Comprehensive and spationtemporal genetic analyses of clonal evolution of metastatic and recurrent pediatric solid tumors

• Project/Area Number: 26293242
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: The University of Tokyo
• Principal Investigator: Takita Junko 東京大学, 医学部附属病院, 准教授 (00359621)
• Co-Investigator(Kenkyū-buntansha): 加藤 元博 国立研究開発法人国立成育医療研究センター, 小児がんセンター 移植・細胞治療科, 医長 (40708690) ; 安戸 裕貴 東京大学, 医学部附属病院, 助教 (70422285)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000); Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2014: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
• Keywords: 小児固形腫瘍 / 膵芽腫 / クローン進化 / β―カテニン / 小児難治性腫瘍 / 神経芽腫 / ゲノムコピー数の異常 / ALK / MYCN / 難治がん / 次世代シークエンサー / 標的分子 / 肝芽腫 / 単一細胞シークエンス / クローナルエボリューション

Outline of Final Research Achievements

To explore recurrent gene mutations in PBL, we performed Whole exome sequencing (WES) on paired tumor-normal DNA samples from one refractory case (PBL001). Seven spatially separated tumor samples resected at 3 different time points were used for WES. All metastatic samples in a case (PBL001) showed higher frequencies of mutations (mean number = 61.2). Notably, among the 240 mutated genes, no additional genes other than CTNNB1 were recurrently altered, confirming the obvious impact of CTNNB1 mutations in PBL pathogenesis. Likewise, 11p uniparental disomy (UPD) was also detected all samples examined. Sequencing of multiple samples from PBL001 revealed intra-tumor heterogeneity within primary and metastatic sites, as well as clonal evolution with a truncal CTNNB1 mutation and 11p UPD. Importantly, a truncal CTNNB1 mutation and 11p UPD provided further evidence that a CTNNB1 mutation was likely to be virtually necessary for development and progression of PBL.

Research Products

• [Journal Article] Blastic transformation of juvenile myelomonocytic leukemia caused by the copy number gain of oncogenic KRAS. (2017)
  • Author(s): Osumi T, Kato M, Ouchi-Uchiyama M, Tomizawa D, Kataoka K, Fujii Y, Seki M, Takita J, Ogawa S, Uchiyama T, Ohki K, Kiyokawa N.
  • Journal Title: Pediatr Blood Cancer. Volume: in press
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Partial monosomy of 10p and duplication of another chromosome in two patients (2017)
  • Author(s): Ohta S, Isojima T, Mizuno Y, Kato M, Mimaki M, Seki M, Sato Y, Ogawa S, Takita J, Kitanaka S, Oka A.
  • Journal Title: Pediatr Int. Volume: 59 Issue: 1 Pages: 99
  • DOI: 10.1111/ped.13181
  • URL: https://localhost/en/publications/e6b63b6e-a8ee-4df5-aeaa-faa36b9d1987
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] ZNF384-related fusion genes consist of a subgroup with a characteristic immunophenotype in childhood B-cell precursor acute lymphoblastic leukemia. (2017)
  • Author(s): Hirabayashi S, Ohki K, Nakabayashi K, Ichikawa H, Momozawa Y, Okamura K, Yaguchi A, Terada K, Saito Y, Yoshimi A, Ogata-Kawata H, Sakamoto H, Kato M, Fujimura J, Hino M, Kinoshita A, Kakuda H, Kurosawa H, Kato K, Kajiwara R, Moriwaki K, Morimoto T, Nakamura K, Noguchi Y, Osumi T, Sakashita K, Takita J, et al.
  • Journal Title: Haematologica. Volume: 102 Issue: 1 Pages: 118-129
  • DOI: 10.3324/haematol.2016.151035
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Metachronous anaplastic sarcoma of the kidney and thyroid follicular carcinoma as manifestations of DICER1 abnormalities. (2017)
  • Author(s): Yoshida M, Hamanoue S, Seki M, Tanaka M, Yoshida K, Goto H, Ogawa S, Takita J, Tanaka Y.
  • Journal Title: Hum Pathol. Volume: - Pages: 205-209
  • DOI: 10.1016/j.humpath.2016.06.024
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Long-term outcome of six-month maintenance chemotherapy for acute lymphoblastic leukemia in children. (2017)
  • Author(s): Kato M, Ishimaru S, Seki M, Yoshida K, Shiraishi Y, Chiba K, Kakiuchi N, Sato Y, Ueno H, Tanaka H, Inukai T, Tomizawa D, Hasegawa D, Osumi T, Arakawa Y, Aoki T, Okuya M, Kaizu K, Kato K, Taneyama Y, Goto H, Taki T, Takagi M, Sanada M, Koh K, Takita J, Miyano S, Ogawa S, Ohara A, Tsuchida M, Manabe A.
  • Journal Title: Leukemia. Volume: 31 Issue: 3 Pages: 580-584
  • DOI: 10.1038/leu.2016.274
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A case of SLE presenting with mixed type fulminant autoimmune hemolytic anemia. (2016)
  • Author(s): Hirano Y, Itonaga T, Yasudo H, Isojima T, Miura K, Harita Y, Sekiguchi M, Kato M, Takita J, Oka A.
  • Journal Title: Pediatr Int. Volume: - Issue: 6 Pages: 527-530
  • DOI: 10.1111/ped.12849
  • Peer Reviewed / Open Access
• [Journal Article] Recurrent DUX4 fusions in B cell acute lymphoblastic leukemia of adolescents and young adults (2016)
  • Author(s): Takahiko Yasuda, Shinobu Tsuzuki, Masahito Kawazu, Fumihiko Hayakawa, Shinya Kojima, Toshihide Ueno, Naoto Imoto, Shinji Kohsaka, Akiko Kunita, Koichiro Doi, Toru Sakura, Toshiaki Yujiri, Eisei Kondo, Katsumichi Fujimaki, Yasunori Ueda, Yasutaka Aoyama, Shigeki Ohtake, Junko Takita, Eirin Sai, Masafumi Taniwaki, et al.
  • Journal Title: Nature genetics Volume: in press Issue: 5 Pages: 409-417
  • DOI: 10.1038/ng.3535
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Whole-exome sequencing reveals the spectrum of gene mutations and the clonal evolution patterns in paediatric acute myeloid leukaemia. (2016)
  • Author(s): Shiba N, Yoshida K, Shiraishi Y, Okuno Y, Yamato G, Hara Y, Nagata Y, Chiba K, Tanaka H, Terui K, Kato M, Park MJ, Ohki K, Shimada A, Takita J, Tomizawa D, Kudo K, Arakawa H, Adachi S, Taga T, Tawa A, Ito E, Horibe K, Sanada M, Miyano S, Ogawa S, Hayashi Y.
  • Journal Title: Br J Haematol. Volume: 175 Issue: 3 Pages: 476-489
  • DOI: 10.1111/bjh.14247
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Adults with germline CBL mutation complicated with juvenile myelomonocytic leukemia at infancy. (2016)
  • Author(s): Muraoka M, Okuma, C, Kanamitsu K, Ishida H, Kanazawa Y, Washino K, Seki M, Kato M, Takita J, Sato Y, Ogawa S, Tsukahara H, and Oda M.
  • Journal Title: J Hum Genet Volume: - Issue: 6 Pages: 523-526
  • DOI: 10.1038/jhg.2016.8
  • NAID: 40020857008
  • Peer Reviewed / Open Access
• [Journal Article] ALKR1275Q perturbs extracellular matrix, enhances cell invasion, and leads to the development of neuroblastoma in cooperation with MYCN. (2016)
  • Author(s): Ueda T, Nakata Y, Yamasaki N, Oda H, Sentani K, Kanai A, Onishi N, Ikeda K, Sera Y, Honda Z, Tanaka K, Sata M, Ogawa S, Yasui W, Saya H, Takita J, Honda H.
  • Journal Title: Oncogene. Volume: 25 Pages: 4447-4458
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Molecular genetic and cytogenetic analysis of a primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma. (2016)
  • Author(s): Kato K, Oh Y, Takita J, Gunji Y, Kobayashi C, Yoshimi A, Nakao T, Noma M, Koike K, Morimoto A, Iijima S, Hojo H, Tsuchida M.
  • Journal Title: Int J Hematol. Volume: 103 Issue: 2 Pages: 196-201
  • DOI: 10.1007/s12185-015-1895-9
  • Peer Reviewed / Open Access
• [Journal Article] 小児白血病のゲノム・エピゲノム異常と臨床応用． (2016)
  • Author(s): 滝田順子
  • Journal Title: 臨床血液 Volume: 57 Pages: 2294-2300
  • NAID: 130005250022
  • Peer Reviewed / Open Access
• [Journal Article] 骨髄増殖性腫瘍のマネジメントと最近の展開】 若年性骨髄単球性白血病の病態と遺伝子異常． (2016)
  • Author(s): 滝田順子
  • Journal Title: 血液内科 Volume: 73 Pages: 340-344
  • Peer Reviewed / Open Access
• [Journal Article] 【ガイドラインと最新文献による小児科学レビュー2016-'17】 疾患編 血液、腫瘍 固形腫瘍． (2016)
  • Author(s): 滝田順子
  • Journal Title: 小児科学レビュー Volume: 17 Pages: 375-382
  • Peer Reviewed / Open Access
• [Journal Article] 小児血液・腫瘍患者のカテーテルへのcolonizationに対する抗生剤ロック療法． (2016)
  • Author(s): 片山菜穂子, 加藤元博, 渡邉健太郎, 樋渡光輝, 張田豊, 滝田順子, 岡明
  • Journal Title: 日本小児血液・がん学会雑誌 Volume: 52 Pages: 409-413
  • NAID: 130005125281
  • Peer Reviewed / Open Access
• [Journal Article] 慢性心不全を合併したDown症候群患児に発症した急性巨核芽球性白血病． (2016)
  • Author(s): 竹原広基, 関口昌央, 加藤元博, 塩澤亮輔, 林泰祐, 清水信隆, 渡邉健太郎, 樋渡光輝, 滝田順子, 岡明
  • Journal Title: 日本小児科学会雑誌 Volume: 120 Pages: 752-755
  • Peer Reviewed / Open Access
• [Journal Article] ALK増幅難治性神経芽腫におけるCrizotinibの使用経験． (2016)
  • Author(s): 長澤武, 渡邉健太郎, 加藤元博, 関口昌央, 樋渡光輝, 岡明, 滝田順子
  • Journal Title: 日本小児血液・がん学会雑誌 Volume: 53 Pages: 8-12
  • NAID: 130005148138
  • Peer Reviewed / Open Access
• [Journal Article] 中心静脈カテーテルからの逆流採血方法の差異とタクロリムス血中濃度測定の誤差に関する検討． (2016)
  • Author(s): 関口昌央，荒川ゆうき，大隅朋生，磯部清孝，滝田順子，花田良二，富澤大輔，松本公一，岡明，康勝好，加藤元博
  • Journal Title: 日本造血細胞移植学会誌 Volume: 5 Pages: 87-92
  • NAID: 130005165315
  • Peer Reviewed / Open Access
• [Journal Article] ALKR1275Q perturbs extracellular matrix, enhances cell invasion and leads to the development of neuroblastoma in cooperation with MYCN. (2016)
  • Author(s): Ueda T, Nakata Y, Yamasaki N, Oda H, Sentani K, Kanai A, Onishi N, Ikeda K, Sera Y, Honda ZI, Tanaka K, Sata M, Ogawa S, Yasui W, Saya H, Takita J, Honda H.
