E, Aoki M
  • Journal Title: Neurol Clin Neurosci Volume: 未定 Issue: 4 Pages: 137-139
  • DOI: 10.1111/ncn3.164
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Multiple Sclerosis in Japan appears to be a milder disease compared to the UK. (2015)
  • Author(s): Piccolo L, Kumar G, Nakashima I, Misu T, Kong Y, Wakerley B, Ryan S, Cavey A, Fujihara K, Palace J.
  • Journal Title: J Neurol Volume: 印刷中
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Editorial commentary: MOG-IgG serological status matters in paediatric ADEM (2015)
  • Author(s): Misu T, Sato D, Nakashima I, Fujihara K
  • Journal Title: J Neurol Neurosurg Psychiatry Volume: 86 Issue: 3 Pages: 242-242
  • DOI: 10.1136/jnnp-2014-308723
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Editorial: AQP4 in biopsied demyelinating lesions as a diagnostic clue to NMOSD and MS (2015)
  • Author(s): Fujihara K, Misu T
  • Journal Title: Neurology Volume: 84 Issue: 2 Pages: 110-111
  • DOI: 10.1212/wnl.0000000000001135
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Pain- prevalence, pathogenesis and therapy in neuromyelitis optica (2014)
  • Author(s): Bradl M, Kanamori Y, Nakashima I, Misu T, Fujihara K, Lassmann H, Sandkuhler J
  • Journal Title: Nat Rev Neurol Volume: 10 Issue: 9 Pages: 529-536
  • DOI: 10.1038/nrneurol.2014.129
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The investigation of optic neuritis: a review and proposed protocol (2014)
  • Author(s): Petzold A, Wattjes M, Costello F, Rivera JF, Fraser C, Fujihara K, Leavitt J, Marignier R, Paul F, Schippling S, Sindic C, Villoslada P, Weinshenker B, Plant G
  • Journal Title: Nat Rev Neurol Volume: 10 Issue: 8 Pages: 447-458
  • DOI: 10.1038/nrneurol.2014.108
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Changes in Th17 and regulatory T cells after fingolimod initiation to treat multiple sclerosis (2014)
  • Author(s): 7. Sato DK
  • Journal Title: J Neuroimmunol Volume: 268 Issue: 1-2 Pages: 95-98
  • DOI: 10.1016/j.jneuroim.2014.01.008
  • Peer Reviewed
• [Journal Article] Anti-N-methyl-aspartate receptor encephalitis with multiphasic demyelination (2014)
  • Author(s): Kaneko K, Sato, DK, Misu T Kurosawa K, Nakashima I, Fujihara K, Aoki M
  • Journal Title: Ann Neurol Volume: 76 Issue: 3 Pages: 462-464
  • DOI: 10.1002/ana.24224
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Idiopathic aquaporin-4 antibody negative longitudinally extensive transverse myelitis. (2014)
  • Author(s): Hyun JW, Kim SH, Huh SY, Kim W, Yun J, Joung A, Sato DK, Fujihara K, Kim HJ.
  • Journal Title: Mult Scler Volume: 印刷中
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Japanese cases of neuromyelitis optica spectrum disorders associated with myasthenia gravis and a review of the literature. (2014)
  • Author(s): Ikeguchi R, Shimizu Y, Suzuki S, Shimizu S, Kabasawa C, Hashimoto S, Masuda M, Nagene Y, Utsugisawa K, Suzuki, Y, Takahashi T, Utsumi H, Fujihara K, Suzuki N, Uchiyama S.
