| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Outline of Final Research Achievements |
As accumulating studies indicate that gut resident T cells may be the key player regulating the extraintestinal autoimmunity, we used myelin antigen specific T cell receptor transgenic mice and found that gut intraepithelial autoreactive CD4+T cells suppress autoimmune inflammation in the CNS in LAG3 dependent manner. We also revealed the involvement of mucosal associated invariant T (MAIT) cells, a member of innate-like lymphocytes found abundantly in the mucosal tissue. MAIT cell frequency decreased in the peripheral blood of various inflammatory diseases such as arthritis, ulcerative colitis (UC) and systemic lupus erythematosus (SLE). The activation status of MAIT cells was correlated with disease activity of UC and SLE as well as plasma levels of IL-18. Furthermore, MAIT cells increased in the inflamed mucosa and their frequency was correlated with clinical and endoscopic disease activity in UC patients, suggesting their contribution to the pathogenesis of inflammatory disorders.
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