  • Journal Title: Oncogene. Volume: 無 Issue: 34 Pages: 4447-4458
  • DOI: 10.1038/onc.2015.519
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genomic analysis of clonal origin of Langerhans cell histiocytosis following acute lymphoblastic leukemia (2015)
  • Author(s): 2.Kato M, Seki M, Yoshida K, Sato Y, Oyama R, Arakawa Y, Kishimoto H, Taki T, Akiyama M, Shiraishi Y, Chiba K, Tanaka H, Mitsuiki N, Kajiwara M, Mizutani S, Sanada M, Miyano S, Ogawa S, Koh K, Takita J.
  • Journal Title: British Journal of Haematology Volume: Nov 5 Issue: 1 Pages: 169-172
  • DOI: 10.1111/bjh.13841
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Somatic mosaic mutations of IDH1 and NPM1 associated with cup-like acute myeloid leukemia in a patient with Maffucci syndrome (2015)
  • Author(s): Akiyama M, Yamaoka M, Mikami-Terao Y, Ohyama W, Yokoi K, Arakawa Y, Takita J, Suzuki H, Yamada H
  • Journal Title: International Journal of Hematology Volume: 102 Issue: 6 Pages: 723-8
  • DOI: 10.1007/s12185-015-1892-z
  • Peer Reviewed / Open Access
• [Journal Article] Support for school reentry and relationships between children with cancer, peers, and teachers (2015)
  • Author(s): Soejima T, Sato I, Takita J, Koh K, Maeda M, Ida K, Kamibeppu K.
  • Journal Title: Pediatr Int. Volume: 57 Issue: 6 Pages: 1101
  • DOI: 10.1111/ped.12730
  • URL: https://pure.teikyo.jp/en/publications/12383616-e1f2-416c-8779-7019c5df7dff
  • Peer Reviewed / Open Access
• [Journal Article] Integrated genetic and epigenetic analysis defines novel molecular subgroups in rhabdomyosarcoma. (2015)
  • Author(s): Seki M, Nishimura R, Yoshida K, Shimamura T, Shiraishi Y, Sato Y, Kato M, Chiba K, Tanaka H, Hoshino N, Nagae G, Shiozawa Y, Okuno Y, Hosoi H, Tanaka Y, Okita H, Miyachi M, Souzaki R, Taguchi T, Koh K, Hanada R, Kato K, Nomura Y, Akiyama M, Oka A, Igarashi T, Miyano S, Aburatani H, Hayashi Y, Ogawa S, Takita J.
  • Journal Title: Nat Commun. Volume: 6 Issue: 1 Pages: 7557-7557
  • DOI: 10.1038/ncomms8557
  • NAID: 120005623266
  • Peer Reviewed / Open Access
• [Journal Article] Neonatal acute megakaryoblastic leukemia mimicking congenital neuroblastoma (2015)
  • Author(s): Kawasaki Y, Makimoto M, Nomura K, Hoshino A, Hamashima T, Hiwatari M, Nakazawa A, Takita J, Yoshida T, Kanegane H.
  • Journal Title: Clin Case Rep. Volume: 3 Issue: 3 Pages: 145-9
  • DOI: 10.1002/ccr3.183
  • Peer Reviewed / Open Access
• [Journal Article] Upregulation of MAPK negative feedback regulators and RET in mutant ALK neuroblastoma: implications for targeted treatment. (2015)
  • Author(s): Lambertz I, Kumps C, Claeys S, Lindner S, Beckers A, Janssens E, Carter DR, Cazes A, Cheung BB, De Mariano M, De Bondt A, De Brouwer S, Delattre O, Gibbons J, Janoueix-Lerosey I, Laureys G, Liang C, Marshall GM, Porcu M, Takita J et all.
  • Journal Title: Clin Cancer Res. Volume: 21 Issue: 14 Pages: 3327-39
  • DOI: 10.1158/1078-0432.ccr-14-2024
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Aggressive transformation of anaplastic large cell lymphoma with increased number of ALK-translocated chromosomes. (2015)
  • Author(s): Hoshino A, Nomura K, Hamashima T, Isobe T, Seki M, Hiwatari M, Yoshida K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ogawa S, Takita J, Kanegane H.
  • Journal Title: Int J Hematol. Volume: 101 Issue: 2 Pages: 198-202
  • DOI: 10.1007/s12185-014-1701-0
  • Peer Reviewed / Open Access
• [Journal Article] Allogeneic haematopoietic stem cell transplantation for infant acute lymphoblastic leukaemia with KMT2A (MLL) rearrangements: a retrospective study from the paediatric acute lymphoblastic leukaemia working group of the Japan Society for Haematopoietic Cell Transplantation. (2015)
  • Author(s): Kato M, Hasegawa D, Koh K, Kato K, Takita J, Inagaki J, Yabe H, Goto H, Adachi S, Hayakawa A, Takeshita Y, Sawada A, Atsuta Y, Kato K.
  • Journal Title: Br J Haematol. Volume: 168 Issue: 4 Pages: 564-70
  • DOI: 10.1111/bjh.13174
  • Peer Reviewed / Open Access
• [Journal Article] Early use of allogeneic hematopoietic stem cell transplantation for infants with MLL gene-rearrangement-positive acute lymphoblastic leukemia. (2015)
  • Author(s): Koh K, Tomizawa D, Moriya Saito A, Watanabe T, Miyamura T, Hirayama M, Takahashi Y, Ogawa A, Kato K, Sugita K, Sato T, Deguchi T, Hayashi Y, Takita J, Takeshita Y, Tsurusawa M, Horibe K, Mizutani S, Ishii E.
  • Journal Title: Leukemia Volume: 29(2) Issue: 2 Pages: 290-6
  • DOI: 10.1038/leu.2014.172
  • Peer Reviewed / Open Access
• [Journal Article] Identification of a homozygous JAK3 V674A mutation caused by acquired uniparental disomy in a relapsed early T-cell precursor ALL patient. (2015)
  • Author(s): Kawashima-Goto S, Imamura T, Seki M, Kato M, Yoshida K, Sugimoto A, Kaneda D, Fujiki A, Miyachi M, Nakatani T, Osone S, Ishida H, Taki T, Takita J, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ogawa S, Hosoi H.
  • Journal Title: Int J Hematol. Volume: 101 Issue: 4 Pages: 411-6
  • DOI: 10.1007/s12185-014-1711-y
  • Peer Reviewed / Open Access
• [Journal Article] Upregulation of MAPK negative feedback regulators and RET in mutant ALK neuroblastoma: implications for targeted treatment. (2015)
  • Author(s): Lambertz I, Kumps C, Claeys S, Lindner S, Beckers A, Janssens E, Carter DR, Cazes A, Cheung BB, De Mariano M, De Bondt A, De Brouwer S, Delattre O, Gibbons J, Janoueix-Lerosey I, Laureys G, Liang C, Marshall GM, Porcu M, Takita J et al.
  • Journal Title: Clin Cancer Res. Volume: -
  • Peer Reviewed / Open Access
• [Journal Article] 小児の臨床検査 小児の遺伝子・染色体検査 (2015)
  • Author(s): 滝田 順子
  • Journal Title: 検査と技術 Volume: 43 Pages: 58-62
  • Peer Reviewed / Open Access
• [Journal Article] Cyclic fluctuation of blood pressure in neonatal neuroblastoma. (2014)
  • Author(s): Fujishiro J, Sugiyama M, Ishimaru T, Uotani C, Tsuchida S, Takahashi N, Shiozawa R, Takita J, Iwanaka T.
  • Journal Title: Pediatr Int. Volume: 56 Issue: 6 Pages: 934-7
  • DOI: 10.1111/ped.12399
  • Peer Reviewed / Open Access
• [Journal Article] Systemic lupus erythematosus complicated with liver cirrhosis in a patient with Papillon-Lefevre syndrome (2014)
  • Author(s): Yasudo, H., Ando, T., Takeuchi, M., Nakano, H., Itonaga, T., Takehara, H., Isojima, T., Miura, K., Harita, Y., Takita, J., and Oka, A.
  • Journal Title: Lupus Volume: 23 Issue: 14 Pages: 1523-1527
  • DOI: 10.1177/0961203314547794
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic significance of leukopenia in childhood acute lymphoblastic leukemia. (2014)
  • Author(s): Shiozawa Y, Takita J, Kato M, Sotomatsu M, Koh K, Ida K, Hayashi Y.
  • Journal Title: Oncol Lett. Volume: 7 Pages: 1169-74
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Relapsed Acute Lymphoblastic Leukemia with Unusual Multiple Bone Invasions: A case report. (2014)
  • Author(s): Hangai M, Watanabe K, Shiozawa R, Hiwatari M, Ida K, Takita J.
  • Journal Title: Oncol Lett. Volume: 7 Pages: 991-3
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Flotillin-1 regulates oncogenic signaling in neuroblastoma cells by regulating ALK membrane association. (2014)
  • Author(s): Tomiyama A, Uekita T, Kamata R, Sasaki K, Takita J, Ohira M, Nakagawara A, Kitanaka C, Mori K, Yamaguchi H, Sakai R.