  • Journal Title: Clin Neurol Neurosurg Volume: 125 Pages: 217-221
  • DOI: 10.1016/j.clineuro.2014.07.036
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] BENEFIT 8-year results provide further support for the long-term value of early treatment of multiple sclerosis (2014)
  • Author(s): 13. Fujihara K
  • Journal Title: J Neurol Neurosurg Psychiatry Volume: 未定 Issue: 11 Pages: 1179-1179
  • DOI: 10.1136/jnnp-2013-306720
  • Peer Reviewed
• [Journal Article] Editorial: Secondary progression and innate immunity in NMO: a possible link to alemtuzumab (2014)
  • Author(s): Fujihara K, Nakashima I
  • Journal Title: Neuroimmunology & Neuroinflammation Volume: 1(3) Issue: 3
  • DOI: 10.1212/nxi.0000000000000038
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Toward more-accurate diagnosis in neuromyelitis optica (2014)
  • Author(s): Fujihara K, Palace J
  • Journal Title: Nat Rev Neurol Volume: 10 Issue: 12 Pages: 679-681
  • DOI: 10.1038/nrneurol.2014.216
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] AQP4-reactive and MOG-reactive NMOSD are mutually exclusive diesases (2017)
  • Author(s): Fujihara K
  • Organizer: 9th Annual International Roundtable Conference on NMO (Guthy-Jackson Charitable Foundation)
  • Place of Presentation: ロサンジェルス(米国)
  • Year and Date: 2017-03-14
  • Int'l Joint Research / Invited
• [Presentation] MS in Asia (2017)
  • Author(s): Fujihara K
  • Organizer: The 4th international Porto Congress of Multiple Sclerosis
  • Place of Presentation: ポルト(ポルトガル)
  • Year and Date: 2017-03-09
  • Int'l Joint Research / Invited
• [Presentation] 多発性硬化症と視神経脊髄炎に関連したバイオマーカー：AQP4抗体とMOG抗体 (2016)
  • Author(s): 藤原一男
  • Organizer: 第56回日本臨床化学会年次学術集会
  • Place of Presentation: くまもと県民交流館パレア(熊本県・熊本市）
  • Year and Date: 2016-12-02
  • Invited
• [Presentation] McDonald criteria in Asian populations (2016)
  • Author(s): Fujihara K
  • Organizer: International Panel on Diagnosis of Multiple Sclerosis
  • Place of Presentation: フィラデルフィア(米国)
  • Year and Date: 2016-11-03
  • Int'l Joint Research / Invited
• [Presentation] Aquaporin 4 antibody in neuromyelitis optica spectrum disorders (2016)
  • Author(s): Fujihara K
  • Organizer: The 13th International Wrokshop on Autoantibodies and Autoimmunity
  • Place of Presentation: 京都(日本)
  • Year and Date: 2016-10-11
  • Int'l Joint Research / Invited
• [Presentation] 多発性硬化症の鑑別診断と治療の選択 (2016)
  • Author(s): 藤原一男
  • Organizer: 第28回日本神経免疫学会学術集会
  • Place of Presentation: ブリックホール(長崎県・長崎市)
  • Year and Date: 2016-09-29
  • Invited
• [Presentation] Pathomechanisms of AQP4-Ig+, MOG-IgG+ and Seronegative Diseases (2016)
  • Author(s): Fujihara K
  • Organizer: 32th Congress of European Committee on Treatment and Research in Multiple Sclerosis (ECTRIMS)
  • Place of Presentation: ロンドン(イギリス)
  • Year and Date: 2016-09-14
  • Int'l Joint Research / Invited
• [Presentation] New trial designs and treatment approach for NMO (2016)
  • Author(s): Fujihara K
  • Organizer: 32th Congress of Eurpean Committee on Treatment and Research in Multiple Sclerosis (ECTRIMS)
  • Place of Presentation: ロンドン(イギリス)
  • Year and Date: 2016-09-14
  • Int'l Joint Research / Invited
• [Presentation] Classic MS: Update on Pathogenesis (2016)
  • Author(s): Fujihara K
  • Organizer: 15th Axsian and Oceanian Congress of Neurology (AOCN)
  • Place of Presentation: クアラルンプール(マレーシア)
  • Year and Date: 2016-08-19
  • Int'l Joint Research / Invited
• [Presentation] Implications of The New Diagnostic Criteria of NMOSD (2015) (2016)
  • Author(s): Fujihara K
  • Organizer: 15th Axsian and Oceanian Congress of Neurology (AOCN)
  • Place of Presentation: クアラルンプール(マレーシア)
  • Year and Date: 2016-08-19
  • Int'l Joint Research / Invited
