| Project/Area Number |
26293233
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中川 種昭 慶應義塾大学, 医学部, 教授 (00227745)
仲 哲治 国立研究開発法人医薬基盤・健康・栄養研究所, その他部局等, その他 (30303936)
鈴木 勝也 慶應義塾大学, 医学部, 講師 (70306695)
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| Research Collaborator |
TAKESHITA Masaru 慶應義塾大学, 医学部リウマチ内科, 特任助教 (10571135)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Keywords | 関節リウマチ / FAM20A / キナーゼ / 分泌型キナーゼ / 膠原病・アレルギー内科学 / リウマチ内科学 |
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| Outline of Final Research Achievements |
We have identified FAM20A which regulates post-transcriptional protein modification as a molecule associated with pathophysiology of rheumatoid arthritis in the previous research using peripheral blood. In this research, we generated anti-FAM20A antibody and deeply analyzed association between FAM20A and affected sites. Our investigation successfully revealed the expression affected site and its induction by inflammatory cytokines. These findings suggested that post-transcriptional protein modification involved in pathophysiology of rheumatoid arthritis.
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