  • Journal Title: Cancer Res. Volume: 74(14) Issue: 14 Pages: 3790-3801
  • DOI: 10.1158/0008-5472.can-14-0241
  • Peer Reviewed / Open Access
• [Journal Article] Biallelic DICER1 mutations in sporadic pleuropulmonary blastoma (2014)
  • Author(s): Seki M, Yoshida K, Shiraishi Y, Shimamura T, Sato Y, Nishimura R, Okuno Y, Chiba K, Tanaka H, Kato K, Kato M, Hanada R, Nomura Y, Park MJ, Ishida T, Oka A, Igarashi T, Miyano S, Hayashi Y, Ogawa S, Takita J
  • Journal Title: Cancer Res Volume: 74 Issue: 10 Pages: 2742-9
  • DOI: 10.1158/0008-5472.can-13-2470
  • Peer Reviewed / Open Access
• [Journal Article] Genome-wide approach to identify second gene targets for malignant rhabdoid tumors using high-density oligonucleotide microarrays (2014)
  • Author(s): Takita J, Chen Y, Kato M, Ohki K, Sato Y, Ohta S, Sugita K, Nishimura R, Hoshino N, Seki M, Sanada M, Oka A, Hayashi Y, Ogawa S
  • Journal Title: Cancer Sci Volume: 105 Issue: 3 Pages: 258-64
  • DOI: 10.1111/cas.12352
  • Peer Reviewed / Open Access
• [Journal Article] Japanese Dent disease has a wider clinical spectrum than Dent disease in Europe/USA : genetic and clinical studies of 86 unrelated patients with low-molecular-weight proteinuria (2014)
  • Author(s): Sekine T, Komoda F, Miura K, Takita J, Shimadzu M, et al
  • Journal Title: Nephrol Dial Transplant Volume: 29 Issue: 2 Pages: 376-84
  • DOI: 10.1093/ndt/gft394
  • Peer Reviewed / Open Access
• [Journal Article] The effect of the order of total body irradiation and chemotherapy on graft-versus-host disease (2014)
  • Author(s): Kato M, Shiozawa R, Koh K, Nagatoshi Y, Takita J, Ida K, Kikuchi A, Hanada R
  • Journal Title: J Pediatr Hematol Oncol Volume: 36 Issue: 1 Pages: e9-e12
  • DOI: 10.1097/mph.0b013e318279e81c
  • URL: https://localhost/en/publications/b17b10c9-c953-414f-8ecd-ae39afc4c800
  • Peer Reviewed / Open Access
• [Journal Article] Ectopic Neuroblastoma in Monozygotic Twins With Different Ages of Onset : Possible Twin-to-Twin Metastasis In Utero With Distinct Genetic Alterations After Birth (2014)
  • Author(s): Taketani T, Takita J, Ueyama J, Kanai R, Kumori K, Maruyama R, Hayashi K, Ogawa S, Fukuda S, Yamaguchi S
  • Journal Title: J Pediatr Hematol Oncol Volume: 36 Issue: 2 Pages: 166-168
  • DOI: 10.1097/mph.0b013e318290c686
  • Peer Reviewed / Open Access
• [Journal Article] 【ビジュアル小児外科疾患のフォローアップ・プログラム-手術直後から遠隔期の問題点まで】 神経芽腫(解説/特集)． (2014)
  • Author(s): 滝田 順子
  • Journal Title: 小児外科 Volume: 46 Pages: 1159-63
  • Peer Reviewed / Open Access
• [Journal Article] 高用量シクロフォスファミドによるHLA一致同胞間骨髄幹細胞移植後に致死的心毒性をきたした一例 (2014)
  • Author(s): 渡邉 健太郎, 加藤 元博, 田中 淳, 中井 まりえ, 関 正史, 林 泰佑, 塩澤 亮輔, 樋渡 光輝, 吉田 健一, 小川 誠司, 松坂 恵介, 深山 正久, 滝田 順子, 岡 明
  • Journal Title: 日本造血細胞移植学会雑誌 Volume: 3 Pages: 120-3
  • NAID: 130004699749
  • Peer Reviewed / Open Access
• [Journal Article] 次世代シーケンサーによる小児血液、腫瘍疾患における研究の進展 小児固形腫瘍における治療標的の探索 (2014)
  • Author(s): 滝田 順子
  • Journal Title: 日本小児血液・がん学会雑誌 Volume: 51 Pages: 278-84
  • Peer Reviewed / Open Access
• [Journal Article] 【小児の治療指針】 血液・腫瘍 悪性リンパ腫 (2014)
  • Author(s): 滝田 順子
  • Journal Title: 小児科診療 Volume: 77巻増刊 Pages: 486-8
  • Peer Reviewed / Open Access
• [Journal Article] 【急性リンパ性白血病(ALL)】 小児ALLの予後因子と治療 (2014)
  • Author(s): 滝田順子
  • Journal Title: 血液内科 Volume: 68 Pages: 203-9
  • Peer Reviewed / Open Access
• [Journal Article] 急性リンパ性白血病に対するゲノム解析の成果 (2014)
  • Author(s): 滝田順子
  • Journal Title: 血液内科 Volume: 69 Pages: 713-9
  • Peer Reviewed / Open Access
• [Journal Article] 急性リンパ性白血病（ALL） (2014)
  • Author(s): 滝田順子
  • Journal Title: 血液フロンティア Volume: 24 Pages: 55-63
  • Peer Reviewed / Open Access
• [Presentation] 小児胚細胞腫瘍における遺伝子発現に基づく分類 (2016)
  • Author(s): 久保田泰央，関正史，塩澤亮輔，吉田健一，佐藤悠佑，白石友一，千葉健一，田中洋子，樋渡光輝，宮野悟，岡明，林泰秀，田中祐吉，小川誠司，滝田順子
  • Organizer: 第58回日本小児血液・がん学会学術集会
  • Place of Presentation: 品川プリンスホテル （東京）
  • Year and Date: 2016-12-17
• [Presentation] Identifications of fatal SPI1fusions and highly aggressive phenotype with SPI1 overexpression in pediatric T cell acute lymphoblastic leukemia/lymphoma (2016)
  • Author(s): Seki M, Kimura S, Yoshida K, Isobe T, Ueno H, Shiozawa Y, Shiraishi Y, Chiba K, Takagi M, Iwama A, Ohki K, Kato M, Koh K, Hanada R, Moritake H, Kobayashi R, Deguchi T, Hashii Y, Imamura T, Sato A, Horibe K, Kiyokawa N, Manabe A, Ohara A, Sanada M, Hayashi Y, Miyano S, Oka A, Ogawa S, Takita J
  • Organizer: 第58回日本小児血液・がん学会学術集会
  • Place of Presentation: 品川プリンスホテル （東京）
  • Year and Date: 2016-12-16
• [Presentation] 小児固形腫瘍における治療標的の探索 (2016)
  • Author(s): 滝田順子
  • Organizer: 第58回日本小児血液・がん学会学術集会
  • Place of Presentation: 品川プリンスホテル （東京）
  • Year and Date: 2016-12-15
• [Presentation] Integrative genome-wide analysis of pancreatoblastoma (2016)
  • Author(s): Isobe T, Seki M, Yoshida K, Shiraishi Y, Chiba K, Tanaka H, Sato Y, Kataoka K, Suzuki H, Shimamura T, Kawai T, Kato M, Iguchi A, Hama A, Taguchi T, Akiyama M, Fujimura J, Inoue A, Ito T, Deguchi T, Kiyotani C, Yagyu S, Iehara T, Hosoi H, Oka A, Tanaka Y, Hata K, Miyano S, Ogawa S, Takita J
  • Organizer: 第58回日本小児血液・がん学会学術集会
  • Place of Presentation: 品川プリンスホテル （東京）
  • Year and Date: 2016-12-15
• [Presentation] 長期生存している再発神経芽腫の2例 (2016)
  • Author(s): 半谷まゆみ，三谷友一，関正史，樋渡光輝，岡明，滝田順子
  • Organizer: 第58回日本小児血液・がん学会学術集会
  • Place of Presentation: 品川プリンスホテル （東京）
  • Year and Date: 2016-12-15
• [Presentation] 再発神経芽腫において獲得された片親性ダイソミーによるALK遺伝子のホモ変異 (2016)
  • Author(s): 木村俊介，長谷川大輔，代田惇朗，関正史，吉本優理，平林真介，細谷要介，滝田順子，真部淳
  • Organizer: 第58回日本小児血液・がん学会学術集会
  • Place of Presentation: 品川プリンスホテル （東京）
  • Year and Date: 2016-12-15
• [Presentation] DNA損傷応答機構の破綻が進行神経芽腫のリスクとなり、PARP阻害剤への感受性を亢進する (2016)
  • Author(s): 高木正稔，吉田美沙，根本佳乃，玉一博之，土田里香，関正史，瓜生久美子，星野論子，西井里菜，宮本智史，齋藤正博，花田良二，金子英雄，深尾敏幸，白石友一，千葉健一，田中洋子，宮野悟，佐藤悠佑，片岡圭亮，奥野友介，吉田健一，岡明，森尾友宏，大平美紀，林泰秀，中川原章，小川誠司，水谷修紀，滝田順子
  • Organizer: 第58回日本小児血液・がん学会学術集会
  • Place of Presentation: 品川プリンスホテル （東京）
  • Year and Date: 2016-12-15
• [Presentation] Integrated genetic and epigenetic analysis defines novel molecular subgroups in rhabdomyosarcom． (2016)
  • Author(s): Seki M, Nishimura R, Yoshida K, Shimamura T, Shiraishi Y, Sato Y, Kato M, Chiba K, Tanaka H, Hoshino N, Nagae G, Shiozawa Y, Okuno Y, Hosoi H, Tanaka Y, Okita H, Miyachi M, Souzaki R, Taguchi T, Koh K, Hanada R, Kato K, Nomura Y, Akiyama M, Oka A, Igarashi T, Miyano S, Aburatni H, Hayashi Y, Ogawa S, Takita J
  • Organizer: 第58回日本小児血液・がん学会学術集会
  • Place of Presentation: 品川プリンスホテル （東京）
  • Year and Date: 2016-12-15
• [Presentation] ダウン症候群児における急性リンパ性白血病のメチル化解析 (2016)
  • Author(s): 久保田泰央，瓜生久美子，河合智子，伊東竜也，花田勇，土岐力，関正史，吉田健一，佐藤悠佑，白石友一，千葉健一，田中洋子，宮野悟，岡明，林泰秀，小川誠司，照井君典，佐藤篤，秦健一郎，伊藤悦朗，滝田順子
  • Organizer: 第58回日本小児血液・がん学会学術集会
  • Place of Presentation: 品川プリンスホテル （東京）
  • Year and Date: 2016-12-15
• [Presentation] 小児T 細胞性リンパ性白血病におけるTAL1スーパーエンハンサー変異とSTIL-TAL1融合遺伝子の臨床的特徴 (2016)
  • Author(s): 木村俊介，関正史，吉田健一，上野浩生，白石友一，千葉健一、田中洋子，鈴木啓道，片岡圭亮，大木健太郎，加藤元博，康勝好，花田良二，清河信敬，小林正夫，真部淳，小原明，林泰秀，宮野悟，小川誠司，滝田順子
  • Organizer: 第58回日本小児血液・がん学会学術集会
  • Place of Presentation: 品川プリンスホテル （東京）
  • Year and Date: 2016-12-15
• [Presentation] 当科で経験した臍帯血移植後のヒトヘルペスウイルス６型脳炎加療例について (2016)
  • Author(s): 三谷友一，半谷まゆみ，渡邊健太郎，関正史，樋渡光輝，滝田順子
  • Organizer: 第58回日本小児血液・がん学会学術集会
  • Place of Presentation: 品川プリンスホテル （東京）
  • Year and Date: 2016-12-15
• [Presentation] 小児がんに対する新規分子標的療法の開発 (2016)
  • Author(s): 樋渡光輝，関正史，滝田順子
  • Organizer: 第58回日本小児血液・がん学会学術集会
  • Place of Presentation: 品川プリンスホテル （東京）
  • Year and Date: 2016-12-15
• [Presentation] 肝芽腫のゲノム・エピゲノム解析 (2016)
  • Author(s): 関口昌央，関正史，磯部知弥，星野論子，吉田健一，白石友一，河合智子，吉田美沙，千葉健一，田中洋子，宗崎良太，秦健一郎，田中祐吉，田口智章，宮野悟，林泰秀，小川誠司，滝田順子
  • Organizer: 第58回日本小児血液・がん学会学術集会
  • Place of Presentation: 品川プリンスホテル （東京）
  • Year and Date: 2016-12-15
• [Presentation] Gene Expression Profiles and Methylation Analysis in Down Syndrome Related Acute Lymphoblastic Leukemia (2016)
  • Author(s): Kubota Y, Uryu K, Kawai T, Ito T, Hanada I, Toki T, Seki M, Yoshida K, kataoka K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Oka A, Yasuhide Hayashi Y, Ogawa S, Terui K, Sato A, Hata K, Ito E, Takita J
  • Organizer: 58th ASH Annual Meeting & Exposition
  • Place of Presentation: San Diego (U.S.A)
  • Year and Date: 2016-12-05
  • Int'l Joint Research
• [Presentation] Genome-Wide Mutational Landscape of Infant Acute Lymphoblastic Leukemia (2016)
  • Author(s): IsobeＴ, Yoshida K, Kobayashi C, Shiraishi Y, Chiba K, Tanaka H, Fukuda S, Yamamoto S, Tatsuno K, Aoki Y, Miyamura T, Tsutsumi S, Kiyokawa N, Ishihara T, Tomizawa D,Ishii E,Miyano S, Ogawa S, Aburatani H, Mizutani S, Takita J, Takagi M:
  • Organizer: 58th ASH Annual Meeting & Exposition
  • Place of Presentation: San Diego (U.S.A.)
