| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2017: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2016: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2015: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Outline of Final Research Achievements |
Autophagy is an intracellular catabolic process that can maintain cellular homeostasis during several stress conditions such as starvation and mitochondrial oxidative stress. Growing evidences have shown that altered autophagy activity is associated with the pathogenesis of a variety of diseases. The present study revealed that mammalian autophagy is essential for maintaining energy homeostasis via enhancing ketogenesis during starvation, and that diabetes-related dysregulation of autophagy is involved in the pathogenesis of diabetic vascular complications, such as diabetic nephropathy. These observation suggest that autophagy activation should shed a light on therapy for diabetic complications and contribute to health promotion in diabetic patients.
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