| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2016: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2015: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Outline of Final Research Achievements |
All hematpoietic / immune cells including B cells are generated from hematopoietic stem cells(HSCs). HSCs gradually specify their differentiation potential to finally commit to the B cell lineage. Although transcription factors (TFs) are shown to be essential for the cell fate decision, the roles of the TFs in regulating cellular metabolisms remain to be determined. We have recently established a culture system to examine the molecular mechanisms of B cell fate determination. Using this sytem, we demonstrated that the insulin signals are important for early B cell differentiation.
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