  • Year and Date: 2016-12-05
  • Int'l Joint Research
• [Presentation] Identifications of Highly Aggressive Phenotype with SP11 Overexpression in Pediatric T Cell Acute Lymphoblastic Leukemia/Lymphoma (2016)
  • Author(s): Seki M, Kimura S, Yoshida K, Isobe T, 他24名，Hayashi Y, Mano H, Miyano S, Oka A, Ogawa S, Takita J
  • Organizer: 58th ASH Annual Meeting & Exposition
  • Place of Presentation: San Diego (U.S.A)
  • Year and Date: 2016-12-05
  • Int'l Joint Research
• [Presentation] TAL1 Super Enhancer Aberration and Stil-TAL1 Fusion in Pediatric T Cell Acute Lymphoblastic Leukemia (2016)
  • Author(s): Kimura S, Seki M, Yoshida K,Ueno H, Shiraishi Y, Chiba K, Tanaka H, Suzuki H, Kataoka K, Ohki K, Kato M, Koh K, Hanada R, Kiyokawa N, Kobayashi M, Manabe A, Ohara A, MD, Hayashi Y, Miyano S, Ogawa S, Takita J
  • Organizer: 58th ASH Annual Meeting & Exposition
  • Place of Presentation: San Diego (U.S.A)
  • Year and Date: 2016-12-05
  • Int'l Joint Research
• [Presentation] ALK関連小児固形腫瘍の遺伝学的特性 (2016)
  • Author(s): 滝田順子
  • Organizer: 第一回日本肉腫学会・日本臨床肉腫学会合同年次集会
  • Place of Presentation: 京都平安ホテル （京都）
  • Year and Date: 2016-12-02
  • Invited
• [Presentation] Recurrent Ewing’s sarcoma complicated with subsequent thyroid cancer in an autistic male patient: a case report (2016)
  • Author(s): Sekiguchi M, Seki M, Watanabe K, Hiwatari M, Nagayama K, Niwa T, Kawano H, Oka A, Takita J
  • Organizer: 日本肉腫学会/日本臨床肉腫学会合同シンポジウム
  • Place of Presentation: 京都平安ホテル （京都）
  • Year and Date: 2016-12-01
• [Presentation] Genetic and epigenetic alterations of pediatric leukemia (2016)
  • Author(s): Takita J
  • Organizer: Pediatric Hematology Forum 2016
  • Place of Presentation: 名古屋
  • Year and Date: 2016-11-19
  • Invited
• [Presentation] A case of 14q terminal deletion syndrome with pleuropulmonary blastoma (2016)
  • Author(s): Kubota Y, Seki M, Yoshida K, Sato Y, Oka A, Ogawa S, Takita J
  • Organizer: Asian Society for Pediatric Research 2016
  • Place of Presentation: Bangkok (Thailand)
  • Year and Date: 2016-11-10
  • Int'l Joint Research
• [Presentation] Integrated Genetic and Epigenetic Analysis of Hepatoblastoma (2016)
  • Author(s): Sekiguchi M, Seki M, Isobe M, Hoshino N, Yoshida K, Shiraishi Y, Kawai T, Yoshida M, Chiba K, Tanaka H, Sozaki R, Hata K, Tanaka Y, Taguch T, Miyano S, Hayashi Y, Ogawa S, Takita J
  • Organizer: Asian Society for Pediatric Research 2016
  • Place of Presentation: Bangkok (Thailand)
  • Year and Date: 2016-11-10
  • Int'l Joint Research
• [Presentation] Genome-wide multi-omic analysis of pediatric pancreatoblastom (2016)
  • Author(s): Isobe T, Seki M, Yoshida K, Iguchi A, Hama A, Taguchi T, Tanaka Y,Akiyama M, Fujimura J, Inoue A, Ito T, Deguchi T, Kato M, Kiyotani C, Yagyu S, Iehara T, Hosoi H, Miyano S, Ogawa S, Takita J
  • Organizer: The 48th Annual Congress of the International Society of Paediatric Oncology
  • Place of Presentation: Dubline (Ireland)
  • Year and Date: 2016-10-21
  • Int'l Joint Research
• [Presentation] Gene expression-based classification of paediatric germ cell tumors (2016)
  • Author(s): Kubota Y、Seki M、Isobe T、Yoshida K, Sat Y、Kataoka K、Shiraishi Y、Chiba K、Tanaka H、Hiwatari M、Miyano S、Hayashi Y、Oka A、Ogawa S、Takita J
  • Organizer: The 48th Annual Congress of the International Society of Paediatric Oncology
  • Place of Presentation: Dubline (Ireland)
  • Year and Date: 2016-10-21
  • Int'l Joint Research
• [Presentation] TAL1 super enhancer aberration and STIL-TAL1 fusion in pediatric T cell acute lymphoblastic leukemia (T-ALL) (2016)
  • Author(s): Kimura S, Seki M, Yoshida K, ShiraishiY, Chiba K, Tanaka H, Suzuki H, Kataoka K, Kato M, Koh K, Hanada R, Imamura T, Kiyokawa N, Hashii Y, Ohara A, Deguchi T, Horibe K, Hayashi Y, Miyano S, Ogawa S, Takita J
  • Organizer: The 48th Annual Congress of the International Society of Paediatric Oncology
  • Place of Presentation: Dubline (Ireland)
  • Year and Date: 2016-10-21
  • Int'l Joint Research
• [Presentation] TAL1 abnormalities in childhood T-Cell acute lymphoblastic leukemia (2016)
  • Author(s): Seki M, Yoshida K, Kimura S, Isobe T, ShiraishiY, Kato M, Koh K, Hanada R, DeguchiT, Imamura T, Horibe K, Kiyokawa N, Manabe A, Ohara A, Sanada M, Mano H, HayashiY, Miyano S, Oka A, Ogawa S, Takita J
  • Organizer: The 48th Annual Congress of the International Society of Paediatric Oncology
  • Place of Presentation: Dubline (Ireland)
  • Year and Date: 2016-10-19
  • Int'l Joint Research
• [Presentation] Genetic and epigenetic alterations of pediatric leukemia and application (2016)
  • Author(s): Takita J
  • Organizer: 日本血液学会
  • Place of Presentation: パシフィコ横浜 (横浜）
  • Year and Date: 2016-10-15
  • Invited
• [Presentation] Identifications of novel recurrent SP11 fusions in highly aggressive phenotype of pediatric T-ALL (2016)
  • Author(s): Seki M, Yoshida K, Kimura S, Ueno H, Shiraishi Y, Takagi M, Iwama A, Kataoka K, Shiozawa Y, Kato M, Moritake H, Koh K, Hanada R, Hashii Y, Deguchi T, Kobayashi R, Sato A, Imamura T, Horibe K, Ohki K, Kiyokawa N, Manabe A, Ohara A, Sanada M, Mano H, Oka A, Miyano S, Hayashi Y, Ogawa S, Takita J
  • Organizer: 第78回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜 (横浜）
  • Year and Date: 2016-10-13
• [Presentation] Loss of DNA damage response in advanced neuroblastoma and potential a therapeutic target for RARP inhibitor (2016)
  • Author(s): Takagi M, Takita J
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜 (横浜）
  • Year and Date: 2016-10-08
• [Presentation] 統合的ゲノム解析による小児Ｔ細胞性急性リンパ性白血病における新規標的の同定 (2016)
  • Author(s): 滝田順子
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜 (横浜）
  • Year and Date: 2016-10-08
• [Presentation] Clustering analysis on gene expression data of pediatric hepatoblastoma (2016)
  • Author(s): Sekiguchi M, Seki M, Hoshino N, Yoshida K, Shiraishi Y, Yoshida M, Souzaki R, Tanaka Y, Taguchi T, Miyano S, Hayashi Y, Ogawa S, Takita J
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜 (横浜）
  • Year and Date: 2016-10-08
• [Presentation] Mutation analysis of NOTCH1and FBXW7 in pediatric T cell acute lymphoblastic leukemia (T-ALL) (2016)
  • Author(s): Kimura S, Seki M, Yoshida K, Shiraishi Y, Chiba K, Tanaka H, Akiyama M, Koh K, Miyano S, Imamura T, Ogawa S, Takita J
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜 (横浜）
  • Year and Date: 2016-10-07
• [Presentation] 小児胚細胞腫瘍の遺伝子発現プロファイルに基づくクラスタリング (2016)
  • Author(s): 久保田泰央，関正史，吉田健一，佐藤悠佑，白石友一，千葉健一，田中洋子，田中祐吉，宮野悟，岡明，林泰秀，小川誠司，滝田順子．
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜 (横浜）
  • Year and Date: 2016-10-07
• [Presentation] 小児T-ALLにおけるSPI1高発現を呈する新規高悪性度群の同定 (2016)
  • Author(s): 関正史、吉田健一、木村俊介、白石友一、今村俊彦、堀部敬三、清河信敬、小原明、眞田昌、間野博行、宮野悟、小川誠司、滝田順子
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜 (横浜）
  • Year and Date: 2016-10-07
• [Presentation] Genetic characteristic of 500 neuroblastomas using genomewide combined with immunohistochemistry (2016)