• [Presentation] The Diagnostic Challenge of Multiple Sclerosis (2016)
  • Author(s): Fujihara K
  • Organizer: APAC MS Summit
  • Place of Presentation: ソウル韓国()
  • Year and Date: 2016-07-16
  • Int'l Joint Research / Invited
• [Presentation] Epidemiology of Multiple Sclerosis in Asia: An Overview (PACTRIMS) (2016)
  • Author(s): Fujihara K
  • Organizer: 17th Annual Meeting of Brazilian Committee on Treatment and Research in Multiple Sclerosis (BCTRIMS)
  • Place of Presentation: サンパウロ(ブラジル)
  • Year and Date: 2016-06-22
  • Int'l Joint Research / Invited
• [Presentation] Critical Comparative Analysis of the Revised 2006 Criteria and the International Consensus Criteria (2015) for Diagnosis of NMOSD (2016)
  • Author(s): Fujihara K
  • Organizer: 17th Annual Meeting of Brazilian Committee on Treatment and Research in Multiple Sclerosis (BCTRIMS)
  • Place of Presentation: サンパウロ(ブラジル)
  • Year and Date: 2016-06-22
  • Int'l Joint Research / Invited
• [Presentation] International consensus diagnostic criteria of NMOSD. In Session V: NMO/NMO Spectrum Diseases (in honor of Eugene Devic) (2016)
  • Author(s): Fujihara K
  • Organizer: IX. Clinical Neuroimmunology Symposium
  • Place of Presentation: クシャダス(トルコ)
  • Year and Date: 2016-06-03
  • Int'l Joint Research / Invited
• [Presentation] Neuromyelitis optica spectrum disorders (NMOSD) and MOG-IgG (2016)
  • Author(s): Fujihara K
  • Organizer: The 2nd Chinese International Summit Meeting of Neuroinfection, Immunity and Cerebrovascular Diseases
  • Place of Presentation: 北京(中国)
  • Year and Date: 2016-05-20
  • Int'l Joint Research / Invited
• [Presentation] 視神経脊髄炎の新しい診断基準 (2016)
  • Author(s): 藤原一男
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸国際会議場(兵庫県・神戸市)
  • Year and Date: 2016-05-18
  • Invited
• [Presentation] Pathogenesis of NMOSD (Session IV, NMO/SD): What we know --- What we don’t (2016)
  • Author(s): Fujihara K
  • Organizer: Guthy-Jackson Charitable Foundation 8th Annual Neuromyelitis Optica Roundtable Conference
  • Place of Presentation: Los Angeles (USA)
  • Year and Date: 2016-03-01
  • Int'l Joint Research / Invited
• [Presentation] Optic Neuritis: Pathology and Differential Diagnosis (2016)
  • Author(s): Fujihara K
  • Organizer: European Charcot Foundation Symposium, 17th Annual Meeting of Brazilian Committee on Treatment and Research in Multiple Sclerosis (BCTRIMS)
  • Place of Presentation: サンパウロ(ブラジル)
  • Int'l Joint Research / Invited
• [Presentation] Progressive MS in Asia (2016)
  • Author(s): Fujihara K
  • Organizer: European Charcot Foundation Symposium: Progressive MS in the 9th Annual Congress of Pan-Asian Committee on Treatment and Research in Multiple Sclerosis (PACTRIMS)
  • Place of Presentation: バンコク(タイ)
  • Int'l Joint Research / Invited
• [Presentation] Case examples of other MS mimics (2016)
  • Author(s): Fujihara K
  • Organizer: MAGNIMS Teaching Course: Using MRi to diagnose MS and related disorders in the 9th Annual Congress of Pan-Asian Committee on Treatment and Research in Multiple Sclerosis (PACTRIMS)
  • Place of Presentation: バンコク(タイ)
  • Int'l Joint Research / Invited
• [Presentation] Teaching Course: How to diagnose and treat indistinguishable early cases of inflammatory CNS diseases in Asians, New Diagnostic Criteria of NMOSD (2015)
  • Author(s): Fujihara K
  • Organizer: The 8th Annual Meeting of Pan-Asian Committee for Treatmetn and Research in Multiple Sclerosis (PACTRIMS)
  • Place of Presentation: Seoul (Republic of Korea)
  • Year and Date: 2015-11-20
  • Int'l Joint Research / Invited
• [Presentation] New insights into the Molecular Pathogenesis of NMO Spectrum Disorders (2015)
  • Author(s): Fujihara K
  • Organizer: European Charcot Foudantion Symposium in The 8th Annual Meeting of Pan-Asian Committee for Treatmetn and Research in Multiple Sclerosis (PACTRIMS)
