| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2016: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
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| Outline of Final Research Achievements |
LMIR3-deficient colonic mast cells were pivotal in the exacerbation of DSS-induced colitis in LMIR3-deficeint mice. Ceramide vesicles attenuated DSS-induced colitis by inhibiting ATP-mediated activation of colonic mast cells through ceraimide-LMIR3 binding. On the other hand, LMIR3-deficient mice were highly resistant to septic peritonitis induced by cecal ligation and puncture (CLP). Ceramide-LMIR3 binding inhibited the release of neutrophil chemoattractaaants from mast cells and neutrophils in response to E. coli, thereby suppressing neutrophil recruitment to sites of infection. Accordingly, disrupting ceramide-LMIR3 interactions prevents septic peritonitis by stimulating neutrophil recruitment.
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