  • Author(s): Uryu K, Yoshida K, Kataoka K, Seki M, Hiwatari M, Hayashi Y, Nakazawa A, Takimoto T, Tajiri T, Nakagawara A, Miyano S, Ogawa S, Takita J
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜 (横浜）
  • Year and Date: 2016-10-06
• [Presentation] 小児固形腫瘍の治療と分子病態の解明 (2016)
  • Author(s): 滝田順子
  • Organizer: 2016年小児血液・がんセミナー in 関西
  • Place of Presentation: 新大阪丸ビル別館 (大阪)
  • Year and Date: 2016-09-25
  • Invited
• [Presentation] 小児固形腫瘍のゲノム・エピゲノム異常 (2016)
  • Author(s): 滝田順子
  • Organizer: 臨床遺伝子学セミナー
  • Place of Presentation: 家の光会館コンベンションホール (東京)
  • Year and Date: 2016-08-21
  • Invited
• [Presentation] 分子生物学の進歩：神経芽腫 (2016)
  • Author(s): 滝田順子
  • Organizer: TCCSG夏季例会
  • Place of Presentation: 東京
  • Year and Date: 2016-07-23
  • Invited
• [Presentation] Integrated Genetic Analysis of Pediatric T-cell Acute Lymphoblastic Leukemia (2016)
  • Author(s): Takita J
  • Organizer: The 5th JCA-AACR Special Joint Conference
  • Place of Presentation: Tokyo Bay Maihama Hotel Club Resort (千葉)
  • Year and Date: 2016-07-15
  • Invited
• [Presentation] Genetic and epigenetic alterations in childhood leukemia (2016)
  • Author(s): Takita J
  • Organizer: The 5th JCA-AACR Special Joint Conference
  • Place of Presentation: Tokyo Bay Maihama Hotel Club Resort (千葉)
  • Year and Date: 2016-07-14
  • Invited
• [Presentation] DNA methylation analysis in acute lymphoblatic leukemia of Down syndrome (2016)
  • Author(s): Kubota Y, Uryu K, Kawai T, Ito T, Hanada I, Toki T, Seki M, Yoshida K, Sato Y, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Oka A, Hayashi Y, Ogawa S, Terui K, Sato A, Hata K, Ito E, Takita J
  • Organizer: The 35th Sapporo International Cancer Symposium 2016
  • Place of Presentation: ロイトン札幌 （札幌）
  • Year and Date: 2016-06-24
  • Int'l Joint Research
• [Presentation] Identification of novel pathways and molecules able to down regulate oncogenes expression by in vitro drug screening approaches in neuroblastoma cells (2016)
  • Author(s): Hiwatari M, Seki M, Oka A, Takita J
  • Organizer: Advances in Neuroblastoma Research
  • Place of Presentation: Cairns (Australia)
  • Year and Date: 2016-06-21
  • Int'l Joint Research
• [Presentation] Genetic characteristics of 494 neuroblastomas using genome-wide analysis combined with immunohistochemistry (2016)
  • Author(s): Uryu K, Nishimura R, Yoshida K, Kataoka K, Shiraishi Y, Chiba K , Tanaka H, Seki M , Hoshino N, Hiwatari M, Oka A, Hayashi Y, Nakazawa A, Takimoto T, Tajiri T, Nakagawara A, Miyano S, Ogawa S, Takita J
  • Organizer: Advances in Neuroblastoma Research
  • Place of Presentation: Cairns (Australia)
  • Year and Date: 2016-06-20
  • Int'l Joint Research
• [Presentation] 小児固形腫瘍の分子病態の解明 (2016)
  • Author(s): 滝田順子
  • Organizer: 第22回北愛媛小児血液・悪性腫瘍研究会
  • Place of Presentation: 愛媛
  • Year and Date: 2016-06-17
  • Invited
• [Presentation] 小児固形腫瘍の病態解明を目指した統合的ゲノム・エピゲノム解析 (2016)
  • Author(s): 滝田順子
  • Organizer: 第12回北関東小児がんセミナー
  • Place of Presentation: 群馬
  • Year and Date: 2016-05-21
  • Invited
• [Presentation] 中枢神経浸潤を伴うALCLに対し大量MTX療法と髄注を強化した化学療法を行った2歳男児例 (2016)
  • Author(s): 関口昌央，樋渡光輝，半谷まゆみ，久保田泰央，滝田順子，岡明
  • Organizer: 第119回日本小児科学会学術集会
  • Place of Presentation: ロイトン札幌 （札幌）
  • Year and Date: 2016-05-14
• [Presentation] 血病を合併したマフッチ症候群におけるエクソーム解析 (2016)
  • Author(s): 関正史，吉田健一，加藤元博，秋山正晴，百名伸之，真部淳，小川誠司，滝田順子，岡明
  • Organizer: 第119回日本小児科学会学術集会
  • Place of Presentation: ロイトン札幌 （札幌）
  • Year and Date: 2016-05-13
• [Presentation] Down-ALLとnon Down-All における遺伝子背景の相違 (2016)
  • Author(s): 瓜生久美子，吉田健一，関正史，樋渡光輝，康勝好，後藤裕明，小川誠司，宮野悟，滝田順子，岡明
  • Organizer: 第119回日本小児科学会学術集会
  • Place of Presentation: ロイトン札幌 （札幌）
  • Year and Date: 2016-05-13
• [Presentation] 神経芽腫に対する新規分子標的療法の開発 (2016)
  • Author(s): 樋渡光輝，関正史，星野論子，瓜生久美子，滝田順子，岡明
  • Organizer: 第119回日本小児科学会学術集会
  • Place of Presentation: ロイトン札幌（ 札幌）
  • Year and Date: 2016-05-13
• [Presentation] 神経芽腫におけるATMとその関連遺伝子の解析 (2016)
  • Author(s): 吉田美沙，瓜生久美子，関正史，星野論子，樋渡光輝，吉田健一，小川誠司，林泰秀，滝田順子，岡明
  • Organizer: 第119回日本小児科学会学術集会
  • Place of Presentation: ロイトン札幌 （札幌）
  • Year and Date: 2016-05-13
• [Presentation] Major Symposium, Characteristics of ALK-related pediatric cancers (2016)
  • Author(s): Takita J
  • Organizer: AACR2016
  • Place of Presentation: New Orleans ( U.S..A.)
  • Year and Date: 2016-04-18
  • Int'l Joint Research / Invited
• [Presentation] TAL1 and MYB Abnormalities in Childhood T-Cell Acute Lymphoblastic Leukemia． (2015)
  • Author(s): Seki M, Yoshida K, Shiraishi Y, Chiba K, Tanaka H, Kato M, Kimura S, Hanada R, Koh K, Miyano S, Imamura T, Horibeb K, Kiyokawa N, Manabe A, Ohara A, Hayashi Y, Oka A, Ogawa S, Takita J．
  • Organizer: 57th American Society of Hematology Annual Meeting
  • Place of Presentation: San Diego, U.S.A.
  • Year and Date: 2015-12-05
  • Int'l Joint Research
• [Presentation] Integrated genetic/epigenetic analysis of rhabdomyosarcoma． (2015)
  • Author(s): 滝田順子
  • Organizer: 日本肉腫学会記念シンポジウム
  • Place of Presentation: 京都平安ホテル（京都）
  • Year and Date: 2015-12-03
• [Presentation] 神経芽腫における統合的ゲノム解析． (2015)
  • Author(s): 滝田順子
  • Organizer: 第57回日本小児血液・がん学会学術集会
  • Place of Presentation: 甲府富士屋ホテル（甲府、山梨）
  • Year and Date: 2015-11-27
• [Presentation] Genetic characterization of ALK positive neuroblastoma using genome-wide analysis combined with immunohistochemistry. (2015)
  • Author(s): Uryu K, Nishimura R, Yoshida K, Seki M, Hoshino N, Kato M, Hiwatari M, Oka A, Hayashi Y, Nakazawa A, Tajiri T, Nakagawara A, Miyano S, Ogawa S, Takita J.
  • Organizer: 第57回日本小児血液・がん学会学術集会
  • Place of Presentation: 甲府富士屋ホテル（甲府、山梨）
  • Year and Date: 2015-11-27
• [Presentation] A comparison of the genetic feature in Down syndrome-ALL and non-Down syndrome-ALL. (2015)
  • Author(s): Uryu K, Yoshida K, Seki M, Hoshino N, Kato M, Hiwatari M, Oka A, Ogawa S, Miyano S, Kikuchi A, Takita J.
  • Organizer: 第57回日本小児血液・がん学会学術集会
  • Place of Presentation: 甲府富士屋ホテル（甲府、山梨）
  • Year and Date: 2015-11-27
• [Presentation] 小児胚細胞腫瘍のゲノム網羅的解析． (2015)
  • Author(s): 久保田泰央，関正史，樋渡光輝，加藤元博，吉田健一，佐藤悠佑，白石友一，千葉健一，田中洋子，宮野悟，康勝好，林泰秀，小川誠司，滝田順子．
  • Organizer: 第57回日本小児血液・がん学会学術集会
  • Place of Presentation: 甲府富士屋ホテル（甲府、山梨）
  • Year and Date: 2015-11-27
• [Presentation] Identification of subgroup of pediatric ALL who can and cannot be cured by short maintenance therapy． (2015)
  • Author(s): Kato M，Manabe A, Ishimaru S, Seki M, Yoshida K, Sato Y, Tomizawa D, Hasegawa D, Inukai T, Arakawa Yi, Aoki T, Okuya M, Kaizu K, Kato K, Taneyama Y, Takita J, Ogawa Si, Koh K, Tsuchida M, Ohara A
  • Organizer: 第57回日本小児血液・がん学会学術集会
  • Place of Presentation: 甲府富士屋ホテル（甲府、山梨）
  • Year and Date: 2015-11-27
• [Presentation] 膵芽腫におけるゲノム異常を特徴付ける11p15.5ヘテロ接合生喪失とCTNNB1体細胞変異． (2015)
  • Author(s): 関正史, 磯部知哉, 吉田健一, 白石友一, 千葉健一, 田中洋子, 佐藤悠介, 加藤元博, 井口晶裕, 濱麻人, 宗崎良太, 田口智章, 田中祐吉, 秋山政晴, 藤村純也, 井上彰子, 伊藤剛, 出口隆生, 宮野悟, 小川誠司, 滝田順子.