  • Place of Presentation: Seoul (Republic of Korea)
  • Year and Date: 2015-11-19
  • Int'l Joint Research / Invited
• [Presentation] MS in Special Populations:Is there an “Eatern Type of MS” ? (2015)
  • Author(s): Fujihara K
  • Organizer: Istanbul MS Days 2015
  • Place of Presentation: Istanbul (Turkey)
  • Year and Date: 2015-11-13
  • Int'l Joint Research / Invited
• [Presentation] Teaching Course 14: Neuroimmunology and Multiple Sclerosis, Update in NMO (2015)
  • Author(s): Fujihara K
  • Organizer: The 22nd World Congress of Neurology
  • Place of Presentation: Santiago (Chile)
  • Year and Date: 2015-11-01
  • Int'l Joint Research / Invited
• [Presentation] Main Topic 6.2: Multiple Sclerosis and Other Demyelinating Diseases, Our Current Understanding of NMO and its Spectrum Disorders (2015)
  • Author(s): Fujihara K
  • Organizer: The 22nd World Congress of Neurology
  • Place of Presentation: Santiago (Chile)
  • Year and Date: 2015-11-01
  • Int'l Joint Research / Invited
• [Presentation] Topic 5: Incidence, Prevalence and Phenotypes of Demyelinating Diseases Outside Europe and NA: Asia (2015)
  • Author(s): Fujihara K
  • Organizer: The 31st Congress of European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS)
  • Place of Presentation: Barcelona (Spain)
  • Year and Date: 2015-10-09
  • Int'l Joint Research / Invited
• [Presentation] Teaching Course 12: Neuromyelitis Optica Spectrum Disorders: Pathophysiology of NMOSD. (2015)
  • Author(s): Fujihara K
  • Organizer: The 31st Congress of European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS)
  • Place of Presentation: Barcelona (Spain)
  • Year and Date: 2015-10-07
  • Int'l Joint Research / Invited
• [Presentation] B S Singhal Oration: The Concept of Neuromyelitis Optica Spectrum Disorders: Its Evolution and Lessons (2015)
  • Author(s): Fujihara K
  • Organizer: The 16th Annual Conference of Indian Academy of Neurology
  • Place of Presentation: Agra (India)
  • Year and Date: 2015-10-03
  • Int'l Joint Research / Invited
• [Presentation] Challenging Cases: A young lady with severe myasthenia and emaciation (2015)
  • Author(s): Fujihara K
  • Organizer: The 16th Annual Conference of Indian Academy of Neurology
  • Place of Presentation: Agra (India)
  • Year and Date: 2015-10-02
  • Int'l Joint Research / Invited
• [Presentation] Special Lecture: Is the Disease Activity of Multiple Sclerosis Inevitable ? (1) MS treatment decision in Japan (2015)
  • Author(s): Fujihara K
  • Organizer: 第27回日本神経免疫学会学術集会
  • Place of Presentation: 岐阜市(岐阜)
  • Year and Date: 2015-09-15
  • Int'l Joint Research / Invited
• [Presentation] Devic’s Neuromyelitis Optica: astrocytopathic disease vs. non-astrocytopathic disease (2015)
  • Author(s): Fujihara K
  • Organizer: The 16th Annual Meeting of Brazillian Committee for Treatment and Research in Multiple Sclerosis (BCTRIMS)
  • Place of Presentation: Foz de Iguacu (Brazil)
  • Year and Date: 2015-08-21
  • Int'l Joint Research / Invited
• [Presentation] Update on diagnosis and monitoring of NMO Spectrum Disorders: body fluids (2015)
  • Author(s): Fujihara K
  • Organizer: European Charcot Foundation Symposium in The 16th Annual Meeting of Brazillian Committee for Treatment and Research in Multiple Sclerosis (BCTRIMS)
  • Place of Presentation: Foz de Iguacu (Brazil)
  • Year and Date: 2015-08-21
  • Int'l Joint Research / Invited
• [Presentation] Demyelinating diseases in Asia: complexity and heterogeneity (2015)
  • Author(s): Fujihara K
  • Organizer: 2015 APAC MS Summit
  • Place of Presentation: Hong Kong (China)
  • Year and Date: 2015-07-18
  • Int'l Joint Research / Invited
