| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Outline of Final Research Achievements |
In this study, we investigate how autophagy failure modify the pathophysiology observed in diabetic state. We revealed that in pancreatic beta cells, the activation of autophagy weakens the toxicity induced by human IAPP. In addition, while model mice of atherosclerosis forms atheroma in artery, however, the morphology of the atherosclerotic lesions are quite different from those in human, we found that crossing with smooth muscle cell specific autophagy failure mode, model mice of atherosclerosis showed the similar morphology in the lesion to human atherosclerosis. These results suggest that autophagy failure plays critical role in the formation of human diseases.
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