  • Organizer: 第57回日本小児血液・がん学会学術集会
  • Place of Presentation: 甲府富士屋ホテル（甲府、山梨）
  • Year and Date: 2015-11-27
• [Presentation] MLL遺伝子を含んだ3方向転座を有した乳児白血病の1例． (2015)
  • Author(s): 樋渡光輝, 関正史, 加藤元博, 吉田健一, 小川誠司, 滝田順子.
  • Organizer: 第57回日本小児血液・がん学会学術集会
  • Place of Presentation: 甲府富士屋ホテル（甲府、山梨）
  • Year and Date: 2015-11-27
• [Presentation] 甲状腺濾胞癌の発生を契機に生殖細胞のDICER1遺伝子異常を同定した2症例．. (2015)
  • Author(s): 吉田美沙, 村岡枝里香, 関正史, 吉田健一, 浜之上聡, 武山絵里子, 田中水緒, 後藤裕明, 宮野悟, 小川誠司, 滝田順子, 田中祐吉.
  • Organizer: 第57回日本小児血液・がん学会学術集会
  • Place of Presentation: 甲府富士屋ホテル（甲府、山梨）
  • Year and Date: 2015-11-27
• [Presentation] 過去10年間に当院で治療した小児骨肉腫の検討． (2015)
  • Author(s): 半谷まゆみ, 関口昌央, 久保田泰央, 関正史, 樋渡光輝, 岡明, 滝田順子．
  • Organizer: 第57回日本小児血液・がん学会学術集会
  • Place of Presentation: 甲府富士屋ホテル（甲府、山梨）
  • Year and Date: 2015-11-27
• [Presentation] ユーイング肉腫再発時に甲状腺がん微小肺転移が発見された一例． (2015)
  • Author(s): 関口昌央, 関正史, 加藤元博, 渡邉健太郎, 樋渡光輝, 丹羽隆善, 河野博隆, 岡明, 滝田順子．
  • Organizer: 第57回日本小児血液・がん学会学術集会
  • Place of Presentation: 甲府富士屋ホテル（甲府、山梨）
  • Year and Date: 2015-11-27
• [Presentation] 小児がんにおける治療分子標的の探索 (2015)
  • Author(s): 滝田順子
  • Organizer: 第53回日本癌治療学会学術集会
  • Place of Presentation: 国立京都国際会館（京都）
  • Year and Date: 2015-10-30
• [Presentation] Whole exome and transcriptome analyses in pediatric T-cell acute lymp hoblastic leukemia. (2015)
  • Author(s): Seki M, Yoshida K, Shiraishi Y, Chiba K, Tanaka H, Kato M, Imamura T, Hanada R, Miyano S, Hayashi Y, Ogawa S, Takita J.
  • Organizer: 第77回日本血液学会学術集会
  • Place of Presentation: ＡＮＡクラウンプラザホテル金沢（金沢、石川）
  • Year and Date: 2015-10-16
• [Presentation] 2015 JCA-Mauvernay Award受賞記念講演 (2015)
  • Author(s): 滝田順子
  • Organizer: 第74回日本癌学会学術総会．
  • Place of Presentation: 名古屋国際会議場（名古屋、愛知）
  • Year and Date: 2015-10-10
• [Presentation] シンポジウム Integrated genetic/epigenetic analysis of pediatric solid tumors． (2015)
  • Author(s): 滝田順子
  • Organizer: 第74回日本癌学会学術総会．
  • Place of Presentation: 名古屋国際会議場（名古屋、愛知）
  • Year and Date: 2015-10-08
• [Presentation] エクソーム解析を用いた膵芽腫における腫瘍内ヘテロ不均一性の解析． (2015)
  • Author(s): 関正史、磯部知弥、吉田健一、白石友一、千葉健一、田中洋子、佐藤悠佑、加藤元博、井口晶裕、宮野悟、小川誠司、滝田順子．
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場（名古屋、愛知）
  • Year and Date: 2015-10-08
• [Presentation] 小児胚細胞腫瘍のゲノム網羅的な変異・構造解析． (2015)
  • Author(s): 久保田泰央、関正史、吉田健一、佐藤悠佑、白石友一、千葉健一、田中洋子、樋渡光輝、加藤元博、宮野悟、林泰秀、小川誠司、滝田順子．
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場（名古屋、愛知）
  • Year and Date: 2015-10-08
• [Presentation] 「がんゲノミクスに立脚した難治性小児がんの克服」～ゲノム研究の先に目指すもの～ (2015)
  • Author(s): 滝田順子
  • Organizer: 第19回山梨血液研究会サマーセミナー
  • Place of Presentation: 山梨大学（甲府、山梨）
  • Year and Date: 2015-07-24
• [Presentation] 精神発達遅滞を合併した左肺動脈起始異常症の診断においてSNPアレイが有用であった一例． (2015)
  • Author(s): 西川由衣, 平田陽一郎, 田中優, 進藤孝洋, 犬塚亮, 清水信隆, 関正史, 滝田順子, 岡 明.
  • Organizer: 第51回日本小児循環器学会
  • Place of Presentation: ホテル日航東京（東京）
  • Year and Date: 2015-07-18
• [Presentation] 化膿性リンパ節炎を契機に診断した小児甲状腺乳頭がんの1例． (2015)
  • Author(s): 磯島豪, 日高もえ, 加藤元博, 三浦健一郎, 安戸裕貴, 張田豊, 関正史, 滝田順子, 北中幸子, 岡 明．
  • Organizer: 第88回日本内分泌学会学術総会
  • Place of Presentation: ホテルニューオータニ（東京）
  • Year and Date: 2015-04-25
• [Presentation] 特別企画 「小児がんの克服を目指してベンチからベッドサイドへ」 (2015)
  • Author(s): 滝田順子
  • Organizer: 第１１８回日本小児科学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪）
  • Year and Date: 2015-04-18
• [Presentation] Integrated genetic and epigenetic analysis defines novel molecular clusters in rhabdomyosarcoma. (2015)
  • Author(s): Seki M, Nishimura R, Yoshida K, Shimamura T, Shiraishi Y, Sato Y, Kato M, Chiba K, Tanaka H, Nagae G, Okuno Y, Hoso H, Tanaka Y, Ohkita H, Miyashi M, Taguchi T, Koh K, Hanada R, Oka A, Miyano S, Aburatani H, Hayashi Y, Ogawa S, Takita J
  • Organizer: American Association for Cancer Research 2015
  • Place of Presentation: Pensylvania, U.S.A
  • Year and Date: 2015-04-18
  • Int'l Joint Research
• [Presentation] Clonal evolution and integral analysis of hepatoblastoma. (2015)
  • Author(s): Hoshino N, Seki M, Kato M, Yoshida K, Sato Y, Nakazawa A, Miyano S, Oka A, Iwanaka T, Hayashi Y, Ogawa S, Takita J
  • Organizer: American Association for Cancer Research 2015
  • Place of Presentation: Pensylvania, U.S.A
  • Year and Date: 2015-04-18
  • Int'l Joint Research
• [Presentation] 小児がんの克服を目指して”ベンチからベッドサイドへ” (2015)
  • Author(s): 滝田順子
  • Organizer: 第１１８回日本小児科学会学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2015-04-17 – 2015-04-19
• [Presentation] 統合的ゲノム解析によるLCH合併T−ALLにおける分子病態の解明． (2015)
  • Author(s): 関正史，大山亮，加藤元博，吉田健一，荒川ゆうき，岸本宏志，花田良二，滝田順子，康勝好，岡明
  • Organizer: 第１１８回日本小児科学会学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2015-04-17 – 2015-04-19
• [Presentation] RNA シークエンスを用いた年長児の神経芽腫症例の解析． (2015)
  • Author(s): 樋渡光輝，関正史，加藤元博，吉田健一，小川誠司，滝田順子
  • Organizer: 第１１８回日本小児科学会学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2015-04-17 – 2015-04-19
• [Presentation] 肝芽腫におけるエクソーム，トランスクリプトーム，SNPアレイを用いた統合的解析． (2015)
  • Author(s): 星野論子，関正史，加藤元博，吉田健一，宗崎良太，田口智章，林泰秀，岩中督，滝田順子，岡明
  • Organizer: 第１１８回日本小児科学会学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2015-04-17 – 2015-04-19
• [Presentation] RNA シークエンスを用いた年長児の神経芽腫症例の解析． (2015)
  • Author(s): 樋渡光輝，関正史, 加藤元博, 吉田健一, 小川誠司, 滝田順子
  • Organizer: 第118回日本小児科学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪）
  • Year and Date: 2015-04-17
• [Presentation] 統合的ゲノム解析によるLCH 合併T‐ALL における分子病態の解明． (2015)
  • Author(s): 関正史，大山亮，加藤元博，吉田健一，荒川ゆうき，岸本宏志，花田良二，滝田順子，康勝好，岡明．
  • Organizer: 第118回日本小児科学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪）
  • Year and Date: 2015-04-17
• [Presentation] 肝芽腫におけるエクソーム，トランスクリプトーム，SNPアレイを用いた統合的解析． (2015)
  • Author(s): 星野論子，関正史，加藤元博，吉田健一，宗崎良太，田口智章，林泰秀，岩中督，滝田順子，岡明．
  • Organizer: 第118回日本小児科学会学術集会
  • Place of Presentation: 大阪国際会議場、大阪
  • Year and Date: 2015-04-17
• [Presentation] 先天性孤立性肺静脈狭窄症を合併したMowat-Wilson症候群の1例． (2015)
  • Author(s): 進藤考洋, 古谷憲孝, 関正史, 犬塚亮, 林泰佑, 平田陽一郎, 清水信隆, 生井良幸, 滝田順子, 岡明．
  • Organizer: 第118回日本小児科学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪）
  • Year and Date: 2015-04-17
• [Presentation] 化膿性リンパ節炎を契機に診断した小児甲状腺乳頭がんの1例． (2015)
  • Author(s): 日高もえ, 磯島豪, 加藤元博, 三浦健一郎, 安戸裕貴, 張田豊, 関正史, 滝田順子, 北中幸子, 岡明．
  • Organizer: 第118回日本小児科学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪）
  • Year and Date: 2015-04-17
• [Presentation] The Genetic landscape of neuroblastoma. (2015)
  • Author(s): Uryu K, Nishimura R, Yoshida K, Seki M, Kato M, Oka A, Hayashi Y, Tajiri T, Nakagawara A, Ogawa S, Takita J.
  • Organizer: The 11th Asian Society for Pediatric Research
  • Place of Presentation: グランキューブ大阪（大阪）
  • Year and Date: 2015-04-15
  • Int'l Joint Research
• [Presentation] Integrated genetic and epigenetic analysis in rhabdomyosarcoma. (2015)
  • Author(s): Seki M, Yoshida K, Hosoi H, Tanaka Y, Okita H, Hanada R, Igarashi T, Oka A, Hayahshi Y, Ogawa S, Takita J.