• [Presentation] Focus on NMO Spectrum Disorders (2015)
  • Author(s): Fujihara K
  • Organizer: Top Seminars in Multiple Sclerosis 2015
  • Place of Presentation: Baveno (Italy)
  • Year and Date: 2015-05-28
  • Int'l Joint Research / Invited
• [Presentation] Evolving concept of NMO Spectrum Disorders: what can we learn ? (2015)
  • Author(s): Fujihara K
  • Organizer: The 1st Chinese International Summit Meetin g of Neurimmunology and Neuroinfections
  • Place of Presentation: Beijing (China)
  • Year and Date: 2015-05-15
  • Int'l Joint Research / Invited
• [Presentation] NMO and its Spectrum Disorders: an international perspective (2015)
  • Author(s): Fujihara K
  • Organizer: The 67th Annual Meeting of American Academy of Neurology
  • Place of Presentation: Washington DC (USA)
  • Year and Date: 2015-04-18
  • Int'l Joint Research / Invited
• [Presentation] Symposium 11: グリアの最前線「視神経脊髄炎(NMO)におけるアストロサイト障害と新たな展開」 (2014)
  • Author(s): 藤原一男
  • Organizer: 第36回日本生物学的精神医学会、第57回日本神経化学会合同年会
  • Place of Presentation: 奈良市(奈良県(新公会堂)
  • Year and Date: 2014-09-28 – 2014-09-30
  • Invited
• [Presentation] Workshop 10: Updates on Demyelinating Diseases, Demyelination after discovery of aquaporin 4 (multiple sclerosis, neuromyelitis optica) (2014)
  • Author(s): Fujihara K
  • Organizer: The 18th International Congress of Neuropathology (ICN2014)
  • Place of Presentation: Rio de Janeiro (Brazil)
  • Year and Date: 2014-09-16 – 2014-09-18
  • Invited
• [Presentation] Teaching Course 6: Neuromyelitis Optica (NMO), AQP4-Antibody-Seronegative NMOSD (2014)
  • Author(s): Fujihara K
  • Organizer: Joint 2014 ACTRIMS-ECTRIMS Meeting (MSBoston2014)
  • Place of Presentation: Boston (USA)
  • Year and Date: 2014-09-08 – 2014-09-12
  • Invited
• [Presentation] Parallel Session 2: MS subpopulations and disease variants, (PS2.2) Neuromyelitis Optica Spectrum Disorders: Evolution and Current Concept (2014)
  • Author(s): Fujihara K
  • Organizer: Joint 2014 ACTRIMS-ECTRIMS Meeting (MSBoston2014)
  • Place of Presentation: Boston (USA)
  • Year and Date: 2014-09-08 – 2014-09-12
  • Invited
• [Presentation] Syndrome that mimic NMO: OSMS (2014)
  • Author(s): Fujihara K
  • Organizer: European NMO Meeting 2014
  • Place of Presentation: London (Crawley) (United Kingdom)
  • Year and Date: 2014-06-19 – 2014-06-20
  • Invited
• [Presentation] Pathology and phathophysiology: Astrocytopathy (2014)
  • Author(s): Fujihara K
  • Organizer: European NMO Meeting 2014
  • Place of Presentation: London (Crawley) (United Kingdom)
  • Year and Date: 2014-06-19 – 2014-06-20
  • Invited
• [Book] Pocket Drugs 2017 (2017)
  • Author(s): 藤原一男
  • Total Pages: 6
  • Publisher: 医学書院
• [Book] Dynamic diagnosisに必要な脊椎脊髄の神経症候学 (2017)
  • Author(s): 藤原一男
  • Total Pages: 3
  • Publisher: 三輪書店
• [Book] Dynamic diagnosisに必要な脊椎脊髄の神経症候 (2017)
  • Author(s): 藤原一男
  • Total Pages: 2
  • Publisher: 三輪書店
• [Book] 神経疾患最新の治療 2018-2020 (2017)
  • Author(s): 黒田 宙、藤原一男
  • Publisher: 南江堂
• [Book] 神経内科clinical questions and pearls「中枢脱髄性疾患」 (2017)
  • Author(s): 7.高井良樹、藤原一男
  • Publisher: 中外医学社
• [Book] 臨床神経内科学(改訂6版) (2016)
  • Author(s): 藤原一男
  • Total Pages: 13
  • Publisher: 南山堂
• [Book] Pocket Drugs 2016 (2016)
  • Author(s): 藤原一男
  • Total Pages: 6
  • Publisher: 医学書院
• [Book] ポケット版 神経内科 検査・処置マニュアル (2016)
  • Author(s): 2.黒田 宙、藤原一男
  • Total Pages: 6
  • Publisher: 新興医学出版社
• [Book] Pocket Drugs 2015 (2015)
  • Author(s): 藤原一男
  • Total Pages: 5
  • Publisher: 医学書院
• [Book] Annual Review神経2014 (2014)
  • Author(s): 中村正史、中島一郎、藤原一男
  • Total Pages: 7
  • Publisher: 中外医学社
• [Remarks] 東北大学大学院医学系研究科多発性硬化症治療学寄附講座
  • URL: http://www.ms.med.tohoku.ac.jp/index.html
• [Remarks] 東北大学大学院医学系研究科多発性硬化症治療学寄附講座ホームページ
  • URL: http://www.ms.med.tohoku.ac.jp/index.html