  • Organizer: The 11th Asian Society for Pediatric Research
  • Place of Presentation: グランキューブ大阪（大阪）
  • Year and Date: 2015-04-15
  • Int'l Joint Research
• [Presentation] Genetic alterations in ATM pathway related genes in neuroblastoma. (2015)
  • Author(s): Yoshida M, Kato M, Uryu K, Hoshino N, Seki M, Hiwatari M, Yoshida K, Oka A, Ogawa S, Hayashi Y, Takita J.
  • Organizer: The 11th Asian Society for Pediatric Research
  • Place of Presentation: グランキューブ大阪（大阪）
  • Year and Date: 2015-04-15
  • Int'l Joint Research
• [Presentation] Clonal evolution and pathology in hepatoblastoma with familial adenomatous polyposis. (2015)
  • Author(s): Hoshino N, Seki M, Yoshida K, Kato M, Sato Y, Nakagawa A, Miyano S, Iwanaka T, Oka A, Ogawa S, Takita J.
  • Organizer: The 11th Asian Society for Pediatric Research
  • Place of Presentation: グランキューブ大阪（大阪）
  • Year and Date: 2015-04-15
  • Int'l Joint Research
• [Presentation] Transcriptome profiling of neuroblastoma in higher stages by RNA-Sequencing. (2015)
  • Author(s): Hiwatari M, Seki M, Kato M, Yoshida K, Ogawa S, Oka A, Takita J
  • Organizer: The 11th Asian Society for Pediatric Research
  • Place of Presentation: グランキューブ大阪（大阪）
  • Year and Date: 2015-04-15
  • Int'l Joint Research
• [Presentation] 統合的ゲノム解析による小児腫瘍の病態解明 (2014)
  • Author(s): 滝田順子
  • Organizer: 第５回信濃町小児がんクラスター症例検討会
  • Place of Presentation: 東京
  • Year and Date: 2014-12-26
  • Invited
• [Presentation] Whole Exome and Transcriptome Analyses in Pediatric T-Cell Acute Lymphoblastic Leukemia. (2014)
  • Author(s): Seki M, Yoshida K, Shiraishi Y, Chiba K, Tanaka H, Kato M, Hanada R, Miyano S, ide Hayashi Y, Ogawa S, Takita J
  • Organizer: 56th Annual Meeting of American Society of Hematology
  • Place of Presentation: San Francisco, U.S.A.
  • Year and Date: 2014-12-06 – 2014-12-09
• [Presentation] Transcriptome profiling of neuroblastoma by RNA-Seq. (2014)
  • Author(s): Hiwatari M, Seki M, Shiozawa R, Kato M, Yoshida K, Ogawa S, Takita J.
  • Organizer: 第56回日本小児血液・がん学会学術集会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2014-11-28 – 2014-11-30
• [Presentation] ntegrated analysis of clonal evolution in hepatoblastoma with familial adenomatous polyposis. (2014)
  • Author(s): Hoshino N, Seki M, Yoshida K, Kato M, Sato Y, Kasahara M, Nakazawa A, Miyano S, Hayashi Y, Oka A, Iwanaka T, Takita J.
  • Organizer: 第56回日本小児血液・がん学会学術集会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2014-11-28 – 2014-11-30
• [Presentation] Landscape of genomic alteration of pediatric germ cell tumors. (2014)
  • Author(s): Shiozawa R, Seki M, Hoshino N, Yoshida K, Yoshida M, Uryu K, Hiwatari M, Kato M, Ogawa S, Oka A, Takita J.
  • Organizer: 第56回日本小児血液・がん学会学術集会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2014-11-28 – 2014-11-30
• [Presentation] Integrated genetic and epigenetic analysis defines novel molecular clusters in rhabdomyosarcoma. (2014)
  • Author(s): Seki M, Nishimura R, Yoshida K, Shimamura T, Shiraishi Y, Sato Y, Hoshino N, Nagae G, Okuno Y, Hosoi H, Tanaka Y, Okita H, Taguchi T, Hanada R, Oka A, Miyano S, Aburatani H, Hayashi Y, Ogawa S, Takita J.
  • Organizer: 第56回日本小児血液・がん学会学術集会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2014-11-28 – 2014-11-30
• [Presentation] The role of epigenetic dysregulation in neuroblastoma. (2014)
  • Author(s): Hoshino N, Seki M, Yoshida K, Kato M, Nishimura R, Sato Y, Miyano S, Nagae G, Hayashi Y, Oka A, Aburatani H, Iwanaka T, Ogawa S, Takita J
  • Organizer: 第56回日本小児血液・がん学会学術集会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2014-11-28 – 2014-11-30
• [Presentation] 中心静脈カテーテル関連血流感染 (CRBSI) の予防に対する試みとその効果． (2014)
  • Author(s): 渡邉健太郎，加藤元博，張田豊，関口昌央，塩澤亮輔，樋渡光輝，滝田順子，岡明
  • Organizer: 第56回日本小児血液・がん学会学術集会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2014-11-28 – 2014-11-30
• [Presentation] 再発膵芽腫のマルチサンプリングによる腫瘍内不圴一およびクローン進化の考察． (2014)
  • Author(s): 磯部知弥，関正史，吉田健一，白石友一，千葉健一，田中洋子，佐藤悠佑，加藤元博，井口晶裕，濱麻人，田中祐吉，宮野悟，小川誠司，岡明，滝田順子
  • Organizer: 第56回日本小児血液・がん学会学術集会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2014-11-28 – 2014-11-30
• [Presentation] 重篤な慢性心不全を合併した21トリソミー児のAMKLに対する緩和的化学療法． (2014)
  • Author(s): 関口昌央，加藤元博，渡邉健太郎，塩澤亮輔，樋渡光輝，林泰佑，平田陽一郎，滝田順子，岡明
  • Organizer: 第56回日本小児血液・がん学会学術集会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2014-11-28 – 2014-11-30
• [Presentation] 神経芽腫におけるターゲット遺伝子の深々度シークエンス． (2014)
  • Author(s): 瓜生久美子，西村力，吉田健一，関正史，星野論子，吉田美沙，加藤元博，樋渡光輝，岡明，林泰秀，田尻達郎，中川原章，滝田順子
  • Organizer: 第56回日本小児血液・がん学会学術集会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2014-11-28 – 2014-11-30
• [Presentation] 神経芽腫におけるATM pathway 関連遺伝子の異常． (2014)
  • Author(s): 吉田美沙，関正史，加藤元博，瓜生久美子，星野論子，西村力，樋渡光輝，吉田健一，岡明，小川誠司，林泰秀，滝田順子
  • Organizer: 第56回日本小児血液・がん学会学術集会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2014-11-28 – 2014-11-30
• [Presentation] 神経芽腫再発２例に対する網羅的ゲノム解析． (2014)
  • Author(s): 物井綾香，関正史，吉田健一，佐藤悠佑，加藤元博，樋渡光輝，星野論子，竹谷健，白石友一，千葉健一，田中洋子，宮野悟，岡明，林泰秀，小川誠司，滝田順子
  • Organizer: 第56回日本小児血液・がん学会学術集会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2014-11-28 – 2014-11-30
• [Presentation] 先天性高悪性脳腫瘍の１例． (2014)
  • Author(s): 木本豪，加藤元博，関口昌央，渡邉健太郎，塩澤亮輔，樋渡光輝，阿部浩幸，田中麻理子，武笠晃丈，滝田順子，岡明
  • Organizer: 第56回日本小児血液・がん学会学術集会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2014-11-28 – 2014-11-30
• [Presentation] 慢性活動性EBV感染症の１倍検例． (2014)
  • Author(s): 塩澤亮輔，樋渡光輝，加藤元博，田中淳，滝田順子，岡明
  • Organizer: 第56回日本小児血液・がん学会学術集会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2014-11-28 – 2014-11-30
• [Presentation] ALK陽性思春期神経芽腫に対するクリゾチニブの治療経験． (2014)
  • Author(s): 松野良介，大貫裕太，藤田祥央，花村麻衣子，塚田大樹，秋山康介，外山大輔，池田祐一，関正史，加藤元博，樋渡光輝，滝田順子，磯山恵一
  • Organizer: 第56回日本小児血液・がん学会学術集会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2014-11-28 – 2014-11-30
• [Presentation] 未分化大細胞型リンパ腫におけるALK転座染色体の過剰を伴った急性転化． (2014)
  • Author(s): 星野顕宏，野村恵子，関正史，樋渡光輝，吉田健一，小川誠司，滝田順子，金兼弘和
  • Organizer: 第56回日本小児血液・がん学会学術集会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2014-11-28 – 2014-11-30
• [Presentation] 腎静脈浸潤を認めた先天性間葉芽腎腫の一例． (2014)
  • Author(s): 藤代準，杉山正彦，新井真理，石丸哲也，吉田真理子，魚谷千都恵，宮川亨平，加藤元博，滝田順子，土田晋也，高橋尚人，岩中督
  • Organizer: 第56回日本小児血液・がん学会学術集会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2014-11-28 – 2014-11-30
• [Presentation] FFGFR－1増幅を伴う治療抵抗性未分化肉腫の１例． (2014)
  • Author(s): 杣津晋平，合井久美子，渡邊敦，犬飼岳史，蓮田憲夫，高野邦夫，近藤哲夫，中澤温子，宮地充，細井創，滝田順子，後藤裕明，杉田莞爾
  • Organizer: 第56回日本小児血液・がん学会学術集会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2014-11-28 – 2014-11-30
• [Presentation] Congenital and childhood plexiform (multinodular) cellar schwannoma の１乳児例． (2014)
  • Author(s): 宮川亨平，藤代準，高見尚平，加藤怜子，出家亨一，魚谷千都絵，吉田真理子，石丸哲也，新井真理，杉山正彦，岩中督，加藤元博，渡邉健太郎，滝田順子，柴原順二
  • Organizer: 第56回日本小児血液・がん学会学術集会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2014-11-28 – 2014-11-30
• [Presentation] 小児造血細胞移植後フォローアップ外来の取り組みと課題． (2014)
  • Author(s): 岩崎美和，割田陽子，滝田順子，加藤元博，樋渡光輝，大友英子，宮里由香里
  • Organizer: 第56回日本小児血液・がん学会学術集会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2014-11-28 – 2014-11-30
• [Presentation] Integrated genomic analysis of pediatric solid tumors (2014)
  • Author(s): 滝田順子
  • Organizer: 第11回日独先端科学（JGFoS）シンポジウム
  • Place of Presentation: ヴレーメン ドイツ
  • Year and Date: 2014-10-31 – 2014-11-02
  • Invited
• [Presentation] Integrative genome analysis of T cell acute lymphoblastic leukemia with subsequent development of Langerhans cell histocytosis. (2014)
  • Author(s): Seki M, Kat M, Ohyama R, Yoshida K, Sato Y, Shiraishi Y, Chiba K, Tanaka H, Arakawa Y, Kishimot H, Sanada M, Miyano S, Oka A, Hanada R, Ogawa S, Koh K, Takita J
  • Organizer: 第76回日本血液学会学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2014-10-31 – 2014-11-02
• [Presentation] Genome-wide Epigenetic and copy number analyses in Rhabdomyosarcoma. (2014)
  • Author(s): Seki M, Shimamura T, Yoshida K, Sato Y, Nishimura R, Kato M, Nagae G, Oka A, Miyano S, Aburatani H, Hayashi Y, Ogawa S, Takita J
  • Organizer: 46th Congress of the International Society of Paediatric Oncology
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2014-10-22 – 2014-10-25
• [Presentation] Genome-wide approach to identify gene targets of pancreatoblastoma. (2014)
  • Author(s): Isobe T, Seki M, Yoshida K, Shiraishi Y, Chiba K, Tanaka H, Sato Y, Kato M, Hama A, Tanaka Y, Miyano S, Hayashi Y, Ogawa S, Oka A, Takita J
  • Organizer: 46th Congress of the International Society of Paediatric Oncology
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2014-10-22 – 2014-10-25
• [Presentation] Allogeneic hematopoietic stem cell transplantation for infants with acute lymphoblastic leukemia. (2014)
  • Author(s): Kato M, Hasegawa D, Koh K, Inagaki J, Kato K, Goto H, Takita J, Yabe H, Sawada A, Atsuta Y, Kato K
  • Organizer: 46th Congress of the International Society of Paediatric Oncology
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2014-10-22 – 2014-10-25
• [Presentation] The influences of school reentry support on relationships that adolescents with cancer share with peers and teachers. (2014)
  • Author(s): Soejima T, Sato I, Takita J, Koh K, Maeda M, Ida K, Kamibeppu K
  • Organizer: 46th Congress of the International Society of Paediatric Oncology
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2014-10-22 – 2014-10-25
• [Presentation] 次世代シーケンサーによる小児胚細胞腫瘍の変異解析． (2014)
  • Author(s): 塩澤亮輔，関正史，星野論子，吉田健一，吉田美沙，瓜生久美子，加藤元博，小川誠司，滝田順子，岡明
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] 神経芽腫大規模検体におけるgenetic landscape と予後解析． (2014)
  • Author(s): 瓜生久美子，西村力，吉田健一，関正史，星野論子，吉田美沙，加藤元博，樋渡光輝，林泰秀，田尻達郎，中川原章，小川誠司，滝田順子
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] 神経芽腫における11q領域に関連した責任遺伝子探索． (2014)
  • Author(s): 吉田美沙，関正史，加藤元博，瓜生久美子，星野論子，西村力，樋渡光輝，吉田健一，岡明，小川誠司，林泰秀，滝田順子
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] エクソーム解析とトランスクリプトーム解析を用いた肝芽腫における統合解析． (2014)
  • Author(s): 星野論子，関正史，吉田健一，加藤元博，白石友一，佐藤悠佑，千葉健一，宮野悟，林泰秀，岩中督，岡明，小川誠司，滝田順子
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] 新規ALK結合蛋白質であるFlotillin-1は、ALKの細胞膜結合の調整節を介してALKシグナルを制御する． (2014)
  • Author(s): 冨山新太，上北尚正，山口英樹，上野英明，滝田順子，佐々木一樹，中川原章，森健太郎，堺隆一
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] 胸膜肺芽腫におけるDICER 1 RNase IIIB ドメイン変異のmiRNA産生への影響． (2014)
  • Author(s): 関正史，吉田健一，白石友一，佐藤悠佑，島村徹平，千葉健一，田中洋子，花田良二，岡明，宮野悟，林泰秀，小川誠司，滝田順子
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] 小児がんの病態解明と治療標的の探索～その征服を目指して～ (2014)
  • Author(s): 滝田順子
  • Organizer: 平成26年度TCCSG総会
  • Place of Presentation: 東京
  • Year and Date: 2014-05-26
  • Invited
• [Presentation] Genome-Wide Methylation Analysis in Neuroblastoma. (2014)
  • Author(s): Seki M, Kato M, Ohyam R, Yoshida K, Sato Y, Shiraishi Y, Chiba K, Tanaka H, Arakaw Y, Kishimoto H, Sanada M, Miyano S, Oka A, Hanada R, Ogawa S, Koh K, Takit J
  • Organizer: Advances in Neuroblastoma Research 2014
  • Place of Presentation: Cologne, Germany
  • Year and Date: 2014-05-13 – 2014-05-16
• [Presentation] Analysis for Neuroblastoma Tumors to Reveal Novel Target Using Next-Generation RNA Sequencing (2014)
  • Author(s): Hiwatari M, Seki M, Kato M, Yoshida K, Ogawa S, Takita J
  • Organizer: Advances in Neuroblastoma Research 2014
  • Place of Presentation: Cologne, Germany
  • Year and Date: 2014-05-13 – 2014-05-16
• [Presentation] Genetic Landscapes of Childhood T-Cell Acute Lymphoblastic Leukemia. (2014)
  • Author(s): Seki M, Yoshida K, Shiraishi Y, Chiba K, Tanaka H, Kato M, Hiwatari M, Sanada M, Hanada R, Miyano S, Oka A, Hayashi Y, Ogawa S, Takita J
  • Organizer: Pediatric Academic Societies and Aisan Society for Pediatric Research 2014
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2014-05-03 – 2014-05-06
• [Presentation] Genome-wide analysis of T cell acute lymphoblastic leukemia with subsequent development of Langerhans cell histocytosis. (2014)
  • Author(s): Seki M, Kato M, Oyama R, Yoshida K, Sato Y, Shiraishi Y, Chiba K, Tanaka H, Arakawa Y, Kishimoto H, Miyano S, Oka A, Hanada R, Ogawa S, Koh K, Takita J
  • Organizer: 9th Biennial Childhood Leukemia Symposium
  • Place of Presentation: Prague, Czech Republic
  • Year and Date: 2014-04-28 – 2014-04-29
• [Presentation] The Genetic landscape of neuroblastoma. (2014)
  • Author(s): Uryu K, Nishimura R, Yoshida K, Seki M, Kato M, Oka A, Hayashi Y, Tajiri T, Nakagawara A, Ogawa S, Takita J
  • Organizer: The 11th Asian Society for Pediatric Research 2015
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2014-04-15 – 2014-04-18
• [Presentation] Integrated genetic and epigenetic analysis in rhabdomyosarcoma. (2014)
  • Author(s): Seki M, Yoshida K, Hosoi H, Tanaka Y, Okita H, Hanada R, Igarashi T, Oka A, Hayahshi Y, Ogawa S, Takita J
  • Organizer: The 11th Asian Society for Pediatric Research 2015
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2014-04-15 – 2014-04-18
• [Presentation] Genetic alterations in ATM pathway related genes in neuroblastoma. (2014)
  • Author(s): Yoshida M, Kato M, Uryu K, Hoshino N, Seki M, Hiwatari M, Yoshida K, Oka A, Ogawa S, Hayashi Y, Takita J
  • Organizer: The 11th Asian Society for Pediatric Research 2015
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2014-04-15 – 2014-04-18
• [Presentation] Clonal evolution and pathology in hepatoblastoma with familial adenomatous polyposis. (2014)
  • Author(s): Hoshino N, Seki M, Yoshida K, Kato M, Sato Y, Nakagawa A, Miyano S, Iwanaka T, Oka A, Ogawa S, Takita J
  • Organizer: The 11th Asian Society for Pediatric Research 2015
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2014-04-15 – 2014-04-18
• [Presentation] RNAシーケンス解析による横冠筋肉腫における新規転座の検索． (2014)
  • Author(s): 関 正史, 西村 力, 吉田 健一, 加藤 元博, 樋渡 光輝, 宮野 悟, 林 泰秀, 小川 誠司, 滝田 順子, 岡 明
  • Organizer: 第117回日本小児科学会学術集会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2014-04-11 – 2014-04-13
• [Presentation] 次世代シーケンサを用いた横紋筋肉腫の遺伝子変異全体図． (2014)
  • Author(s): 西村 力, 吉田 健一, 白石 友一, 関 正史, 真田 昌, 岡 明, 林 泰秀, 宮野 悟, 小川 誠司, 滝田 順子．
  • Organizer: 第117回日本小児科学会学術集会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2014-04-11 – 2014-04-13
• [Presentation] 全エクソーム解析を用いた肝芽腫における網羅的ゲノム解析． (2014)
  • Author(s): 星野 論子, 西村 力, 関 正史, 加藤 元博, 吉田 健一, 宮野 悟, 林 泰秀, 小川 誠司, 岡 明, 滝田 順子．
  • Organizer: 第117回日本小児科学会学術集会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2014-04-11 – 2014-04-13
• [Presentation] 次世代シークエンサーを用いた神経芽腫における11q領域の責任遺伝子探索． (2014)
  • Author(s): 吉田 美沙, 関 正史, 星野 論子, 樋渡 光輝, 加藤 元博, 吉田 健一, 小川 誠司, 林 泰秀, 滝田 順子, 岡 明．
  • Organizer: 第117回日本小児科学会学術集会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2014-04-11 – 2014-04-13
• [Presentation] 神経芽腫120検体におけるゲノム異常と予後解析． (2014)
  • Author(s): 瓜生 久美子, 関 正史, 加藤 元博, 星野 論子, 樋渡 光輝, 中川原 章, 林 泰秀, 小川 誠司, 滝田 順子, 岡 明．
  • Organizer: 第117回日本小児科学会学術集会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2014-04-11 – 2014-04-13
• [Presentation] 当院でのテイコプラニン標準投与における血中濃度解析． (2014)
  • Author(s): 塩澤 亮輔, 渡邉 健太郎, 樋渡 光輝, 加藤 元博, 滝田 順子, 岡 明．
  • Organizer: 第117回日本小児科学会学術集会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2014-04-11 – 2014-04-13
• [Presentation] 再発を繰り返すランゲルハンス組織球症の1例． (2014)
  • Author(s): 樋渡 光輝, 渡邉 健太郎, 塩澤 亮輔, 加藤 元博, 滝田 順子, 岡 明．
  • Organizer: 第117回日本小児科学会学術集会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2014-04-11 – 2014-04-13
• [Book] 神経芽腫．小児科診療ガイドライン－最後の診療指針― 第３版 (2016)
  • Author(s): 滝田順子
  • Publisher: 総合医学社